{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:55:21Z","timestamp":1760954121402},"reference-count":46,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.ejca.2006.01.021","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T12:10:19Z","timestamp":1143547819000},"page":"972-980","source":"Crossref","is-referenced-by-count":44,"title":["Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma"],"prefix":"10.1016","volume":"42","author":[{"given":"Eun Ju","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Bin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mog","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Hoseok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joungho","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Yoon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joobae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2006.01.021_bib1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/ijc.2910540413","article-title":"Estimates of the worldwide incidence of eighteen major cancers in 1985","volume":"54","author":"Parkin","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/ijc.2910540309","article-title":"Increasing incidence of both major histological types of esophageal carcinoma among men in Sweden","volume":"54","author":"Hansson","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib3","first-page":"191","article-title":"Esophageal cancer","volume":"XVIII","author":"Ozols","year":"1994","journal-title":"Curr Probl Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib4","first-page":"2996","article-title":"Allelotype analysis of esophageal squamous cell carcinoma","volume":"54","author":"Shibagaki","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib5","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/hmg\/3.11.1969","article-title":"Accumulation of genetic alterations during esophageal carcinogenesis","volume":"3","author":"Mori","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ejca.2006.01.021_bib6","first-page":"891","article-title":"Frequent microsatellite alterations on chromosome 3p in esophageal squamous cell carcinoma","volume":"55","author":"Ogasawara","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)81034-X","article-title":"The FHIT gene spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancer","volume":"84","author":"Ohta","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ejca.2006.01.021_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.onc.1201169","article-title":"FHIT gene alterations in esophageal cancer and ulcerative colitis (UC","volume":"15","author":"Zou","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.ejca.2006.01.021_bib9","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/sj.onc.1201330","article-title":"Frequent deletions of FHIT and FRA3B in Barret\u2019s metaplasis and esophageal adenocarcinomas","volume":"15","author":"Michael","year":"1997","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.ejca.2006.01.021_bib10","first-page":"4098","article-title":"Genetic progression and heterogeneity associated with the development of esophageal squamous cell carcinoma","volume":"61","author":"Roth","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/35106058","article-title":"FRA3B and other common fragile site: The weakest links","volume":"1","author":"Huebner","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib12","first-page":"3724","article-title":"Allele loss and promoter hypermethylation of VHL, RAR-\u03b2, RASSF1A, and FHIT tumour suppressor genes on chromosome 3p in esophageal squamous cell carcinoma","volume":"63","author":"Kuroki","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib13","first-page":"1177","article-title":"Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus","volume":"60","author":"Mori","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/1097-0142(20000701)89:1<5::AID-CNCR2>3.0.CO;2-Z","article-title":"Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient\u2019s prognosis and smoking history","volume":"89","author":"Shimada","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib15","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1073\/pnas.080063497","article-title":"Muir-Torre-like syndrome in Fhit-deficient mice","volume":"97","author":"Fong","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"15","key":"10.1016\/j.ejca.2006.01.021_bib16","first-page":"3429","article-title":"Methylation of the 5\u2032 CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas","volume":"58","author":"Tanaka","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib17","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/carcin\/23.10.1713","article-title":"Detection of multiple gene hypermethylation in the development of esophageal squamous cell carcinoma","volume":"23","author":"Nie","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejca.2006.01.021_bib18","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ejca.2006.01.021_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ijc.2910580211","article-title":"Multiple occurrence of carcinoma in the upper aerodigestive tract associated with esophageal cancer: reference to smoking, drinking and family history","volume":"58","author":"Morita","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib20","first-page":"2121","article-title":"Association between cigarette smoking and FHIT gene alterations in lung cancer","volume":"57","author":"Sozzi","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib21","first-page":"5032","article-title":"Loss of FHIT function in lung cancer and preinvasive bronchial lesions","volume":"58","author":"Sozzi","year":"1998","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.ejca.2006.01.021_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/bjc.1998.445","article-title":"Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus","volume":"78","author":"Marchetti","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib23","first-page":"1804","article-title":"Chromosome 3p14 alterations in lung cancer: Evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos","volume":"58","author":"Nelson","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib24","first-page":"5478","article-title":"Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma","volume":"58","author":"Tomizawa","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib25","first-page":"4798","article-title":"Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers","volume":"59","author":"Tseng","year":"1999","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.ejca.2006.01.021_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1054\/bjoc.2000.1528","article-title":"Loss of heterozygosity is related to p53 mutations and smoking in lung cancer","volume":"84","author":"Zienolddiny","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/gcc.10061","article-title":"Direct correlation between FRA3B expression and cigarette smoking","volume":"34","author":"Stein","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.ejca.2006.01.021_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1183\/09031936.03.00090202","article-title":"Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53","volume":"21","author":"Mascaux","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ejca.2006.01.021_bib29","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1093\/carcin\/bgh217","article-title":"Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung","volume":"25","author":"Kim","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejca.2006.01.021_bib30","doi-asserted-by":"crossref","first-page":"10250","DOI":"10.1073\/pnas.191345898","article-title":"The tumour spectrum in FHIT-deficient mice","volume":"98","author":"Zansei","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.ejca.2006.01.021_bib31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000055376","article-title":"Reduced Fhit expression occurs in the early stage of esophageal tumourigenesis: no correlation with p53 expression and apoptosis","volume":"61","author":"Kitamura","year":"2001","journal-title":"Oncology"},{"key":"10.1016\/j.ejca.2006.01.021_bib32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(00)81078-8","article-title":"The FHIT gene 3p14.2 is abnormal in lung cancer","volume":"85","author":"Sozzi","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ejca.2006.01.021_bib33","doi-asserted-by":"crossref","first-page":"13771","DOI":"10.1073\/pnas.94.25.13771","article-title":"Replacement of Fhit in cancer cells suppresses tumourigenicity","volume":"94","author":"Siprashvili","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ejca.2006.01.021_bib34","first-page":"3333","article-title":"Induction of apoptosis and inhibition of tumourigenicity and tumour growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression","volume":"59","author":"Lin","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib35","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.1073\/pnas.96.15.8489","article-title":"The tumour-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control","volume":"96","author":"Sard","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ejca.2006.01.021_bib36","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1073\/pnas.061020098","article-title":"FHIT gene therapy prevents tumour development in Fhit-deficient mice","volume":"98","author":"Dumon","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.ejca.2006.01.021_bib37","first-page":"1578","article-title":"Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells","volume":"61","author":"Ishii","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib38","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1001\/jama.286.19.2441","article-title":"Potential cancer therapy with the fragile histidine triad gene","volume":"286","author":"Ishii","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ejca.2006.01.021_bib39","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/BF03401849","article-title":"Aberration of FHIT gene is associated with increased tumour proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas","volume":"7","author":"Pavelic","year":"2001","journal-title":"Mol Med"},{"key":"10.1016\/j.ejca.2006.01.021_bib40","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1073\/pnas.062030799","article-title":"Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumourigenicity in lung and cervical cancer cell lines","volume":"99","author":"Roz","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ejca.2006.01.021_bib41","first-page":"1183","article-title":"Restoration of Fragile Histidine Triad (FHIT) expression induces apoptosis and suppresses tumourigenicity in breast cancer cell lines","volume":"63","author":"Sevignani","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib42","doi-asserted-by":"crossref","first-page":"8439","DOI":"10.1038\/sj.onc.1207847","article-title":"Dose-dependent effect of FHIT-inducible expression in Calu-1 lung cancer","volume":"23","author":"Cavazzoni","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ejca.2006.01.021_bib43","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/jnci\/90.6.426","article-title":"Protein expression and functional analysis of the FHIT gene in human tumour cells","volume":"90","author":"Otterson","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejca.2006.01.021_bib44","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/jnci\/92.4.338","article-title":"Restored expression of fragile histidine triad protein and tumourigenicity of cervical carcinoma cells","volume":"92","author":"Wu","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejca.2006.01.021_bib45","first-page":"2780","article-title":"Differential susceptibility of renal carcinoma cell lines to tumour suppression by exogenous Fhit expression","volume":"60","author":"Werner","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2006.01.021_bib46","first-page":"4827","article-title":"Fragile histidine triad expression delays tumour development and induces apoptosis in human pancreatic cancer","volume":"61","author":"Dumon","year":"2001","journal-title":"Cancer Res"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804906001195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804906001195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T17:06:05Z","timestamp":1555520765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804906001195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0959804906001195"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2006.01.021","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}