{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:06:27Z","timestamp":1779703587151,"version":"3.53.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017489","name":"Dutch Colorectal Cancer Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["CKTO 2006-02\/NKI 2006-4167"],"award-info":[{"award-number":["CKTO 2006-02\/NKI 2006-4167"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejca.2025.115672","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T21:42:24Z","timestamp":1754430144000},"page":"115672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A novel approach to assess the prognostic value of toxicity profiles in gastric cancer patients undergoing preoperative treatment"],"prefix":"10.1016","volume":"228","author":[{"given":"Romy M.","family":"van Amelsfoort","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-3557","authenticated-orcid":false,"given":"Rita","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin P.M.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Cats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9992-0760","authenticated-orcid":false,"given":"Nicole C.T.","family":"van Grieken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Sikorska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma Meershoek","family":"Klein Kranenbarg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Putter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cock J.H.","family":"van de Velde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna W.","family":"van Sandick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-7421","authenticated-orcid":false,"given":"Marcel","family":"Verheij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-730X","authenticated-orcid":false,"given":"Iris","family":"Walraven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejca.2025.115672_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10.1016\/j.ejca.2025.115672_bib2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1053\/srao.2002.30817","article-title":"Gastric cancer--patterns of relapse after surgical resection","volume":"12","author":"Gunderson","year":"2002","journal-title":"Semin Radiat Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2025.115672_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1470-2045(10)70070-X","article-title":"Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial","volume":"11","author":"Songun","year":"2010","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2025.115672_bib4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S1470-2045(18)30132-3","article-title":"Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial","volume":"19","author":"Cats","year":"2018","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2025.115672_bib5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.annonc.2020.11.004","article-title":"Adjuvant chemotherapy is superior to chemoradiation after D2 surgery for gastric cancer in the per-protocol analysis of the randomized CRITICS trial","volume":"32","author":"de Steur","year":"2021","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2025.115672_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa055531","article-title":"Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer","volume":"355","author":"Cunningham","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejca.2025.115672_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/1471-2407-11-329","article-title":"Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS)","volume":"11","author":"Dikken","year":"2011","journal-title":"BMC Cancer"},{"issue":"10","key":"10.1016\/j.ejca.2025.115672_bib8","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1056\/NEJMoa010187","article-title":"Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction","volume":"345","author":"Macdonald","year":"2001","journal-title":"N Engl J Med"},{"issue":"10184","key":"10.1016\/j.ejca.2025.115672_bib9","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/S0140-6736(18)32557-1","volume":"393","author":"Al-Batran","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ejca.2025.115672_bib10","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Bethesda, MD: US. Department of Health and Human Services. 2009."},{"key":"10.1016\/j.ejca.2025.115672_bib11","series-title":"International Encyclopedia of Statistical Science","first-page":"633","article-title":"Hierarchical clustering","author":"Murtagh","year":"2011"},{"issue":"4","key":"10.1016\/j.ejca.2025.115672_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.21037\/atm.2017.02.05","article-title":"Hierarchical cluster analysis in clinical research with heterogeneous study population: highlighting its visualization with r","volume":"5","author":"Zhang","year":"2017","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.ejca.2025.115672_bib13","series-title":"AJCC cancer staging manual","article-title":"American joint committee on cancer","author":"Greene","year":"2002"},{"issue":"1987","key":"10.1016\/j.ejca.2025.115672_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0377-0427(87)90125-7","article-title":"Silhouettes: a graphical aid to the interpretation and validation of cluster analysis","volume":"20","author":"Rousseeuw","year":"1987","journal-title":"J Comput Appl Math"},{"key":"10.1016\/j.ejca.2025.115672_bib15","first-page":"2837","article-title":"Information theoretic measures for clusterings comparison: variants, properties, normalization and correction for chance","volume":"11","author":"Nguyen","year":"2010","journal-title":"J Mach Learn Res"},{"issue":"9","key":"10.1016\/j.ejca.2025.115672_bib16","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1470-2045(05)70255-2","article-title":"Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials","volume":"6","author":"Di Maio","year":"2005","journal-title":"Lancet Oncol"},{"issue":"11","key":"10.1016\/j.ejca.2025.115672_bib17","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/sj.bjc.6690583","article-title":"The leucocyte nadir, a predictor of chemotherapy efficacy?","volume":"80","author":"Kvinnsland","year":"1999","journal-title":"Br J Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2025.115672_bib18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1470-2045(16)00038-3","article-title":"Longitudinal adverse event assessment in oncology clinical trials: the toxicity over time (ToxT) analysis of alliance trials NCCTG N9741 and 979254","volume":"17","author":"Thanarajasingam","year":"2016","journal-title":"Lancet Oncol"},{"issue":"10","key":"10.1016\/j.ejca.2025.115672_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv216","article-title":"The imperative for a new approach to toxicity analysis in oncology clinical trials","volume":"107","author":"Thanarajasingam","year":"2015","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"10.1016\/j.ejca.2025.115672_bib20","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1097\/NCC.0b013e318269040f","article-title":"Comparison between patient-reported and clinician-observed symptoms in oncology","volume":"36","author":"Xiao","year":"2013","journal-title":"Cancer Nurs"},{"issue":"3","key":"10.1016\/j.ejca.2025.115672_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.6004\/jnccn.2021.7057","article-title":"CRITICS investigators. Quality of life is associated with survival in patients with gastric cancer: results from the randomized CRITICS trial","volume":"20","author":"van Amelsfoort","year":"2022","journal-title":"J Natl Compr Canc Netw"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980492500454X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095980492500454X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T09:44:58Z","timestamp":1779702298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095980492500454X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":21,"alternative-id":["S095980492500454X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2025.115672","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel approach to assess the prognostic value of toxicity profiles in gastric cancer patients undergoing preoperative treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2025.115672","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"115672"}}