{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:51:24Z","timestamp":1787863884036,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ejca.2023.113472","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T11:33:26Z","timestamp":1702121606000},"page":"113472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature"],"prefix":"10.1016","volume":"197","author":[{"given":"M.C.F.","family":"Mulders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Audhoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Van Koetsveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Feelders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.J.","family":"Hofland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.W.","family":"de Herder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0416-999X","authenticated-orcid":false,"given":"R.","family":"Kraaij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hofland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejca.2023.113472_bib1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1210\/endrev\/bnz004","article-title":"Advances in the diagnosis and management of well-differentiated neuroendocrine neoplasms","volume":"41","author":"Hofland","year":"2020","journal-title":"Endocr Rev"},{"issue":"10","key":"10.1016\/j.ejca.2023.113472_bib2","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1001\/jamaoncol.2017.0589","article-title":"Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States","volume":"3","author":"Dasari","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejca.2023.113472_bib3","article-title":"Incidence and survival of neuroendocrine neoplasia in England 1995-2018: A retrospective, population-based study","volume":"23","author":"White","year":"2022","journal-title":"Lancet Reg Health Eur"},{"issue":"3","key":"10.1016\/j.ejca.2023.113472_bib4","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1530\/ERC-13-0125","article-title":"Incidence of gastroenteropancreatic neuroendocrine tumours: a systematic review of the literature","volume":"21","author":"Fraenkel","year":"2014","journal-title":"Endocr Relat Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2023.113472_bib5","doi-asserted-by":"crossref","DOI":"10.1007\/s11912-021-01029-7","article-title":"Epidemiology, incidence, and prevalence of neuroendocrine neoplasms: are there global differences?","volume":"23","author":"Das","year":"2021","journal-title":"Curr Oncol Rep"},{"issue":"7781","key":"10.1016\/j.ejca.2023.113472_bib6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-019-1689-y","article-title":"Pan-cancer whole-genome analyses of metastatic solid tumours","volume":"575","author":"Priestley","year":"2019","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ejca.2023.113472_bib7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1470-2045(17)30110-9","article-title":"Frequency of carcinoid syndrome at neuroendocrine tumour diagnosis: a population-based study","volume":"18","author":"Halperin","year":"2017","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.ejca.2023.113472_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13146","article-title":"European Neuroendocrine Tumor Society (ENETS) 2022 Guidance Paper for Carcinoid Syndrome and Carcinoid Heart Disease","volume":"34","author":"Grozinsky-Glasberg","year":"2022","journal-title":"J Neuroendocr"},{"issue":"1","key":"10.1016\/j.ejca.2023.113472_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-019-5459-x","article-title":"Assessment of change in quality of life, carcinoid syndrome symptoms and healthcare resource utilization in patients with carcinoid syndrome","volume":"19","author":"Halperin","year":"2019","journal-title":"Bmc Cancer"},{"issue":"6536","key":"10.1016\/j.ejca.2023.113472_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc4552","article-title":"The microbiome and human cancer","volume":"371","author":"Sepich-Poore","year":"2021","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ejca.2023.113472_bib11","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3390\/cimb44050136","article-title":"The Role of the Microbiome in Gastroentero-Pancreatic Neuroendocrine Neoplasms (GEP-NENs)","volume":"44","author":"Mohamed","year":"2022","journal-title":"Curr Issues Mol Biol"},{"issue":"9","key":"10.1016\/j.ejca.2023.113472_bib12","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/ibd.21923","article-title":"Common biostructure of the colonic microbiota in neuroendocrine tumors and Crohn's disease and the effect of therapy","volume":"18","author":"D\u00f6rffel","year":"2012","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"10.1016\/j.ejca.2023.113472_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms5040066","article-title":"The Gut Microbiome Feelings of the Brain: A Perspective for Non-Microbiologists","volume":"5","author":"Lerner","year":"2017","journal-title":"Microorganisms"},{"issue":"2","key":"10.1016\/j.ejca.2023.113472_bib14","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ejca.2023.113472_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2017.05.034","article-title":"Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways","volume":"170","author":"Bellono","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ejca.2023.113472_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest--non-parametric missing value imputation for mixed-type data.","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.ejca.2023.113472_bib17","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1038\/s41591-021-01552-x","article-title":"Reporting guidelines for human microbiome research: the STORMS checklist","volume":"27","author":"Mirzayi","year":"2021","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ejca.2023.113472_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-021-02306-1","article-title":"Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox","volume":"22","author":"Wirbel","year":"2021","journal-title":"Genome Biol"},{"key":"10.1016\/j.ejca.2023.113472_bib19","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"issue":"7","key":"10.1016\/j.ejca.2023.113472_bib20","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jamaoncol.2022.0494","article-title":"The potential of the gut microbiome to reshape the cancer therapy paradigm: a review","volume":"8","author":"Liu","year":"2022","journal-title":"JAMA Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2023.113472_bib21","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.7150\/thno.66464","article-title":"Faecal microbiome and metabolic signatures in rectal neuroendocrine tumors","volume":"12","author":"Hu","year":"2022","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.ejca.2023.113472_bib22","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.ejca.2023.113472_bib23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1158\/2159-8290.CD-20-0263","article-title":"Lower Airway Dysbiosis Affects Lung Cancer Progression","volume":"11","author":"Tsay","year":"2021","journal-title":"Cancer Discov"},{"issue":"4","key":"10.1016\/j.ejca.2023.113472_bib24","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41591-022-01779-2","article-title":"Targeting the gut and tumor microbiota in cancer","volume":"28","author":"Park","year":"2022","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.ejca.2023.113472_bib25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/gutjnl-2021-324755","article-title":"A faecal microbiota signature with high specificity for pancreatic cancer","volume":"71","author":"Kartal","year":"2022","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ejca.2023.113472_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7010014","article-title":"What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases","volume":"7","author":"Rinninella","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejca.2023.113472_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106291","article-title":"Saccharomyces boulardii, a yeast probiotic, inhibits gut motility through upregulating intestinal serotonin transporter and modulating gut microbiota","volume":"181","author":"Gu","year":"2022","journal-title":"Pharm Res"},{"issue":"1","key":"10.1016\/j.ejca.2023.113472_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26581-5","article-title":"Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine","volume":"12","author":"Elias","year":"2021","journal-title":"Nat Commun"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804923007748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804923007748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:41:31Z","timestamp":1760733691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804923007748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":28,"alternative-id":["S0959804923007748"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2023.113472","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2023.113472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"113472"}}