{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:21:14Z","timestamp":1780554074389,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.ejca.2009.12.006","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T06:06:06Z","timestamp":1263535566000},"page":"720-728","source":"Crossref","is-referenced-by-count":53,"title":["The stromal part of adenocarcinomas of the oesophagus: Does it conceal targets for therapy?"],"prefix":"10.1016","volume":"46","author":[{"given":"Ewout F.W.","family":"Courrech Staal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel W.J.M.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna W.","family":"van Sandick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijn M.","family":"Takkenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent T.H.B.M.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.C.","family":"Junggeburt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette M.J.","family":"Spitzer-Naaykens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Karsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk H.","family":"Hartgrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma E.","family":"Mesker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob A.E.M.","family":"Tollenaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2009.12.006_bib1","series-title":"TNM classification of malignant tumours","author":"Sobin","year":"2002"},{"key":"10.1016\/j.ejca.2009.12.006_bib2","series-title":"AJCC Cancer staging handbook: \u201cTNM classification of malignant tumors\u201d","author":"Greene","year":"2002"},{"key":"10.1016\/j.ejca.2009.12.006_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/01.sla.0000251703.35919.02","article-title":"An evaluation of prognostic factors and tumor staging of resected carcinoma of the esophagus","volume":"245","author":"Wijnhoven","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejca.2009.12.006_bib4","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/cncr.10868","article-title":"Prognostic factors for the survival of patients with esophageal carcinoma in the US: the importance of tumor length and lymph node status","volume":"95","author":"Eloubeidi","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2009.12.006_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/01.pas.0000189182.92815.12","article-title":"Extracapsular lymph node involvement in node-positive patients with adenocarcinoma of the distal esophagus or gastroesophageal junction","volume":"30","author":"Lagarde","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejca.2009.12.006_bib6","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jtcvs.2006.07.039","article-title":"The prognostic importance of the number of involved lymph nodes in esophageal cancer: implications for revisions of the American Joint Committee on Cancer staging system","volume":"132","author":"Rizk","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ejca.2009.12.006_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jso.20569","article-title":"Staging of esophageal carcinoma: length of tumor and number of involved regional lymph nodes","volume":"94","author":"Bollschweiler","year":"2006","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.ejca.2009.12.006_bib8","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1245\/s10434-006-9286-3","article-title":"Assessment of clinical outcome in patients with esophageal squamous cell carcinoma using TNM classification score and molecular biological classification","volume":"14","author":"Takeno","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejca.2009.12.006_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00000658-200103000-00005","article-title":"Molecular biology of Barrett\u2019s adenocarcinoma","volume":"233","author":"Wijnhoven","year":"2001","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejca.2009.12.006_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s004280050053","article-title":"The multiple roles of tumour stroma","volume":"430","author":"Wernert","year":"1997","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ejca.2009.12.006_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jcp.10142","article-title":"New insights into the role of extracellular matrix during tumor onset and progression","volume":"192","author":"Pupa","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ejca.2009.12.006_bib12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/path.1398","article-title":"Role of tissue stroma in cancer cell invasion","volume":"200","author":"De Wever","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.ejca.2009.12.006_bib13","first-page":"387","article-title":"The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage","volume":"29","author":"Mesker","year":"2007","journal-title":"Cell Oncol"},{"key":"10.1016\/j.ejca.2009.12.006_bib14","first-page":"169","article-title":"Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I\u2013II colon cancer patients","volume":"31","author":"Mesker","year":"2009","journal-title":"Cell Oncol"},{"key":"10.1016\/j.ejca.2009.12.006_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0016-5085(84)80016-5","article-title":"Clinical, epidemiologic, and morphologic comparison between adenocarcinomas arising in Barrett\u2019s esophageal mucosa and in the gastric cardia","volume":"86","author":"Kalish","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejca.2009.12.006_bib16","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<520::AID-CNCR2>3.0.CO;2-L","article-title":"Pathologic prognostic factors in Barrett\u2019s associated adenocarcinoma: a follow-up study of 96 patients","volume":"85","author":"Torres","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2009.12.006_bib17","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1200\/JCO.2005.04.9445","article-title":"Prognostic factors in adenocarcinoma of the esophagus or gastroesophageal junction","volume":"24","author":"Lagarde","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2009.12.006_bib18","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1158\/1078-0432.CCR-06-2191","article-title":"Stromal myofibroblasts predict disease recurrence for colorectal cancer","volume":"13","author":"Tsujino","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejca.2009.12.006_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1023\/B:MCBI.0000028746.54447.6c","article-title":"Tumour-stroma interactions in carcinogenesis: basic aspects and perspectives","volume":"261","author":"Kiaris","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ejca.2009.12.006_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng1001-117","article-title":"TGF-beta signaling in tumor suppression and cancer progression","volume":"29","author":"Derynck","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejca.2009.12.006_bib21","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/mc.20259","article-title":"Overexpression of TGF-beta1 in esophageal (Barrett\u2019s) adenocarcinoma is associated with advanced stage of disease and poor prognosis","volume":"45","author":"von Rahden","year":"2006","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.ejca.2009.12.006_bib22","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1158\/1078-0432.CCR-1096-03","article-title":"Plasma level of transforming growth factor beta1 measured from the azygos vein predicts prognosis in patients with esophageal cancer","volume":"10","author":"Fukuchi","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejca.2009.12.006_bib23","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00268-001-0242-x","article-title":"Connective tissue growth factor gene expression alters tumor progression in esophageal cancer","volume":"26","author":"Koliopanos","year":"2002","journal-title":"World J Surg"},{"key":"10.1016\/j.ejca.2009.12.006_bib24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrc1477","article-title":"Friends or foes \u2013 Bipolar effects of the tumour stroma in cancer","volume":"4","author":"Mueller","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ejca.2009.12.006_bib25","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/bjs.4778","article-title":"Pathological determinants of survival in node-negative oesophageal cancer","volume":"91","author":"Khan","year":"2004","journal-title":"Br J Surg"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804909009186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804909009186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T20:08:12Z","timestamp":1590523692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804909009186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0959804909009186"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2009.12.006","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}