{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:36:11Z","timestamp":1789011371251,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ejcancer.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.ejca.2013.08.027","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T06:16:36Z","timestamp":1383632196000},"page":"411-417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Improving results of autologous stem cell transplantation for Philadelphia-positive acute lymphoblastic leukaemia in the era of tyrosine kinase inhibitors: A report from the Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation"],"prefix":"10.1016","volume":"50","author":[{"given":"Sebastian","family":"Giebel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert Claude","family":"Gorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Caillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Leguay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas","family":"Schaap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricette","family":"Michallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Dombret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2013.08.027_b0005","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1182\/blood-2002-03-0704","article-title":"Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia \u2013 results of the prospective multicenter LALA-94 trial","volume":"100","author":"Dombret","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s00277-006-0099-z","article-title":"Outcome of treatment in adults with Philadelphia chromosome-positive and\/or BCR-ABL \u2013 positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG)","volume":"85","author":"Wrzesie\u0144-Ku\u015b","year":"2006","journal-title":"Ann Hematol"},{"key":"10.1016\/j.ejca.2013.08.027_b0015","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1182\/blood-2009-01-199380","volume":"113","author":"Fielding","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0020","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1182\/blood-2006-11-052373","article-title":"Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)","volume":"110","author":"Pfeifer","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbmt.2012.08.021","article-title":"Long-term follow-up of the imatinib GRAAPH-2003 study in newly diagnosed patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: a GRAALL study","volume":"19","author":"Tanguy-Schmidt","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ejca.2013.08.027_b0030","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1200\/JCO.2010.28.1287","article-title":"Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: Northern Italy Leukemia Group protocol 09\/00","volume":"28","author":"Bassan","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2013.08.027_b0035","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1182\/blood.V120.21.138.138","article-title":"Is less chemotherapy detrimental in adults with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) treated with high-dose imatinib? Results of the prospective randomized Graaph-2005 study","volume":"120","author":"Chalandon","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0040","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O","article-title":"Estimation of failure probabilities in the presence of competing risks: new representations of old estimators","volume":"18","author":"Gooley","year":"1999","journal-title":"Stat Med"},{"key":"10.1016\/j.ejca.2013.08.027_b0045","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"issue":"18","key":"10.1016\/j.ejca.2013.08.027_b0050","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1182\/blood-2010-01-242750","article-title":"Treat Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"116","author":"Fielding","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0055","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1182\/blood-2003-08-2958","article-title":"Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate","volume":"103","author":"Thomas","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0060","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1200\/JCO.2005.03.2177","article-title":"High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group","volume":"24","author":"Yanada","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2013.08.027_b0065","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/sj.leu.2403886","article-title":"Clinical effect of imatinib added to intensive combination chemotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"19","author":"Lee","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.ejca.2013.08.027_b0070","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1182\/blood-2005-11-4386","article-title":"Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)","volume":"108","author":"Wassmann","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0075","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1182\/blood-2006-03-011908","article-title":"Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study","volume":"109","author":"de Labarthe","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0080","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/bmt.2009.308","article-title":"Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL","volume":"45","author":"Giebel","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ejca.2013.08.027_b0085","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3109\/10428194.2011.557168","article-title":"Stable non-transforming minimal residual disease in Philadelphia chromosome positive acute lymphoblastic leukemia after autologous transplantation: origin from neoplastic yet \u2018pre-leukemic\u2019 stem cells?","volume":"52","author":"B\u00f6hm","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.ejca.2013.08.027_b0090","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1182\/blood.V120.21.816.816","article-title":"Autologous transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia achieves outcomes similar to allogeneic transplantation \u2013 results of CALGB 10001 (Alliance)","volume":"120","author":"Wetzler","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2013.08.027_b0095","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bbmt.2011.08.011","article-title":"Long-term follow-up of allogeneic hematopoietic stem cell transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: impact of tyrosine kinase inhibitors on treatment outcomes","volume":"18","author":"Kebriaei","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ejca.2013.08.027_b0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1756-8722-5-29","article-title":"Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"5","author":"Chen","year":"2012","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.ejca.2013.08.027_b0105","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1200\/JCO.2004.07.130","article-title":"Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission","volume":"22","author":"Kiehl","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2013.08.027_b0110","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00277-009-0719-5","article-title":"Outcome of HLA-matched related allogeneic hematopoietic stem cell transplantation for patients with acute leukemia in first complete remission treated in Eastern European centers. Better results in recent years","volume":"88","author":"Giebel","year":"2009","journal-title":"Ann Hematol"},{"key":"10.1016\/j.ejca.2013.08.027_b0115","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1200\/JCO.2008.20.1400","article-title":"Higher incidence of relapse with peripheral blood rather than marrow as a source of stem cells in adults with acute myelocytic leukemia autografted during the first remission","volume":"27","author":"Gorin","year":"2009","journal-title":"J Clin Oncol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980491300909X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980491300909X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T10:09:23Z","timestamp":1596794963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095980491300909X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S095980491300909X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2013.08.027","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improving results of autologous stem cell transplantation for Philadelphia-positive acute lymphoblastic leukaemia in the era of tyrosine kinase inhibitors: A report from the Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2013.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}