{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:05:20Z","timestamp":1793642720586,"version":"4.5.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Union's Seventh Framework Programme","award":["261474"],"award-info":[{"award-number":["261474"]}]},{"name":"Hepatoblastoma Foundation"},{"name":"Madeleine Schickedanz Children's Cancer Foundation"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.ejca.2015.09.023","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T09:31:22Z","timestamp":1448962282000},"page":"92-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":253,"special_numbering":"C","title":["The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model"],"prefix":"10.1016","volume":"52","author":[{"given":"Piotr","family":"Czauderna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Haeberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiso","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Rangaswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Krailo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Maibach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Malogolowkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Leuschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Lopez-Terrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoro","family":"Hishiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Perilongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"von Schweinitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Derosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecka","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2015.09.023_bib1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/jhep.2003.50375","article-title":"Epidemiology of primary hepatic malignancies in U.S. children","volume":"38","author":"Darbari","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ejca.2015.09.023_bib2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/pbc.24217","article-title":"Hepatoblastoma clinical research: lessons learned and future challenges","volume":"59","author":"Perilongo","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cncr.10632","article-title":"Pretreatment prognostic factors and treatment results in children with hepatoblastoma. A report of the German Cooperative Paediatric Liver Tumor Study HB-94","volume":"95","author":"Fuchs","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1200\/JCO.2005.07.145","article-title":"Predictive value of the Pretreatment extent of disease system in hepatoblastoma: results from the international society of pediatric oncology liver tumor study group SIOPEL-1 study","volume":"23","author":"Aronson","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2015.09.023_bib5","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/pbc.22088","article-title":"Pretreatment prognostic factors in hepatoblastoma: a report of the Children's Oncology Group","volume":"53","author":"Meyers","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib6","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.ejca.2011.12.011","article-title":"Prognostic stratification for children with hepatoblastoma: the SIOPEL experience","volume":"48","author":"Maibach","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib7","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ejca.2006.08.028","article-title":"Cecchetto G Italian Study on Rare Tumours in Paediatric Age (TREP); Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). The challenge of very rare tumours in childhood: the Italian TREP project","volume":"43","author":"Ferrari","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejca.2003.06.003","article-title":"Risk adapted treatment for childhood hepatoblastoma; final report of the second study of the International Society of Paediatric Oncology \u2013 SIOPEL 2","volume":"40","author":"Perilongo","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib9","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa0810613","article-title":"Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma","volume":"361","author":"Perilongo","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2015.09.023_bib10","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1200\/JCO.2009.22.4857","article-title":"Successful treatment of childhood high-risk hepatoblatoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study","volume":"28","author":"Zsiros","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2015.09.023_bib11","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1200\/JCO.2000.18.14.2665","article-title":"Randomized comparison of cisplatin\/vincristine\/fluorouracil and cisplatin\/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group","volume":"18","author":"Ortega","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2015.09.023_bib12","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1200\/JCO.2010.29.3837","article-title":"Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the Children's Oncology Group","volume":"29","author":"Malogolowkin","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2015.09.023_bib13","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1002\/cncr.24667","article-title":"Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group","volume":"115","author":"Katzenstein","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib14","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0022-3468(95)90762-9","article-title":"Complete resection before development of drug resistance is essential for survival from advanced hepatoblastoma \u2014 a report from the German cooperative pediatric liver tumor study HB-89","volume":"30","author":"Von Schweinitz","year":"1995","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ejca.2015.09.023_bib15","first-page":"159","article-title":"Differentiated treatment protocols for high- and standard-risk hepatoblastoma e an interim report of the German liver tumor study HB99","volume":"215","author":"Haeberle","year":"2003","journal-title":"Klin Padiatr"},{"key":"10.1016\/j.ejca.2015.09.023_bib16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/jpsu.2002.32886","article-title":"Outcome of hepatoblastoma treatment with JPLT-1 protocol-1: a report from the Japanese study group for pediatric liver tumor","volume":"37","author":"Sasaki","year":"2002","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ejca.2015.09.023_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00383-010-2708-0","article-title":"Outcome of hepatoblastoma treated using the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocol- 2: report from the JPLT","volume":"27","author":"Hishiki","year":"2011","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.ejca.2015.09.023_bib18","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1200\/JCO.2005.02.6013","article-title":"Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma","volume":"24","author":"Malogolowkin","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2015.09.023_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00247-006-0361-5","article-title":"2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group","volume":"37","author":"Roebuck","year":"2007","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.ejca.2015.09.023_bib20","series-title":"The statistical analysis of failure time data","author":"Kalbfleisch","year":"2002"},{"key":"10.1016\/j.ejca.2015.09.023_bib21","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/S0959-8049(00)00074-5","article-title":"Pretreatment prognostic factors for children with hepatoblastoma \u2013 results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1","volume":"36","author":"Brown","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2015.09.023_bib22","first-page":"19","article-title":"Towards an international pediatric liver tumor consensus classification: Proceedings of the Los Angeles COG International Pathology Pediatric Liver Tumors Symposium","volume":"26","author":"Lopez-Terrada","year":"2014","journal-title":"Modern Pathology"},{"key":"10.1016\/j.ejca.2015.09.023_bib24","unstructured":"www.siopel.org SIOPEL website, last accessed August 2014."},{"key":"10.1016\/j.ejca.2015.09.023_bib25","unstructured":"www.cineca.it CINECA website last accessed August 2014."},{"key":"10.1016\/j.ejca.2015.09.023_bib26","unstructured":"www.rarecarenet.eu Surveillance of Rare Cancers in Europe (RARECARE)."}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804915008692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804915008692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T09:50:48Z","timestamp":1657014648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804915008692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":25,"alternative-id":["S0959804915008692"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2015.09.023","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2015.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}