{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:34:43Z","timestamp":1790778883132,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"7","content-domain":{"domain":["ejcancer.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.ejca.2014.01.008","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T20:10:28Z","timestamp":1395951028000},"page":"1259-1268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Randomised phase II trial of photodynamic therapy plus oral fluoropyrimidine, S-1, versus photodynamic therapy alone for unresectable hilar cholangiocarcinoma"],"prefix":"10.1016","volume":"50","clinical-trial-number":[{"clinical-trial-number":"nct00869635","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Do Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Lyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Woong","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Bum","family":"Eum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Wan","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Koo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Bok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ejca.2014.01.008_b0005","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1136\/gutjnl-2011-301748","article-title":"Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update","volume":"61","author":"Khan","year":"2012","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.ejca.2014.01.008_b0010","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cgh.2007.12.004","article-title":"Unresectable cholangiocarcinoma: comparison of survival in biliary stenting alone versus stenting with photodynamic therapy","volume":"6","author":"Kahaleh","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.ejca.2014.01.008_b0015","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.32.6.685","article-title":"Palliation of proximal malignant biliary obstruction by endoscopic endoprosthesis insertion","volume":"32","author":"Polydorou","year":"1991","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.ejca.2014.01.008_b0020","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/BF01296439","article-title":"Management of malignant hilar biliary obstruction by endoscopy. Results and prognostic factors","volume":"37","author":"Ducreux","year":"1992","journal-title":"Dig Dis Sci"},{"issue":"2","key":"10.1016\/j.ejca.2014.01.008_b0025","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0016-5107(88)71271-7","article-title":"Long-term follow-up of patients with hilar malignant stricture treated by endoscopic internal biliary drainage","volume":"34","author":"Deviere","year":"1988","journal-title":"Gastrointest Endosc"},{"issue":"5","key":"10.1016\/j.ejca.2014.01.008_b0030","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.gastro.2003.07.015","article-title":"Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study","volume":"125","author":"Ortner","year":"2003","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.ejca.2014.01.008_b0035","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1111\/j.1572-0241.2005.00318.x","article-title":"Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy","volume":"100","author":"Zoepf","year":"2005","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.ejca.2014.01.008_b0040","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cgh.2007.02.021","article-title":"Factors associated with increased survival after photodynamic therapy for cholangiocarcinoma","volume":"5","author":"Prasad","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.ejca.2014.01.008_b0045","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.gastro.2003.09.008","article-title":"A spotlight on cholangiocarcinoma","volume":"125","author":"Gores","year":"2003","journal-title":"Gastroenterology"},{"issue":"14","key":"10.1016\/j.ejca.2014.01.008_b0050","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJMoa0908721","article-title":"Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer","volume":"362","author":"Valle","year":"2010","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ejca.2014.01.008_b0055","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/MOG.0b013e32832e6e1f","article-title":"Photodynamic therapy for cholangiocarcinoma: overview and new developments","volume":"25","author":"Ortner","year":"2009","journal-title":"Curr Opin Gastroenterol"},{"issue":"4","key":"10.1016\/j.ejca.2014.01.008_b0060","doi-asserted-by":"crossref","first-page":"390","DOI":"10.5946\/ce.2013.46.4.390","article-title":"Photodynamic therapy in unresectable cholangiocarcinoma: not for the uncommitted","volume":"46","author":"Talreja","year":"2013","journal-title":"Clin Endosc"},{"issue":"10","key":"10.1016\/j.ejca.2014.01.008_b0065","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/sj.bjc.6602208","article-title":"Phase II study of S-1 in patients with advanced biliary tract cancer","volume":"91","author":"Ueno","year":"2004","journal-title":"Br J Cancer"},{"issue":"13","key":"10.1016\/j.ejca.2014.01.008_b0070","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1200\/JCO.2012.43.3680","article-title":"Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan: GEST study","volume":"31","author":"Ueno","year":"2013","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.ejca.2014.01.008_b0075","first-page":"748","article-title":"Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts","volume":"78","author":"Tatsumi","year":"1987","journal-title":"Jpn J Cancer Res"},{"issue":"17","key":"10.1016\/j.ejca.2014.01.008_b0080","first-page":"4004","article-title":"Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats","volume":"53","author":"Shirasaka","year":"1993","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.ejca.2014.01.008_b0085","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000195538","article-title":"Efficacy and safety of S-1 monotherapy in patients with advanced biliary tract adenocarcinoma: retrospective analysis of 162 patients","volume":"76","author":"Park","year":"2009","journal-title":"Oncology"},{"issue":"4","key":"10.1016\/j.ejca.2014.01.008_b0165","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00000658-200110000-00010","article-title":"Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma","volume":"234","author":"Jarnagin","year":"2001","journal-title":"Ann Surg"},{"issue":"9","key":"10.1016\/j.ejca.2014.01.008_b0170","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/ajg.2009.254","article-title":"EUS-guided biliary drainage with one-step placement of a fully covered metal stent for malignant biliary obstruction: a prospective feasibility study","volume":"104","author":"Park","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"10.1016\/j.ejca.2014.01.008_b0100","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1002\/cncr.23454","article-title":"Rate of bilirubin regression after stenting in malignant biliary obstruction for the initiation of chemotherapy: how soon should we repeat endoscopic retrograde cholangiopancreatography?","volume":"112","author":"Weston","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2014.01.008_b0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1023\/A:1020106129820","article-title":"DDQ-15 health-related quality of life instrument for patients with digestive disorders","volume":"2","author":"Hebert","year":"2001","journal-title":"Health Serv Outcomes Res Methodol"},{"issue":"2","key":"10.1016\/j.ejca.2014.01.008_b0110","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2014.01.008_b0115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/MOG.0b013e3283292383","article-title":"A conceptual proposal for staging ductal cholangiocarcinoma","volume":"25","author":"Blechacz","year":"2009","journal-title":"Curr Opin Gastroenterol"},{"issue":"2","key":"10.1016\/j.ejca.2014.01.008_b0120","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.510310205","article-title":"Photodynamic therapy for advanced bile duct cancer: evidence for improved palliation and extended survival","volume":"31","author":"Berr","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.ejca.2014.01.008_b0125","unstructured":"Pereira S, Hughes SK, Roughton M, O\u2019Donoghue P, Wasan HS, Valle J, et al. Photostent-02: porfimer sodium photodynamic therapy plus stenting versus stenting alone in patients with advanced or metastatic cholangiocarcinomas and other biliary tract tumours: a multicentre, randomised phase III trial [abstract]. Presented the European Society for Medical Oncology (ESMO) 2010 congress, October 8\u201312, Milan, Italy; 2010. [Abstract 8020]."},{"issue":"Suppl 2","key":"10.1016\/j.ejca.2014.01.008_b0130","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.6004\/jnccn.2012.0174","article-title":"Photodynamic therapy in cholangiocarcinoma","volume":"10","author":"Kahaleh","year":"2012","journal-title":"J Natl Compr Canc Netw"},{"issue":"5","key":"10.1016\/j.ejca.2014.01.008_b0135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-2005-861294","article-title":"Prospective study of the effectiveness of percutaneous transhepatic photodynamic therapy for advanced bile duct cancer and the role of intraductal ultrasonography in response assessment","volume":"37","author":"Shim","year":"2005","journal-title":"Endoscopy"},{"issue":"3","key":"10.1016\/j.ejca.2014.01.008_b0140","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1440-1746.2005.03582.x","article-title":"Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma","volume":"20","author":"Harewood","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.ejca.2014.01.008_b0145","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0016-5107(03)70021-2","article-title":"Phase II study of photodynamic therapy and metal stent as palliative treatment for nonresectable hilar cholangiocarcinoma","volume":"57","author":"Dumoulin","year":"2003","journal-title":"Gastrointest Endosc"},{"issue":"3","key":"10.1016\/j.ejca.2014.01.008_b0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1477-2574.2011.00424.x","article-title":"Longterm outcome of photodynamic therapy compared with biliary stenting alone in patients with advanced hilar cholangiocarcinoma","volume":"14","author":"Cheon","year":"2012","journal-title":"HPB (Oxford)"},{"issue":"13","key":"10.1016\/j.ejca.2014.01.008_b0155","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1200\/JCO.2007.15.2090","article-title":"Potential regional differences for the tolerability profiles of fluoropyrimidines","volume":"26","author":"Haller","year":"2008","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.ejca.2014.01.008_b0160","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1349-7006.2010.01793.x","article-title":"Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients","volume":"102","author":"Chuah","year":"2011","journal-title":"Cancer Sci"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804914000422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804914000422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:16:09Z","timestamp":1565309769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804914000422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0959804914000422"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2014.01.008","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomised phase II trial of photodynamic therapy plus oral fluoropyrimidine, S-1, versus photodynamic therapy alone for unresectable hilar cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2014.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}