{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:25Z","timestamp":1791288925650,"version":"4.3.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Union 7th Framework Program","award":["HEALTH-F2-2010-259735"],"award-info":[{"award-number":["HEALTH-F2-2010-259735"]}]},{"name":"Deutsche Forschungsgesellschaft"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.ejca.2011.07.016","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T16:09:06Z","timestamp":1320077346000},"page":"1739-1749","source":"Crossref","is-referenced-by-count":333,"title":["Plasma methoxytyramine: A novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status"],"prefix":"10.1016","volume":"48","author":[{"given":"Graeme","family":"Eisenhofer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques W.M.","family":"Lenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Siegert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Friberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Milosevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Marston","family":"Linehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri J.","family":"Timmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pacak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejca.2011.07.016_b0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1677\/erc.1.00829","article-title":"Malignant pheochromocytoma: current status and initiatives for future progress","volume":"11","author":"Eisenhofer","year":"2004","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2011.07.016_b0010","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1677\/ERC-07-0074","article-title":"The diagnosis and management of malignant phaeochromocytoma and paraganglioma","volume":"14","author":"Chrisoulidou","year":"2007","journal-title":"Endocr Relat Cancer"},{"issue":"2","key":"10.1016\/j.ejca.2011.07.016_b0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1677\/erc.1.00913","article-title":"Low molecular weight proteomic information distinguishes metastatic from benign pheochromocytoma","volume":"12","author":"Brouwers","year":"2005","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.ejca.2011.07.016_b0020","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1196\/annals.1353.058","article-title":"Gene expression profiling of benign and malignant pheochromocytoma","volume":"1073","author":"Brouwers","year":"2006","journal-title":"Ann NY Acad Sci"},{"issue":"6","key":"10.1016\/j.ejca.2011.07.016_b0025","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.surg.2008.02.007","article-title":"Prognostic indicators of malignancy in adrenal pheochromocytomas: clinical, histopathologic, and cell cycle\/apoptosis gene expression analysis","volume":"143","author":"Strong","year":"2008","journal-title":"Surgery"},{"issue":"6","key":"10.1016\/j.ejca.2011.07.016_b0030","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/SLA.0b013e3181b248bb","article-title":"Candidate genes associated with malignant pheochromocytomas by genome-wide expression profiling","volume":"250","author":"Suh","year":"2009","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.ejca.2011.07.016_b0035","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1677\/ERC-10-0109","article-title":"Expression of trophic amidated peptides and their receptors in benign and malignant pheochromocytomas: high expression of adrenomedullin RDC1 receptor and implication in tumoral cell survival","volume":"17","author":"Thouennon","year":"2010","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.ejca.2011.07.016_b0040","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1677\/ERC-09-0118","article-title":"Microarray analysis reveals differential expression of benign and malignant pheochromocytoma","volume":"17","author":"Waldmann","year":"2010","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.ejca.2011.07.016_b0045","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1677\/ERC-10-0142","article-title":"MicroRNA profiling of benign and malignant pheochromocytoma identifies novel diagnostic and therapeutic targets","volume":"17","author":"Meyer-Rochow","year":"2010","journal-title":"Endocr Relat Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2011.07.016_b0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0090-4295(98)00612-8","article-title":"Pheochromocytomas: can malignant potential be predicted?","volume":"53","author":"John","year":"1999","journal-title":"Urology"},{"issue":"34","key":"10.1016\/j.ejca.2011.07.016_b0055","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1200\/JCO.2005.03.1484","article-title":"Genetic testing in pheochromocytoma or functional paraganglioma","volume":"23","author":"Amar","year":"2005","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.ejca.2011.07.016_b0060","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1210\/jc.2006-0423","article-title":"High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing","volume":"91","author":"Brouwers","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.ejca.2011.07.016_b0065","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2265.1986.tb01706.x","article-title":"A re-evaluation of dopamine excretion in phaeochromocytoma","volume":"25","author":"Tippett","year":"1986","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9","key":"10.1016\/j.ejca.2011.07.016_b0070","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/BF03345810","article-title":"High incidence of malignant pheochromocytoma in a surgical unit. 26 cases out of 100 patients operated from 1971 to 1991","volume":"15","author":"Proye","year":"1992","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"10.1016\/j.ejca.2011.07.016_b0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/08037050152669729","article-title":"Dopamine and dopa urinary excretion in patients with pheochromocytoma \u2013 diagnostic implications","volume":"10","author":"Januszewicz","year":"2001","journal-title":"Blood Press"},{"issue":"1","key":"10.1016\/j.ejca.2011.07.016_b0080","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1530\/eje.0.1470085","article-title":"The value of plasma markers for the clinical behaviour of phaeochromocytomas","volume":"147","author":"van der Harst","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ejca.2011.07.016_b0085","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1210\/jc.2004-2025","article-title":"Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine","volume":"90","author":"Eisenhofer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.ejca.2011.07.016_b0090","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1093\/clinchem\/32.11.2030","article-title":"Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase","volume":"32","author":"Eisenhofer","year":"1986","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.ejca.2011.07.016_b0095","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/clinchem\/39.1.97","article-title":"Determination of metanephrines in plasma by liquid chromatography with electrochemical detection","volume":"39","author":"Lenders","year":"1993","journal-title":"Clin Chem"},{"issue":"6","key":"10.1016\/j.ejca.2011.07.016_b0100","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/01.HYP.36.6.1045","article-title":"Malignant pheochromocytoma. Chromaffin granule transmitters and response to treatment","volume":"36","author":"Rao","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.ejca.2011.07.016_b0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1196\/annals.1353.042","article-title":"Changes in urinary total metanephrine excretion in recurrent and malignant pheochromocytomas and secreting paragangliomas","volume":"1073","author":"Amar","year":"2006","journal-title":"Ann NY Acad Sci"},{"issue":"3","key":"10.1016\/j.ejca.2011.07.016_b0110","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1210\/jc.2010-1946","article-title":"Clinical risk factors for malignancy and overall survival in patients with pheochromocytomas and sympathetic paragangliomas: primary tumor size and primary tumor location as prognostic indicators","volume":"96","author":"Ayala-Ramirez","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejca.2011.07.016_b0115","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/00000658-197405000-00029","article-title":"Current management of pheochromocytoma","volume":"179","author":"Remine","year":"1974","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.ejca.2011.07.016_b0120","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/BF00353738","article-title":"The pheochromocytoma: a benign, intra-adrenal, hypertensive, sporadic unilateral tumor. Does it exist?","volume":"18","author":"Proye","year":"1994","journal-title":"World J Surg"},{"issue":"6","key":"10.1016\/j.ejca.2011.07.016_b0125","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00000658-199906000-00001","article-title":"Clinical experience over 48 years with pheochromocytoma","volume":"229","author":"Goldstein","year":"1999","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.ejca.2011.07.016_b0130","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1530\/eje.0.1410619","article-title":"Pheochromocytoma in Italy: a multicentric retrospective study","volume":"141","author":"Mannelli","year":"1999","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10.1016\/j.ejca.2011.07.016_b0135","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1053\/ejso.2002.1413","article-title":"The management of benign and malignant pheochromocytoma and abdominal paraganglioma","volume":"29","author":"Edstrom Elder","year":"2003","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2011.07.016_b0140","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1210\/jc.2004-1398","article-title":"Year of diagnosis, features at presentation, and risk of recurrence in patients with pheochromocytoma or secreting paraganglioma","volume":"90","author":"Amar","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.ejca.2011.07.016_b0145","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.juro.2010.12.050","article-title":"Predictive factors for malignant pheochromocytoma: analysis of 136 patients","volume":"185","author":"Feng","year":"2011","journal-title":"J Urol"},{"issue":"4","key":"10.1016\/j.ejca.2011.07.016_b0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4111\/kju.2011.52.4.241","article-title":"Predictive characteristics of malignant pheochromocytoma","volume":"52","author":"Park","year":"2011","journal-title":"Korean J Urol"},{"key":"10.1016\/j.ejca.2011.07.016_b0155","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1210\/jc.2008-1093","article-title":"Biochemically silent abdominal paragangliomas in patients with mutations in the Sdhb gene","volume":"93","author":"Timmers","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"16","key":"10.1016\/j.ejca.2011.07.016_b0160","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1200\/JCO.2006.09.6297","article-title":"Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma","volume":"25","author":"Timmers","year":"2007","journal-title":"J Clin Oncol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980491100791X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980491100791X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T15:20:57Z","timestamp":1593184857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095980491100791X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S095980491100791X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2011.07.016","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}