{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:37:57Z","timestamp":1787999877028,"version":"build-2784847793"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejca.2025.115707","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T14:52:34Z","timestamp":1754751154000},"page":"115707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Neurological adverse events of ICI therapy: A ten-year comprehensive management from a multidisciplinary team"],"prefix":"10.1016","volume":"228","author":[{"given":"Anna Maria","family":"Di Giacomo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Bartalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"D\u2019Alonzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Cerase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Cutarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9647-4662","authenticated-orcid":false,"given":"Elena","family":"Simonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Valente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ravara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Colucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Gibilisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Insana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-5909","authenticated-orcid":false,"given":"Silvia","family":"Bocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Croce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Sani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Carbonari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Covre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nila","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ginanneschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejca.2025.115707_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12964-022-00854-y","article-title":"Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons","volume":"20","author":"Naimi","year":"2022","journal-title":"Cell Commun Signal"},{"issue":"2","key":"10.1016\/j.ejca.2025.115707_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.alit.2022.01.001","article-title":"Immune-related adverse events in various organs caused by immune checkpoint inhibitors","volume":"71","author":"Okiyama","year":"2022","journal-title":"Allergol Int"},{"issue":"7","key":"10.1016\/j.ejca.2025.115707_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002890","article-title":"Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors","volume":"9","author":"Guidon","year":"2021","journal-title":"J Immunother Cancer"},{"issue":"16","key":"10.1016\/j.ejca.2025.115707_bib4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1212\/WNL.0000000000011795","article-title":"Neurologic adverse events of immune checkpoint inhibitors: a systematic review","volume":"96","author":"Marini","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.ejca.2025.115707_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/1756286420985323","article-title":"Paraneoplastic neurological syndromes: clinical presentations and management","volume":"14","author":"Devine","year":"2021","journal-title":"Ther Adv Neurol Disord"},{"issue":"12","key":"10.1016\/j.ejca.2025.115707_bib6","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1001\/jamaoncol.2018.3923","article-title":"Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and Meta-analysis","volume":"4","author":"Wang","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejca.2025.115707_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/5126717","article-title":"The terrible triad of checkpoint inhibition: a case report of myasthenia gravis, myocarditis, and myositis induced by cemiplimab in a patient with metastatic cutaneous squamous cell carcinoma","volume":"2020","author":"Jeyakumar","year":"2020","journal-title":"Case Rep Immunol"},{"issue":"1","key":"10.1016\/j.ejca.2025.115707_bib8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/jcm12010130","article-title":"Myasthenia gravis induced by immune checkpoint inhibitors: an emerging neurotoxicity in Neuro-Oncology practice: case series","volume":"12","author":"Marco","year":"2022","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.ejca.2025.115707_bib9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/14740338.2020.1738382","article-title":"Neurologic complications of immune checkpoint inhibitors","volume":"19","author":"Haugh","year":"2020","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.ejca.2025.115707_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.120089","article-title":"CNS and PNS manifestation in immune checkpoint inhibitors: a systematic review","volume":"432","author":"Khan","year":"2022","journal-title":"J Neurol Sci"},{"issue":"16","key":"10.1016\/j.ejca.2025.115707_bib11","doi-asserted-by":"crossref","first-page":"5774","DOI":"10.3390\/ijms21165774","article-title":"Immune-Driven pathogenesis of neurotoxicity after exposure of cancer patients to immune checkpoint inhibitors","volume":"21","author":"Vilari\u00f1o","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.ejca.2025.115707_bib12","first-page":"367","article-title":"Immune checkpoint inhibitor-associated myositis: a distinct form of inflammatory myopathy","volume":"28","author":"Saygin","year":"2022","journal-title":"J Clin Rheuma Pr Rep Rheum Musculoskelet Dis"},{"issue":"6","key":"10.1016\/j.ejca.2025.115707_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/ard-2022-223792","article-title":"Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis","volume":"82","author":"Pinal-Fernandez","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.ejca.2025.115707_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa181","article-title":"Immune checkpoint inhibitor-associated myopathy: a clinicoseropathologically distinct myopathy","volume":"2","author":"Shelly","year":"2020","journal-title":"Brain Commun"},{"issue":"3","key":"10.1016\/j.ejca.2025.115707_bib15","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s10072-021-05561-z","article-title":"Characterization and management of neurological adverse events during immune-checkpoint inhibitors treatment: an Italian multicentric experience","volume":"43","author":"Diamanti","year":"2022","journal-title":"Neurol Sci"},{"issue":"4","key":"10.1016\/j.ejca.2025.115707_bib16","first-page":"501","article-title":"Neurological adverse events related to immune checkpoint inhibitors: a practical review","volume":"17","author":"Zammit","year":"2024","journal-title":"Pharm Basel Switz"},{"issue":"3","key":"10.1016\/j.ejca.2025.115707_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad169","article-title":"Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity","volume":"5","author":"Farina","year":"2023","journal-title":"Brain Commun"},{"issue":"16_","key":"10.1016\/j.ejca.2025.115707_bib18","article-title":"Triple m overlap syndrome (TMOS): evaluating immune checkpoint inhibitor-related overlap syndrome of myocarditis, myositis and myasthenia gravis using an international pharmacovigilance database","volume":"42","author":"Naqash","year":"2024","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2025.115707_bib19","first-page":"501","article-title":"Neurological adverse events related to immune checkpoint inhibitors: a practical review","volume":"17","author":"Zammit","year":"2024","journal-title":"Pharm (Basel)"},{"issue":"16","key":"10.1016\/j.ejca.2025.115707_bib20","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJMoa1910836","article-title":"Five-year survival with combined nivolumab and ipilimumab in advanced melanoma","volume":"381","author":"Larkin","year":"2019","journal-title":"N Engl J Med"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804925004897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804925004897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T09:44:54Z","timestamp":1779702294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804925004897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":20,"alternative-id":["S0959804925004897"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2025.115707","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurological adverse events of ICI therapy: A ten-year comprehensive management from a multidisciplinary team","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2025.115707","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"115707"}}