{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:12:00Z","timestamp":1790143920707,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Comitato M. L. Verga and Fondazione Tettamanti"},{"DOI":"10.13039\/100007363","name":"Fondazione Citt\u00e0 della Speranza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["AB IG 2017 (#20564)"],"award-info":[{"award-number":["AB IG 2017 (#20564)"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Transcall2","award":["AB ID 189"],"award-info":[{"award-number":["AB ID 189"]}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe e.V., Bonn","doi-asserted-by":"publisher","award":["50\u20132698 Schr1"],"award-info":[{"award-number":["50\u20132698 Schr1"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe e.V., Bonn","doi-asserted-by":"publisher","award":["50\u20132410 Ba7"],"award-info":[{"award-number":["50\u20132410 Ba7"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"name":"St. Anna Kinderkrebsforschung"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.ejca.2019.09.004","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T17:36:35Z","timestamp":1571333795000},"page":"61-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Outcome of adolescent patients with acute lymphoblastic leukaemia aged 10\u201314 years as compared with those aged 15\u201317 years: Long-term results of 1094 patients of the AIEOP-BFM ALL 2000 study"],"prefix":"10.1016","volume":"122","author":[{"given":"Anna Maria","family":"Testi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-6898","authenticated-orcid":false,"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Valsecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"M\u00f6ricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Cario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Niggli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kuhlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Parasole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Caterina","family":"Putti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Flotho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Rizzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Barisone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Linderkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4774-0279","authenticated-orcid":false,"given":"Melchior","family":"Lauten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinolf","family":"Suttorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiseppe","family":"Basso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-4929","authenticated-orcid":false,"given":"Valentino","family":"Conter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schrappe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2019.09.004_bib1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/bjh.12292","volume":"161","author":"Pichler","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejca.2019.09.004_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/annonc\/mds518","article-title":"Adolescents with acute lymphoblastic leukemia treated at pediatric versus adult hospitals","volume":"24","author":"Pole","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2019.09.004_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/pbc.22962","article-title":"Different outcome in older children with acute lymphoblastic leukemia with different treatment protocols in The Netherlands","volume":"58","author":"Boudestein","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2019.09.004_bib4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1200\/JCO.2010.32.0325","article-title":"Improved prognosis for older adolescents with acute lymphoblastic leukemia","volume":"29","author":"Pui","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2019.09.004_bib5","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3324\/haematol.2012.080432","article-title":"Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts","volume":"98","author":"Chiaretti","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.ejca.2019.09.004_bib6","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1182\/blood-2009-10-248146","article-title":"Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study","volume":"115","author":"Conter","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2019.09.004_bib7","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1182\/blood-2011-03-338707","article-title":"Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study","volume":"118","author":"Schrappe","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2019.09.004_bib8","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1182\/blood-2015-09-670729","article-title":"Dexamethasone vs prednisone in induction treatment of pediatric ALL: results of the randomized trial AIEOP-BFM ALL 2000","volume":"127","author":"M\u00f6ricke","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2019.09.004_bib9","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3324\/haematol.2011.047613","article-title":"Prediction of outcome by early bone marrow response in childhood acute lymphoblastic leukemia treated in the ALL-BFM 95 trial: differential effects in precursor B-cell and T-cell leukemia","volume":"97","author":"Lauten","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.ejca.2019.09.004_bib10","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1182\/blood-2008-01-130237","article-title":"What determines the outcome for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children\u2019s Cancer Group and Cancer and Leukemia Group B studies","volume":"112","author":"Stock","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2019.09.004_bib11","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1200\/JCO.2007.13.7265","article-title":"Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Espanol de Tratamiento en Hematologia pediatric-based protocol ALL-96","volume":"26","author":"Ribera","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2019.09.004_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/pbc.20749","article-title":"Adolescents with acute lymphoblastic leukemia: outcome on UK national Paediatric (ALL97) and Adult (UKALLXII\/E2993) trials","volume":"48","author":"Ramanujachar","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2019.09.004_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1182\/blood-2018-02-778530","article-title":"Acute lymphoblastic leukemia in adolescent and young adults: treat as adults or as children?","volume":"132","author":"Boissel","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2019.09.004_bib14","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/leu.2008.5","article-title":"Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia","volume":"22","author":"Flohr","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.ejca.2019.09.004_bib15","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias: European group for the immunological characterization of leukemias (EGIL)","volume":"9","author":"Bene","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.ejca.2019.09.004_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s002770050494","article-title":"Multiplex PCR: a rapid screening method for detection of gene rearrangements in childhood acute lymphoblastic leukemia","volume":"78","author":"Viehmann","year":"1999","journal-title":"Ann Hematol"},{"key":"10.1016\/j.ejca.2019.09.004_bib17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1200\/JCO.2006.08.6397","article-title":"Favorable outcome for adolescents with acute lymphoblastic leukemia treated on dana-farber cancer Institute acute lymphoblastic leukemia consortium protocols","volume":"25","author":"Barry","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2019.09.004_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12185-014-1622-y","article-title":"Treatment outcomes of adolescent acute lymphoblastic leukemia treated on Tokyo Children\u2019s Cancer Study Group (TCCSG) clinical trials","volume":"100","author":"Kato","year":"2014","journal-title":"Int J Hematol"},{"key":"10.1016\/j.ejca.2019.09.004_bib19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/bjh.13847","article-title":"Efficacy and toxicity of a paediatric protocol in teenagers and young adults with Philadelphia chromosome negative acute lymphoblastic leukaemia: results from UKALL 2003","volume":"172","author":"Hough","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejca.2019.09.004_bib20","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1200\/JCO.2008.20.8959","article-title":"Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the children\u2019s oncology group","volume":"27","author":"Nachman","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2019.09.004_bib21","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1200\/JCO.2015.64.6364","article-title":"Successful therapy reduction and intensification for childhood acute lymphoblastic leukemia based on minimal residual disease monitoring: study ALL10 from the Dutch childhood oncology group","volume":"34","author":"Pieters","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2019.09.004_bib22","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/leu.2014.229","article-title":"Long-term outcome of a pediatric-inspired regimen used for adults aged 18-50 years with newly diagnosed acute lymphoblastic leukemia","volume":"29","author":"DeAngelo","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.ejca.2019.09.004_bib23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood-2012-04-418640","article-title":"Bortezomib with chemotherapy is highly effective in advanced B-precursor acute lymphoblastic leukemia: therapeutic advances in childhood leukemia and lymphoma (TACL) study","volume":"120","author":"Messinger","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2019.09.004_bib24","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1200\/JCO.2014.56.3247","article-title":"Phase II trial of the anti-CD19 bispecific T cell engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia","volume":"32","author":"Topp","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2019.09.004_bib25","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMoa1609783","article-title":"Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia","volume":"376","author":"Kantarjian","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2019.09.004_bib26","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/pbc.24437","article-title":"Children\u2019s Oncology Groups 2013 blueprint for research: stem cell transplantation","volume":"60","author":"Grupp","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2019.09.004_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/2040620714565963","article-title":"Novel agents for the treatment of childhood acute leukemia","volume":"6","author":"Annesley","year":"2015","journal-title":"Ther Adv Hematol"},{"key":"10.1016\/j.ejca.2019.09.004_bib28","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1182\/blood-2018-04-841676","article-title":"Genomic and outcome analysis of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group","volume":"132","author":"Roberts","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2019.09.004_bib29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa1403088","article-title":"Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia","volume":"371","author":"Roberts","year":"2014","journal-title":"N Engl J Med"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980491930721X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980491930721X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:25:43Z","timestamp":1760732743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095980491930721X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":29,"alternative-id":["S095980491930721X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2019.09.004","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcome of adolescent patients with acute lymphoblastic leukaemia aged 10\u201314 years as compared with those aged 15\u201317 years: Long-term results of 1094 patients of the AIEOP-BFM ALL 2000 study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2019.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}