{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:54:42Z","timestamp":1791140082675,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.ejca.2007.07.027","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T11:19:33Z","timestamp":1189250373000},"page":"2396-2403","source":"Crossref","is-referenced-by-count":43,"title":["Childhood leukaemia and infectious exposure: A report from the United Kingdom Childhood Cancer Study (UKCCS)"],"prefix":"10.1016","volume":"43","author":[{"given":"Jill","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Ansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.ejca.2007.07.027_bib1","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1038\/sj.onc.1207898","article-title":"Infections and immune factors in cancer: the role of epidemiology","volume":"23","author":"Kinlen","year":"2004","journal-title":"Oncogene"},{"issue":"Feb 9","key":"10.1016\/j.ejca.2007.07.027_bib2","article-title":"Infection, immune responses and the aetiology of childhood leukaemia","author":"Greaves","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.ejca.2007.07.027_bib3","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/ije\/dyl193","article-title":"Childhood leukaemia and socioeconomic status: fact or artefact? A report from the United Kingdom childhood cancer study (UKCCS)","volume":"35","author":"Smith","year":"2006","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.ejca.2007.07.027_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/ije\/dyi248","article-title":"Socioeconomic status and childhood leukaemia: a review","volume":"35","author":"Poole","year":"2006","journal-title":"Int J Epidemiol"},{"issue":"9","key":"10.1016\/j.ejca.2007.07.027_bib5","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s10552-005-0402-7","article-title":"Childhood Cancer and Social Contact: the Role of Paternal Occupation (United Kingdom)","volume":"16","author":"Fear","year":"2005","journal-title":"Cancer Causes Control"},{"issue":"6","key":"10.1016\/j.ejca.2007.07.027_bib6","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/ije\/30.6.1428","article-title":"Case-control study of parental age, parity and socioeconomic level in relation to childhood cancers","volume":"30","author":"Dockerty","year":"2001","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.ejca.2007.07.027_bib7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ejca.2004.11.006","article-title":"Perinatal and reproductive factors: a report on haematological malignancies from the UKCCS","volume":"41","author":"Roman","year":"2005","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2007.07.027_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.bjc.6601384","article-title":"Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia","volume":"90","author":"Jourdan-Da Silva","year":"2004","journal-title":"Br J Cancer"},{"issue":"7503","key":"10.1016\/j.ejca.2007.07.027_bib9","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1136\/bmj.38428.521042.8F","article-title":"Day care in infancy and risk of childhood acute lymphoblastic leukaemia: findings from UK case-control study","volume":"330","author":"Gilham","year":"2005","journal-title":"Br Med J"},{"issue":"1","key":"10.1016\/j.ejca.2007.07.027_bib10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1054\/bjoc.1999.0905","article-title":"Patterns of infection and day care utilization and risk of childhood acute lymphoblastic leukaemia","volume":"82","author":"Neglia","year":"2000","journal-title":"Br J Cancer"},{"issue":"9","key":"10.1016\/j.ejca.2007.07.027_bib11","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.bjc.6600274","article-title":"Daycare attendance and risk of childhood acute lymphoblastic leukaemia","volume":"86","author":"Ma","year":"2002","journal-title":"Br J Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2007.07.027_bib12","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/aje\/kwk039","article-title":"Childhood acute lymphoblastic leukemia and infections in the first year of life: a report from the United Kingdom Childhood Cancer Study","volume":"165","author":"Roman","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"9","key":"10.1016\/j.ejca.2007.07.027_bib13","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/sj.bjc.6690548","article-title":"Infections, vaccinations, and the risk of childhood leukaemia","volume":"80","author":"Dockerty","year":"1999","journal-title":"Br J Cancer"},{"issue":"2","key":"10.1016\/j.ejca.2007.07.027_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-3016.2005.00634.x","article-title":"Allergy and infectious disease histories and the risk of childhood acute lymphoblastic leukaemia","volume":"19","author":"Rosenbaum","year":"2005","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"4","key":"10.1016\/j.ejca.2007.07.027_bib15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/oxfordjournals.aje.a114431","article-title":"Childhood leukemia and infectious diseases in the first year of life: a register-based case-control study","volume":"124","author":"Steensel-Moll","year":"1986","journal-title":"Am J Epidemiol"},{"issue":"3\u20134","key":"10.1016\/j.ejca.2007.07.027_bib16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/sj.bjc.6690395","article-title":"Association of childhood leukaemia with factors related to the immune system","volume":"80","author":"Schuz","year":"1999","journal-title":"Br J Cancer"},{"issue":"5086","key":"10.1016\/j.ejca.2007.07.027_bib17","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/bmj.1.5086.1495","article-title":"A survey of childhood malignancies","volume":"30","author":"Stewart","year":"1958","journal-title":"Br Med J"},{"issue":"812","key":"10.1016\/j.ejca.2007.07.027_bib18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/bmj.2.5812.485","article-title":"Reported influenza in pregnancy and subsequent cancer in the child","volume":"2","author":"Fedrick","year":"1972","journal-title":"Br Med J"},{"issue":"3","key":"10.1016\/j.ejca.2007.07.027_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/aje\/kwg137","article-title":"Maternal herpesvirus infections and risk of acute lymphoblastic leukemia in the offspring","volume":"158","author":"Lehtinen","year":"2003","journal-title":"Am J Epidemiol"},{"issue":"5887","key":"10.1016\/j.ejca.2007.07.027_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/bmj.4.5887.265","article-title":"Association between influenza during pregnancy and childhood leukaemia","volume":"4","author":"Hakulinen","year":"1973","journal-title":"Br Med J"},{"issue":"3","key":"10.1016\/j.ejca.2007.07.027_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1008873103921","article-title":"Evidence that childhood acute lymphoblastic leukemia is associated with an infectious agent linked to hygiene conditions","volume":"9","author":"Smith","year":"1998","journal-title":"Cancer Causes Control"},{"issue":"6","key":"10.1016\/j.ejca.2007.07.027_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/mpo.10084","article-title":"Perinatal exposure to infection and risk of childhood leukemia","volume":"38","author":"Naumburg","year":"2002","journal-title":"Med Pediatr Oncol"},{"issue":"Mar 27","key":"10.1016\/j.ejca.2007.07.027_bib23","article-title":"Allergy and risk of childhood leukaemia: results from the UKCCS","author":"Hughes","year":"2007","journal-title":"Int J Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2007.07.027_bib24","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1054\/bjoc.1999.1045","article-title":"The United Kingdom Childhood Cancer Study: objectives, materials and methods","volume":"82","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejca.2007.07.027_bib25","unstructured":"World Health Organization. International Statistical Classification of Diseases and Health Related Problems; 1992."},{"key":"10.1016\/j.ejca.2007.07.027_bib26","unstructured":"British Medical Association, Royal Pharmaceutical Society of Great Britain. British National Formulary \u2013 number 24 (September 1992). London, British Medical Association and The Pharmaceutical Press; 1992."},{"issue":"9194","key":"10.1016\/j.ejca.2007.07.027_bib27","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0140-6736(99)10074-6","article-title":"Exposure to power-frequency magnetic fields and the risk of childhood cancer. UK Childhood Cancer Study Investigators","volume":"354","author":"Day","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ejca.2007.07.027_bib28","article-title":"Statistical Methods in Cancer Research","volume":"vol. 1","author":"Breslow","year":"1980"},{"issue":"9365","key":"10.1016\/j.ejca.2007.07.027_bib29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(03)12987-X","article-title":"Down\u2019s syndrome","volume":"361","author":"Roizen","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejca.2007.07.027_bib30","unstructured":"Stata Statistical Software: Release 9 [computer program]. College Station, Texas: Stata Corporation; 2005."},{"issue":"2","key":"10.1016\/j.ejca.2007.07.027_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/archpedi.159.2.167","article-title":"Validity of maternal report of acute health care use for children younger than 3 years","volume":"159","author":"Souza-Vazirani","year":"2005","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"1","key":"10.1016\/j.ejca.2007.07.027_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/oxfordjournals.pubmed.a042571","article-title":"Mothers\u2019 reports of childhood vaccinations and infections and their concordance with general practitioner records","volume":"13","author":"McKinney","year":"1991","journal-title":"J Public Health Med"},{"issue":"6","key":"10.1016\/j.ejca.2007.07.027_bib33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/oxfordjournals.aje.a115759","article-title":"The validity of questionnaire reports of a history of acute otitis media","volume":"132","author":"Alho","year":"1990","journal-title":"Am J Epidemiol"},{"issue":"131","key":"10.1016\/j.ejca.2007.07.027_bib34","first-page":"1","article-title":"Early childhood chronic illness: comparability of maternal reports and medical records","author":"Miller","year":"2001","journal-title":"Vital Health Stat 2"},{"issue":"62","key":"10.1016\/j.ejca.2007.07.027_bib35","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/thx.2006.072124","article-title":"Recorded infections and antibiotics in early life: associations with allergy in UK children and their parents","volume":"20","author":"Harris","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.ejca.2007.07.027_bib36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1365-2133.2004.06436.x","article-title":"Atopic dermatitis and the \u2019hygiene hypothesis\u2019: too clean to be true?","volume":"152","author":"Flohr","year":"2005","journal-title":"Br J of Dermatology"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804907005850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804907005850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:16:31Z","timestamp":1556842591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804907005850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":36,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0959804907005850"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2007.07.027","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}