{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:50:26Z","timestamp":1788861026881,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ejca.2018.10.013","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:42:52Z","timestamp":1543970572000},"page":"126-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours\u00a0Strategy Group (SIOPEL) report"],"prefix":"10.1016","volume":"106","author":[{"given":"Daniel C.","family":"Aronson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edola B.","family":"Weeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Maibach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Czauderna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Dall\u2019Igna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-6178","authenticated-orcid":false,"given":"Jean","family":"de Ville de Goyet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Branchereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Perilongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joszef","family":"Zsiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Semeraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Chardot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wildhaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Morland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Brugi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2018.10.013_bib1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ejca.2005.02.004","article-title":"Guidelines for surgical treatment of hepatoblastoma in the modern era \u2013 recommendations from the childhood liver tumour strategy group of the international society of paediatric oncology (SIOPEL)","volume":"41","author":"Czauderna","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/MOP.0000000000000042","article-title":"Hepatoblastoma state of the art: pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation","volume":"26","author":"Meyers","year":"2014","journal-title":"Curr Opin Pediatr"},{"issue":"4","key":"10.1016\/j.ejca.2018.10.013_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/0971-9261.142001","article-title":"The treatment of hepatoblastoma: its evolution and the current status as per the SIOPEL trials","volume":"19","author":"Aronson","year":"2014","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"10.1016\/j.ejca.2018.10.013_bib4","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/1097-0142(19851015)56:8<1926::AID-CNCR2820560805>3.0.CO;2-G","article-title":"Adriamycin and cisplatin for hepatoblastoma","volume":"56","author":"Quinn","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib5","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1200\/JCO.2000.18.22.3819","article-title":"Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach \u2014 results of the first prospective study of the International Society of Pediatric Oncology","volume":"18","author":"Pritchard","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2018.10.013_bib6","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa0810613","article-title":"Cisplatin versus cisplatin plus doxorubicin for standard risk hepatoblastoma","volume":"361","author":"Perilongo","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2018.10.013_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00383-010-2708-0","article-title":"Outcome of hepatoblastomas treated using the Japanese study group for pediatric liver tumor (JPLT) protocol-2: report from the JPLT","volume":"27","author":"Hishiki","year":"2011","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.ejca.2018.10.013_bib8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S1470-2045(13)70272-9","article-title":"Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study","volume":"14","author":"Zsiros","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejca.2018.10.013_bib9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jpedsurg.2004.01.035","article-title":"Association between surgical margins and long-term outcome in advanced hepatoblastoma","volume":"39","author":"Dicken","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ejca.2018.10.013_bib10","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/cncr.10282","article-title":"Surgical view of the treatment of patients with hepatoblastoma. Results from the first prospective trial of the international society of pediatric oncology liver tumor study group (SIOPEL-1)","volume":"94","author":"Schnater","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib11","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1002\/cncr.25722","article-title":"Successful nontransplant resection of POST-TEXT III and IV hepatoblastoma","volume":"117","author":"Lautz","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib12","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/pbc.24217","article-title":"Hepatoblastoma clinical research: lessons learned and future challenges","volume":"59","author":"Perilongo","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejca.2003.06.003","article-title":"Risk-adapted treatment for childhood hepatoblastoma: final report of the second study of the International Society of Paediatric Oncology SIOPEL 2","volume":"40","author":"Perilongo","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib14","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1200\/JCO.2009.22.4857","article-title":"Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study","volume":"28","author":"Zsiros","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2018.10.013_bib15","first-page":"1245","article-title":"Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the international society of pediatric oncology liver tumor study group SIOPEL-1 study","volume":"23","author":"Aronson","year":"2005","journal-title":"J Clin Orthod"},{"key":"10.1016\/j.ejca.2018.10.013_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00247-006-0361-5","article-title":"2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group","volume":"37","author":"Roebuck","year":"2007","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.ejca.2018.10.013_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1097-0215(20000115)85:2<151::AID-IJC1>3.0.CO;2-6","article-title":"Hepatocyte growth-factor-scatter factor can stimulate post-operative tumor cell proliferation in childhood hepatoblastoma","volume":"85","author":"Von Schweinitz","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cncr.10632","article-title":"Pretreatment prognostic factors and treatment results in children with hepatoblastoma","volume":"95","author":"Fuchs","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2018.10.013_bib19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1470-2045(16)30598-8","article-title":"Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration","volume":"18","author":"Meyers","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejca.2018.10.013_bib20","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1200\/JCO.2000.18.14.2665","article-title":"Randomized comparison of cisplatin\/vincristine\/fluorouracil and cisplatin\/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group","volume":"18","author":"Ortega","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2018.10.013_bib21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/0022-3468(91)90677-L","article-title":"The surgical management of children with incompletely resected hepatic cancer is facilitated by intensive chemotherapy","volume":"26","author":"King","year":"1991","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ejca.2018.10.013_bib22","first-page":"177","article-title":"Hepatoblastoma with microscopic residual disease after surgery: data from SIOPEL 1 and 2 studies","volume":"35","author":"Brugi\u00e8res","year":"2000","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.ejca.2018.10.013_bib23","first-page":"25","article-title":"Hepatoblastoma with microscopic residual tumor after surgery: results from SIOPEL-2 and 3 trials","volume":"51","author":"Aronson","year":"2008","journal-title":"Pediatr Blood Cancer (SIOP abstracts \u2013 2008)"},{"key":"10.1016\/j.ejca.2018.10.013_bib24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jpedsurg.2009.09.025","article-title":"Outcome of central hepatectomy for hepatoblastomas","volume":"45","author":"Gu\u00e9rin","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ejca.2018.10.013_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/SLA.0000000000001936","article-title":"POST-TEXT III and IV hepatoblastoma: extended hepatic resection avoids liver transplantation in selected cases","volume":"266","author":"Fuchs","year":"2017","journal-title":"Ann Surg"},{"issue":"16","key":"10.1016\/j.ejca.2018.10.013_bib26","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1002\/cncr.26714","article-title":"Comments on surgical treatment of locally advanced hepatoblastoma","volume":"118","author":"Czauderna","year":"2012","journal-title":"Cancer"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804918314527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804918314527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T14:26:46Z","timestamp":1544797606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804918314527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":26,"alternative-id":["S0959804918314527"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2018.10.013","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours\u00a0Strategy Group (SIOPEL) report","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2018.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}