{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:56Z","timestamp":1791820856955,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006304","name":"Aalborg Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ejca.2024.114338","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T01:41:53Z","timestamp":1726882913000},"page":"114338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Temporal changes in survival among adult patients with acute lymphoblastic leukaemia diagnosed in the period 1998-2020 \u2013 A Danish nationwide population-based cohort study"],"prefix":"10.1016","volume":"212","author":[{"given":"Daniel Tuyet","family":"Kristensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine Louise","family":"J\u00e5tun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Runason","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Toft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja","family":"Dimitrijevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Due","family":"\u00d8rskov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Stidsholt","family":"Roug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarec Christoffer","family":"El-Galaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Tang","family":"Severinsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2024.114338_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40164-020-00170-6","article-title":"Leukemia incidence trends at the global, regional, and national level between 1990 and 2017","volume":"9","author":"Dong","year":"2020","journal-title":"Exp Hematol Oncol"},{"key":"10.1016\/j.ejca.2024.114338_bib2","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1200\/JCO.2014.59.1636","article-title":"Childhood acute lymphoblastic leukemia: progress through collaboration","volume":"33","author":"Pui","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2024.114338_bib3","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1182\/blood-2016-11-749507","article-title":"Overall survival among older US adults with ALL remains low despite modest improvement since 1980: SEER analysis","volume":"129","author":"Geyer","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2024.114338_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/blood.2019001168","article-title":"Trends in survival of young adult patients with acute lymphoblastic leukemia in Sweden and the United States","volume":"134","author":"Bj\u00f6rkholm","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2024.114338_bib5","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1182\/blood-2008-06-164863","article-title":"Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century","volume":"113","author":"Pulte","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2024.114338_bib6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/leu.2015.230","article-title":"Improved survival in adult patients with acute lymphoblastic leukemia in the Netherlands: a population-based study on treatment, trial participation and survival","volume":"30","author":"Dinmohamed","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.ejca.2024.114338_bib7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/leu.2017.265","article-title":"Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia","volume":"32","author":"Toft","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.ejca.2024.114338_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27426","article-title":"Increased clinical trial enrollment among adolescent and young adult cancer patients between 2006 and 2012\u20132013 in the United States","volume":"66","author":"Parsons","year":"2019","journal-title":"Pedia Blood Cancer"},{"key":"10.1016\/j.ejca.2024.114338_bib9","doi-asserted-by":"crossref","unstructured":"Stock W, Luger SM, Advani AS, Yin J, Harvey RC, Mullighan CG, et al. A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403. 2019.","DOI":"10.1182\/blood-2018-10-881961"},{"key":"10.1016\/j.ejca.2024.114338_bib10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2147\/CLEP.S48411","article-title":"Data quality in the Danish National acute Leukemia registry: a hematological data resource","volume":"5","author":"\u00d8stg\u00e5rd","year":"2013","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.ejca.2024.114338_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2141.2011.09020.x","article-title":"Adult acute lymphoblastic leukaemia in Denmark. A national population-based retrospective study on acute lymphoblastic leukaemia in Denmark 1998-2008","volume":"157","author":"Toft","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejca.2024.114338_bib12","doi-asserted-by":"crossref","first-page":"v69","DOI":"10.1093\/annonc\/mdw025","article-title":"Acute lymphoblastic leukaemia in adult patients: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Hoelzer","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2024.114338_bib13","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1182\/blood-2006-10-051912","article-title":"Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII\/Eastern Cooperative Oncology Group (ECOG) 2993 trial","volume":"109","author":"Moorman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2024.114338_bib14","first-page":"1","article-title":"Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000\u20132016: a Danish population-based study","author":"Hjort Jakobsen","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejca.2024.114338_bib15","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1182\/bloodadvances.2017014944","article-title":"Patterns of care and outcomes in adolescent and young adult acute lymphoblastic leukemia: a population-based study","volume":"2","author":"Muffly","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.ejca.2024.114338_bib16","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1200\/JCO.2017.76.8192","article-title":"Intensified therapy of acute lymphoblastic leukemia in adults: report of the randomized GRAALL-2005 clinical trial","volume":"36","author":"Huguet","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2024.114338_bib17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1001\/jamaoncol.2017.5305","article-title":"Pediatric-inspired treatment regimens for adolescents and young adults with Philadelphia chromosome\u2013negative acute lymphoblastic leukemia","volume":"4","author":"Siegel","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejca.2024.114338_bib18","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.3324\/haematol.2020.251686","article-title":"Pediatric-inspired chemotherapy incorporating pegaspargase is safe and results in high rates of minimal residual disease negativity in adults up to the age of 60 years with Philadelphia chromosome-negative acute lymphoblastic leukemia","volume":"106","author":"Geyer","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.ejca.2024.114338_bib19","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1056\/NEJMra1400972","article-title":"Acute lymphoblastic leukemia in children","volume":"373","author":"Hunger","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2024.114338_bib20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/10428194.2021.1992620","article-title":"Improved survival after allogeneic transplantation for acute lymphoblastic leukemia in adults: a Danish population-based study","volume":"63","author":"Gj\u00e6rde","year":"2022","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.ejca.2024.114338_bib21","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1158\/1078-0432.CCR-21-2675","article-title":"20-year steady increase in survival of adult patients with relapsed philadelphia-positive acute lymphoblastic leukemia post allogeneic hematopoietic cell transplantation","volume":"28","author":"Bazarbachi","year":"2022","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejca.2024.114338_bib22","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.3324\/haematol.2016.144311","article-title":"International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed\/refractor y acute lymphoblastic leukemia","volume":"101","author":"G\u00f6kbuget","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.ejca.2024.114338_bib23","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMoa1609783","article-title":"Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia","volume":"376","author":"Kantarjian","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2024.114338_bib24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1509277","article-title":"Inotuzumab ozogamicin versus standard therapy for acute lymphoblastic leukemia","volume":"375","author":"Kantarjian","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2024.114338_bib25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1182\/bloodadvances.2016001495","article-title":"US intergroup study of chemotherapy plus dasatinib and allogeneic stem cell transplant in Philadelphia chromosome positive ALL","volume":"1","author":"Ravandi","year":"2016","journal-title":"Blood Adv"},{"key":"10.1016\/j.ejca.2024.114338_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.beha.2017.05.001","article-title":"Which tyrosine kinase inhibitor should we use to treat Philadelphia chromosome-positive acute lymphoblastic leukemia?","volume":"30","author":"Short","year":"2017","journal-title":"Best Pr Res Clin Haematol"},{"key":"10.1016\/j.ejca.2024.114338_bib27","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1080\/0284186X.2020.1741680","article-title":"Potentials, challenges and future of chimeric antigen receptor T-cell therapy in non-Hodgkin lymphomas","volume":"59","author":"El-Galaly","year":"2020","journal-title":"Acta Oncol (Madr)"},{"key":"10.1016\/j.ejca.2024.114338_bib28","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/s41417-021-00418-1","article-title":"Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study","volume":"29","author":"Sheykhhasan","year":"2022","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.ejca.2024.114338_bib29","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMoa1709866","article-title":"Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia","volume":"378","author":"Maude","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2024.114338_bib30","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/S2352-3026(22)00319-2","article-title":"Ponatinib and blinatumomab for Philadelphia chromosome-positive acute lymphoblastic leukaemia: a US, single-centre, single-arm, phase 2 trial","volume":"10","author":"Jabbour","year":"2023","journal-title":"Lancet Haematol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804924009948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804924009948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T21:30:27Z","timestamp":1737667827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804924009948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":30,"alternative-id":["S0959804924009948"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2024.114338","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal changes in survival among adult patients with acute lymphoblastic leukaemia diagnosed in the period 1998-2020 \u2013 A Danish nationwide population-based cohort study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2024.114338","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"114338"}}