{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:12:43Z","timestamp":1791317563563,"version":"4.3.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ejca.2021.09.047","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T12:18:20Z","timestamp":1636978700000},"page":"247-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients"],"prefix":"10.1016","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3178-8924","authenticated-orcid":false,"given":"Christopher","family":"Wills","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhou","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Summers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda I.","family":"Phipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-3984","authenticated-orcid":false,"given":"Katie","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada A.","family":"Al-Tassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Maughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Houlston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-9318","authenticated-orcid":false,"given":"Ulrike","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly A.","family":"Newcomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Gallinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-980X","authenticated-orcid":false,"given":"Loic L.","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-221X","authenticated-orcid":false,"given":"Rish K.","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-4122","authenticated-orcid":false,"given":"Steven R.","family":"Alberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-6534","authenticated-orcid":false,"given":"Hannah D.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-5483","authenticated-orcid":false,"given":"Valentina","family":"Escott-Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3033-5851","authenticated-orcid":false,"given":"Malcolm G.","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-8458","authenticated-orcid":false,"given":"Jeremy P.","family":"Cheadle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ejca.2021.09.047_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc2645","article-title":"Genetic prognostic and predictive markers in colorectal cancer","volume":"9","author":"Walther","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2021.09.047_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/gut.2005.068189","article-title":"Effect of physical activity and body size on survival after diagnosis with colorectal cancer","volume":"55","author":"Haydon","year":"2006","journal-title":"Gut"},{"issue":"7630","key":"10.1016\/j.ejca.2021.09.047_bib3","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/bmj.39367.495995.AE","article-title":"Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study","volume":"335","author":"Reeves","year":"2007","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.ejca.2021.09.047_bib4","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/sj.bjc.6604027","article-title":"Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer","volume":"97","author":"Leitch","year":"2007","journal-title":"Br J Cancer"},{"issue":"5795","key":"10.1016\/j.ejca.2021.09.047_bib5","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","article-title":"Type, density, and location of immune cells within human colorectal tumors predict clinical outcome","volume":"313","author":"Galon","year":"2006","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.ejca.2021.09.047_bib6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1200\/JCO.2005.01.086","article-title":"Systematic review of microsatellite instability and colorectal cancer prognosis","volume":"23","author":"Popat","year":"2005","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.ejca.2021.09.047_bib7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/gut.2007.135004","article-title":"Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis","volume":"57","author":"Walther","year":"2008","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.ejca.2021.09.047_bib8","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1200\/JCO.2005.03.5253","article-title":"Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment","volume":"24","author":"Dotor","year":"2006","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2021.09.047_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/ijc.20487","article-title":"Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients","volume":"112","author":"Marcuello","year":"2004","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2021.09.047_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1158\/1078-0432.CCR-07-1537","article-title":"Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with colorectal cancer","volume":"14","author":"Kim","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.ejca.2021.09.047_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.gastro.2012.04.052","article-title":"Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer","volume":"143","author":"Phipps","year":"2012","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.ejca.2021.09.047_bib12","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/carcin\/bgs147","article-title":"GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes","volume":"33","author":"Dai","year":"2012","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.ejca.2021.09.047_bib13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/carcin\/bgs335","article-title":"Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival","volume":"34","author":"Garcia-Albeniz","year":"2013","journal-title":"Carcinogenesis"},{"issue":"10","key":"10.1016\/j.ejca.2021.09.047_bib14","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/carcin\/bgt179","article-title":"Genetic susceptibility variants associated with colorectal cancer prognosis","volume":"34","author":"Abuli","year":"2013","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.ejca.2021.09.047_bib15","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1245\/s10434-012-2657-z","article-title":"The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer","volume":"20","author":"Takatsuno","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.ejca.2021.09.047_bib16","doi-asserted-by":"crossref","first-page":"117816","DOI":"10.1371\/journal.pone.0117816","article-title":"A retrospective observational study of the relationship between single nucleotide polymorphisms associated with the risk of developing colorectal cancer and survival","volume":"10","author":"Morris","year":"2015","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.ejca.2021.09.047_bib17","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1158\/1078-0432.CCR-14-3136","article-title":"Analyses of 7,635 patients with colorectal cancer using independent training and validation cohorts show that rs9929218 in CDH1 is a prognostic marker of survival","volume":"21","author":"Smith","year":"2015","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.ejca.2021.09.047_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/ger059","article-title":"COGENT (COlorectal cancer GENeTics) revisited","volume":"27","author":"Houlston","year":"2012","journal-title":"Mutagenesis"},{"issue":"1","key":"10.1016\/j.ejca.2021.09.047_bib19","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1038\/s41467-019-09775-w","article-title":"Association analyses identify 31 new risk loci for colorectal cancer susceptibility","volume":"10","author":"Law","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ejca.2021.09.047_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/carcin\/bgv161","article-title":"Common genetic variation and survival after colorectal cancer diagnosis: a genome-wide analysis","volume":"37","author":"Phipps","year":"2016","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.ejca.2021.09.047_bib21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12885-019-5346-5","article-title":"A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer","volume":"19","author":"Penney","year":"2019","journal-title":"BMC Cancer"},{"issue":"9783","key":"10.1016\/j.ejca.2021.09.047_bib22","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/S0140-6736(11)60613-2","article-title":"Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial","volume":"377","author":"Maughan","year":"2011","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ejca.2021.09.047_bib23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S1470-2045(14)70106-8","article-title":"Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial","volume":"15","author":"Wasan","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejca.2021.09.047_bib24","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1038\/srep10442","article-title":"A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer","volume":"5","author":"Al-Tassan","year":"2015","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.ejca.2021.09.047_bib25","doi-asserted-by":"crossref","first-page":"1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLoS Genet"},{"issue":"7571","key":"10.1016\/j.ejca.2021.09.047_bib26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Altshuler","year":"2015","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ejca.2021.09.047_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1534\/g3.111.001198","article-title":"Genotype imputation with thousands of genomes","volume":"1","author":"Howie","year":"2011","journal-title":"G3: Genes|Genomes|Genetics"},{"issue":"2","key":"10.1016\/j.ejca.2021.09.047_bib28","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/mpr.1608","article-title":"A tutorial on conducting genome-wide association studies: quality control and statistical analysis","volume":"27","author":"Marees","year":"2018","journal-title":"Int J Methods Psychiatr Res"},{"key":"10.1016\/j.ejca.2021.09.047_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/0471142905.hg0119s68","article-title":"Quality control procedures for genome-wide association studies","author":"Turner","year":"2011","journal-title":"Curr Protoc Human Genet"},{"issue":"5","key":"10.1016\/j.ejca.2021.09.047_bib30","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/429864","article-title":"A note on exact tests of hardy-weinberg Equilibrium","volume":"76","author":"Wigginton","year":"2005","journal-title":"Am J Hum Genet"},{"issue":"6","key":"10.1016\/j.ejca.2021.09.047_bib31","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng.2303","article-title":"Exome sequencing and the genetic basis of complex traits","volume":"44","author":"Kiezun","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejca.2021.09.047_bib32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J Roy Stat Soc B Stat Methodol"},{"key":"10.1016\/j.ejca.2021.09.047_bib33","series-title":"qvalue: Q-value estimation for false discovery rate control","author":"Storey","year":"2019"},{"issue":"3","key":"10.1016\/j.ejca.2021.09.047_bib34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"11","key":"10.1016\/j.ejca.2021.09.047_bib35","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1093\/bioinformatics\/bty920","article-title":"gwasurvivr: an R package for genome-wide survival analysis","volume":"35","author":"Rizvi","year":"2019","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.ejca.2021.09.047_bib36","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/bioinformatics\/btm108","article-title":"GenABEL: an R library for genome-wide association analysis","volume":"23","author":"Aulchenko","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejca.2021.09.047_bib37","series-title":"R: A language and environment for statistical computing","year":"2018"},{"issue":"4","key":"10.1016\/j.ejca.2021.09.047_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"10.1016\/j.ejca.2021.09.047_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejca.2021.09.047_bib40","first-page":"bat054-bat","article-title":"A guide to best practices for Gene Ontology (GO) manual annotation","volume":"2013","author":"Balakrishnan","year":"2013","journal-title":"Database \u2013 J Biol Database Curation"},{"issue":"5","key":"10.1016\/j.ejca.2021.09.047_bib41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1089\/bio.2015.29031.hmm","article-title":"The genotype-tissue expression (GTEx) project","volume":"13","author":"Carithers","year":"2015","journal-title":"Biopreserv Biobanking"},{"issue":"6220","key":"10.1016\/j.ejca.2021.09.047_bib42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ejca.2021.09.047_bib43","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1158\/1055-9965.EPI-06-0785","article-title":"Dietary flavonoids and the risk of colorectal cancer","volume":"16","author":"Theodoratou","year":"2007","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"9","key":"10.1016\/j.ejca.2021.09.047_bib44","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1002\/ijc.32550","article-title":"Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: a large population-based cohort study","volume":"145","author":"He","year":"2019","journal-title":"Int J Cancer"},{"issue":"8","key":"10.1016\/j.ejca.2021.09.047_bib45","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41416-018-0117-7","article-title":"Genome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome","volume":"119","author":"Theodoratou","year":"2018","journal-title":"Br J Cancer"},{"issue":"17","key":"10.1016\/j.ejca.2021.09.047_bib46","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.ejca.2021.09.047_bib47","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/carcin\/bgv049","article-title":"ERBB4 is over-expressed in human colon cancer and enhances cellular transformation","volume":"36","author":"Williams","year":"2015","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.ejca.2021.09.047_bib48","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0959-8049(02)00004-7","article-title":"Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery","volume":"38","author":"Lee","year":"2002","journal-title":"Eur J Cancer"},{"issue":"12","key":"10.1016\/j.ejca.2021.09.047_bib49","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.7150\/thno.43744","article-title":"Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ejca.2021.09.047_bib50","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.canlet.2020.01.007","article-title":"Loss of cytoskeleton protein ADD3 promotes tumor growth and angiogenesis in glioblastoma multiforme","volume":"474","author":"Kiang","year":"2020","journal-title":"Cancer Lett"},{"issue":"3","key":"10.1016\/j.ejca.2021.09.047_bib51","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bbamcr.2018.10.001","article-title":"Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression","volume":"1866","author":"Lechuga","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Res"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804921011679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804921011679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:34:43Z","timestamp":1760733283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804921011679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":51,"alternative-id":["S0959804921011679"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2021.09.047","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2021.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}