{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:51:19Z","timestamp":1792633879571,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ejca.2021.09.026","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T15:28:47Z","timestamp":1636558127000},"page":"182-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["High-resolution three-dimensional imaging for precise staging in melanoma"],"prefix":"10.1016","volume":"159","author":[{"given":"Simon F.","family":"Merz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricarda","family":"Ulankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Bornemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schimming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-9449","authenticated-orcid":false,"given":"Klaus","family":"Griewank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fclal","family":"Cibir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Stoffels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Aspelmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Brandau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hadaschik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-628X","authenticated-orcid":false,"given":"Gernot","family":"Ebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-6055","authenticated-orcid":false,"given":"Matthias","family":"Gunzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Klode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2021.09.026_bib1","first-page":"472","article-title":"Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual","volume":"67","author":"Gershenwald","year":"2017","journal-title":"Ca - Cancer J Clin"},{"key":"10.1016\/j.ejca.2021.09.026_bib2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4048\/jbc.2017.20.3.217","article-title":"Sentinel lymph node biopsy in breast cancer: a clinical review and update","volume":"20","author":"Zahoor","year":"2017","journal-title":"J Breast Cancer"},{"key":"10.1016\/j.ejca.2021.09.026_bib3","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.18295\/squmj.2016.17.01.002","article-title":"Sentinel Lymph Node Biopsy: a new approach in the management of head and neck cancers","volume":"17","author":"Sharma","year":"2017","journal-title":"Sultan Qaboos Univ Med J"},{"key":"10.1016\/j.ejca.2021.09.026_bib4","doi-asserted-by":"crossref","first-page":"8515","DOI":"10.3748\/wjg.v19.i46.8515","article-title":"Lymph node staging in colorectal cancer: old controversies and recent advances","volume":"19","author":"Resch","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ejca.2021.09.026_bib5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ejca.2021.05.026","article-title":"Deep learning approach to predict sentinel lymph node status directly from routine histology of primary melanoma tumours","volume":"154","author":"Brinker","year":"2021","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2021.09.026_bib6","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/annonc\/mdl176","article-title":"Clinical relevance of melanoma micrometastases (<0.1 mm) in sentinel nodes: are these nodes to be considered negative?","volume":"17","author":"van Akkooi","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2021.09.026_bib7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/SLA.0b013e31818fefe0","article-title":"Sentinel node tumor burden according to the Rotterdam criteria is the most important prognostic factor for survival in melanoma patients: a multicenter study in 388 patients with positive sentinel nodes","volume":"248","author":"van Akkooi","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejca.2021.09.026_bib8","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.ejca.2009.08.015","article-title":"Expert opinion in melanoma: the sentinel node; EORTC Melanoma Group recommendations on practical methodology of the measurement of the microanatomic location of metastases and metastatic tumour burden","volume":"45","author":"van Akkooi","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2021.09.026_bib9","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1200\/JCO.2010.31.6760","article-title":"Prognosis in patients with sentinel node-positive melanoma is accurately defined by the combined Rotterdam tumor load and Dewar topography criteria","volume":"29","author":"van der Ploeg","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2021.09.026_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ejca.2011.08.019","article-title":"Treatment influencing down-staging in EORTC Melanoma Group sentinel node histological protocol compared with complete step-sectioning: a national multicentre study","volume":"48","author":"Riber-Hansen","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2021.09.026_bib11","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1245\/s10434-008-9847-8","article-title":"Extensive pathological analysis of selected melanoma sentinel lymph nodes: high metastasis detection rates at reduced workload","volume":"15","author":"Riber-Hansen","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejca.2021.09.026_bib12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.pas.0000152134.36030.b7","article-title":"Characterization of micrometastatic disease in melanoma sentinel lymph nodes by enhanced pathology: recommendations for standardizing pathologic analysis","volume":"29","author":"Spanknebel","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejca.2021.09.026_bib13","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1245\/s10434-009-0540-3","article-title":"False-negative sentinel node biopsy","volume":"16","author":"Nieweg","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejca.2021.09.026_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/CMR.0b013e3282f702bf","article-title":"Evidence-based and interdisciplinary consensus-based German guidelines: systemic medical treatment of melanoma in the adjuvant and palliative setting","volume":"18","author":"Garbe","year":"2008","journal-title":"Melanoma Res"},{"key":"10.1016\/j.ejca.2021.09.026_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13063-019-3197-7","article-title":"Sentinel lymph node excision with or without preoperative hybrid single-photon emission computed tomography\/computed tomography (SPECT\/CT) in melanoma: study protocol for a multicentric randomised controlled trial","volume":"20","author":"Stoffels","year":"2019","journal-title":"Trials"},{"key":"10.1016\/j.ejca.2021.09.026_bib16","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1681\/ASN.2016020232","article-title":"Fully automated evaluation of total glomerular number and capillary tuft size in nephritic kidneys using lightsheet microscopy","volume":"28","author":"Klingberg","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejca.2021.09.026_bib17","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/s41467-019-10338-2","article-title":"Contemporaneous 3D characterization of acute and chronic myocardial I\/R injury and response","volume":"10","author":"Merz","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ejca.2021.09.026_bib18","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejca.2021.09.026_bib19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2017.03.008","article-title":"Tridimensional visualization and analysis of early human development","volume":"169","author":"Belle","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejca.2021.09.026_bib20","series-title":"Foundations of vision","author":"Wandell","year":"1995"},{"key":"10.1016\/j.ejca.2021.09.026_bib21","series-title":"Computed tomography","author":"Kalender","year":"2005"},{"key":"10.1016\/j.ejca.2021.09.026_bib22","first-page":"13","article-title":"Diagnostic and prognostic biomarkers in melanoma","volume":"7","author":"Weinstein","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1016\/j.ejca.2021.09.026_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejca.2013.08.023","article-title":"The prognostic significance of sentinel node tumour burden in melanoma patients: an international, multicenter study of 1539 sentinel node-positive melanoma patients","volume":"50","author":"van der Ploeg","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2021.09.026_bib24","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/modpathol.2009.137","article-title":"Cutting a sentinel lymph node into slices is the optimal first step for examination of sentinel lymph nodes in melanoma patients","volume":"22","author":"Mitteldorf","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ejca.2021.09.026_bib25","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1365-2559.2007.02681.x","article-title":"Prognostic significance of histopathological parameters in sentinel nodes of melanoma patients","volume":"50","author":"Satzger","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.ejca.2021.09.026_bib26","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1002\/1097-0142(20010601)91:11<2110::AID-CNCR1239>3.0.CO;2-Q","article-title":"A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma","volume":"91","author":"Starz","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2021.09.026_bib27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/1097-0142(20000715)89:2<236::AID-CNCR5>3.0.CO;2-0","article-title":"The Augsburg Consensus. Techniques of lymphatic mapping, sentinel lymphadenectomy, and completion lymphadenectomy in cutaneous malignancies","volume":"89","author":"Cochran","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2021.09.026_bib28","doi-asserted-by":"crossref","first-page":"18631","DOI":"10.1038\/srep18631","article-title":"ACT-PRESTO: rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging","volume":"6","author":"Lee","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ejca.2021.09.026_bib29","doi-asserted-by":"crossref","first-page":"7076910","DOI":"10.1155\/2016\/7076910","article-title":"Microwave-assisted tissue preparation for rapid fixation, decalcification, antigen retrieval, cryosectioning, and immunostaining","volume":"2016","author":"Katoh","year":"2016","journal-title":"Int J Cell Biol"},{"key":"10.1016\/j.ejca.2021.09.026_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/10520290902879763","article-title":"Microwave irradiation for fixation and immunostaining of endothelial cells in situ","volume":"84","author":"Katoh","year":"2009","journal-title":"Biotech Histochem"},{"key":"10.1016\/j.ejca.2021.09.026_bib31","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.2147\/IJN.S107194","article-title":"Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications","volume":"11","author":"Wang","year":"2016","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.ejca.2021.09.026_bib32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jbiomech.2007.10.023","article-title":"The free diffusion of macromolecules in tissue-engineered skeletal muscle subjected to large compression strains","volume":"41","author":"Gefen","year":"2008","journal-title":"J Biomech"},{"key":"10.1016\/j.ejca.2021.09.026_bib33","doi-asserted-by":"crossref","first-page":"9269","DOI":"10.1038\/s41598-017-09117-0","article-title":"CUBIC pathology: three-dimensional imaging for pathological diagnosis","volume":"7","author":"Nojima","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ejca.2021.09.026_bib34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s13534-019-00122-y","article-title":"Light sheet microscopy for histopathology applications","volume":"9","author":"Poola","year":"2019","journal-title":"Biomed Eng Lett"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804921011266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804921011266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:34:16Z","timestamp":1760733256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804921011266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":34,"alternative-id":["S0959804921011266"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2021.09.026","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.22.20159103","asserted-by":"object"}]},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-resolution three-dimensional imaging for precise staging in melanoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2021.09.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}