{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:13:02Z","timestamp":1785888782084,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ejca.2015.07.040","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T14:44:30Z","timestamp":1439390670000},"page":"2508-2516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Survival of breast cancer patients with synchronous or metachronous central nervous system metastases"],"prefix":"10.1016","volume":"51","author":[{"given":"V.K.Y.","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.M.","family":"Gijtenbeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Brandsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.V.","family":"Beerepoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.S.","family":"Sonke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van der Heiden-van der Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.ejca.2015.07.040_b0005","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1200\/JCO.2004.12.149","article-title":"Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System","volume":"22","author":"Barnholtz-Sloan","year":"2004","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.ejca.2015.07.040_b0010","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/cncr.10541","article-title":"Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma","volume":"94","author":"Schouten","year":"2002","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jso.2930230311","article-title":"Breast carcinoma: pattern of metastasis at autopsy","volume":"23","author":"Lee","year":"1983","journal-title":"J Surg Oncol"},{"issue":"12","key":"10.1016\/j.ejca.2015.07.040_b0020","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/1097-0142(19831215)52:12<2349::AID-CNCR2820521231>3.0.CO;2-B","article-title":"Central nervous system metastasis from breast carcinoma. Autopsy study","volume":"52","author":"Tsukada","year":"1983","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2015.07.040_b0025","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/annonc\/mdp407","article-title":"Breast cancer brain metastases: differences in survival depending on biological subtype, RPA RTOG prognostic class and systemic treatment after whole-brain radiotherapy (WBRT)","volume":"21","author":"Niwinska","year":"2010","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0030","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10549-007-9806-2","article-title":"Brain metastases in breast cancer: prognostic factors and management","volume":"111","author":"Lee","year":"2008","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"10.1016\/j.ejca.2015.07.040_b0035","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1002\/cncr.23088","article-title":"Clinicopathologic characteristics and prognostic factors in 420 metastatic breast cancer patients with central nervous system metastasis","volume":"110","author":"Altundag","year":"2007","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2015.07.040_b0040","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.breast.2012.12.006","article-title":"Clinical outcomes and treatment practice patterns of patients with HER2-positive metastatic breast cancer in the post-trastuzumab era","volume":"22","author":"Olson","year":"2013","journal-title":"Breast (Edinburgh, Scotland)"},{"issue":"11","key":"10.1016\/j.ejca.2015.07.040_b0045","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1093\/annonc\/mdi371","article-title":"Isolated central nervous system metastases in patients with HER2-overexpressing advanced breast cancer treated with first-line trastuzumab-based therapy","volume":"16","author":"Burstein","year":"2005","journal-title":"Ann Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2015.07.040_b0050","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6601970","article-title":"Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer","volume":"91","author":"Clayton","year":"2004","journal-title":"Br J Cancer"},{"issue":"12","key":"10.1016\/j.ejca.2015.07.040_b0055","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1002\/cncr.11436","article-title":"Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma","volume":"97","author":"Bendell","year":"2003","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0060","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11060-013-1083-9","article-title":"The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer","volume":"112","author":"Sperduto","year":"2013","journal-title":"J Neurooncol"},{"issue":"5","key":"10.1016\/j.ejca.2015.07.040_b0065","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.ijrobp.2011.02.027","article-title":"Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases","volume":"82","author":"Sperduto","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejca.2015.07.040_b0070","first-page":"Cd009454","article-title":"Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases","volume":"3","author":"Soon","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.ejca.2015.07.040_b0075","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","article-title":"Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952\u201326001 study","volume":"29","author":"Kocher","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2015.07.040_b0080","first-page":"Cd003869","article-title":"Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases","volume":"4","author":"Tsao","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl. 7","key":"10.1016\/j.ejca.2015.07.040_b0085","doi-asserted-by":"crossref","first-page":"vii11","DOI":"10.1093\/annonc\/mds232","article-title":"Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"23","author":"Cardoso","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2015.07.040_b0090","unstructured":"DSfN-O. Practice guideline \u2018Brain metastases\u2019 3.0 Utrecht: IKNL; 2011. Available from: http:\/\/www.oncoline.nl\/brain-metastases [updated 2014; cited 2014 December 22]."},{"key":"10.1016\/j.ejca.2015.07.040_b0095","unstructured":"DSfN-O. Practice guideline \u2018Leptomeningeal metastases from solid tumours\u2019 1.1 Utrecht: IKNL; 2006. Available from: http:\/\/www.oncoline.nl\/leptomeningeal-metastases [updated 2010; cited 2014 October 12]."},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0100","first-page":"181","article-title":"Imaging of metastatic breast cancer: distribution and radiological assessment at presentation","volume":"13","author":"Whitlock","year":"2001","journal-title":"Clin Oncol"},{"issue":"52","key":"10.1016\/j.ejca.2015.07.040_b0105","first-page":"A4141","article-title":"Practice guideline \u2018Brain metastases\u2019 (revision)","volume":"155","author":"Gijtenbeek","year":"2011","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"1","key":"10.1016\/j.ejca.2015.07.040_b0110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11060-004-8093-6","article-title":"Brain metastases: epidemiology and pathophysiology","volume":"75","author":"Gavrilovic","year":"2005","journal-title":"J Neurooncol"},{"issue":"11","key":"10.1016\/j.ejca.2015.07.040_b0115","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/annonc\/mdq220","article-title":"Survival differences among women with de novo stage IV and relapsed breast cancer","volume":"21","author":"Dawood","year":"2010","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/ije\/22.3.369","article-title":"Completeness of cancer registration in Limburg, The Netherlands","volume":"22","author":"Schouten","year":"1993","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ejca.2015.07.040_b0125","series-title":"TNM Classification of Malignant Tumours. International Union Against Cancer (UICC)","author":"Sobin","year":"2010"},{"key":"10.1016\/j.ejca.2015.07.040_b0130","series-title":"TNM Classification of Malignant Tumours. International Union Against Cancer (UICC)","author":"Sobin","year":"2002"},{"key":"10.1016\/j.ejca.2015.07.040_b0135","first-page":"A1984","article-title":"Percentage of local recurrence following treatment for breast cancer is not a suitable performance indicator","volume":"154","author":"van der Heiden-van-der-Loo","year":"2010","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10.1016\/j.ejca.2015.07.040_b0140","series-title":"ICD-O international classification of diseases for oncology","author":"Fritz","year":"2000"},{"issue":"1","key":"10.1016\/j.ejca.2015.07.040_b0145","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10549-012-2243-x","article-title":"Brain metastases after breast-conserving therapy and systemic therapy: incidence and characteristics by biologic subtype","volume":"136","author":"Arvold","year":"2012","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.1016\/j.ejca.2015.07.040_b0150","doi-asserted-by":"crossref","first-page":"e479","DOI":"10.1016\/j.ijrobp.2012.01.054","article-title":"Importance of extracranial disease status and tumor subtype for patients undergoing radiosurgery for breast cancer brain metastases","volume":"83","author":"Dyer","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejca.2015.07.040_b0155","doi-asserted-by":"crossref","first-page":"b5087","DOI":"10.1136\/bmj.b5087","article-title":"Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes","volume":"340","author":"Levesque","year":"2010","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0160","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11060-012-0976-3","article-title":"Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery","volume":"110","author":"Vern-Gross","year":"2012","journal-title":"J Neurooncol"},{"issue":"4","key":"10.1016\/j.ejca.2015.07.040_b0165","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0360-3016(96)00619-0","article-title":"Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials","volume":"37","author":"Gaspar","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ejca.2015.07.040_b0170","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ijrobp.2007.06.074","article-title":"A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database","volume":"70","author":"Sperduto","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0175","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ijrobp.2009.08.025","article-title":"Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients","volume":"77","author":"Sperduto","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ejca.2015.07.040_b0180","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/neuonc\/not200","article-title":"Assessment of prognostic scores in brain metastases from breast cancer","volume":"16","author":"Tabouret","year":"2014","journal-title":"Neuro-oncology"},{"issue":"2","key":"10.1016\/j.ejca.2015.07.040_b0185","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10549-011-1349-x","article-title":"Improved survival of patients with primary distant metastatic breast cancer in the period of 1995\u20132008. A nationwide population-based study in the Netherlands","volume":"128","author":"Ruiterkamp","year":"2011","journal-title":"Breast Cancer Res Treatment"},{"key":"10.1016\/j.ejca.2015.07.040_b0190","doi-asserted-by":"crossref","unstructured":"In: van der Heiden-van der Loo M, Visser O, Siesling S, Voogd A, van der Wall E, Sonke G, editors. Improvement in survival in MBC mostly seen in patients with HER2 positive disease and <50 years. 9th European Breast Cancer Conference (EBCC-9), 2014; 2014.","DOI":"10.1016\/S0959-8049(14)70111-X"},{"issue":"11","key":"10.1016\/j.ejca.2015.07.040_b0195","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1038\/bjc.2012.163","article-title":"Incidence and time trends of brain metastases admissions among breast cancer patients in Sweden","volume":"106","author":"Frisk","year":"2012","journal-title":"Br J Cancer"},{"issue":"16","key":"10.1016\/j.ejca.2015.07.040_b0200","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1200\/JCO.2004.08.095","article-title":"Breast cancer with synchronous metastases: trends in survival during a 14-year period","volume":"22","author":"Andre","year":"2004","journal-title":"J Clin Oncol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804915007467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804915007467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T04:00:59Z","timestamp":1599451259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804915007467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":40,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0959804915007467"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2015.07.040","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Survival of breast cancer patients with synchronous or metachronous central nervous system metastases","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2015.07.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}