{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:25:31Z","timestamp":1788989131719,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007311","name":"Deutsche Kinderkrebsstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008658","name":"Deutsches Krebsforschungszentrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012353","name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ejca.2019.03.019","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T11:41:59Z","timestamp":1555933319000},"page":"27-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience"],"prefix":"10.1016","volume":"114","author":[{"given":"Elke","family":"Pfaff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-8943","authenticated-orcid":false,"given":"Ahmed","family":"El Damaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gnana Prakash","family":"Balasubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Blattner-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"Worst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian W.","family":"Pajtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis M.","family":"van Tilburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Milde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jakobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Fiesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Fr\u00fchwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Hern\u00e1iz Driever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich W.","family":"Thomale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin U.","family":"Schuhmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Metzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Bochennek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"D\u00fcrken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-4752","authenticated-orcid":false,"given":"Michael","family":"Karremann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Knirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ebinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 O.","family":"von Bueren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Herold-Mende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Reuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kiening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Eggert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof M.","family":"Kramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"B\u00e4chli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2019.03.019_bib1","unstructured":"INFORM. INFORM Registry webpage. Available from: http:\/\/www.dkfz.de\/en\/inform\/index.html."},{"key":"10.1016\/j.ejca.2019.03.019_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejca.2016.06.009","article-title":"Next-generation personalised medicine for high-risk paediatric cancer patients - the INFORM pilot study","volume":"65","author":"Worst","year":"2016","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2019.03.019_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1470-2045(06)70615-5","article-title":"Diffuse brainstem glioma in children: critical review of clinical trials","volume":"7","author":"Hargrave","year":"2006","journal-title":"Lancet Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2019.03.019_bib4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/neuonc\/noq205","article-title":"Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group","volume":"13","author":"Cohen","year":"2011","journal-title":"Neuro Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2019.03.019_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00066-017-1218-6","article-title":"Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen : acute toxicity in pediatric high-grade glioma patients","volume":"194","author":"Seidel","year":"2018","journal-title":"Strahlenther Onkol"},{"issue":"6","key":"10.1016\/j.ejca.2019.03.019_bib6","first-page":"1026","article-title":"Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children's Cancer Group","volume":"33","author":"Albright","year":"1993","journal-title":"Neurosurgery"},{"issue":"6","key":"10.1016\/j.ejca.2019.03.019_bib7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3171\/jns.1993.79.6.0845","article-title":"Surgical management of brain-stem tumors in children: results and statistical analysis of 75 cases","volume":"79","author":"Pierre-Kahn","year":"1993","journal-title":"J Neurosurg"},{"issue":"3","key":"10.1016\/j.ejca.2019.03.019_bib8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3171\/2017.2.PEDS1665","article-title":"Update on the diagnostic value and safety of stereotactic biopsy for pediatric brainstem tumors: a systematic review and meta-analysis of 735 cases","volume":"20","author":"Hamisch","year":"2017","journal-title":"J Neurosurg Pediatr"},{"issue":"10","key":"10.1016\/j.ejca.2019.03.019_bib9","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s00381-015-2832-1","article-title":"Biopsy in a series of 130 pediatric diffuse intrinsic Pontine gliomas","volume":"31","author":"Puget","year":"2015","journal-title":"Child Nerv Syst"},{"key":"10.1016\/j.ejca.2019.03.019_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fonc.2015.00237","article-title":"DIPG in children \u2013 what can we learn from the past?","volume":"5","author":"Vanan","year":"2015","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2019.03.019_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/pbc.25266","article-title":"Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)","volume":"62","author":"Kieran","year":"2015","journal-title":"Pediatr Blood Canc"},{"key":"10.1016\/j.ejca.2019.03.019_bib12","series-title":"Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma","author":"Gupta","year":"2018"},{"issue":"7384","key":"10.1016\/j.ejca.2019.03.019_bib13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature10833","article-title":"Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma","volume":"482","author":"Schwartzentruber","year":"2012","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ejca.2019.03.019_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00401-012-0998-0","article-title":"K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas","volume":"124","author":"Khuong-Quang","year":"2012","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.ejca.2019.03.019_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ng.1102","article-title":"Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas","volume":"44","author":"Wu","year":"2012","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.ejca.2019.03.019_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ng.2938","article-title":"The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma","volume":"46","author":"Wu","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejca.2019.03.019_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-015-0269-0","article-title":"Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics","volume":"4","author":"Hoffman","year":"2016","journal-title":"Acta Neuropathol Commun"},{"issue":"5","key":"10.1016\/j.ejca.2019.03.019_bib18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/ng.2936","article-title":"Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations","volume":"46","author":"Buczkowicz","year":"2014","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.ejca.2019.03.019_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng.2925","article-title":"Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma","volume":"46","author":"Taylor","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejca.2019.03.019_bib20","unstructured":"Molecular Neuropathology. Platform for next generation neuropathology. Available from: https:\/\/www.molecularneuropathology.org\/mnp."},{"issue":"7697","key":"10.1016\/j.ejca.2019.03.019_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ejca.2019.03.019_bib22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2012.08.024","article-title":"Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma","volume":"22","author":"Sturm","year":"2012","journal-title":"Cancer Cell"},{"issue":"18","key":"10.1016\/j.ejca.2019.03.019_bib23","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1182\/blood-2013-04-496893","article-title":"EZH2 mutations are frequent and represent an early event in follicular lymphoma","volume":"122","author":"Bodor","year":"2013","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.ejca.2019.03.019_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cncy.21262","article-title":"EZH2 and CD79B mutational status over time in B-cell non-Hodgkin lymphomas detected by high-throughput sequencing using minimal samples","volume":"121","author":"Saieg","year":"2013","journal-title":"Cancer Cytopathol"},{"issue":"49","key":"10.1016\/j.ejca.2019.03.019_bib25","doi-asserted-by":"crossref","first-page":"20980","DOI":"10.1073\/pnas.1012525107","article-title":"Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas","volume":"107","author":"Sneeringer","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.ejca.2019.03.019_bib26","doi-asserted-by":"crossref","first-page":"e91940","DOI":"10.1371\/journal.pone.0091940","article-title":"NTRK1 fusion in glioblastoma multiforme","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.ejca.2019.03.019_bib27","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/nm.4204","article-title":"Recurrent MET fusion genes represent a drug target in pediatric glioblastoma","volume":"22","author":"International Cancer Genome Consortium PedBrain Tumor","year":"2016","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ejca.2019.03.019_bib28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1470-2045(18)30119-0","article-title":"Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1\/2 study","volume":"19","author":"Laetsch","year":"2018","journal-title":"Lancet Oncol"},{"issue":"6","key":"10.1016\/j.ejca.2019.03.019_bib29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ng.159","article-title":"Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation","volume":"40","author":"Kondo","year":"2008","journal-title":"Nat Genet"},{"issue":"6134","key":"10.1016\/j.ejca.2019.03.019_bib30","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1126\/science.1232245","article-title":"Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma","volume":"340","author":"Lewis","year":"2013","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ejca.2019.03.019_bib31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ccr.2013.10.006","article-title":"Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas","volume":"24","author":"Bender","year":"2013","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.ejca.2019.03.019_bib32","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1101\/gad.217778.113","article-title":"The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression","volume":"27","author":"Chan","year":"2013","journal-title":"Genes Dev"},{"issue":"5","key":"10.1016\/j.ejca.2019.03.019_bib33","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1470-2045(18)30145-1","article-title":"Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study","volume":"19","author":"Italiano","year":"2018","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2019.03.019_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11060-017-2643-1","article-title":"Preliminary results of immune modulating antibody MDV9300 (pidilizumab) treatment in children with diffuse intrinsic pontine glioma","volume":"136","author":"Fried","year":"2018","journal-title":"J Neuro Oncol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804919302205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804919302205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:24:21Z","timestamp":1760732661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804919302205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":34,"alternative-id":["S0959804919302205"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2019.03.019","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2019.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}