{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:23:14Z","timestamp":1785338594919,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejca.2020.06.037","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:06:40Z","timestamp":1596845200000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["SOX10 is as specific as S100 protein in detecting metastases of melanoma in lymph nodes and is recommended for sentinel lymph node assessment"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-3422","authenticated-orcid":false,"given":"Anna","family":"Szumera-Cie\u0107kiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-2003","authenticated-orcid":false,"given":"Francesca","family":"Bosisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Teterycz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-610X","authenticated-orcid":false,"given":"Asier","family":"Antoranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Delogu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senada","family":"Koljenovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart A.","family":"van de Wiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willeke","family":"Blokx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9on C.","family":"van Kempen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-5429","authenticated-orcid":false,"given":"Piotr","family":"Rutkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Christopher van Akkooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Massi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.ejca.2020.06.037_bib1","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa1613210","article-title":"Completion dissection or observation for sentinel-node metastasis in melanoma","volume":"376","author":"Faries","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2020.06.037_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejca.2019.03.010","article-title":"An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma","volume":"114","author":"Cook","year":"2019","journal-title":"Eur J Canc"},{"issue":"2","key":"10.1016\/j.ejca.2020.06.037_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.humpath.2013.02.007","article-title":"Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update","volume":"45","author":"Ordonez","year":"2014","journal-title":"Hum Pathol"},{"issue":"4","key":"10.1016\/j.ejca.2020.06.037_bib4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/jclinpath-2018-205417","article-title":"Update on eighth edition American Joint Committee on Cancer classification for cutaneous melanoma and overview of potential pitfalls in histological examination of staging parameters","volume":"72","author":"Trinidad","year":"2019","journal-title":"J Clin Pathol"},{"issue":"Suppl 1","key":"10.1016\/j.ejca.2020.06.037_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41379-019-0402-x","article-title":"Melanoma pathology reporting and staging","volume":"33","author":"Scolyer","year":"2020","journal-title":"Mod Pathol"},{"issue":"10","key":"10.1016\/j.ejca.2020.06.037_bib6","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1097\/PAS.0000000000001326","article-title":"Isolated imunohistochemistry-positive cells without morphologic characteristics of melanoma should not result in designation as a positive sentinel lymph node according to the AJCC 8th edition staging system","volume":"43","author":"Scolyer","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.ejca.2020.06.037_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.stem.2012.12.007","article-title":"The sox family of transcription factors: versatile regulators of stem and progenitor cell fate","volume":"12","author":"Sarkar","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.ejca.2020.06.037_bib8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1593\/neo.04637","article-title":"Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation","volume":"7","author":"Gershon","year":"2005","journal-title":"Neoplasia"},{"issue":"8","key":"10.1016\/j.ejca.2020.06.037_bib9","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1073\/pnas.0906596107","article-title":"Genomic code for Sox10 activation reveals a key regulatory enhancer for cranial neural crest","volume":"107","author":"Betancur","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.ejca.2020.06.037_bib10","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1172\/JCI10828","article-title":"Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret","volume":"106","author":"Lang","year":"2000","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ejca.2020.06.037_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejpn.2005.10.004","article-title":"Shah-Waardenburg syndrome and PCWH associated with SOX10 mutations: a case report and review of the literature","volume":"10","author":"Verheij","year":"2006","journal-title":"Eur J Paediatr Neurol"},{"issue":"4","key":"10.1016\/j.ejca.2020.06.037_bib12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/ajmg.a.38109","article-title":"22q11.2q13 duplication including SOX10 causes sex-reversal and peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease","volume":"173","author":"Falah","year":"2017","journal-title":"Am J Med Genet"},{"issue":"11","key":"10.1016\/j.ejca.2020.06.037_bib13","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1093\/nar\/gkx259","article-title":"BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation","volume":"45","author":"Marathe","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"10.1016\/j.ejca.2020.06.037_bib14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11010-011-0823-4","article-title":"Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors","volume":"354","author":"Wan","year":"2011","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"10.1016\/j.ejca.2020.06.037_bib15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/PAP.0b013e318297a9d0","article-title":"Value of SOX10 immunostaining in tumor diagnosis","volume":"20","author":"Ordonez","year":"2013","journal-title":"Adv Anat Pathol"},{"issue":"6","key":"10.1016\/j.ejca.2020.06.037_bib16","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/PAS.0000000000000398","article-title":"Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors","volume":"39","author":"Miettinen","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.ejca.2020.06.037_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/PAI.0000000000000097","article-title":"SOX10: a useful marker for identifying metastatic melanoma in sentinel lymph nodes","volume":"23","author":"Willis","year":"2015","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"3","key":"10.1016\/j.ejca.2020.06.037_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/PAI.0000000000000072","article-title":"Sox10 is superior to S100 in the diagnosis of meningioma","volume":"23","author":"Ng","year":"2015","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"9","key":"10.1016\/j.ejca.2020.06.037_bib19","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1600-0560.2010.01568.x","article-title":"SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar","volume":"37","author":"Ramos-Herberth","year":"2010","journal-title":"J Cutan Pathol"},{"issue":"6","key":"10.1016\/j.ejca.2020.06.037_bib20","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/CMR.0b013e3283403ccd","article-title":"SOX10 expression in superficial spreading and nodular malignant melanomas","volume":"20","author":"Agnarsdottir","year":"2010","journal-title":"Melanoma Res"},{"issue":"5","key":"10.1016\/j.ejca.2020.06.037_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/PAI.0b013e318244ff4b","article-title":"Sox10 and S100 in the diagnosis of soft-tissue neoplasms","volume":"20","author":"Karamchandani","year":"2012","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"5","key":"10.1016\/j.ejca.2020.06.037_bib22","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1365-2559.2009.03415.x","article-title":"Diagnostic value of Sox10 immunohistochemical staining for the detection of metastatic melanoma in sentinel lymph nodes","volume":"55","author":"Blochin","year":"2009","journal-title":"Histopathology"},{"issue":"1","key":"10.1016\/j.ejca.2020.06.037_bib23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/PAI.0000000000000146","article-title":"Can SOX-10 or KBA.62 replace S100 protein in immunohistochemical evaluation of sentinel lymph nodes for\u00a0metastatic melanoma?","volume":"24","author":"Vrotsos","year":"2016","journal-title":"Appl Immunohistochem Mol\u00a0Morphol"},{"issue":"8","key":"10.1016\/j.ejca.2020.06.037_bib24","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.5858\/arpa.2016-0518-RA","article-title":"Application of immunohistochemistry in undifferentiated neoplasms: a practical approach","volume":"141","author":"Kandukuri","year":"2017","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"10.1016\/j.ejca.2020.06.037_bib25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/PAI.0b013e3182910a3d","article-title":"Tumor stem cells (CD271, c-kit, SOX10) in Melanomas: prognostic and outcome implications","volume":"22","author":"Mohamed","year":"2014","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"9","key":"10.1016\/j.ejca.2020.06.037_bib26","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1097\/PAS.0b013e3181658c14","article-title":"Sox10: a pan-schwannian and melanocytic marker","volume":"32","author":"Nonaka","year":"2008","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.ejca.2020.06.037_bib27","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/DAD.0b013e3182042893","article-title":"Identification of nodal metastases in melanoma using sox-10","volume":"33","author":"Jennings","year":"2011","journal-title":"Am J Dermatopathol"},{"issue":"4","key":"10.1016\/j.ejca.2020.06.037_bib28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.5858\/arpa.2014-0077-OA","article-title":"A newly developed mouse monoclonal SOX10 antibody is a highly sensitive and specific marker for malignant melanoma, including spindle cell and desmoplastic melanomas","volume":"139","author":"Tacha","year":"2015","journal-title":"Arch Pathol Lab Med"},{"issue":"7","key":"10.1016\/j.ejca.2020.06.037_bib29","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2217\/fon.10.81","article-title":"Use of immunohistochemistry in the diagnosis of melanocytic lesions: applications and pitfalls","volume":"6","author":"Ivan","year":"2010","journal-title":"Future Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2020.06.037_bib30","first-page":"198","article-title":"S100 protein family and its application in clinical practice","volume":"12","author":"Sedaghat","year":"2008","journal-title":"Hippokratia"},{"issue":"2","key":"10.1016\/j.ejca.2020.06.037_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0006-291X(03)01190-2","article-title":"Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays","volume":"307","author":"Hsieh","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.ejca.2020.06.037_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/his.12298","article-title":"Immunohistochemistry of soft tissue tumours - review with emphasis on 10 markers","volume":"64","author":"Miettinen","year":"2014","journal-title":"Histopathology"},{"key":"10.1016\/j.ejca.2020.06.037_bib33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.humpath.2018.11.005","article-title":"A combination of GATA3 and SOX10 is useful for the diagnosis of metastatic triple-negative breast cancer","volume":"85","author":"Tozbikian","year":"2019","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ejca.2020.06.037_bib34","first-page":"152801","article-title":"Combined use of SOX10 and GATA3 in mammary carcinoma","author":"Qazi","year":"2019","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.ejca.2020.06.037_bib35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.humpath.2017.08.011","article-title":"Utility of Sox10 labeling in metastatic breast carcinomas","volume":"67","author":"Nelson","year":"2017","journal-title":"Hum Pathol"},{"issue":"6","key":"10.1016\/j.ejca.2020.06.037_bib36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00428-019-02557-1","article-title":"SOX10 expression in mammary invasive ductal carcinomas and benign breast tissue","volume":"474","author":"Chiu","year":"2019","journal-title":"Virchows Arch Int J Pathol"},{"issue":"2","key":"10.1016\/j.ejca.2020.06.037_bib37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/PAS.0000000000000527","article-title":"Metastatic malignant melanoma with complete loss of differentiation markers (undifferentiated\/dedifferentiated melanoma): analysis of 14 patients emphasizing phenotypic plasticity and the value of molecular testing as surrogate diagnostic marker","volume":"40","author":"Agaimy","year":"2016","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"10.1016\/j.ejca.2020.06.037_bib38","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1038\/jid.2015.127","article-title":"Circulating melanoma cell subpopulations: their heterogeneity and differential responses to treatment","volume":"135","author":"Gray","year":"2015","journal-title":"J Invest Dermatol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804920303713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804920303713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:28:47Z","timestamp":1760732927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804920303713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":38,"alternative-id":["S0959804920303713"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2020.06.037","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SOX10 is as specific as S100 protein in detecting metastases of melanoma in lymph nodes and is recommended for sentinel lymph node assessment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2020.06.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}