{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:33:48Z","timestamp":1786988028764,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.ejca.2008.01.014","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T10:07:32Z","timestamp":1202897252000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Decreased expression of galectin-3 is associated with metastatic potential of liver fluke-associated cholangiocarcinoma"],"prefix":"10.1016","volume":"44","author":[{"given":"Mutita","family":"Junking","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaisiri","family":"Wongkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banchob","family":"Sripa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanlayanee","family":"Sawanyawisuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sopit","family":"Wongkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.ejca.2008.01.014_bib1","doi-asserted-by":"crossref","first-page":"7982","DOI":"10.1073\/pnas.0402669101","article-title":"Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm","volume":"101","author":"Gray","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.ejca.2008.01.014_bib2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/ijc.2910460520","article-title":"Evidence for the role of 34-kDa galactoside-binding lectin in transformation and metastasis","volume":"46","author":"Raz","year":"1990","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2008.01.014_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/(SICI)1096-9896(199605)179:1<43::AID-PATH541>3.0.CO;2-N","article-title":"Decreased expression of galectin-3 is associated with progression of human breast cancer","volume":"179","author":"Castronovo","year":"1996","journal-title":"J Pathol"},{"issue":"24","key":"10.1016\/j.ejca.2008.01.014_bib4","first-page":"6239","article-title":"The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells","volume":"59","author":"Gong","year":"1999","journal-title":"Cancer Res"},{"issue":"7\u20139","key":"10.1016\/j.ejca.2008.01.014_bib5","first-page":"527","article-title":"Extracellular functions of galectin-3","volume":"19","author":"Ochieng","year":"2004","journal-title":"Glycoconj J"},{"issue":"18","key":"10.1016\/j.ejca.2008.01.014_bib6","doi-asserted-by":"crossref","first-page":"15819","DOI":"10.1074\/jbc.M200154200","article-title":"Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation","volume":"277","author":"Yu","year":"2002","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.ejca.2008.01.014_bib7","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1128\/MCB.24.10.4395-4406.2004","article-title":"Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs","volume":"24","author":"Takenaka","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"7\u20139","key":"10.1016\/j.ejca.2008.01.014_bib8","first-page":"499","article-title":"Understanding the biochemical activities of galectin-1 and galectin-3 in the nucleus","volume":"19","author":"Patterson","year":"2004","journal-title":"Glycoconj J"},{"issue":"18","key":"10.1016\/j.ejca.2008.01.014_bib9","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1158\/0008-5472.CAN-04-1816","article-title":"Galectin-3, a novel binding partner of beta-catenin","volume":"64","author":"Shimura","year":"2004","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.ejca.2008.01.014_bib10","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.pmed.0040201","article-title":"Liver fluke induces cholangiocarcinoma","volume":"4","author":"Sripa","year":"2007","journal-title":"PLoS Med"},{"issue":"6","key":"10.1016\/j.ejca.2008.01.014_bib11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0168-8278(02)00297-0","article-title":"Changing international trends in mortality rates for liver, biliary and pancreatic tumours","volume":"37","author":"Khan","year":"2002","journal-title":"J Hepatol"},{"issue":"12","key":"10.1016\/j.ejca.2008.01.014_bib12","first-page":"4634","article-title":"Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverrini-infected Syrian golden hamsters","volume":"38","author":"Thamavit","year":"1978","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.ejca.2008.01.014_bib13","first-page":"489","article-title":"A high incidence of liver cancer in Khon Kaen Province, Thailand","volume":"21","author":"Vatanasapt","year":"1990","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"8681","key":"10.1016\/j.ejca.2008.01.014_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0140-6736(90)90591-R","article-title":"Cholangiocarcinoma in north-east Thailand","volume":"335","author":"Vatanasapt","year":"1990","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ejca.2008.01.014_bib15","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0020-7519(94)90009-4","article-title":"Parasite-associated morbidity: liver fluke infection and bile duct cancer in northeast Thailand","volume":"24","author":"Sithithaworn","year":"1994","journal-title":"Int J Parasitol"},{"issue":"1","key":"10.1016\/j.ejca.2008.01.014_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/01.pgp.0000179613.40215.c0","article-title":"Galectin-3 and CD1a-positive dendritic cells are involved in the development of an invasive phenotype in vulvar squamous lesions","volume":"25","author":"Brustmann","year":"2006","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"10.1016\/j.ejca.2008.01.014_bib17","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0002-9440(10)64927-9","article-title":"Role of galectin-3 in breast cancer metastasis: involvement of nitric oxide","volume":"160","author":"Song","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ejca.2008.01.014_bib18","series-title":"AJCC cancer staging manual","author":"Greene","year":"2002"},{"issue":"22","key":"10.1016\/j.ejca.2008.01.014_bib19","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.3748\/wjg.v11.i22.3392","article-title":"Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)","volume":"11","author":"Sripa","year":"2005","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ejca.2008.01.014_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1046-2023(02)00023-3","article-title":"Analysis of gene function in somatic mammalian cells using small interfering RNAs","volume":"26","author":"Elbashir","year":"2002","journal-title":"Methods"},{"issue":"3","key":"10.1016\/j.ejca.2008.01.014_bib21","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/02841860600871061","article-title":"Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target","volume":"46","author":"Sawanyawisuth","year":"2007","journal-title":"Acta Oncol"},{"issue":"7\u20139","key":"10.1016\/j.ejca.2008.01.014_bib22","first-page":"537","article-title":"Expression of galectins in cancer: a critical review","volume":"19","author":"van den Brule","year":"2004","journal-title":"Glycoconj J"},{"issue":"3","key":"10.1016\/j.ejca.2008.01.014_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1053\/hupa.2001.22767","article-title":"Expression of endogenous galectin-1 and galectin-3 in intrahepatic cholangiocarcinoma","volume":"32","author":"Shimonishi","year":"2001","journal-title":"Hum Pathol"},{"issue":"4","key":"10.1016\/j.ejca.2008.01.014_bib24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00000658-199604000-00007","article-title":"Factors influencing postoperative morbidity, mortality, and survival after resection for hilar cholangiocarcinoma","volume":"223","author":"Su","year":"1996","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.ejca.2008.01.014_bib25","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0002-9610(02)00853-X","article-title":"Analysis of the relationships between clinicopathologic factors and survival time in intrahepatic cholangiocarcinoma","volume":"183","author":"Kawarada","year":"2002","journal-title":"Am J Surg"},{"issue":"8","key":"10.1016\/j.ejca.2008.01.014_bib26","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1073\/pnas.90.8.3466","article-title":"Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma","volume":"90","author":"Lotz","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.ejca.2008.01.014_bib27","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/0959-8049(94)90464-2","article-title":"Differential expression of the 67-kD laminin receptor and 31-kD human laminin-binding protein in human ovarian carcinomas","volume":"30A","author":"van den Brule","year":"1994","journal-title":"Eur J Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2008.01.014_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.canlet.2004.07.004","article-title":"Decreased relative expression level of trefoil factor 3 mRNA to galectin-3 mRNA distinguishes thyroid follicular carcinoma from adenoma","volume":"219","author":"Takano","year":"2005","journal-title":"Cancer Lett"},{"issue":"3","key":"10.1016\/j.ejca.2008.01.014_bib29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0014-5793(00)01547-7","article-title":"Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis","volume":"473","author":"Matarrese","year":"2000","journal-title":"FEBS Lett"},{"issue":"45","key":"10.1016\/j.ejca.2008.01.014_bib30","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1038\/sj.onc.1207997","article-title":"Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3","volume":"23","author":"Califice","year":"2004","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.ejca.2008.01.014_bib31","first-page":"4635","article-title":"Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma","volume":"6","author":"Honjo","year":"2000","journal-title":"Clin Cancer Res"},{"issue":"Pt 14","key":"10.1016\/j.ejca.2008.01.014_bib32","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1242\/jcs.110.14.1585","article-title":"Novel alpha-GalNAc containing glycans on cytokeratins are recognized invitro by galectins with type II carbohydrate recognition domains","volume":"110","author":"Goletz","year":"1997","journal-title":"J Cell Sci"},{"issue":"4","key":"10.1016\/j.ejca.2008.01.014_bib33","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbagen.2005.12.020","article-title":"Galectin-3: an open-ended story","volume":"1760","author":"Dumic","year":"2006","journal-title":"Biochim Biophys Acta"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804908000105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804908000105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:16:30Z","timestamp":1760732190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804908000105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0959804908000105"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2008.01.014","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased expression of galectin-3 is associated with metastatic potential of liver fluke-associated cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2008.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}