{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:06:30Z","timestamp":1791061590556,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.ejca.2004.06.028","type":"journal-article","created":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T09:09:01Z","timestamp":1092733741000},"page":"2389-2395","source":"Crossref","is-referenced-by-count":41,"title":["Independent prognostic factors for distant metastases and survival in patients with primary uveal melanoma"],"prefix":"10.1016","volume":"40","author":[{"given":"Alexander","family":"Schmittel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos E.","family":"Bechrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Martus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Mutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Scheibenbogen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Bornfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Foerster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Keilholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2004.06.028_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0039-6257(88)90173-7","article-title":"Epidemiologic aspects of uveal melanoma","volume":"32","author":"Egan","year":"1988","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1001\/archopht.1992.01080140101036","article-title":"A review of mortality from choroidal melanoma. II. A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988","volume":"110","author":"Diener-West","year":"1992","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0039-6257(91)90001-V","article-title":"Management of posterior uveal melanoma","volume":"36","author":"Shields","year":"1991","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib4","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/1097-0142(19951101)76:9<1665::AID-CNCR2820760925>3.0.CO;2-J","article-title":"Treatment of uveal melanoma metastatic to the liver: a review of the M. D. Anderson Cancer Center experience and prognostic factors","volume":"76","author":"Bedikian","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2004.06.028_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0161-6420(91)32285-1","article-title":"Survival of patients with metastases from uveal melanoma","volume":"98","author":"Gragoudas","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ejca.2004.06.028_bib6","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/1097-0142(19931001)72:7<2219::AID-CNCR2820720725>3.0.CO;2-J","article-title":"Prognosis and treatment of disseminated uveal melanoma","volume":"72","author":"Kath","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2004.06.028_bib7","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1001\/archopht.1983.01040020896012","article-title":"A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma","volume":"101","author":"Seddon","year":"1983","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0039-6257(96)80024-5","article-title":"Prognostic parameters in uveal melanoma: a review","volume":"41","author":"Mooy","year":"1996","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archopht.1977.04450010065005","article-title":"Prognostic factors in choroidal and ciliary body melanomas","volume":"95","author":"Shammas","year":"1977","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib10","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0161-6420(98)99037-6","article-title":"Long-term survival in choroidal and ciliary body melanoma after enucleation versus plaque radiation therapy","volume":"105","author":"Augsburger","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ejca.2004.06.028_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0360-3016(01)01560-7","article-title":"Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma","volume":"51","author":"Egger","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ejca.2004.06.028_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/PL00007880","article-title":"Long-term follow-up of Ru-106\/Rh-106 brachytherapy for posterior uveal melanoma","volume":"238","author":"Lommatzsch","year":"2000","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib13","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archopht.119.7.969","article-title":"Collaborative Ocular Melanoma Study Group. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. COMS Report No. 18","volume":"119","author":"Diener-West","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1097-0215(19960703)67:1<54::AID-IJC11>3.0.CO;2-C","article-title":"Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptides in vivo","volume":"67","author":"Jager","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejca.2004.06.028_bib15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<219::AID-IJC10>3.0.CO;2-S","article-title":"Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1","volume":"80","author":"Marchand","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejca.2004.06.028_bib16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ijc.10328","article-title":"Long-term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides","volume":"99","author":"Scheibenbogen","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejca.2004.06.028_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/ijc.10961","article-title":"Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides","volume":"104","author":"Scheibenbogen","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejca.2004.06.028_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/archopht.117.2.170","article-title":"Plaque radiotherapy of uveal melanoma with predominant ciliary body involvement","volume":"117","author":"G\u00fcnd\u00fcz","year":"1999","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0360-3016(90)90530-W","article-title":"Ciliary body melanoma treated with helium particle irradiation","volume":"19","author":"Decker","year":"1990","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ejca.2004.06.028_bib20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00008390-200106000-00007","article-title":"Prognostic factors in uveal melanoma","volume":"11","author":"Singh","year":"2001","journal-title":"Melanoma Res."},{"key":"10.1016\/j.ejca.2004.06.028_bib21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/(SICI)1096-9896(200006)191:2<120::AID-PATH591>3.0.CO;2-P","article-title":"The prognostic value of cyclin D1, p53, and MDM2 protein expression in uveal melanoma","volume":"191","author":"Coupland","year":"2000","journal-title":"J. Pathol."},{"key":"10.1016\/j.ejca.2004.06.028_bib22","first-page":"2023","article-title":"Expression of epidermal growth factor receptor: risk factor in uveal melanoma","volume":"41","author":"Hurks","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejca.2004.06.028_bib23","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/archopht.121.8.1117","article-title":"Prognostic value of S-100-beta serum concentration in patients with uveal melanoma","volume":"121","author":"Missotten","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/archopht.121.1.68","article-title":"Tumor basal area ans metastatic death after proton beam irradiation for choroideal melanoma","volume":"121","author":"Li","year":"2003","journal-title":"Arch. Opthalmol."},{"key":"10.1016\/j.ejca.2004.06.028_bib25","doi-asserted-by":"crossref","unstructured":"Assessment of metastatic disease status at death in 435 patients with large choroideal melanoma in the Collaborative Ocular Melanoma Study (COMS). Arch Opthalmol 2001, 119, 670-676","DOI":"10.1001\/archopht.119.5.670"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804904005295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804904005295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T16:52:23Z","timestamp":1549299143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804904005295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":25,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0959804904005295"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2004.06.028","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}