{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:12:22Z","timestamp":1792239142751,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ejca.2020.12.023","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T01:04:25Z","timestamp":1612919065000},"page":"30-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":154,"special_numbering":"C","title":["Clinical practice guidelines for BRCA1 and BRCA2 genetic testing"],"prefix":"10.1016","volume":"146","author":[{"given":"Pascal","family":"Pujol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Barberis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philp","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Piulats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore D.","family":"Capoluongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Garcia Foncillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Ray-Coquard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Penault-Llorca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Narod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu K.","family":"Arun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti S.","family":"Aapro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Normanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diether","family":"Lambrechts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignace","family":"Vergote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Anahory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Baertschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Baudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves-Jean","family":"Bignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Corsini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Cussenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"De la Motte Rouge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Duboys de Labarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Duchamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Duriez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Fizazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Galibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Gladieff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gligorov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Hammel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Imbert-Bouteille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Jacot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kogut-Kubiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Jean","family":"Lamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Nambot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Neuzillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylviane","family":"Olschwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Rebillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Rideau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Spano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Treilleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Vandromme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Vendrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Vintraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E.","family":"Al\u00e9s Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2020.12.023_bib1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejca.2020.12.023_bib2","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.ejca.2020.12.023_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10549-013-2669-9","article-title":"Lack of referral for genetic counseling and testing in BRCA1\/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests","volume":"141","author":"Pujol","year":"2013","journal-title":"Breast Canc Res Treat"},{"key":"10.1016\/j.ejca.2020.12.023_bib4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.amepre.2017.01.027","article-title":"Use of BRCA mutation test in the U.S., 2004\u20132014","volume":"52","author":"Guo","year":"2017","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.ejca.2020.12.023_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10549-017-4332-3","article-title":"Preferences for breast cancer risk reduction among BRCA1\/BRCA2 mutation carriers: a discrete-choice experiment","volume":"165","author":"Liede","year":"2017","journal-title":"Breast Canc Res Treat"},{"key":"10.1016\/j.ejca.2020.12.023_bib6","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1200\/JCO.19.02960","article-title":"Germline and somatic tumor testing in epithelial ovarian cancer: ASCO guideline","volume":"38","author":"Konstantinopoulos","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/1758835919897530","article-title":"How and when to refer patients for oncogenetic counseling in the era of PARP inhibitors","volume":"12","author":"Neviere","year":"2020","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib8","doi-asserted-by":"crossref","first-page":"19463","DOI":"10.18632\/oncotarget.24728","article-title":"Main implications related to the switch to 1\/2 tumor testing in ovarian cancer patients: a proposal of a consensus","volume":"9","author":"Capoluongo","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejca.2020.12.023_bib9","first-page":"2321","article-title":"A systematic review of international guidelines and recommendations for the genetic screening, diagnosis, genetic counseling, and treatment of BRCA-mutated breast cancer","volume":"11","author":"Forbes","year":"2019","journal-title":"Canc Manag Res"},{"key":"10.1016\/j.ejca.2020.12.023_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41416-018-0127-5","article-title":"BRCA1\/2 testing: therapeutic implications for breast cancer management","volume":"119","author":"Tung","year":"2018","journal-title":"Br J Canc"},{"key":"10.1016\/j.ejca.2020.12.023_bib11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.6004\/jnccn.2020.0017","article-title":"NCCN guidelines insights: genetic\/familial high-risk assessment: breast, ovarian, and pancreatic, version 1.2020","volume":"18","author":"Daly","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.ejca.2020.12.023_bib12","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1200\/JCO.20.00299","article-title":"Management of hereditary breast cancer: American society of clinical oncology, American society for radiation oncology, and society of surgical oncology guideline","volume":"38","author":"Tung","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1001\/jama.2019.10987","article-title":"Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer: US preventive Services Task Force recommendation statement","volume":"322","author":"Owens","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.ejca.2020.12.023_bib14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1200\/JCO.2015.64.3809","article-title":"American cancer society\/American society of clinical oncology breast cancer survivorship care guideline","volume":"34","author":"Runowicz","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib15","series-title":"Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer","year":"2020"},{"key":"10.1016\/j.ejca.2020.12.023_bib16","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/s41431-018-0224-1","article-title":"Guidelines for reporting secondary findings of genome sequencing in cancer genes: the SFMPP recommendations","volume":"26","author":"Pujol","year":"2018","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ejca.2020.12.023_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics9030083","article-title":"From targeting somatic mutations to finding inherited cancer predispositions: the other side of the coin","volume":"9","author":"Pujol","year":"2019","journal-title":"Diagnostics"},{"key":"10.1016\/j.ejca.2020.12.023_bib18","doi-asserted-by":"crossref","first-page":"100439","DOI":"10.1016\/j.jemep.2019.100439","article-title":"R\u00e9flexions \u00e9thiques sur le d\u00e9pistage g\u00e9n\u00e9tique pr\u00e9conceptionnel en population g\u00e9n\u00e9rale : le d\u00e9bat fran\u00e7ais et l\u2019avis de la Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine Pr\u00e9dictive et Personnalis\u00e9e","volume":"12","author":"Pujol","year":"2020","journal-title":"Ethics, Medicine and Public Health"},{"key":"10.1016\/j.ejca.2020.12.023_bib19","unstructured":"Guideline development checklist n.d. http:\/\/cebgrade.mcmaster.ca\/guidecheck.html [accessed 1 September 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib20","unstructured":"Welcome to G-I-N \u2014 guidelines international Network n.d. https:\/\/g-i-n.net\/ [accessed 1 September 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib21","unstructured":"BRCAPRO n.d. https:\/\/projects.iq.harvard.edu\/bayesmendel\/brcapro [accessed 31 August 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib22","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1200\/JCO.2002.05.121","article-title":"BRCAPRO validation, sensitivity of genetic testing of BRCA1\/BRCA2, and prevalence of other breast cancer susceptibility genes","volume":"20","author":"Berry","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib23","unstructured":"BOADICEA web application - centre for cancer genetic epidemiology n.d. https:\/\/ccge.medschl.cam.ac.uk\/boadicea\/boadicea-web-application\/ [accessed 31 August 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib24","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/sj.bjc.6602175","article-title":"The BOADICEA model of genetic susceptibility to breast and ovarian cancer","volume":"91","author":"Antoniou","year":"2004","journal-title":"Br J Canc"},{"key":"10.1016\/j.ejca.2020.12.023_bib25","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1056\/NEJM199705153362002","article-title":"BRCA1Mutations in women attending clinics that evaluate the risk of breast cancer","volume":"336","author":"Couch","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2020.12.023_bib26","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/annonc\/mdy192","article-title":"4th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 4)\u2020","volume":"29","author":"Cardoso","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib27","unstructured":"OncologyPRO. Making a difference for advanced breast cancer patients n.d. https:\/\/oncologypro.esmo.org\/meeting-resources\/eso-esmo-advanced-breast-cancer-fifth-international-consensus-conference-abc5\/making-a-difference-for-advanced-breast-cancer-patients [accessed 1 September 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib28","unstructured":"Institut National Du Cancer. Th\u00e9saurus - Femmes porteuses d\u2019une mutation de BRCA1 ou BRCA2\/D\u00e9tection pr\u00e9coce du cancer du sein et des annexes et strat\u00e9gies de r\u00e9duction du risque - ref : RECOBRCATHES17 n.d. http:\/\/www.e-cancer.fr\/ [accessed 28 August 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib29","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41591-018-0009-7","article-title":"Carboplatin in BRCA1\/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial","volume":"24","author":"Tutt","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.ejca.2020.12.023_bib30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1706450","article-title":"Olaparib for metastatic breast cancer in patients with a germline BRCA mutation","volume":"377","author":"Robson","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2020.12.023_bib31","series-title":"Abstract GS6-07: EMBRACA: a phase 3 trial comparing talazoparib, an oral PARP inhibitor, to physician's choice of therapy in patients with advanced breast cancer and a germline BRCA mutation. General Session Abstracts","author":"Litton","year":"2018"},{"key":"10.1016\/j.ejca.2020.12.023_bib32","unstructured":"Program Planner n.d. https:\/\/www.abstractsonline.com\/pp8\/#!\/9045\/presentation\/10773 [accessed 1 September 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib33","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2019.4004","article-title":"Broad application of multigene panel testing for breast cancer susceptibility-Pandora\u2019s box is opening wider","author":"Robson","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib34","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1200\/JCO.20.00046","article-title":"Implementation of germline testing for prostate cancer: philadelphia prostate cancer consensus conference 2019","volume":"38","author":"Giri","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJMoa1903387","article-title":"Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer","volume":"381","author":"Golan","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2020.12.023_bib36","doi-asserted-by":"crossref","first-page":"v254","DOI":"10.1093\/annonc\/mdz247.003","article-title":"POLO: health-related quality of life (HRQoL) of olaparib maintenance treatment versus placebo in patients with a germline BRCA mutation and metastatic pancreatic cancer (mPC)","volume":"30","author":"Hammel","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American college of medical genetics and genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.ejca.2020.12.023_bib38","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jmoldx.2016.10.002","article-title":"Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the association for molecular pathology, American society of clinical oncology, and college of American pathologists","volume":"19","author":"Li","year":"2017","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.ejca.2020.12.023_bib39","unstructured":"Describing sequence variants n.d. http:\/\/www.hgvs.org\/mutnomen [accessed 1 September 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib40","unstructured":"Guideline development checklist n.d. http:\/\/cebgrade.mcmaster.ca\/guidecheck.html [accessed 1 September 2020]."},{"key":"10.1016\/j.ejca.2020.12.023_bib41","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2020.38.15_suppl.6041","article-title":"Low rates of BRCA1 and BRCA2 testing for patients with ovarian cancer in ASCO's CancerLinQ, a real-world database","volume":"38","author":"Dewdney","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.03.039","article-title":"Pathogenic germline variants in 10,389 adult cancers","volume":"173","author":"Huang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ejca.2020.12.023_bib43","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/cncr.30498","article-title":"A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes","volume":"123","author":"Buys","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2020.12.023_bib44","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/jamaoncol.2017.0424","article-title":"Associations between cancer predisposition testing panel genes and breast cancer","volume":"3","author":"Couch","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2350-9-116","article-title":"Selecting a BRCA risk assessment model for use in a familial cancer clinic","volume":"9","author":"Panchal","year":"2008","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.ejca.2020.12.023_bib46","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.2140","article-title":"Exome sequencing-based screening for BRCA1\/2 expected pathogenic variants among adult biobank participants","volume":"1","author":"Manickam","year":"2018","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ejca.2020.12.023_bib47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1001\/jama.2014.17442","article-title":"Proposed shift in screening for breast cancer--reply","volume":"313","author":"King","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.ejca.2020.12.023_bib48","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.1073\/pnas.1415979111","article-title":"Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2","volume":"111","author":"Gabai-Kapara","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ejca.2020.12.023_bib49","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2019.3323","article-title":"A cost-effectiveness analysis of multigene testing for all patients with breast cancer","author":"Sun","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejca.2020.12.023_bib50","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/gim.2017.231","article-title":"Cost-effectiveness analysis of germ-line BRCA testing in women with breast cancer and cascade testing in family members of mutation carriers","volume":"20","author":"Tuffaha","year":"2018","journal-title":"Genet Med"},{"key":"10.1016\/j.ejca.2020.12.023_bib51","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1200\/JCO.2017.76.2781","article-title":"Evaluation of a streamlined oncologist-led BRCA mutation testing and counseling model for patients with ovarian cancer","volume":"36","author":"Colombo","year":"2018","journal-title":"J Clin Oncol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804920314489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804920314489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:29:42Z","timestamp":1760732982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804920314489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":51,"alternative-id":["S0959804920314489"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2020.12.023","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical practice guidelines for BRCA1 and BRCA2 genetic testing","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2020.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}