{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:51:04Z","timestamp":1789779064505,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejca.2024.115159","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T11:22:18Z","timestamp":1732965738000},"page":"115159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy \u2013 A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg"],"prefix":"10.1016","volume":"214","author":[{"given":"Julian","family":"K\u00f6tt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Zell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"R\u00fcnger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Abeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Geidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Hansen-Abeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Heidrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weichenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Ugurel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Leiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Berking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gutzmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Livingstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke von","family":"Wasielewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedegund","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Haferkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Herbst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Kellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Utikal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian A.","family":"Wohlfeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pf\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Terheyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Meiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"M\u00f6bes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Welzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Ziller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kaatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kreuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Sindrilaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Dippel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sachse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Weishaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svea","family":"H\u00fcning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Heinzerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Loquai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaston","family":"Schley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Gambichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"L\u00f6ffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grabbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Devereux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesscia C.","family":"Hassel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Ch.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Raap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalid","family":"Assaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus-Detlev","family":"Klemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cord","family":"Sunderk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke C.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tronnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Thies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus V.","family":"Heppt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Eggermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"T\u00fcting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander T.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan W.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Gebhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejca.2024.115159_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1200\/JCO.21.02229","article-title":"Long-term outcomes with nivolumab plus ipilimumab or nivolumab alone versus ipilimumab in patients with advanced melanoma","volume":"40","author":"Wolchok","year":"2022","journal-title":"J Clin Oncol: J Am Soc Clin Oncol"},{"issue":"10304","key":"10.1016\/j.ejca.2024.115159_bib2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0140-6736(21)01206-X","article-title":"Immune checkpoint inhibitors in melanoma","volume":"398","author":"Carlino","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ejca.2024.115159_bib3","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1056\/NEJM200012213432504","article-title":"Prognosis of cancers associated with venous thromboembolism","author":"S\u00f8rensen","year":"2000","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ejca.2024.115159_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2022.152311","article-title":"Characterization of the impact of immune checkpoint inhibitors on platelet activation and aggregation","volume":"228","author":"Schl\u00fcter","year":"2023","journal-title":"Immunobiology"},{"key":"10.1016\/j.ejca.2024.115159_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102322","article-title":"Interplay between coagulation and inflammation in cancer: limitations and therapeutic opportunities","volume":"102","author":"Bauer","year":"2022","journal-title":"Cancer Treat Rev"},{"issue":"2","key":"10.1016\/j.ejca.2024.115159_bib6","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S0049-3848(07)70125-1","article-title":"Tissue factor and PAR signaling in tumor progression","volume":"120","author":"Ruf","year":"2007","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.ejca.2024.115159_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3892\/ol.2011.291","article-title":"Protease-activated receptors in cancer: a systematic review","volume":"2","author":"Han","year":"2011","journal-title":"Oncol Lett"},{"issue":"5","key":"10.1016\/j.ejca.2024.115159_bib8","first-page":"1210","article-title":"Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor","volume":"86","author":"Bromberg","year":"2001","journal-title":"Thromb Haemost"},{"issue":"39","key":"10.1016\/j.ejca.2024.115159_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaw8405","article-title":"Myeloid cell-synthesized coagulation factor X dampens antitumor immunity","volume":"4","author":"Graf","year":"2019","journal-title":"Sci Immunol"},{"issue":"525","key":"10.1016\/j.ejca.2024.115159_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay4860","article-title":"Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-\u03b2","volume":"12","author":"Metelli","year":"2020","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.ejca.2024.115159_bib11","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1182\/blood.2020005710","article-title":"Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model","volume":"137","author":"Feinauer","year":"2021","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ejca.2024.115159_bib12","article-title":"Involvement of platelet-derived VWF in metastatic growth of melanoma in the brain","volume":"3","author":"Robador","year":"2021","journal-title":"Neurooncol Adv"},{"issue":"12","key":"10.1016\/j.ejca.2024.115159_bib13","doi-asserted-by":"crossref","first-page":"e731","DOI":"10.1016\/S1470-2045(17)30607-1","article-title":"De-novo and acquired resistance to immune checkpoint targeting","volume":"18","author":"Syn","year":"2017","journal-title":"Lancet Oncol"},{"issue":"10240","key":"10.1016\/j.ejca.2024.115159_bib14","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0140-6736(20)30366-4","article-title":"Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial","volume":"395","author":"Burn","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ejca.2024.115159_bib15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1158\/1940-6207.CAPR-21-0244","article-title":"Effect of aspirin on melanoma incidence in older persons: extended follow-up of a large randomized double-blind placebo-controlled trial","volume":"15","author":"Yan","year":"2022","journal-title":"Cancer Prev Res (Philos)"},{"issue":"1","key":"10.1016\/j.ejca.2024.115159_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12967-021-02712-w","article-title":"Treatment with therapeutic anticoagulation is not associated with immunotherapy response in advanced cancer patients","volume":"19","author":"Johannet","year":"2021","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.ejca.2024.115159_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001361","article-title":"Integrated analysis of concomitant medications and oncological outcomes from PD-1\/PD-L1 checkpoint inhibitors in clinical practice","volume":"8","author":"Cortellini","year":"2020","journal-title":"J Immunother Cancer"},{"issue":"20","key":"10.1016\/j.ejca.2024.115159_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13205103","article-title":"Anticoagulation with Factor Xa inhibitors is associated with improved overall response and progression-free survival in patients with metastatic malignant melanoma receiving immune checkpoint inhibitors-a retrospective, real-world cohort study","volume":"13","author":"Haist","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ejca.2024.115159_bib19","article-title":"djuvant aspirin treatment in PIK3CA-mutated colon cancer patients: the phase III prospective, randomized, placebo-controlled, multicenter SAKK 41\/13 trial","volume":"2024","author":"G\u00fcller","year":"2024","journal-title":"ESMO Congr"},{"key":"10.1016\/j.ejca.2024.115159_bib20","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2020007338","article-title":"Venous thromboembolism in cancer patients: a population-based cohort study","author":"Mulder","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.ejca.2024.115159_bib21","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.thromres.2020.09.038","article-title":"Venous and arterial thromboembolic events with immune checkpoint inhibitors: a systematic review","volume":"196","author":"Solinas","year":"2020","journal-title":"Thromb Res"},{"issue":"1","key":"10.1016\/j.ejca.2024.115159_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001719","article-title":"Incidence of thromboembolism in patients with melanoma on immune checkpoint inhibitor therapy and its adverse association with survival","volume":"9","author":"Sussman","year":"2021","journal-title":"J Immunother Cancer"},{"issue":"20","key":"10.1016\/j.ejca.2024.115159_bib23","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1182\/blood-2014-08-595686","article-title":"von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans","volume":"125","author":"Bauer","year":"2015","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.ejca.2024.115159_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006456","article-title":"Prognostic value of von Willebrand factor levels in patients with metastatic melanoma treated by immune checkpoint inhibitors","volume":"11","author":"Stadler","year":"2023","journal-title":"J Immunother Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2024.115159_bib25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3324\/haematol.2022.281315","article-title":"Von Willebrand factor in the plasma and in the tumor tissue predicts cancer-associated thrombosis and mortality","volume":"108","author":"Karampinis","year":"2023","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.ejca.2024.115159_bib26","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1002\/cncr.23062","article-title":"Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients","volume":"110","author":"Khorana","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.ejca.2024.115159_bib27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clinimag.2021.12.012","article-title":"Incidence of pulmonary embolism and impact on mortality in patients with malignant melanoma","volume":"83","author":"Rennebaum","year":"2022","journal-title":"Clin Imaging"},{"issue":"4","key":"10.1016\/j.ejca.2024.115159_bib28","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/ijc.30498","article-title":"D-dimers in malignant melanoma: association with prognosis and dynamic variation in disease progress","volume":"140","author":"Desch","year":"2017","journal-title":"Int J Cancer J Int du Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2024.115159_bib29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/CMR.0b013e328353efd8","article-title":"Risk of intracranial hemorrhage with anticoagulation therapy in melanoma patients with brain metastases","volume":"22","author":"Alvarado","year":"2012","journal-title":"Melanoma Res"},{"issue":"8","key":"10.1016\/j.ejca.2024.115159_bib30","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1056\/NEJMoa1814630","article-title":"Rivaroxaban for thromboprophylaxis in high-risk ambulatory patients with cancer","volume":"380","author":"Khorana","year":"2019","journal-title":"N Engl J Med"},{"issue":"22","key":"10.1016\/j.ejca.2024.115159_bib31","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2023.7843","article-title":"Direct oral anticoagulants vs low-molecular-weight heparin and recurrent VTE in patients with cancer: a randomized clinical trial","volume":"329","author":"Schrag","year":"2023","journal-title":"JAMA"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804924017660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804924017660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T21:32:17Z","timestamp":1734384737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804924017660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":31,"alternative-id":["S0959804924017660"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2024.115159","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy \u2013 A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2024.115159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"115159"}}