{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:09:33Z","timestamp":1790762973539,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.ejca.2007.03.010","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T07:13:59Z","timestamp":1177658039000},"page":"1290-1299","source":"Crossref","is-referenced-by-count":25,"title":["Analysis of population characteristics related to the total effective xenoestrogen burden: A biomarker of xenoestrogen exposure in breast cancer"],"prefix":"10.1016","volume":"43","author":[{"given":"Mariana F.","family":"Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Santa-Marina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus M.","family":"Ibarluzea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Exposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Aurrekoetxea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Torne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Laguna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Pedraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Olea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2007.03.010_bib1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1582-4934.2005.tb00350.x","article-title":"Understanding breast cancer risk. Where do we stand in 2005?","volume":"9","author":"Dumitrescu","year":"2005","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ejca.2007.03.010_bib2","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.1038\/sj.onc.1207726","article-title":"International variation","volume":"23","author":"Parkin","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ejca.2007.03.010_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/eurpub\/13.2.115","article-title":"Examining geographic patterns of mortality. The atlas of mortality in small areas in Spain (1987\u20131995)","volume":"13","author":"Benach","year":"2003","journal-title":"Eur J Public Health"},{"key":"10.1016\/j.ejca.2007.03.010_bib4","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/sj.bjc.6600596","article-title":"Alcohol, tobacco and breast cancer: collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease","volume":"87","author":"Hamajima","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejca.2007.03.010_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/09513590500128492","article-title":"Breast cancer and sex steroids: critical review of epidemiological, experimental and clinical investigations on etiopathogenesis, chemoprevention and endocrine treatment of breast cancer","volume":"20","author":"Gadducci","year":"2005","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ejca.2007.03.010_bib6","first-page":"55","article-title":"Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk","volume":"9","author":"Aronson","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1590\/S0102-311X1998000700013","article-title":"Organochlorine exposure and breast cancer risk in Colombian women","volume":"14","author":"Olaya-Contreras","year":"1998","journal-title":"Cad Saude Publica"},{"key":"10.1016\/j.ejca.2007.03.010_bib8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/aje\/152.4.363","article-title":"Breast cancer, lactation history, and serum organochlorines","volume":"152","author":"Romieu","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejca.2007.03.010_bib9","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/S0140-6736(98)04504-8","article-title":"Organochlorine exposure and risk of breast cancer","volume":"352","author":"Hoyer","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ejca.2007.03.010_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1008926219539","article-title":"Repeated measurements of organochlorine exposure and breast cancer risk (Denmark)","volume":"11","author":"Hoyer","year":"2000","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.ejca.2007.03.010_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1008824131727","article-title":"Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA)","volume":"10","author":"Dorgan","year":"1999","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.ejca.2007.03.010_bib12","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJM199710303371801","article-title":"Plasma organochlorine levels and the risk of breast cancer","volume":"337","author":"Hunter","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2007.03.010_bib13","first-page":"3728","article-title":"Dichlordyltrichloroethane serum levels and breast cancer risk: a case\u2013control study from Mexico","volume":"57","author":"Lopez-Carrillo","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejca.2007.03.010_bib14","first-page":"525","article-title":"Serum concentrations of organochlorine compounds and subsequent development of breast cancer","volume":"8","author":"Helzlsouer","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib15","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/(SICI)1097-0215(19991126)83:5<596::AID-IJC4>3.0.CO;2-P","article-title":"Organochlorines and breast cancer: a case\u2013control study in Brazil","volume":"83","author":"Mendoca","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2007.03.010_bib16","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/jnci\/93.10.768","article-title":"1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five US studies","volume":"93","author":"Laden","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejca.2007.03.010_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.315.7100.81","article-title":"DDT (dicophane) and postmenopausal breast cancer in Europe: case\u2013control study","volume":"315","author":"van\u2019t Veer","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.ejca.2007.03.010_bib18","first-page":"1241","article-title":"Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York","volume":"9","author":"Stellman","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib19","first-page":"271","article-title":"Risk of breast cancer and organochlorine exposure","volume":"9","author":"Wolff","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib20","first-page":"167","article-title":"Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2,2\u2032-bis(p-chlorophenyl)ethylene","volume":"9","author":"Zheng","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1081>3.0.CO;2-W","article-title":"Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the Nurses\u2019 Health Study","volume":"91","author":"Laden","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2007.03.010_bib22","first-page":"686","article-title":"Environmental toxins and breast cancer on Long Island II. Organochlorine compound levels in blood","volume":"11","author":"Gammon","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1289\/ehp.01109s135","article-title":"Pesticides and breast cancer risk: a review of DDT, DDE, and Dieldrin","volume":"109","author":"Snedeker","year":"2001","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ejca.2007.03.010_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1034\/j.1600-0463.2001.090501.x","article-title":"Epidemiology of breast cancer: an environmental disease?","volume":"109","author":"Sasco","year":"2001","journal-title":"APMIS"},{"key":"10.1016\/j.ejca.2007.03.010_bib25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1289\/ehp.01109391","article-title":"Mixtures of four organochlorines enhance human breast cancer cell proliferation","volume":"104","author":"Payne","year":"2001","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ejca.2007.03.010_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/01.ede.0000190603.52867.22","article-title":"Exposure misclassification in studies of agricultural pesticides: insights from biomonitoring","volume":"17","author":"Acquavella","year":"2006","journal-title":"Epidemiol"},{"key":"10.1016\/j.ejca.2007.03.010_bib27","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1093\/clinchem\/41.12.1888","article-title":"Development of a marker of oestrogenic exposure in human serum","volume":"41","author":"Sonnenschein","year":"1995","journal-title":"Clin Chem"},{"key":"10.1016\/j.ejca.2007.03.010_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00216-004-2558-5","article-title":"Assessment of total effective xenoestrogen burden in adipose tissue and identification of chemicals responsible for the combined estrogenic effect","volume":"379","author":"Fernandez","year":"2004","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.ejca.2007.03.010_bib29","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1023\/B:CACO.0000036167.51236.86","article-title":"Breast cancer risk and the combined effect of environmental estrogens","volume":"13","author":"Ibarluzea","year":"2004","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.ejca.2007.03.010_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1289\/ehp.95103s7113","article-title":"The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants","volume":"103","author":"Soto","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ejca.2007.03.010_bib31","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1289\/ehp.95103844","article-title":"The E-screen assay: a comparison of different MCF7 cell stocks","volume":"103","author":"Villalobos","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ejca.2007.03.010_bib32","unstructured":"SPPS Inc. SPSS 9.0 base sintax reference guide. Chicago: SPSS Inc.; 1999."},{"key":"10.1016\/j.ejca.2007.03.010_bib33","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1158\/1055-9965.416.13.3","article-title":"Distribution of persistent, lipid-soluble chemicals in breast and abdominal adipose tissues: lessons learned from a breast cancer study","volume":"13","author":"Petreas","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib34","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1079\/PHN2002396","article-title":"Overweight, obesity and fat distribution in 50- to 64-year-old participants in the European Prospective Investigation into Cancer and Nutrition (EPIC)","volume":"5","author":"Haftenberger","year":"2002","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.ejca.2007.03.010_bib35","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/10408449509017924","article-title":"Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence","volume":"25","author":"Ahlborg","year":"1995","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.ejca.2007.03.010_bib36","first-page":"132","article-title":"High human plasma levels of organochlorine compounds in Greenland","volume":"47","author":"Deutch","year":"2000","journal-title":"Danish Med Bull"},{"key":"10.1016\/j.ejca.2007.03.010_bib37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/ajim.10043","article-title":"Exposures associated with serum organochlorine levels among postmenopausal women from western New York State","volume":"41","author":"Moysich","year":"2002","journal-title":"Am J Ind Med"},{"key":"10.1016\/j.ejca.2007.03.010_bib38","first-page":"179","article-title":"Environmental contaminants and body fat distribution","volume":"8","author":"Schildkraut","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejca.2007.03.010_bib39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/enrs.2002.4334","article-title":"Distribution of organobrominated and organochlorinated contaminants in Belgian human adipose tissue","volume":"88","author":"Covaci","year":"2002","journal-title":"Environ Res"},{"key":"10.1016\/j.ejca.2007.03.010_bib40","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0045-6535(00)00149-1","article-title":"Factors affecting the transfer of organochlorine pesticide residues to breastmilk","volume":"43","author":"Harris","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejca.2007.03.010_bib41","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.chemosphere.2005.07.024","article-title":"Environmental and lifestyle factors for organochlorine exposure among women living in Southern Spain","volume":"62","author":"Cerrillo","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejca.2007.03.010_bib42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.envres.2003.10.001","article-title":"Exposure of women to organochlorine pesticides in Southern Spain","volume":"96","author":"Botella","year":"2004","journal-title":"Environ Res"},{"key":"10.1016\/j.ejca.2007.03.010_bib43","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/jnci\/85.23.1917","article-title":"Upregulation of estradiol C16 alpha-hydroxylation in human breast tissue: a potential biomarker of breast cancer risk","volume":"85","author":"Osborne","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejca.2007.03.010_bib44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2796.2001.00839.x","article-title":"The role of gene\u2013environment interaction in the aetiology of human cancer: examples from cancers of the large bowel, lung and breast","volume":"249","author":"Mucci","year":"2001","journal-title":"J Intern Med"},{"key":"10.1016\/j.ejca.2007.03.010_bib45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1184>3.0.CO;2-H","article-title":"Genetic susceptibility to breast cancer in French-Canadians: Role of carcinogen-metabolizing enzymes and gene\u2013environment interactions","volume":"92","author":"Krajinovic","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2007.03.010_bib46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1191\/096032701670538508","article-title":"The miseries of passive smoking","volume":"20","author":"Nelson","year":"2001","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.ejca.2007.03.010_bib47","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1203\/00006450-200005000-00007","article-title":"Parental smoking and neonatal serum levels of polychlorinated biphenyls and hexachlorobenzene","volume":"47","author":"Lackmann","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ejca.2007.03.010_bib48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0015-0282(02)02984-9","article-title":"Aromatization of androgens in women: current concepts and findings","volume":"7","author":"Simpson","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejca.2007.03.010_bib49","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1210\/jc.83.5.1797","article-title":"Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma","volume":"83","author":"Agarwal","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejca.2007.03.010_bib50","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1124\/pr.57.3.6","article-title":"Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment","volume":"57","author":"Bulun","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.ejca.2007.03.010_bib51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1210\/jc.75.1.195","article-title":"Measurement of estradiol-17-fatty acid esters in human tissues","volume":"75","author":"Larner","year":"1992","journal-title":"J Clin Endocrinol Metab"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804907002274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804907002274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T12:32:21Z","timestamp":1683808341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804907002274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0959804907002274"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2007.03.010","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}