{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:29:02Z","timestamp":1786714142682,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.ejca.2017.02.029","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T13:31:35Z","timestamp":1491571895000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"special_numbering":"C","title":["Establishment and validation of M1 stage subdivisions for de novo metastatic nasopharyngeal carcinoma to better predict prognosis and guide treatment"],"prefix":"10.1016","volume":"77","author":[{"given":"Xiong","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hai","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Nan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Qiang","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Fang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Huang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejca.2017.02.029_bib1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5732\/cjc.010.10377","article-title":"The prevalence and prevention of nasopharyngeal carcinoma in China","volume":"30","author":"Cao","year":"2011","journal-title":"Chin J Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2017.02.029_bib2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000055743","article-title":"Distant metastases from nasopharyngeal cancer","volume":"63","author":"Chiesa","year":"2001","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"6","key":"10.1016\/j.ejca.2017.02.029_bib3","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1097\/00005537-199606000-00019","article-title":"Predicting distant failure in nasopharyngeal cancer","volume":"106","author":"Koukourakis","year":"1996","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.ejca.2017.02.029_bib4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0196-0709(95)90040-3","article-title":"Prognostic significance of keratinization in nasopharyngeal carcinoma","volume":"16","author":"Reddy","year":"1995","journal-title":"Am J Otolaryngol"},{"issue":"3","key":"10.1016\/j.ejca.2017.02.029_bib5","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/0360-3016(95)00516-2","article-title":"Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspects","volume":"32","author":"Altun","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ejca.2017.02.029_bib6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0167-8140(86)80177-3","article-title":"Patterns of failure in nasopharyngeal cancer treated with megavoltage irradiation","volume":"5","author":"Frezza","year":"1986","journal-title":"Radiother Oncol"},{"issue":"11","key":"10.1016\/j.ejca.2017.02.029_bib7","doi-asserted-by":"publisher","first-page":"604","DOI":"10.5732\/cjc.013.10148","article-title":"Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis","volume":"32","author":"Chen","year":"2013","journal-title":"Chin J Cancer"},{"issue":"6","key":"10.1016\/j.ejca.2017.02.029_bib8","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.hoc.2008.08.012","article-title":"Update on the management and therapeutic monitoring of advanced nasopharyngeal cancer","volume":"22","author":"Loong","year":"2008","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.ejca.2017.02.029_bib9","series-title":"AJCC cancer staging handbook from the AJCC cancer staging manual","author":"Edge","year":"2010"},{"issue":"2","key":"10.1016\/j.ejca.2017.02.029_bib10","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/cncr.20358","article-title":"Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group","volume":"101","author":"Hui","year":"2004","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.ejca.2017.02.029_bib11","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.canrad.2006.05.004","article-title":"Metastatic nasopharyngeal carcinoma: clinical study and therapeutic results of 95 cases","volume":"10","author":"Khanfir","year":"2006","journal-title":"Cancer Radiother"},{"issue":"12","key":"10.1016\/j.ejca.2017.02.029_bib12","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1002\/(SICI)1097-0142(19960615)77:12<2423::AID-CNCR2>3.0.CO;2-N","article-title":"Prognosticators determining survival subsequent to distant metastasis from nasopharyngeal carcinoma","volume":"77","author":"Teo","year":"1996","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2017.02.029_bib13","first-page":"341","article-title":"Patient profile and survival in 270 computer tomography-staged patients with nasopharyngeal cancer treated at the Singapore General Hospital","volume":"25","author":"Fong","year":"1996","journal-title":"Ann Acad Med Singap"},{"issue":"6","key":"10.1016\/j.ejca.2017.02.029_bib14","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1200\/JCO.2000.18.6.1324","article-title":"Long-term disease-free survivors in metastatic undifferentiated carcinoma of nasopharyngeal type","volume":"18","author":"Fandi","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2017.02.029_bib15","series-title":"NCCN Guidelines: head and neck cancers. Version 2","author":"National Comprehensive Cancer Network","year":"2013"},{"issue":"4","key":"10.1016\/j.ejca.2017.02.029_bib16","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1200\/JCO.2013.51.3549","article-title":"Long-term disease control in a patient with recurrent bone-only oligometastatic nasopharyngeal carcinoma","volume":"34","author":"Khot","year":"2016","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2017.02.029_bib17","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1002\/hed.21608","article-title":"Definitive treatment of metastatic nasopharyngeal carcinoma: report of 5 cases with review of literature","volume":"34","author":"Setton","year":"2012","journal-title":"Head Neck"},{"issue":"6","key":"10.1016\/j.ejca.2017.02.029_bib18","doi-asserted-by":"publisher","first-page":"e135","DOI":"10.1200\/JCO.2010.31.9053","article-title":"Prolonged remission in a patient with nasopharyngeal carcinoma with a solitary bone metastasis","volume":"29","author":"Lim","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2017.02.029_bib19","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40880-015-0031-9","article-title":"Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system","volume":"37","author":"Shen","year":"2015","journal-title":"Chin J Cancer"},{"issue":"11","key":"10.1016\/j.ejca.2017.02.029_bib20","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/S0959-8049(03)00310-1","article-title":"Design of a prognostic index score for metastatic nasopharyngeal carcinoma","volume":"39","author":"Ong","year":"2003","journal-title":"Eur J Cancer"},{"issue":"23","key":"10.1016\/j.ejca.2017.02.029_bib21","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1200\/JCO.2012.46.0816","article-title":"Prospective study of tailoring whole-body dual-modality [18F]fluorodeoxyglucose positron emission tomography\/computed tomography with plasma Epstein-Barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging","volume":"31","author":"Tang","year":"2013","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2017.02.029_bib22","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada","volume":"92","author":"Therasse","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.ejca.2017.02.029_bib23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"issue":"746","key":"10.1016\/j.ejca.2017.02.029_bib24","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1259\/0007-1285-63-746-108","article-title":"Nasopharyngeal carcinoma: the significance of neck node involvement in relation to the pattern of distant failure","volume":"63","author":"Sham","year":"1990","journal-title":"Br J Radiol"},{"issue":"1","key":"10.1016\/j.ejca.2017.02.029_bib25","first-page":"27","article-title":"Clinical features and management of distant metastases of nasopharyngeal carcinoma","volume":"20","author":"Leung","year":"1991","journal-title":"J Otolaryngol"},{"issue":"4","key":"10.1016\/j.ejca.2017.02.029_bib26","first-page":"229","article-title":"Patterns of distant metastases in nasopharyngeal carcinoma","volume":"12","author":"Huang","year":"1996","journal-title":"Kaohsiung J Med Sci"},{"issue":"22","key":"10.1016\/j.ejca.2017.02.029_bib27","doi-asserted-by":"publisher","first-page":"7497","DOI":"10.1158\/1078-0432.CCR-08-0271","article-title":"The N staging system in nasopharyngeal carcinoma with radiation therapy oncology group guidelines for lymph node levels based on magnetic resonance imaging","volume":"14","author":"Mao","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"23","key":"10.1016\/j.ejca.2017.02.029_bib28","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1093\/jnci\/djr432","article-title":"Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial","volume":"103","author":"Chen","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"13","key":"10.1016\/j.ejca.2017.02.029_bib29","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/j.ejca.2015.05.014","article-title":"New surgical staging system for patients with recurrent nasopharyngeal carcinoma based on the AJCC\/UICC rTNM classification system","volume":"51","author":"You","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2017.02.029_bib30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/biomet\/69.1.239","article-title":"Partial residuals for the proportional hazards regression model","volume":"69","author":"Schoenfeld","year":"1982","journal-title":"Biometrika"},{"issue":"1","key":"10.1016\/j.ejca.2017.02.029_bib31","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv291","article-title":"Establishment and validation of prognostic nomograms for endemic nasopharyngeal carcinoma","volume":"108","author":"Tang","year":"2016","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.ejca.2017.02.029_bib32","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.18632\/oncotarget.6436","article-title":"Development of a ten-signature classifier using a support vector machine integrated approach to subdivide the M1 stage into M1a and M1b stages of nasopharyngeal carcinoma with synchronous metastases to better predict patients' survival","volume":"7","author":"Jiang","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.ejca.2017.02.029_bib33","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1634\/theoncologist.2014-0206","article-title":"M1 stage subdivision and treatment outcome of patients with bone-only metastasis of nasopharyngeal carcinoma","volume":"20","author":"Shen","year":"2015","journal-title":"Oncologist"},{"issue":"3","key":"10.1016\/j.ejca.2017.02.029_bib34","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00280-007-0641-2","article-title":"Phase II study of capecitabine and cisplatin combination as first-line chemotherapy in Chinese patients with metastatic nasopharyngeal carcinoma","volume":"62","author":"Li","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"issue":"2","key":"10.1016\/j.ejca.2017.02.029_bib35","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1023\/A:1008390929826","article-title":"Phase II trial of a paclitaxel and carboplatin combination in Asian patients with metastatic nasopharyngeal carcinoma","volume":"10","author":"Tan","year":"1999","journal-title":"Ann Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2017.02.029_bib36","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1097\/COC.0b013e31821a9452","article-title":"Combined high-dose radiation therapy and systemic chemotherapy improves survival in patients with newly diagnosed metastatic nasopharyngeal cancer","volume":"35","author":"Lin","year":"2012","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2017.02.029_bib37","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1148\/radiol.2016151344","article-title":"Image-based multilevel subdivision of M1 category in TNM staging system for metastatic nasopharyngeal carcinoma","volume":"280","author":"Shen","year":"2016","journal-title":"Radiology"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804917307955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804917307955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T04:38:00Z","timestamp":1601872680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804917307955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":37,"alternative-id":["S0959804917307955"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2017.02.029","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment and validation of M1 stage subdivisions for de novo metastatic nasopharyngeal carcinoma to better predict prognosis and guide treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2017.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}