{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:29:17Z","timestamp":1789655357818,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007363","name":"Fondazione Citta della Speranza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ejca.2015.06.121","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T04:26:02Z","timestamp":1439007962000},"page":"2444-2452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Thymoma and thymic carcinoma in children and adolescents: A report from the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT)"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-4157","authenticated-orcid":false,"given":"Teresa","family":"Stachowicz-Stencel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Brecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Bien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Synakiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Rod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cecchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2015.06.121_b0005","series-title":"Perez and Brady\u2019s principles and practice of radiation oncology","author":"Halperin","year":"2008"},{"key":"10.1016\/j.ejca.2015.06.121_b0010","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1200\/JCO.1990.8.8.1419","article-title":"Chemotherapy of invasive thymoma","volume":"8","author":"Fornasiero","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2015.06.121_b0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.pneumo.2008.12.007","article-title":"Primary thymic carcinoma. Three cases and a review of literature","volume":"65","author":"Ayadi-Kaddour","year":"2009","journal-title":"Rev Pneumol Clin"},{"key":"10.1016\/j.ejca.2015.06.121_b0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1750-1172-6-28","article-title":"Epithelial thymic tumours in paediatric age: a report from the TREP project","volume":"6","author":"Carretto","year":"2011","journal-title":"Orphanet Rare Dis"},{"key":"10.1016\/j.ejca.2015.06.121_b0025","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/pbc.22482","article-title":"Thymic carcinoma in children: a report from the polish pediatric rare tumors study","volume":"54","author":"Stachowicz-Stencel","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2015.06.121_b0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/pbc.20468","article-title":"Thymic carcinoma in children","volume":"47","author":"Yaris","year":"2006","journal-title":"Pediatr Blood Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2015.06.121_b0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.pediatrneurol.2012.02.025","article-title":"Childhood-onset myasthenia gravis with thymoma","volume":"46","author":"Nikolic","year":"2012","journal-title":"Pediatr Neurol"},{"issue":"5","key":"10.1016\/j.ejca.2015.06.121_b0040","doi-asserted-by":"crossref","first-page":"372","DOI":"10.5692\/clinicalneurol.53.372","article-title":"A case of thymoma-associated myasthenia gravis with anti-MuSK antibodies","volume":"53","author":"Ito","year":"2013","journal-title":"Rinsho Shinkeigaku"},{"issue":"4","key":"10.1016\/j.ejca.2015.06.121_b0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/CND.0b013e31828a0090","article-title":"Correlation between acetylcholine receptor antibody levels and thymic pathology in myasthenia gravis: a review","volume":"14","author":"Huang","year":"2013","journal-title":"J Clin Neuromuscul Dis"},{"key":"10.1016\/j.ejca.2015.06.121_b0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.lpm.2013.07.002","article-title":"Thymic tumours: an update","volume":"42","author":"Polo","year":"2013","journal-title":"Presse Med"},{"issue":"11","key":"10.1016\/j.ejca.2015.06.121_b0055","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/pbc.25159","article-title":"Surgical management of thymic epithelial tumors in children: lessons from the French Society of Pediatric Oncology and review of the literature","volume":"61","author":"Rod","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2015.06.121_b0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.critrevonc.2007.04.005","article-title":"Management of thymomas","volume":"65","author":"Wright","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ejca.2015.06.121_b0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/00313029800169056","article-title":"Thymic carcinoma: spectrum of differentiation and histologic types","volume":"30","author":"Suster","year":"1998","journal-title":"Pathology"},{"key":"10.1016\/j.ejca.2015.06.121_b0070","series-title":"Clinical radiation oncology","author":"Gunderson","year":"2007"},{"key":"10.1016\/j.ejca.2015.06.121_b0075","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R","article-title":"Follow up study of thymomas with special reference to their clinical stages","volume":"48","author":"Masaoka","year":"1981","journal-title":"Cancer"},{"issue":"7 Suppl. 3","key":"10.1016\/j.ejca.2015.06.121_b0080","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1097\/JTO.0b013e31821e8cff","article-title":"The Masaoka-Koga stage classification for thymic malignancies: clarification and definition of terms","volume":"6","author":"Detterbeck","year":"2011","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ejca.2015.06.121_b0085","unstructured":"World Health Organization Classification of Tumors. Pathology and genetics of tumors of the lung, pleura, thymus and heart. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC (eds.), Lyon: International Agency for Research on Cancer (IARC) Press; 2004."},{"key":"10.1016\/j.ejca.2015.06.121_b0090","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.ejca.2015.06.121_b0095","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2214\/ajr.176.2.1760433","article-title":"Malignant thymic epithelial tumors: CT-pathologic correlation","volume":"176","author":"Jung","year":"2001","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"10.1016\/j.ejca.2015.06.121_b0100","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/JTO.0b013e3182835549","article-title":"FDG PET-CT aids in the preoperative assessment of patients with newly diagnosed thymic epithelial malignancies","volume":"8","author":"Benveniste","year":"2013","journal-title":"J Thorac Oncol"},{"issue":"2","key":"10.1016\/j.ejca.2015.06.121_b0105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/ejcts\/ezt263","volume":"44","author":"Toba","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"issue":"6","key":"10.1016\/j.ejca.2015.06.121_b0110","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1158\/1078-0432.CCR-12-2929","article-title":"18F-fluorodeoxyglucose positron emission tomography in the management of patients with thymic epithelial tumors","volume":"19","author":"Thomas","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejca.2015.06.121_b0115","first-page":"161","article-title":"Primary mediastinal malignancies: findings in 219 patients","volume":"170","author":"Temes","year":"1999","journal-title":"West J Med"},{"key":"10.1016\/j.ejca.2015.06.121_b0120","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s00415-006-0429-z","article-title":"Paraneoplastic diseases associated with thymoma","volume":"254","author":"Evoli","year":"2007","journal-title":"J Neurol"},{"key":"10.1016\/j.ejca.2015.06.121_b0125","series-title":"Histological typing of tumors of the thymus","author":"Rosai","year":"1999"},{"key":"10.1016\/j.ejca.2015.06.121_b0130","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/cncr.10226","article-title":"The World Health Organization histologic classification system reflects the oncologic behavior of thymoma a clinical study 273 patients","volume":"94","author":"Okumura","year":"2002","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.ejca.2015.06.121_b0135","first-page":"161","article-title":"Early-stage thymic carcinoma: is adjuvant therapy required?","volume":"5","author":"Sakai","year":"2013","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.ejca.2015.06.121_b0140","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/j.athoracsur.2011.07.078","article-title":"Management and outcomes of relapse after treatment for thymoma and thymic carcinoma","volume":"92","author":"Bott","year":"2011","journal-title":"AA Thorac Surg"},{"key":"10.1016\/j.ejca.2015.06.121_b0145","first-page":"8","article-title":"Chemotherapy for thymic carcinoma and advanced thymoma in adults","volume":"23","author":"Wei","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.ejca.2015.06.121_b0150","first-page":"173","article-title":"Thymic neoplasm: a rare disease with a complex clinical presentation","volume":"5","author":"Rashid","year":"2013","journal-title":"J Thorac Dis"},{"issue":"1","key":"10.1016\/j.ejca.2015.06.121_b0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.lungcan.2012.12.012","article-title":"Clinical outcomes with chemotherapy for advanced thymic carcinoma","volume":"80","author":"Okuma","year":"2013","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ejca.2015.06.121_b0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/1097-0142(19910701)68:1<30::AID-CNCR2820680106>3.0.CO;2-4","article-title":"Chemotherapy for invasive thymoma: A 13-year experience","volume":"68","author":"Fornasiero","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2015.06.121_b0165","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/JTO.0b013e3181db3dee","article-title":"Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: a French experience","volume":"5","author":"Grassin","year":"2010","journal-title":"J Thorac Oncol"},{"issue":"6","key":"10.1016\/j.ejca.2015.06.121_b0170","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1586\/era.13.54","article-title":"Thymoma and radiation therapy: a systematic review of medical treatment","volume":"13","author":"Giannopoulou","year":"2013","journal-title":"Expert Rev Anticancer Ther"},{"issue":"1","key":"10.1016\/j.ejca.2015.06.121_b0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1748-717X-8-199","article-title":"Postoperative radiotherapy for completely resected Masaoka stage III thymoma: a retrospective study of 65 cases from a single institution","volume":"8","author":"Fan","year":"2013","journal-title":"Radiat Oncol"},{"issue":"6","key":"10.1016\/j.ejca.2015.06.121_b0180","doi-asserted-by":"crossref","first-page":"890","DOI":"10.18632\/oncotarget.1015","article-title":"Thymoma patients treated in a phase I clinic at MD Anderson Cancer Center: responses to mTOR inhibitors and molecular analyses","volume":"4","author":"Wheler","year":"2013","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.ejca.2015.06.121_b0185","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ctrv.2012.11.005","article-title":"Thymoma and thymic carcinoma in the target therapies era","volume":"39","author":"Lamarca","year":"2013","journal-title":"Cancer Treat Rev"},{"issue":"11","key":"10.1016\/j.ejca.2015.06.121_b0190","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/MPH.0b013e318159a535","article-title":"Advanced pediatric inoperable thymus carcinoma (type C thymoma): case report on a novel therapeutic approach","volume":"29","author":"Kertesz","year":"2007","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.ejca.2015.06.121_b0195","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.bjc.6605740","article-title":"Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience","volume":"103","author":"Strobel","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.ejca.2015.06.121_b0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1470-2045(14)71181-7","article-title":"Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial","volume":"16","author":"Thomas","year":"2015","journal-title":"Lancet Oncol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804915006474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804915006474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T05:58:47Z","timestamp":1537423127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804915006474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":40,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0959804915006474"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2015.06.121","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thymoma and thymic carcinoma in children and adolescents: A report from the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT)","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2015.06.121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}