{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:10:46Z","timestamp":1778785846569,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"am","delay-in-days":310,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K07781"],"award-info":[{"award-number":["18K07781"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K16250"],"award-info":[{"award-number":["18K16250"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.ejca.2022.06.013","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T13:35:55Z","timestamp":1657287355000},"page":"311-322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["A novel risk stratification model based on the Children's Hepatic Tumours International Collaboration-Hepatoblastoma Stratification and deoxyribonucleic acid methylation analysis for hepatoblastoma"],"prefix":"10.1016","volume":"172","author":[{"given":"Takafumi","family":"Kondo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi M.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoko","family":"Ara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Minato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Shinkai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-1054","authenticated-orcid":false,"given":"Tomoro","family":"Hishiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohmei","family":"Ida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Takatori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-5037","authenticated-orcid":false,"given":"Eiso","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Taketomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2022.06.013_bib1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/pbc.24215","article-title":"The epidemiology of hepatoblastoma","volume":"59","author":"Spector","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ejca.2022.06.013_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.sempedsurg.2011.10.011","article-title":"Hepatoblastoma: recent developments in research and treatment","volume":"21","author":"von Schweinitz","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.ejca.2022.06.013_bib3","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1200\/JCO.2005.02.6013","article-title":"Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma","volume":"24","author":"Malogolowkin","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2022.06.013_bib4","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa0810613","article-title":"Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma","volume":"361","author":"Perilongo","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2022.06.013_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2741\/e395","article-title":"Treatment of hepatoblastoma in the German cooperative pediatric liver tumor studies","volume":"4","author":"Haeberle","year":"2012","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.ejca.2022.06.013_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00383-010-2708-0","article-title":"Outcome of hepatoblastomas treated using the Japanese study group for pediatric liver tumor (JPLT) protocol-2: report from the JPLT","volume":"27","author":"Hishiki","year":"2011","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.ejca.2022.06.013_bib7","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1200\/JCO.19.01067","article-title":"Outcome and late complications of hepatoblastomas treated using the Japanese Study Group for Pediatric Liver Tumor 2 protocol","volume":"38","author":"Hiyama","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2022.06.013_bib8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1470-2045(16)30598-8","article-title":"Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration","volume":"18","author":"Meyers","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejca.2022.06.013_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccr.2008.11.002","article-title":"Hepatic stem-like phenotype and interplay of Wnt\/beta-catenin and Myc signaling in aggressive childhood liver cancer","volume":"14","author":"Cairo","year":"2008","journal-title":"Canc Cell"},{"key":"10.1016\/j.ejca.2022.06.013_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.29672","article-title":"New insights into diagnosis and therapeutic options for proliferative hepatoblastoma","volume":"68","author":"Hooks","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.ejca.2022.06.013_bib11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/hep.28888","article-title":"Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups","volume":"65","author":"Sumazin","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.ejca.2022.06.013_bib12","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1038\/s41467-021-25430-9","article-title":"Genetic and epigenetic basis of hepatoblastoma diversity","volume":"12","author":"Nagae","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ejca.2022.06.013_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejca.2020.09.026","article-title":"A combined clinical and biological risk classification improves prediction of outcome in hepatoblastoma patients","volume":"141","author":"Cairo","year":"2020","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2022.06.013_bib14","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.jhep.2014.08.009","article-title":"The genomic landscape of hepatoblastoma and their progenies with HCC-like features","volume":"61","author":"Eichenm\u00fcller","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.ejca.2022.06.013_bib15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/ijc.23613","article-title":"The methylation status of RASSF1A promoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients","volume":"123","author":"Honda","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejca.2022.06.013_bib16","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00383-013-3371-z","article-title":"RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients","volume":"29","author":"Honda","year":"2013","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.ejca.2022.06.013_bib17","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/cas.12928","article-title":"Clinical prognostic value of DNA methylation in hepatoblastoma: four novel tumor suppressor candidates","volume":"107","author":"Honda","year":"2016","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ejca.2022.06.013_bib18","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1158\/1078-0432.CCR-08-3336","article-title":"Genomic screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistance in multiple myeloma","volume":"15","author":"Nojima","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejca.2022.06.013_bib19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ejca.2022.06.013_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040924","article-title":"Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues","volume":"7","author":"Murphy","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ejca.2022.06.013_bib21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1349-7006.2005.00035.x","article-title":"Aberrant methylations in cancer cells: where do they come from?","volume":"96","author":"Ushijima","year":"2005","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ejca.2022.06.013_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jhep.2020.03.025","article-title":"Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications","volume":"73","author":"Carrillo-Reixach","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.ejca.2022.06.013_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00247-018-4078-z","article-title":"2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT)","volume":"48","author":"Towbin","year":"2018","journal-title":"Pediatr Radiol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804922003641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804922003641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:23:08Z","timestamp":1778782988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804922003641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":23,"alternative-id":["S0959804922003641"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2022.06.013","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel risk stratification model based on the Children's Hepatic Tumours International Collaboration-Hepatoblastoma Stratification and deoxyribonucleic acid methylation analysis for hepatoblastoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2022.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}