{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:05:19Z","timestamp":1782453919659,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.ejca.2003.10.023","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T05:57:50Z","timestamp":1071813470000},"page":"1208-1216","source":"Crossref","is-referenced-by-count":116,"title":["Prevention of oral mucositis in paediatric patients treated with chemotherapy"],"prefix":"10.1016","volume":"40","author":[{"given":"K.K.F","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2003.10.023_BIB1","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/S0959-8049(98)00169-5","article-title":"Oral complications during treatment of malignant diseases in childhood","volume":"34","author":"Bonnaure-Mallet","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejca.2003.10.023_BIB2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0030-4220(93)90404-R","article-title":"Oral complications in children with cancer","volume":"75","author":"Childers","year":"1993","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB3","first-page":"289","article-title":"Oral complications in pediatric oncology patients","volume":"13","author":"Fayle","year":"1991","journal-title":"Pediatr. Dent."},{"key":"10.1016\/j.ejca.2003.10.023_BIB4","series-title":"Clinical Oncology","first-page":"741","article-title":"Oral complications","author":"Loprinzi","year":"1995"},{"key":"10.1016\/j.ejca.2003.10.023_BIB5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1368-8375(97)00053-5","article-title":"Mucositis as a biological process","volume":"34","author":"Sonis","year":"1998","journal-title":"Oral Oncol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s005200050004","article-title":"Oral mucositis in patients treated with chemotherapy for solid tumors","volume":"8","author":"Raber-Durlacher","year":"2000","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ejca.2003.10.023_BIB7","series-title":"Principles of Antineoplastic Drug Development and Pharmacology","first-page":"375","article-title":"Cancer chemotherapy and pharmacology in children","author":"Weitman","year":"1996"},{"key":"10.1016\/j.ejca.2003.10.023_BIB8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1043-4542(97)90052-7","article-title":"Assessment and management of chemotherapy-induced mucositis in children","volume":"14","author":"Kennedy","year":"1997","journal-title":"J. Ped. Oncol. Nurs."},{"key":"10.1016\/j.ejca.2003.10.023_BIB9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0964-1955(96)00020-6","article-title":"Chemotherapy-associated oral mucosal lesions in patients with leukemia or lymphoma","volume":"32","author":"Ramirez-Amador","year":"1996","journal-title":"Eur. J. Cancer B Oral Oncol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0885-3924(01)00277-9","article-title":"A comparison of the affective state and quality of life of chemotherapy patients who do and do not develop chemotherapy-induced oral mucositis","volume":"21","author":"Dodd","year":"2001","journal-title":"J. Pain Symptom Manage"},{"key":"10.1016\/j.ejca.2003.10.023_BIB11","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1200\/JCO.2001.19.8.2201","article-title":"Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation","volume":"19","author":"Sonis","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB12","unstructured":"National Institutes of Health. Consensus Development Conference Statement on Oral Complications of Cancer Therapies: Diagnosis, Prevention, and Treatment, 17\u201319 April 1989, Bethesda, MD, 1\u201312."},{"key":"10.1016\/j.ejca.2003.10.023_BIB13","article-title":"Interventions for preventing oral mucositis for patients with cancer receiving treatment (Cochrane review)","volume":"3","author":"Clarkson","year":"2003","journal-title":"The Cochrane Library"},{"key":"10.1016\/j.ejca.2003.10.023_BIB14","article-title":"The effectiveness of strategies for preventing and treating chemotherapy and radiation induced oral mucositis in patients with cancer: a systematic review","volume":"2","author":"Kowanko","year":"1998","journal-title":"The Joanna Briggs Institute for Evidence Based Nursing and Midwifery"},{"key":"10.1016\/j.ejca.2003.10.023_BIB15","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/S0959-8049(01)00132-0","article-title":"Decrease of duration and symptoms in chemotherapy-induced oral mucositis by topical GM-CSF","volume":"37","author":"Hejna","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejca.2003.10.023_BIB16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0964-1955(96)00043-7","article-title":"Transforming growth factor-\u03b23 mediated modulation of cell cycling and attenuation of 5-fluorouracil induced oral mucositis","volume":"33","author":"Sonis","year":"1997","journal-title":"Oral Oncol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB17","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/S0959-8049(01)00248-9","article-title":"Studies on supportive care in oral mucositis","volume":"37","author":"Rijt","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejca.2003.10.023_BIB18","first-page":"808","article-title":"Oral complications from cancer therapy","volume":"23","author":"Madeya","year":"1996","journal-title":"Oncol Nurs. Forum."},{"key":"10.1016\/j.ejca.2003.10.023_BIB19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1054\/bjom.2000.0468","article-title":"Oral management of patients following oncology treatment","volume":"38","author":"Shaw","year":"2000","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.ejca.2003.10.023_BIB20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00000421-198604000-00006","article-title":"Benzydamine HCI, a new agent for the treatment of radiation mucositis of the oropharynx","volume":"9","author":"Kim","year":"1986","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB21","first-page":"99","article-title":"The use benzydamine HCI for the management of cancer therapy-induced mucositis","volume":"4","author":"Schubert","year":"1987","journal-title":"Int. J. Tissue React."},{"key":"10.1016\/j.ejca.2003.10.023_BIB22","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/0360-3016(89)90964-4","article-title":"Prevention of oral mucositis in radiation therapy","volume":"16","author":"Epstein","year":"1989","journal-title":"Int. J. Rad. Oncol. Biol. Phys."},{"key":"10.1016\/j.ejca.2003.10.023_BIB23","first-page":"443","article-title":"The effectiveness and side effects of 0.1% and 0.2% of chlorhexidine mouthrinses","volume":"29","author":"Ernst","year":"1998","journal-title":"Quintessence Int."},{"key":"10.1016\/j.ejca.2003.10.023_BIB24","first-page":"325","article-title":"Development, testing, and application of the oral assessment","volume":"15","author":"Eilers","year":"1988","journal-title":"Oncol. Nurs. Forum"},{"key":"10.1016\/j.ejca.2003.10.023_BIB25","series-title":"Sequential Medical Trials","author":"Armitage","year":"1975"},{"key":"10.1016\/j.ejca.2003.10.023_BIB26","series-title":"Clinical Trials: A Practical Approach","author":"Pocock","year":"1996"},{"key":"10.1016\/j.ejca.2003.10.023_BIB27","series-title":"The Design and Analysis of Sequential Clinical Trials","author":"Whitehead","year":"1997"},{"key":"10.1016\/j.ejca.2003.10.023_BIB28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","article-title":"Analysis of serial measurements in medical research","volume":"300","author":"Matthews","year":"1990","journal-title":"Br. Med. J."},{"key":"10.1016\/j.ejca.2003.10.023_BIB29","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/S0959-8049(01)00098-3","article-title":"Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients","volume":"37","author":"Cheng","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejca.2003.10.023_BIB30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1754-4505.1998.tb01738.x","article-title":"Incidence of oral complications and application of a preventive protocol in children with acute leukemia","volume":"18","author":"Levy-Polack","year":"1998","journal-title":"Special Care Dentistry"},{"key":"10.1016\/j.ejca.2003.10.023_BIB31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0009-9260(88)80538-5","article-title":"The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation","volume":"39","author":"Samaranayake","year":"1988","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB32","first-page":"921","article-title":"Randomized clinical trial of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy","volume":"23","author":"Dodd","year":"1996","journal-title":"Oncol. Nurs. Forum."},{"key":"10.1016\/j.ejca.2003.10.023_BIB33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/028418698429586","article-title":"Clinical and pharmacokinetic risk factors for high-dose methotrexate-induced toxicity in children with acute lymphoblastic leukemia","volume":"37","author":"Rask","year":"1998","journal-title":"Acta Oncol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB34","first-page":"43","article-title":"Oral condition in children treated with bone marrow transplantation","volume":"3","author":"Dahllof","year":"1988","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ejca.2003.10.023_BIB35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0030-4220(93)90198-D","article-title":"Changes in the oral microflora during cytotoxic chemotherapy in children being treated for acute leukemia","volume":"76","author":"O'Sullivan","year":"1993","journal-title":"Oral Surg. Oral. Med. Oral Path."},{"key":"10.1016\/j.ejca.2003.10.023_BIB36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s005990070028","article-title":"Differential effect of benzydamine on pro-versus anti-inflammatory cytokine production","author":"Sironi","year":"2000","journal-title":"Int. J. Clin. Lab. Res."},{"key":"10.1016\/j.ejca.2003.10.023_BIB37","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/1097-0142(20010815)92:4<875::AID-CNCR1396>3.0.CO;2-1","article-title":"Benzydamine HCl for prophylaxis of radiation-induced oral mucositis","volume":"92","author":"Epstein","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2003.10.023_BIB38","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1200\/JCO.1994.12.12.2630","article-title":"Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis","volume":"12","author":"Foote","year":"1994","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejca.2003.10.023_BIB39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0765.1982.tb01135.x","article-title":"Effects of supervised chlorhexidine mouthrinses in children","volume":"17","author":"Lang","year":"1982","journal-title":"J. Periodontol. Res."}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804903009626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804903009626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T21:53:21Z","timestamp":1550267601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804903009626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0959804903009626"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2003.10.023","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}