{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:06:27Z","timestamp":1791007587721,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.ejca.2006.12.009","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T12:16:43Z","timestamp":1172060203000},"page":"867-876","source":"Crossref","is-referenced-by-count":191,"title":["Tumour characteristics, survival and prognostic factors of hereditary breast cancer from BRCA2-, BRCA1- and non-BRCA1\/2 families as compared to sporadic breast cancer cases"],"prefix":"10.1016","volume":"43","author":[{"given":"C.T.M.","family":"Brekelmans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.A.","family":"Tilanus-Linthorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Seynaeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"vd Ouweland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B.E.","family":"Menke-Pluymers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.M.","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kriege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.N.","family":"van Geel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.M.","family":"Eggermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Meijers-Heijboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.M.","family":"Klijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2006.12.009_bib1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/jnci\/91.11.943","article-title":"Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer","volume":"91","author":"Peto","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejca.2006.12.009_bib2","first-page":"486","article-title":"Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes?","volume":"60","author":"Serova","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejca.2006.12.009_bib3","first-page":"107S","article-title":"Immunophenotypic and pathologic differences between BRCA1 and BRCA2 hereditary breast cancers","volume":"18","author":"Phillips","year":"2000","journal-title":"J Clin Oncol"},{"issue":"15","key":"10.1016\/j.ejca.2006.12.009_bib4","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/jnci\/90.15.1138","article-title":"Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations","volume":"90","author":"Lakhani","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejca.2006.12.009_bib5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrc1431","article-title":"BRCA1 and BRCA2: 1994 and beyond","volume":"4","author":"Narod","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ejca.2006.12.009_bib6","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1200\/JCO.1999.17.11.3653","article-title":"Breast carcinomas arising in carriers of mutations in BRCA1 or BRCA2: are they prognostically different?","volume":"17","author":"Phillips","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/annonc\/mdj095","article-title":"Survival and prognostic factors in BRCA1-associated breast cancer","volume":"17","author":"Brekelmans","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib8","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1200\/JCO.1999.17.11.3396","article-title":"Survival in hereditary breast cancer associated with germline mutations of BRCA2","volume":"17","author":"Verhoog","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1023\/A:1005853022804","article-title":"Inherited BRCA2 mutation associated with high grade breast cancer","volume":"47","author":"Agnarsson","year":"1998","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejca.2006.12.009_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJM200102223440801","article-title":"Gene-expression profiles in hereditary breast cancer","volume":"344","author":"Hedenfalk","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2006.12.009_bib11","doi-asserted-by":"crossref","first-page":"7503","DOI":"10.1200\/JCO.2005.01.3698","article-title":"Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors","volume":"23","author":"Honrado","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib12","first-page":"119s","article-title":"Prognostic significance of germline BRCA2 mutations in hereditary breast cancer patients","volume":"18","author":"Verhoog","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0959-8049(00)00098-8","article-title":"Prognosis and clinical presentation of BRCA2-associated breast cancer","volume":"36","author":"Loman","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2006.12.009_bib14","first-page":"368","article-title":"Survival of breast cancer patients in BRCA1, BRCA2, and non-BRCA1\/2 breast cancer families: a relative survival analysis from Finland","volume":"93","author":"Eerola","year":"2001","journal-title":"IJC"},{"key":"10.1016\/j.ejca.2006.12.009_bib15","first-page":"S33","article-title":"Survival and recurrence following breast cancer in BRCA1& 2 mutation carriers","volume":"10","author":"El-Tamer","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib16","first-page":"782","article-title":"The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1, BRCA2","volume":"6","author":"Lakhani","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejca.2006.12.009_bib17","doi-asserted-by":"crossref","unstructured":"The CHEK2-breast cancer consortium. Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nature Genet 2002;31:55\u20139.","DOI":"10.1038\/ng879"},{"key":"10.1016\/j.ejca.2006.12.009_bib18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/jmg.2004.019737","article-title":"Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant","volume":"41","author":"de Bock","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejca.2006.12.009_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10549-005-9054-2","article-title":"Selection bias influences reported contralateral breast cancer incidence and survival in high risk non-BRCA1\/2 patients","volume":"95","author":"Tilanus-Linthorst","year":"2006","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejca.2006.12.009_bib20","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/humu.20340","article-title":"A DGGE system for comprehensieve mutation screening of BRCA1 and BRCA2. Application in a Dutch cancer clinic setting","volume":"27","author":"van der Hout","year":"2006","journal-title":"Human Mutat"},{"key":"10.1016\/j.ejca.2006.12.009_bib21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ng0695-208","article-title":"Rapid detection of BRCA1 mutations by the protein truncation test","volume":"10","author":"Hogervorst","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejca.2006.12.009_bib22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/ng1197-341","article-title":"Large genomic deletions in BRCA1 as major founder mutations among dutch breast cancer families","volume":"17","author":"Petrij-Bosch","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejca.2006.12.009_bib23","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0046-8177(98)90427-0","article-title":"Pathobiologic characteristics of hereditary breast cancer","volume":"29","author":"Lynch","year":"1998","journal-title":"Human Pathol"},{"key":"10.1016\/j.ejca.2006.12.009_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/B:BREA.0000003836.91844.b5","article-title":"p53 inactivation is a rare event in familial breast tumors negative for BRCA1 and BRCA2 mutations","volume":"82","author":"Sensi","year":"2003","journal-title":"Breast Cancer Res Treat"},{"issue":"10","key":"10.1016\/j.ejca.2006.12.009_bib25","first-page":"2200","article-title":"Clinicopathological analysis of BRCA1- or BRCA2- associated hereditary breast carcinoma in Japanese women","volume":"85","author":"Noguchi","year":"1999","journal-title":"Ca"},{"key":"10.1016\/j.ejca.2006.12.009_bib26","first-page":"2335","article-title":"The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study","volume":"83","author":"Armes","year":"1998","journal-title":"Ca"},{"key":"10.1016\/j.ejca.2006.12.009_bib27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11864-005-0022-1","article-title":"Utilizing prognostic and predictive factors in breast cancer","volume":"6","author":"Subramaniam","year":"2005","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib28","doi-asserted-by":"crossref","first-page":"R465","DOI":"10.1186\/bcr1025","article-title":"Relationship of patients\u2019 age to histopathological features of breast tumours in BRCA1 and BRCA2 and mutation-negative breast cancer families","volume":"7","author":"Eerola","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ejca.2006.12.009_bib29","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1158\/1078-0432.CCR-03-1061","article-title":"Estrogen receptor status in BRCA1 and BRCA2-related breast cancer: the influence of age, grade, and histological type","volume":"10","author":"Foulkes","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejca.2006.12.009_bib30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/jnci\/djh025","article-title":"Risk factors for breast cancer according to estrogen and progesterone receptor status","volume":"96","author":"Colditz","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejca.2006.12.009_bib31","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0959-8049(98)00248-2","article-title":"Predicted anti-oestrogen resistance in BRCA-associated familial breast cancers","volume":"34","author":"Osin","year":"1998","journal-title":"EJC"},{"key":"10.1016\/j.ejca.2006.12.009_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ygyno.2004.09.039","article-title":"The risk of ovarian cancer after breast cancer in BRCA1 and BRCA2 carriers","volume":"96","author":"Metcalfe","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejca.2006.12.009_bib33","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1016\/j.ejca.2005.02.037","article-title":"Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy","volume":"41","author":"Kirova","year":"2005","journal-title":"Eur J Cancer"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804906010707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804906010707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T20:32:11Z","timestamp":1556137931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804906010707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0959804906010707"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2006.12.009","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}