{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:16:28Z","timestamp":1778242588140,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Enfermedades infecciosas y microbiologia clinica (English ed.)"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.eimce.2026.503041","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:06:07Z","timestamp":1778241967000},"page":"503041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for drug-induced liver injury in people with HIV on anti-tuberculosis treatment"],"prefix":"10.1016","volume":"44","author":[{"given":"Pedro","family":"Mart\u00ednez-Ayala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Salgado-de la Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Velarde-Ruiz Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz Alicia","family":"Gonz\u00e1lez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Amador-Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Adri\u00e1n Alanis-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Aldana-Ledesma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Gerardo","family":"Alfaro-Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Z\u00fa\u00f1iga-Qui\u00f1onez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vida Ver\u00f3nica","family":"Ruiz-Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina Alejandra","family":"S\u00e1nchez-\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime Federico","family":"Andrade-Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.eimce.2026.503041_bib0175","series-title":"The Path that Ends AIDS: UNAIDS Global AIDS Update 2023","year":"2023"},{"key":"10.1016\/j.eimce.2026.503041_bib0180","series-title":"The Urgency of Now: AIDS at a Crossroads","year":"2024"},{"key":"10.1016\/j.eimce.2026.503041_bib0185","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMra2308181","article-title":"HIV-associated tuberculosis","volume":"391","author":"Meintjes","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.eimce.2026.503041_bib0190","series-title":"Seizing the Moment: Tackling Entrenched Inequalities to End Epidemics: Global AIDS Update 2020","year":"2020"},{"key":"10.1016\/j.eimce.2026.503041_bib0195","series-title":"Danger: UNAIDS Global AIDS Update 2022","year":"2022"},{"key":"10.1016\/j.eimce.2026.503041_bib0200","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/0974-777X.170499","article-title":"Tuberculous drug-induced liver injury and treatment re-challenge in human immunodeficiency virus co-infection","volume":"7","author":"Costiniuk","year":"2015","journal-title":"J Glob Infect Dis"},{"key":"10.1016\/j.eimce.2026.503041_bib0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094271","article-title":"Evaluation of patterns of liver toxicity in patients on antiretroviral and anti-tuberculosis drugs: a prospective four arm observational study in Ethiopian patients","volume":"9","author":"Yimer","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.eimce.2026.503041_bib0210","article-title":"The correlated risk factors for severe liver damage among HIV-positive inpatients with abnormal liver tests","volume":"9","author":"Liu","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.eimce.2026.503041_bib0215","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1093\/cid\/ciz732","volume":"70","author":"Naidoo","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.eimce.2026.503041_bib0220","doi-asserted-by":"crossref","first-page":"888","DOI":"10.5604\/16652681.1171778","article-title":"Drug-induced liver injury in hospitalized HIV patients: high incidence and association with drugs for tuberculosis","volume":"14","author":"Tomich","year":"2015","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.eimce.2026.503041_bib0225","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13104-019-4872-1","article-title":"Drug-induced hepatotoxicity among TB\/HIV co-infected patients in a referral hospital, Ethiopia","volume":"13","author":"Zeleke","year":"2020","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.eimce.2026.503041_bib0230","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1097\/QAD.0b013e32814e6b08","article-title":"Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B","volume":"21","author":"Hoffmann","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.eimce.2026.503041_bib0235","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12879-017-2330-z","article-title":"Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK","volume":"17","author":"Abbara","year":"2017","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.eimce.2026.503041_bib0240","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1164\/rccm.200510-1666ST","article-title":"An official ATS statement: hepatotoxicity of antituberculosis therapy","volume":"174","author":"Saukkonen","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.eimce.2026.503041_bib0245","doi-asserted-by":"crossref","first-page":"506","DOI":"10.7196\/SAMJ.5650","article-title":"Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa","volume":"102","author":"Schutz","year":"2012","journal-title":"S Afr Med J"},{"key":"10.1016\/j.eimce.2026.503041_bib0250","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jceh.2020.11.002","article-title":"The Indian network of drug-induced liver injury: etiology, clinical features, outcome and prognostic markers in 1288 patients","volume":"11","author":"Devarbhavi","year":"2021","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.eimce.2026.503041_bib0255","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1545109711401411","article-title":"Higher risk of severe drug-induced liver injury among Hispanic HIV-infected patients after initiation of highly active antiretroviral therapy","volume":"10","author":"Lamar","year":"2011","journal-title":"J Int Assoc Physicians AIDS Care (Chic)"},{"key":"10.1016\/j.eimce.2026.503041_bib0260","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/ajg.2017.215","article-title":"Idiosyncratic drug induced liver injury in African-Americans is associated with greater morbidity and mortality compared to Caucasians","volume":"112","author":"Chalasani","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.eimce.2026.503041_bib0265","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services (DHHS) n.d. Available from: https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/adult-and-adolescent-arv. [Accessed 16 January 2025]."},{"key":"10.1016\/j.eimce.2026.503041_bib0270","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/hep.30866","article-title":"Diagnosis and treatment of alcohol-associated liver diseases: 2019 practice guidance from the American association for the study of liver diseases","volume":"71","author":"Crabb","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.eimce.2026.503041_bib0275","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ajg.2017.469","article-title":"ACG clinical guideline: alcoholic liver disease","volume":"113","author":"Singal","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.eimce.2026.503041_bib0280","first-page":"332","article-title":"The Mexican consensus on alcoholic hepatitis","volume":"85","author":"Velarde-Ruiz Velasco","year":"2020","journal-title":"Rev Gastroenterol Mex"},{"key":"10.1016\/j.eimce.2026.503041_bib0285","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.eimce.2026.503041_bib0290","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.4102\/sajhivmed.v25i1.1558","article-title":"Management of drug-induced liver injury in people with HIV treated for tuberculosis: 2024 update","volume":"25","author":"Boyles","year":"2024","journal-title":"South Afr J HIV Med"},{"key":"10.1016\/j.eimce.2026.503041_bib0295","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL clinical practice guidelines: drug-induced liver injury","volume":"70","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.eimce.2026.503041_bib0300","series-title":"Roussel Uclaf Causality Assessment Method (RUCAM) in Drug Induced Liver Injury. LiverTox: Clinical and Research Information on Drug-induced Liver Injury","year":"2019"},{"key":"10.1016\/j.eimce.2026.503041_bib0305","first-page":"78","article-title":"Incidence of and risk factors for severe liver toxicity in HIV-infected patients on anti-tuberculosis treatment","volume":"11","author":"Pukenyte","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.eimce.2026.503041_bib0310","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1016\/j.jhep.2005.11.027","article-title":"Hepatotoxicity of antiretrovirals: incidence, mechanisms and management","volume":"44","author":"N\u00fa\u00f1ez","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.eimce.2026.503041_bib0315","article-title":"Incidence and risk factors of anti-tuberculosis drugs induced hepatotoxicity in HIV\/AIDS patients attending the Limbe and Buea regional hospitals","volume":"5","author":"Peter","year":"2014","journal-title":"J AIDS Clin Res"},{"key":"10.1016\/j.eimce.2026.503041_bib0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286306","article-title":"Does diabetes mellitus comorbidity increase the risk of drug-induced liver injury during tuberculosis treatment?","volume":"18","author":"Freire","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.eimce.2026.503041_bib0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2024.101501","article-title":"The Janus of a disease: diabetes and metabolic dysfunction-associated fatty liver disease","volume":"29","author":"Barrera","year":"2024","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.eimce.2026.503041_bib0330","doi-asserted-by":"crossref","first-page":"e3377","DOI":"10.1093\/cid\/ciaa1255","article-title":"A randomized controlled trial of intravenous n-acetylcysteine in the management of anti-tuberculosis drug-induced liver injury","volume":"73","author":"Moosa","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.eimce.2026.503041_bib0335","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12906-015-0861-7","article-title":"A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury","volume":"15","author":"Luangchosiri","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.eimce.2026.503041_bib0340","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/s12879-016-2000-6","article-title":"Effectiveness of hepatoprotective drugs for anti-tuberculosis drug-induced hepatotoxicity: a retrospective analysis","volume":"16","author":"Saito","year":"2016","journal-title":"BMC Infect Dis"}],"container-title":["Enfermedades infecciosas y microbiologia clinica (English ed.)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2529993X26000742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2529993X26000742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:07:19Z","timestamp":1778242039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2529993X26000742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2529993X26000742"],"URL":"https:\/\/doi.org\/10.1016\/j.eimce.2026.503041","relation":{},"ISSN":["2529-993X"],"issn-type":[{"value":"2529-993X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for drug-induced liver injury in people with HIV on anti-tuberculosis treatment","name":"articletitle","label":"Article Title"},{"value":"Enfermedades infecciosas y microbiologia clinica (English ed.)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.eimce.2026.503041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica.","name":"copyright","label":"Copyright"}],"article-number":"503041"}}