{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:24:59Z","timestamp":1785842699351,"version":"3.56.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.ejca.2010.01.028","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T04:28:54Z","timestamp":1266985734000},"page":"1317-1322","source":"Crossref","is-referenced-by-count":48,"title":["Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract"],"prefix":"10.1016","volume":"46","author":[{"given":"M.","family":"El-Bahrawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2010.01.028_bib1","series-title":"Clinical biochemistry","year":"2008"},{"issue":"5","key":"10.1016\/j.ejca.2010.01.028_bib2","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1525-1438.2007.00901.x","article-title":"Primary hepatoid adenocarcinoma of the uterine cervix","volume":"17","author":"Kato","year":"2007","journal-title":"Int J Gynecol Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2010.01.028_bib3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/00016340600593117","article-title":"Hepatoid carcinoma of the ovary and management","volume":"86","author":"Lazaro","year":"2007","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s10147-008-0800-4","article-title":"Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman","volume":"14","author":"Isonishi","year":"2009","journal-title":"Int J Clin Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2010.01.028_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1525-1438.1995.05040314.x","article-title":"Ovarian hepatoid carcinoma without staining for alpha-fetoprotein in the primary site","volume":"5","author":"Nishida","year":"1995","journal-title":"Int J Gynecol Cancer"},{"issue":"6","key":"10.1016\/j.ejca.2010.01.028_bib6","first-page":"745","article-title":"Hepatoid carcinoma of the ovary: characteristics of its immunoreactivity. A case report","volume":"25","author":"Tsung","year":"2004","journal-title":"Eur J Gynaecol Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib7","first-page":"327","article-title":"Ovarian serous adenocarcinoma with functioning stroma and production of estrogen and alpha-fetoprotein","volume":"33","author":"Kataoka","year":"1987","journal-title":"Gan No Rinsho"},{"issue":"5","key":"10.1016\/j.ejca.2010.01.028_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1447-0756.1995.tb01036.x","article-title":"A case of ovarian serous adenocarcinoma suggestive of transformation to an AFP-producing tumor during chemotherapy","volume":"21","author":"Kataoka","year":"1995","journal-title":"J Obstet Gynaecol (Tokyo 1995)"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib9","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0090-8258(03)00407-4","article-title":"Cushing\u2019s syndrome due to ovarian serous adenocarcinoma secreting multiple endocrine substances: a case report and immunohistochemical analysis","volume":"90","author":"Suzuki","year":"2003","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib10","first-page":"241","article-title":"Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report","volume":"28","author":"Cetin","year":"2007","journal-title":"Eur J Gynaecol Oncol"},{"issue":"2","key":"10.1016\/j.ejca.2010.01.028_bib11","first-page":"165","article-title":"Clear cell carcinoma of the ovary simulating a yolk sac tumor","volume":"23","author":"Bahri","year":"2003","journal-title":"Ann Pathol"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib12","first-page":"87","article-title":"Clear cell carcinoma simulating the \u2018endometrioid-like variant\u2019 of yolk sac tumor","volume":"87","author":"Ballotta","year":"1995","journal-title":"Pathologica"},{"issue":"9","key":"10.1016\/j.ejca.2010.01.028_bib13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1097\/00000478-199609000-00003","article-title":"Ovarian endometrioid tumors with yolk sac tumor component, an unusual form of ovarian neoplasm. Analysis of six cases","volume":"20","author":"Nogales","year":"1996","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/gyno.1998.5119","article-title":"Ovarian endometrioid adenocarcinoma with ectopic production of alpha-fetoprotein","volume":"71","author":"Maida","year":"1998","journal-title":"Gynecol Oncol"},{"issue":"11","key":"10.1016\/j.ejca.2010.01.028_bib15","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/BF01245380","article-title":"Immunohistochemical characterization of undifferentiated carcinomas of the ovary","volume":"120","author":"Kuwashima","year":"1994","journal-title":"J Cancer Res Clin Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2010.01.028_bib16","first-page":"372","article-title":"Ovarian mucinous cystadenocarcinoma producing alpha-fetoprotein. A case report","volume":"42","author":"Nomura","year":"1992","journal-title":"Acta Pathol Jpn"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/gyno.1999.5653","article-title":"Alpha-fetoprotein production by a malignant mixed Mullerian tumor of the ovary","volume":"77","author":"Rebischung","year":"2000","journal-title":"Gynecol Oncol"},{"issue":"5(Pt 2)","key":"10.1016\/j.ejca.2010.01.028_bib18","first-page":"831","article-title":"Sertoli-Leydig cell tumor of the ovary: a rare cause of amenorrhea","volume":"79","author":"Larsen","year":"1992","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib19","first-page":"141","article-title":"Elevated serum alpha-fetoprotein associated with Sertoli-Leydig cell tumors of the ovary","volume":"67","author":"Mann","year":"1986","journal-title":"Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.ejca.2010.01.028_bib20","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/1097-0142(19890515)63:10<2047::AID-CNCR2820631029>3.0.CO;2-Y","article-title":"Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein","volume":"63","author":"Motoyama","year":"1989","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/0019-509X.48599","article-title":"Recurrent alpha-fetoprotein secreting Sertoli-Leydig cell tumor of ovary with an unusual presentation","volume":"46","author":"Poli","year":"2009","journal-title":"Indian J Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02133963","article-title":"AFP-producing Sertoli-Leydig cell tumor of the ovary","volume":"236","author":"Sekiya","year":"1985","journal-title":"Arch Gynecol"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yexmp.2006.08.001","article-title":"Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor","volume":"82","author":"Sun","year":"2007","journal-title":"Exp Mol Pathol"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib24","first-page":"65","article-title":"Sertoli-Leydig cell tumor of the ovary with alpha-fetoprotein production","volume":"110","author":"Tetu","year":"1986","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1447-0756.2008.00730.x","article-title":"Ovarian Sertoli-Leydig cell tumor with heterologous gastrointestinal epithelium as a source of alpha-fetoprotein: a case report","volume":"34","author":"Watanabe","year":"2008","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib26","first-page":"107","article-title":"An alpha-fetoprotein producing Sertoli-Leydig cell tumor\u2013a case report","volume":"35","author":"Taniyama","year":"1989","journal-title":"Gan No Rinsho"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib27","first-page":"63","article-title":"Frequency of alpha-fetoprotein production by Sertoli-Leydig cell tumors of the ovary: an immunohistochemical study of eight cases","volume":"2","author":"Gagnon","year":"1989","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1016\/j.ejca.2010.01.028_bib28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0046-8177(99)90083-7","article-title":"Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors: distinguishing a heterologous element from Leydig cells","volume":"30","author":"Mooney","year":"1999","journal-title":"Hum Pathol"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00000478-199301000-00011","article-title":"Granulosa cell tumor of the ovary with diffuse true hepatic differentiation simulating stromal luteinization","volume":"17","author":"Nogales","year":"1993","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.ejca.2010.01.028_bib30","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2169\/internalmedicine.31.260","article-title":"Ovarian and hepatic metastases of gastric carcinoma associated with high serum levels of human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), and carcinoembryonic antigen (CEA): a case report","volume":"31","author":"Sano","year":"1992","journal-title":"Intern Med"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0301-2115(99)00212-2","article-title":"Massive solitary metastasis of hepatocellular carcinoma in the ovary two years after liver transplantation","volume":"90","author":"de Groot","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"10.1016\/j.ejca.2010.01.028_bib32","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/gyno.1996.0317","article-title":"Alpha-Fetoprotein-producing (hepatoid) carcinoma of the fallopian tube","volume":"63","author":"Aoyama","year":"1996","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10.1016\/j.ejca.2010.01.028_bib33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0090-8258(88)80015-5","article-title":"Successful treatment of primary endodermal sinus tumor of the endometrium","volume":"31","author":"Ohta","year":"1988","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0090-8258(88)90238-7","article-title":"Alpha-fetoprotein producing endometrial adenocarcinoma: report of a case","volume":"29","author":"Matsukuma","year":"1988","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib35","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1525-1438.2006.00613.x","article-title":"A case of alpha-fetoprotein-producing adenocarcinoma of the endometrium with a hepatoid component as a potential source for alpha-fetoprotein in a postmenopausal woman","volume":"16","author":"Takeuchi","year":"2006","journal-title":"Int J Gynecol Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2010.01.028_bib36","first-page":"399","article-title":"Alpha-fetoprotein-producing papillary adenocarcinoma originating from a uterine body. A case report","volume":"41","author":"Kubo","year":"1991","journal-title":"Acta Pathol Jpn"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/01.pgp.0000225843.21503.30","article-title":"Alpha-fetoprotein-producing serous carcinoma of the uterus metastasizing to the ovaries, mimicking primary ovarian yolk sac tumor: a case report and review of the literature","volume":"26","author":"Tran","year":"2007","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib38","first-page":"577","article-title":"A case of mixed mesodermal tumor of the uterus with alpha-fetoprotein production","volume":"15","author":"Kawagoe","year":"1985","journal-title":"Jpn J Clin Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2010.01.028_bib39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1440-1827.2003.01467.x","article-title":"Hepatoid carcinoma of the uterus that collided with carcinosarcoma","volume":"53","author":"Takahashi","year":"2003","journal-title":"Pathol Int"},{"issue":"2","key":"10.1016\/j.ejca.2010.01.028_bib40","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0090-8258(03)00512-2","article-title":"Malignant mixed Mullerian tumor of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma component","volume":"91","author":"Takano","year":"2003","journal-title":"Gynecol Oncol"},{"issue":"6","key":"10.1016\/j.ejca.2010.01.028_bib41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1349-7006.1996.tb00267.x","article-title":"Biochemical characterization of alpha-fetoprotein and other serum proteins produced by a uterine endometrial adenocarcinoma","volume":"87","author":"Koyama","year":"1996","journal-title":"Jpn J Cancer Res"},{"issue":"10","key":"10.1016\/j.ejca.2010.01.028_bib42","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1046\/j.1440-1827.2000.01124.x","article-title":"Alpha-fetoprotein producing uterine corpus carcinoma: A hepatoid adenocarcinoma of the endometrium","volume":"50","author":"Toyoda","year":"2000","journal-title":"Pathol Int"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib43","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00004347-199607000-00012","article-title":"Hepatoid adenocarcinoma of the endometrium associated with alpha-fetoprotein production","volume":"15","author":"Hoshida","year":"1996","journal-title":"Int J Gynecol Pathol"},{"issue":"4","key":"10.1016\/j.ejca.2010.01.028_bib44","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/ajcp\/79.4.414","article-title":"Immunocytochemical localization of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and human chorionic gonadotropin (HCG) in cervical neoplasia","volume":"79","author":"Bychkov","year":"1983","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"10.1016\/j.ejca.2010.01.028_bib45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/gyno.1996.0221","article-title":"CUMC-6, a new diploid human cell line derived from a squamous carcinoma of the uterine cervix","volume":"62","author":"Kim","year":"1996","journal-title":"Gynecol Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2010.01.028_bib46","first-page":"395","article-title":"Primary yolk sac tumor (endodermal sinus tumor) of the vulva: case report and review of the literature","volume":"27","author":"Basgul","year":"2006","journal-title":"Eur J Gynaecol Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib47","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ygyno.2004.12.054","article-title":"Yolk sac tumor of the vulva: a case report with long-term disease-free survival","volume":"97","author":"Khunamornpong","year":"2005","journal-title":"Gynecol Oncol"},{"issue":"5\u20136","key":"10.1016\/j.ejca.2010.01.028_bib48","first-page":"521","article-title":"A rare germ-cell tumor site: vaginal endodermal sinus tumor","volume":"18","author":"Arora","year":"2002","journal-title":"Pediatr Surg Int"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib49","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4103\/0377-4929.55008","article-title":"Endodermal sinus tumor of the vagina in children: a report of two cases","volume":"52","author":"Gangopadhyay","year":"2009","journal-title":"Indian J Pathol Microbiol"},{"issue":"2","key":"10.1016\/j.ejca.2010.01.028_bib50","first-page":"164","article-title":"Infantile endodermal sinus tumor presenting with vaginal bleeding: report of a case","volume":"93","author":"Horng","year":"1994","journal-title":"J Formos Med Assoc"},{"issue":"9","key":"10.1016\/j.ejca.2010.01.028_bib51","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/BF02734156","article-title":"Vaginal endodermal sinus tumor","volume":"72","author":"Kumar","year":"2005","journal-title":"Indian J Pediatr"},{"issue":"3","key":"10.1016\/j.ejca.2010.01.028_bib52","first-page":"223","article-title":"Infantile vaginal tumour with alpha-fetoprotein synghesis","volume":"87A","author":"Norgaard-Pedersen","year":"1979","journal-title":"Acta Pathol Microbiol Scand A"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00043426-198921000-00009","article-title":"Endodermal sinus (yolk sac) tumor in infants and children. A clinical and pathologic study: an 11 year review","volume":"11","author":"Shebib","year":"1989","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"7","key":"10.1016\/j.ejca.2010.01.028_bib54","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/08880010600856972","article-title":"Successful treatment of an endodermal sinus tumor of the vagina by chemotherapy alone: a rare case of an infant diagnosed by pathological examination of discharged tumor fragment","volume":"23","author":"Shinkoda","year":"2006","journal-title":"Pediatr Hematol Oncol"},{"issue":"8","key":"10.1016\/j.ejca.2010.01.028_bib55","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1177\/1933719109336617","article-title":"Novel alpha-fetoprotein-V messenger RNA isoforms in humans","volume":"16","author":"Tagaya","year":"2009","journal-title":"Reprod Sci"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib56","first-page":"51","article-title":"Immunohistochemical differentiation of yolk sac-type alpha-fetoprotein from hepatic-type alpha-fetoprotein","volume":"39","author":"Okamoto","year":"1989","journal-title":"Acta Pathol Jpn"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1210\/endo-129-1-217","article-title":"Synergistic action of purified alpha-fetoprotein and growth factors on the proliferation of porcine granulosa cells in monolayer culture","volume":"129","author":"Keel","year":"1991","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.ejca.2010.01.028_bib58","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1210\/endo-126-1-669","article-title":"Human alpha fetoprotein enhances epidermal growth factor proliferative activity upon porcine granulosa cells in monolayer culture","volume":"126","author":"Leal","year":"1990","journal-title":"Endocrinology"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804910000493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804910000493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T20:27:04Z","timestamp":1544646424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804910000493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0959804910000493"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2010.01.028","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}