{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:12:06Z","timestamp":1776103926965,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National, Research, Development and Innovation Office","award":["KTIA AIK 12-1-2013-0041"],"award-info":[{"award-number":["KTIA AIK 12-1-2013-0041"]}]},{"name":"National, Research, Development and Innovation Office","award":["T\u00c1MOP 424A\/1-11-1-2012-0001"],"award-info":[{"award-number":["T\u00c1MOP 424A\/1-11-1-2012-0001"]}]},{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"crossref","award":["40148-11658"],"award-info":[{"award-number":["40148-11658"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hungarian Research Fund","award":["OTKA K109626"],"award-info":[{"award-number":["OTKA K109626"]}]},{"name":"Hungarian Research Fund","award":["OTKA SNN114490"],"award-info":[{"award-number":["OTKA SNN114490"]}]},{"name":"Hungarian Research Fund","award":["OTKA MOB80325"],"award-info":[{"award-number":["OTKA MOB80325"]}]},{"name":"EUREKA","award":["HU_12-1-2012-0057"],"award-info":[{"award-number":["HU_12-1-2012-0057"]}]},{"name":"\u00d6NB Jubil\u00e4umsfonds Projekt","award":["14043"],"award-info":[{"award-number":["14043"]}]},{"name":"\u00d6NB Jubil\u00e4umsfonds Projekt","award":["14574"],"award-info":[{"award-number":["14574"]}]},{"name":"Vienna Fund"},{"DOI":"10.13039\/501100008531","name":"Georg Stumpf Stipendium of the Austrian Society for Surgical Oncology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008531","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Herzfelder Foundation and by the Cancer Institute NSW","award":["11\/TPG\/3-06"],"award-info":[{"award-number":["11\/TPG\/3-06"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ejca.2016.04.018","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T11:09:50Z","timestamp":1465384190000},"page":"64-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma \u2013 A multi-institutional study"],"prefix":"10.1016","volume":"63","author":[{"given":"Mir Alireza","family":"Hoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Rozsas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klikovits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Laszlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahil","family":"Ghanim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Stockhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Ozsvar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Jakopovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Samarzija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luka","family":"Brcic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matyas","family":"Bendek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildiko","family":"Szirtes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-9829","authenticated-orcid":false,"given":"Michaela B.","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Weder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Frauenfelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-0453","authenticated-orcid":false,"given":"Thi Dan Linh","family":"Nguyen-Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Klepetko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"van Zandwijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Dome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Grusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-4153","authenticated-orcid":false,"given":"Balazs","family":"Hegedus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3\u20134","key":"10.1016\/j.ejca.2016.04.018_bib1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/sj.bjc.6690105","article-title":"The European mesothelioma epidemic","volume":"79","author":"Peto","year":"1999","journal-title":"Br J Cancer"},{"issue":"15","key":"10.1016\/j.ejca.2016.04.018_bib2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1056\/NEJMra050152","article-title":"Advances in malignant mesothelioma","volume":"353","author":"Robinson","year":"2005","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.ejca.2016.04.018_bib3","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1038\/bjc.2012.519","article-title":"Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cells","volume":"107","author":"Hoda","year":"2012","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2016.04.018_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yexcr.2014.12.010","article-title":"Overexpression of activin-A and -B in malignant mesothelioma \u2013 attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth","volume":"332","author":"Tamminen","year":"2015","journal-title":"Exp Cell Res"},{"issue":"1-2","key":"10.1016\/j.ejca.2016.04.018_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2011.06.030","article-title":"New insights into the mechanisms of activin action and inhibition","volume":"359","author":"Walton","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.1016\/j.ejca.2016.04.018_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-08-0549","article-title":"The biology of activin: recent advances in structure, regulation and function","volume":"202","author":"Xia","year":"2009","journal-title":"J Endocrinol"},{"issue":"11","key":"10.1016\/j.ejca.2016.04.018_bib7","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/j.1365-2222.2011.03784.x","article-title":"Activin-A: a novel critical regulator of allergic asthma","volume":"41","author":"Kariyawasam","year":"2011","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"10.1016\/j.ejca.2016.04.018_bib8","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1183\/09031936.00082413","article-title":"Role of activin-A in cigarette smoke-induced inflammation and COPD","volume":"43","author":"Verhamme","year":"2014","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.ejca.2016.04.018_bib9","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1096\/fj.07-8080com","article-title":"The activin A-follistatin system: potent regulator of human extracellular matrix mineralization","volume":"21","author":"Eijken","year":"2007","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.ejca.2016.04.018_bib10","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1038\/ajg.2009.318","article-title":"A complex role of activin A in non-alcoholic fatty liver disease","volume":"104","author":"Yndestad","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"13","key":"10.1016\/j.ejca.2016.04.018_bib11","first-page":"3783","article-title":"Down-regulation of activin, activin receptors, and Smads in high-grade breast cancer","volume":"63","author":"Jeruss","year":"2003","journal-title":"Cancer Res"},{"issue":"15","key":"10.1016\/j.ejca.2016.04.018_bib12","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1158\/0008-5472.CAN-07-0805","article-title":"Silencing of FLRG, an antagonist of activin, inhibits human breast tumor cell growth","volume":"67","author":"Razanajaona","year":"2007","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.ejca.2016.04.018_bib13","first-page":"994","article-title":"Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers","volume":"63","author":"Hempen","year":"2003","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.ejca.2016.04.018_bib14","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jhep.2006.06.014","article-title":"Deregulation of the activin\/follistatin system in hepatocarcinogenesis","volume":"45","author":"Grusch","year":"2006","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.ejca.2016.04.018_bib15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1593\/neo.81582","article-title":"Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma","volume":"11","author":"Seder","year":"2009","journal-title":"Neoplasia"},{"issue":"4","key":"10.1016\/j.ejca.2016.04.018_bib16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/JTO.0b013e31819c791a","article-title":"INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma","volume":"4","author":"Seder","year":"2009","journal-title":"J Thorac Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2016.04.018_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1245\/s10434-007-9631-1","article-title":"Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells","volume":"15","author":"Yoshinaga","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejca.2016.04.018_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1478-811X-7-15","article-title":"Activin signaling as an emerging target for therapeutic interventions","volume":"7","author":"Tsuchida","year":"2009","journal-title":"Cell Commun Signal"},{"issue":"8","key":"10.1016\/j.ejca.2016.04.018_bib19","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1365-2362.2012.02647.x","article-title":"Increased serum activin-A differentiates alcoholic from cirrhosis of other aetiologies","volume":"42","author":"Voumvouraki","year":"2012","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"10.1016\/j.ejca.2016.04.018_bib20","first-page":"150","article-title":"Evaluation of circulating activin-A as a serum marker of hepatocellular carcinoma","volume":"24","author":"Pirisi","year":"2000","journal-title":"Cancer Detect Prev"},{"issue":"2","key":"10.1016\/j.ejca.2016.04.018_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10585-006-9010-5","article-title":"Activin A circulating levels in patients with bone metastasis from breast or prostate cancer","volume":"23","author":"Leto","year":"2006","journal-title":"Clin Exp Metastasis"},{"issue":"1","key":"10.1016\/j.ejca.2016.04.018_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/gyno.1999.5417","article-title":"Secretion of activin A in recurrent epithelial ovarian carcinoma","volume":"74","author":"Lambert-Messerlian","year":"1999","journal-title":"Gynecol Oncol"},{"issue":"7","key":"10.1016\/j.ejca.2016.04.018_bib23","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1245\/s10434-010-0926-2","article-title":"Overexpression of activin A in oral squamous cell carcinoma: association with poor prognosis and tumor progression","volume":"17","author":"Chang","year":"2010","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"10.1016\/j.ejca.2016.04.018_bib24","first-page":"843","article-title":"Expression of activin A in tissue and serum of patients with esophageal squamous cell carcinoma and its clinical significance","volume":"35","author":"Liu","year":"2013","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"issue":"2 Pt B","key":"10.1016\/j.ejca.2016.04.018_bib25","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.canlet.2014.10.037","article-title":"Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer","volume":"356","author":"Togashi","year":"2015","journal-title":"Cancer Lett"},{"issue":"12","key":"10.1016\/j.ejca.2016.04.018_bib26","doi-asserted-by":"crossref","first-page":"13388","DOI":"10.18632\/oncotarget.7796","article-title":"High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma","volume":"7","author":"Hoda","year":"2016","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.ejca.2016.04.018_bib27","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1093\/annonc\/mds068","article-title":"Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; no alterations post-lenalidomide and dexamethasone therapy","volume":"23","author":"Terpos","year":"2012","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2016.04.018_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1183\/09031936.00146110","article-title":"Volumetry: an alternative to assess therapy response for malignant pleural mesothelioma?","volume":"38","author":"Frauenfelder","year":"2011","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.ejca.2016.04.018_bib29","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1097\/JTO.0000000000000661","article-title":"A new prognostic score supporting treatment allocation for multimodality therapy for malignant pleural mesothelioma \u2013 a review of 12 years' experience","volume":"10","author":"Opitz","year":"2015","journal-title":"J Thorac Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2016.04.018_bib30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1530\/eje.0.1390487","article-title":"Influence of age and sex on serum concentrations of total dimeric activin A","volume":"139","author":"Loria","year":"1998","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.ejca.2016.04.018_bib31","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1210\/jcem.87.5.8512","article-title":"Serum and tissue expression of activin a in postmenopausal women with breast cancer","volume":"87","author":"Reis","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ejca.2016.04.018_bib32","first-page":"2125","article-title":"Serum immunoreactive activin A levels in normal subjects and patients with various diseases","volume":"81","author":"Harada","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.ejca.2016.04.018_bib33","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.oraloncology.2011.06.011","article-title":"Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A","volume":"47","author":"Sobral","year":"2011","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2016.04.018_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/cancers7010070","article-title":"Intertwining of activin A and TGFbeta signaling: dual roles in cancer progression and cancer cell invasion","volume":"7","author":"Loomans","year":"2014","journal-title":"Cancers (Basel)"},{"issue":"10","key":"10.1016\/j.ejca.2016.04.018_bib35","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1136\/thoraxjnl-2014-205205","article-title":"Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma","volume":"69","author":"Creaney","year":"2014","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.ejca.2016.04.018_bib36","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/bjc.2015.286","article-title":"Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis","volume":"113","author":"Kirschner","year":"2015","journal-title":"Br J Cancer"},{"issue":"9396","key":"10.1016\/j.ejca.2016.04.018_bib37","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(03)14794-0","article-title":"Mesothelin-family proteins and diagnosis of mesothelioma","volume":"362","author":"Robinson","year":"2003","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ejca.2016.04.018_bib38","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1471-0528.2000.tb11102.x","article-title":"Serum inhibin, activin and follistatin in postmenopausal women with epithelial ovarian carcinoma","volume":"107","author":"Menon","year":"2000","journal-title":"BJOG"},{"issue":"10","key":"10.1016\/j.ejca.2016.04.018_bib39","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1164\/rccm.200807-1125OC","article-title":"Kinetics of soluble mesothelin in patients with malignant pleural mesothelioma during treatment","volume":"179","author":"Grigoriu","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.ejca.2016.04.018_bib40","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/bjc.2013.815","article-title":"Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma","volume":"110","author":"Ghanim","year":"2014","journal-title":"Br J Cancer"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0959804916321165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0959804916321165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T22:53:59Z","timestamp":1589669639000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804916321165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":40,"alternative-id":["S0959804916321165"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2016.04.018","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma \u2013 A multi-institutional study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.ejca.2016.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}