{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:10:28Z","timestamp":1790021428664,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ejca.2019.07.023","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T11:57:29Z","timestamp":1568030249000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Can radiomics help to predict skeletal muscle response to chemotherapy in stage IV non-small cell lung cancer?"],"prefix":"10.1016","volume":"120","author":[{"given":"E.E.C.","family":"de Jong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.J.C.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Deist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"van Elmpt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7048-7825","authenticated-orcid":false,"given":"A.","family":"Jochems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"van Timmeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.T.H.","family":"Leijenaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.R.J.","family":"Degens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.W.J.","family":"Schols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-M.C.","family":"Dingemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lambin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejca.2019.07.023_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.ejca.2019.07.023_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2019.07.023_bib3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jcsm.12206","article-title":"Muscle mass and association to quality of life in non-small cell lung cancer patients","volume":"8","author":"Bye","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"12","key":"10.1016\/j.ejca.2019.07.023_bib4","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2019.07.023_bib5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3109\/0284186X.2014.953259","article-title":"Changes in skeletal muscle mass during palliative chemotherapy in patients with advanced lung cancer","volume":"54","author":"Stene","year":"2015","journal-title":"Acta Oncol"},{"issue":"11","key":"10.1016\/j.ejca.2019.07.023_bib6","doi-asserted-by":"crossref","first-page":"S2087","DOI":"10.1016\/j.jtho.2017.09.1150","article-title":"P2.01-048 early changes in body composition in metastatic non-small cell lung cancer (NSCLC) are predictive for poor overall survival","volume":"12","author":"Degens","year":"2017","journal-title":"J Thorac Oncol"},{"issue":"10","key":"10.1016\/j.ejca.2019.07.023_bib7","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/cncr.21013","article-title":"Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones","volume":"103","author":"Fouladiun","year":"2005","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.ejca.2019.07.023_bib8","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.nut.2011.11.026","article-title":"Adipose tissue volume is decreased in recently diagnosed cancer patients with cachexia","volume":"28","author":"Agustsson","year":"2012","journal-title":"Nutrition"},{"issue":"7","key":"10.1016\/j.ejca.2019.07.023_bib9","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/cncr.23802","article-title":"Lipolysis--not inflammation, cell death, or lipogenesis--is involved in adipose tissue loss in cancer cachexia","volume":"113","author":"Ryden","year":"2008","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/j.ejca.2019.07.023_bib10","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1158\/0008-5472.CAN-06-4585","article-title":"Mechanism of increased lipolysis in cancer cachexia","volume":"67","author":"Agustsson","year":"2007","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.ejca.2019.07.023_bib11","doi-asserted-by":"crossref","first-page":"5696","DOI":"10.1210\/en.2007-0183","article-title":"Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids","volume":"148","author":"Zhou","year":"2007","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.ejca.2019.07.023_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/02841860802130001","article-title":"Morphology, metabolism, microcirculation, and strength of skeletal muscles in cancer-related cachexia","volume":"48","author":"Weber","year":"2009","journal-title":"Acta Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2019.07.023_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrclinonc.2012.196","article-title":"Predicting outcomes in radiation oncology--multifactorial decision support systems","volume":"10","author":"Lambin","year":"2013","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2019.07.023_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ejca.2011.11.036","article-title":"Radiomics: extracting more information from medical images using advanced feature analysis","volume":"48","author":"Lambin","year":"2012","journal-title":"Eur J Cancer"},{"issue":"9","key":"10.1016\/j.ejca.2019.07.023_bib15","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.mri.2012.06.010","article-title":"Radiomics: the process and the challenges","volume":"30","author":"Kumar","year":"2012","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.ejca.2019.07.023_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23421","article-title":"Defining the biological basis of radiomic phenotypes in lung cancer","volume":"6","author":"Grossmann","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.ejca.2019.07.023_bib17","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1038\/ncomms5006","article-title":"Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach","volume":"5","author":"Aerts","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.ejca.2019.07.023_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cmpb.2018.02.015","article-title":"Radiomics-based features for pattern recognition of lung cancer histopathology and metastases","volume":"159","author":"Ferreira Junior","year":"2018","journal-title":"Comput Methods Progr Biomed"},{"issue":"3","key":"10.1016\/j.ejca.2019.07.023_bib19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.radonc.2016.04.004","article-title":"Radiomic phenotype features predict pathological response in non-small cell lung cancer","volume":"119","author":"Coroller","year":"2016","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2019.07.023_bib20","doi-asserted-by":"crossref","first-page":"041010","DOI":"10.1117\/1.JMI.2.4.041010","article-title":"Imaging texture analysis for automated prediction of lung cancer recurrence after stereotactic radiotherapy","volume":"2","author":"Mattonen","year":"2015","journal-title":"J Med Imaging (Bellingham)"},{"issue":"1","key":"10.1016\/j.ejca.2019.07.023_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00259-016-3498-y","article-title":"[18F]FDG PET\/CT-based response assessment of stage IV non-small cell lung cancer treated with paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches","volume":"44","author":"de Jong","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"10.1016\/j.ejca.2019.07.023_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00259-016-3498-y","article-title":"[18F]FDG PET\/CT-based response assessment of stage IV non-small cell lung cancer treated with paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches","volume":"44","author":"de Jong","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"11","key":"10.1016\/j.ejca.2019.07.023_bib23","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1080\/0284186X.2017.1351624","article-title":"Influence of gray level discretization on radiomic feature stability for different CT scanners, tube currents and slice thicknesses: a comprehensive phantom study","volume":"56","author":"Larue","year":"2017","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ejca.2019.07.023_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.lungcan.2016.08.007","article-title":"Clinical implications of sarcopenia in patients undergoing complete resection for early non-small cell lung cancer","volume":"101","author":"Suzuki","year":"2016","journal-title":"Lung Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2019.07.023_bib25","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/jcsm.12107","article-title":"Loss of skeletal muscle during neoadjuvant chemotherapy is related to decreased survival in ovarian cancer patients","volume":"7","author":"Rutten","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"10.1016\/j.ejca.2019.07.023_bib26","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.clnu.2016.03.010","article-title":"Skeletal muscle radiodensity is prognostic for survival in patients with advanced non-small cell lung cancer","volume":"35","author":"Sjoblom","year":"2016","journal-title":"Clin Nutr"},{"issue":"6","key":"10.1016\/j.ejca.2019.07.023_bib27","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1109\/TSMC.1973.4309314","article-title":"Textural features for image classification","volume":"3","author":"Haralick","year":"1973","journal-title":"IEEE Trans Syst Man Cybern"},{"issue":"2","key":"10.1016\/j.ejca.2019.07.023_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13539-011-0030-x","article-title":"Intramyocellular lipid droplets increase with progression of cachexia in cancer patients","volume":"2","author":"Stephens","year":"2011","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.ejca.2019.07.023_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1152\/jappl.2000.89.1.104","article-title":"Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content","volume":"89","author":"Goodpaster","year":"1985","journal-title":"J Appl Physiol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804919304319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804919304319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:25:27Z","timestamp":1760732727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804919304319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":29,"alternative-id":["S0959804919304319"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2019.07.023","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can radiomics help to predict skeletal muscle response to chemotherapy in stage IV non-small cell lung cancer?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2019.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}