{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:17:12Z","timestamp":1777529832522,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.ejca.2010.02.019","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T09:18:31Z","timestamp":1268817511000},"page":"1892-1899","source":"Crossref","is-referenced-by-count":18,"title":["Low frequency of MLL-partial tandem duplications in paediatric acute myeloid leukaemia using MLPA as a novel DNA screenings technique"],"prefix":"10.1016","volume":"46","author":[{"given":"Brian V.","family":"Balgobind","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris H.I.M.","family":"Hollink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth R.","family":"van Wering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siebold S.N.","family":"de Graaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Baruchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Stary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Berna","family":"Beverloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgine E.","family":"de Greef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Michel","family":"Zwaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marry M.","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ejca.2010.02.019_bib1","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3324\/haematol.11203","article-title":"Pediatric acute myeloid leukemia: towards high-quality cure of all patients","volume":"92","author":"Kaspers","year":"2007","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.ejca.2010.02.019_bib2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.molmed.2004.08.005","article-title":"MLL: a histone methyltransferase disrupted in leukemia","volume":"10","author":"Hess","year":"2004","journal-title":"Trends Mol Med"},{"issue":"3","key":"10.1016\/j.ejca.2010.02.019_bib3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/01.moh.0000160737.52349.aa","article-title":"Hox regulation of normal and leukemic hematopoietic stem cells","volume":"12","author":"Abramovich","year":"2005","journal-title":"Curr Opin Hematol"},{"issue":"2","key":"10.1016\/j.ejca.2010.02.019_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/path.1710","article-title":"The pathophysiology of HOX genes and their role in cancer","volume":"205","author":"Grier","year":"2005","journal-title":"J Pathol"},{"issue":"7","key":"10.1016\/j.ejca.2010.02.019_bib5","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3324\/haematol.2008.004564","article-title":"NRIP3: a novel translocation partner of MLL detected in a pediatric acute myeloid leukemia with complex chromosome 11 rearrangements","volume":"94","author":"Balgobind","year":"2009","journal-title":"Haematologica"},{"issue":"March 5","key":"10.1016\/j.ejca.2010.02.019_bib6","article-title":"New insights to the MLL recombinome of acute leukemias","author":"Meyer","year":"2009","journal-title":"Leukemia"},{"issue":"June 15","key":"10.1016\/j.ejca.2010.02.019_bib7","article-title":"Novel prognostic subgroups in childhood 11q23\/MLL-rearranged acute myeloid leukemia: results of an international retrospective study","author":"Balgobind","year":"2009","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ejca.2010.02.019_bib8","first-page":"370","article-title":"Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations","volume":"54","author":"Caligiuri","year":"1994","journal-title":"Cancer Res"},{"issue":"10","key":"10.1016\/j.ejca.2010.02.019_bib9","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1172\/JCI25546","article-title":"Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations","volume":"116","author":"Dorrance","year":"2006","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.ejca.2010.02.019_bib10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/sj.leu.2401773","article-title":"Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML","volume":"14","author":"Schnittger","year":"2000","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.ejca.2010.02.019_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/gcc.10219","article-title":"Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia","volume":"37","author":"Steudel","year":"2003","journal-title":"Gene Chromosome Canc"},{"issue":"11","key":"10.1016\/j.ejca.2010.02.019_bib12","first-page":"1502","article-title":"Population-based age-specific incidences of cytogenetic subgroups of acute myeloid leukemia","volume":"90","author":"Bacher","year":"2005","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.ejca.2010.02.019_bib13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.leu.2404024","article-title":"Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement","volume":"20","author":"Shih","year":"2006","journal-title":"Leukemia"},{"issue":"15","key":"10.1016\/j.ejca.2010.02.019_bib14","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1200\/JCO.2002.09.088","article-title":"Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm","volume":"20","author":"Dohner","year":"2002","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2010.02.019_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2141.2005.05791.x","article-title":"Molecular typing of adult acute myeloid leukaemia: significance of translocations, tandem duplications, methylation, and selective gene expression profiling","volume":"131","author":"Olesen","year":"2005","journal-title":"Brit J Haematol"},{"issue":"5","key":"10.1016\/j.ejca.2010.02.019_bib16","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1182\/blood-2003-06-1845","article-title":"Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia","volume":"103","author":"Ozeki","year":"2004","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.ejca.2010.02.019_bib17","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1182\/blood-2003-01-0162","article-title":"FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress","volume":"102","author":"Libura","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ejca.2010.02.019_bib18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.leu.2402352","article-title":"Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23","volume":"16","author":"Shiah","year":"2002","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.ejca.2010.02.019_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.leu.2402708","article-title":"Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells","volume":"17","author":"Munoz","year":"2003","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.ejca.2010.02.019_bib20","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1182\/blood-2004-03-1154","article-title":"Gene expression profiling of pediatric acute myelogenous leukemia","volume":"104","author":"Ross","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ejca.2010.02.019_bib21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/pbc.21318","article-title":"Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: a study of the Japanese childhood AML Cooperative Study Group","volume":"50","author":"Shimada","year":"2008","journal-title":"Pediatr Blood Cancer"},{"issue":"9","key":"10.1016\/j.ejca.2010.02.019_bib22","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.leukres.2006.02.005","article-title":"Lifelong persistence of AML associated MLL partial tandem duplications (MLL\u2013PTD) in healthy adults","volume":"30","author":"Basecke","year":"2006","journal-title":"Leuk Res"},{"issue":"5","key":"10.1016\/j.ejca.2010.02.019_bib23","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1182\/blood.V92.5.1728","article-title":"Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors","volume":"92","author":"Schnittger","year":"1998","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.ejca.2010.02.019_bib24","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/pd.2111","article-title":"Multiplex ligation-dependent probe amplification (MLPA) as a stand-alone test for rapid aneuploidy detection in amniotic fluid cells","volume":"28","author":"Kooper","year":"2008","journal-title":"Prenat Diagn"},{"issue":"1","key":"10.1016\/j.ejca.2010.02.019_bib25","first-page":"1","article-title":"HER-2\/neu amplification testing in breast cancer by multiplex ligation-dependent probe amplification in comparison with immunohistochemistry and in situ hybridization","volume":"31","author":"Moelans","year":"2009","journal-title":"Cell Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2010.02.019_bib26","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes","volume":"114","author":"Vardiman","year":"2009","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.ejca.2010.02.019_bib27","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1200\/JCO.2003.11.031","article-title":"Patient stratification based on prednisolone\u2013vincristine\u2013asparaginase resistance profiles in children with acute lymphoblastic leukemia","volume":"21","author":"Den Boer","year":"2003","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1016\/j.ejca.2010.02.019_bib28","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1182\/blood-2007-09-111872","article-title":"The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia","volume":"111","author":"Van Vlierberghe","year":"2008","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.ejca.2010.02.019_bib29","first-page":"1418","article-title":"Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11","volume":"56","author":"Caligiuri","year":"1996","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.ejca.2010.02.019_bib30","first-page":"1162","article-title":"Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL): clinical, cytogenetic and molecular studies","volume":"9","author":"Hernandez","year":"1995","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.ejca.2010.02.019_bib31","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1182\/blood-2007-06-095075","article-title":"Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis","volume":"111","author":"Balgobind","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ejca.2010.02.019_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.thj.6200216","article-title":"Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML","volume":"4","author":"Barjesteh van Waalwijk van Doorn-Khosrovani","year":"2003","journal-title":"Hematol J"},{"issue":"12","key":"10.1016\/j.ejca.2010.02.019_bib33","first-page":"1911","article-title":"Internal tandem duplication of the flt3 gene found in acute myeloid leukemia","volume":"10","author":"Nakao","year":"1996","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.ejca.2010.02.019_bib34","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1182\/blood.V97.8.2434","article-title":"Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies","volume":"97","author":"Yamamoto","year":"2001","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ejca.2010.02.019_bib35","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/leu.2008.313","article-title":"Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML","volume":"23","author":"Hollink","year":"2009","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.ejca.2010.02.019_bib36","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1182\/blood-2002-02-0492","article-title":"The roles of FLT3 in hematopoiesis and leukemia","volume":"100","author":"Gilliland","year":"2002","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.ejca.2010.02.019_bib37","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/sj.leu.2403870","article-title":"Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia","volume":"19","author":"Goemans","year":"2005","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.ejca.2010.02.019_bib38","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1073\/pnas.95.5.2390","article-title":"The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia","volume":"95","author":"Strout","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.ejca.2010.02.019_bib39","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/sj.leu.2401130","article-title":"Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product","volume":"12","author":"Kiyoi","year":"1998","journal-title":"Leukemia"},{"issue":"11","key":"10.1016\/j.ejca.2010.02.019_bib40","first-page":"1509","article-title":"Identification of gene expression signatures accurately predicting cytogenetic subtypes in pediatric acute myeloid leukemia","volume":"112","author":"Balgobind","year":"2008","journal-title":"ASH Ann Meet Abstr"},{"issue":"16","key":"10.1016\/j.ejca.2010.02.019_bib41","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1056\/NEJMoa031046","article-title":"Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia","volume":"350","author":"Bullinger","year":"2004","journal-title":"New Engl J Med"},{"issue":"1","key":"10.1016\/j.ejca.2010.02.019_bib42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1182\/blood-2005-01-0204","article-title":"The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy","volume":"106","author":"Whitman","year":"2005","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.ejca.2010.02.019_bib43","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1073\/pnas.94.8.3899","article-title":"The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome","volume":"94","author":"Caligiuri","year":"1997","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804910001462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804910001462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T02:55:37Z","timestamp":1591152937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804910001462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0959804910001462"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2010.02.019","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}