{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:22:45Z","timestamp":1791235365965,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ejca.2026.116739","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:14:50Z","timestamp":1776294890000},"page":"116739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["ESGO Consensus Statement on endometrial cancer prevention, risk reduction strategies, and management of women with Lynch syndrome"],"prefix":"10.1016","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7098-8956","authenticated-orcid":false,"given":"Claudia","family":"Marchetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-4459","authenticated-orcid":false,"given":"Murat","family":"Gultekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-5859","authenticated-orcid":false,"given":"Carolina Maria","family":"Sassu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Planchamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Burney","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1843-7342","authenticated-orcid":false,"given":"Sarah J","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-5224","authenticated-orcid":false,"given":"Vasilis","family":"Theodoulidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-7192","authenticated-orcid":false,"given":"Vesna","family":"Kesic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-7590","authenticated-orcid":false,"given":"Beyhan","family":"Ataseven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"L\u00e9curu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Genuardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-0057","authenticated-orcid":false,"given":"Mev","family":"Dominguez-Valentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-3498","authenticated-orcid":false,"given":"Toni T.","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-4905","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Amant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Grigore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Polterauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal Esat","family":"Temiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-9037","authenticated-orcid":false,"given":"Hasan Volkan","family":"Ege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-238X","authenticated-orcid":false,"given":"Simona","family":"Duranti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-904X","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Bizzarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-535X","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Didelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-8997","authenticated-orcid":false,"given":"Nina","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Seebacher-Shariat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3381-5057","authenticated-orcid":false,"given":"Ranjit","family":"Manchanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-0735","authenticated-orcid":false,"given":"Maria","family":"Kyrgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10689-004-7993-0","article-title":"Lynch syndrome genes","volume":"4","author":"Peltom\u00e4ki","year":"2005","journal-title":"Fam Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1158\/1055-9965.EPI-16-0693","article-title":"Prevalence and penetrance of major genes and polygenes for colorectal cancer","volume":"26","author":"Win","year":"2017","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"7","key":"10.1016\/j.ejca.2026.116739_bib3","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1136\/gutjnl-2017-314057","article-title":"Cancer risk and survival in path_MMRcarriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database","volume":"67","author":"M\u00f8ller","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.ejca.2026.116739_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101909","article-title":"Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database","volume":"58","author":"Dominguez-Valentin","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"10","key":"10.1016\/j.ejca.2026.116739_bib5","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/s41436-019-0536-8","article-title":"The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis","volume":"21","author":"Ryan","year":"2019","journal-title":"Genet Med"},{"key":"10.1016\/j.ejca.2026.116739_bib6","unstructured":"National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) \u201cGenetic\/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric\u201d Version 1.2025. Available at: \u3008https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_ceg.pdf\u3009. (accessed Aug 20, 2025)."},{"issue":"22","key":"10.1016\/j.ejca.2026.116739_bib7","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/jama.2011.743","article-title":"French Cancer Genetics Network. Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome","volume":"305","author":"Bonadona","year":"2011","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/gutjnl-2015-309675","article-title":"Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database","volume":"66","author":"M\u00f8ller","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41436-019-0596-9","article-title":"Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database","volume":"22","author":"Dominguez-Valentin","year":"2020","journal-title":"Genet Med"},{"key":"10.1016\/j.ejca.2026.116739_bib10","article-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5 (updated 2024)","author":"Higgins","year":"2024","journal-title":"Cochrane Collab"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1086\/321805","article-title":"Infectious Diseases Society of America; American Society of Blood and Marrow Transplantation. Summary of the Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients","volume":"33","author":"Dykewicz","year":"2001","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.ejca.2026.116739_bib12","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1016\/S1470-2045(25)00167-6","article-title":"ESGO-ESTRO-ESP guidelines for the management of patients with endometrial carcinoma: update 2025","volume":"26","author":"Concin","year":"2025","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ygyno.2020.10.003","article-title":"Testing for lynch syndrome in people with endometrial cancer using immunohistochemistry and microsatellite instability-based testing strategies - A systematic review of test accuracy","volume":"160","author":"Stinton","year":"2021","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib14","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1158\/1078-0432.CCR-0956-3","article-title":"Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer","volume":"10","author":"de Jong","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"10","key":"10.1016\/j.ejca.2026.116739_bib15","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.31557\/APJCP.2024.25.10.3667","article-title":"Simplifying Mismatch Repair Deficiency Screening in Endometrial Adenocarcinoma: Immunohistochemistry with Two-Antibody Panel (PMS2 and MSH6)","volume":"25","author":"Panyavaranant","year":"2024","journal-title":"Asian Pac J Cancer Prev"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/his.15236","article-title":"Mismatch repair deficiency: how reliable is the two-antibody approach? A national real-life study","volume":"85","author":"Vink-B\u00f6rger","year":"2024","journal-title":"Histopathology"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1158\/1940-6207.CAPR-11-0288","article-title":"Identification of cancer patients with Lynch syndrome: clinically significant discordances and problems in tissue-based mismatch repair testing","volume":"5","author":"Bartley","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/annonc\/mdw542","article-title":"Practical guidance for mismatch repair-deficiency testing in endometrial cancer","volume":"28","author":"Stelloo","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejca.2026.116739_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.humpath.2020.07.001","article-title":"Unexpected expression of mismatch repair protein is more commonly seen with pathogenic missense than with other mutations in Lynch syndrome","volume":"103","author":"Chen","year":"2020","journal-title":"Hum Pathol"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10689-013-9671-6","article-title":"Endometrial tumour BRAF mutations and MLH1 promoter methylation as predictors of germline mismatch repair gene mutation status: a literature review","volume":"13","author":"Metcalf","year":"2014","journal-title":"Fam Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/PAS.0000000000001832","article-title":"EPM2AIP1 Immunohistochemistry Can Be Used as Surrogate Testing for MLH1 Promoter Methylation in Endometrial Cancer","volume":"46","author":"Mrkonjic","year":"2022","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00428-025-04132-3","article-title":"EPM2 AIP1 immunohistochemistry as a surrogate of promoter methylation analysis in endometrial carcinoma","volume":"487","author":"Gatius","year":"2025","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ejca.2026.116739_bib23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.humpath.2024.06.017","article-title":"EPM2AIP1 immunohistochemistry is inadequate as a surrogate marker for MLH1 promoter hypermethylation testing in colorectal cancer","volume":"150","author":"Challa","year":"2024","journal-title":"Hum Pathol"},{"issue":"6","key":"10.1016\/j.ejca.2026.116739_bib24","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2021.32.e79","article-title":"MLH1 promoter hypermethylation predicts poorer prognosis in mismatch repair deficiency endometrial carcinomas","volume":"32","author":"Kaneko","year":"2021","journal-title":"J Gynecol Oncol"},{"issue":"11","key":"10.1016\/j.ejca.2026.116739_bib25","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2174\/13816128113199990538","article-title":"Utility of MLH1 methylation analysis in the clinical evaluation of Lynch Syndrome in women with endometrial cancer","volume":"20","author":"Bruegl","year":"2014","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ejca.2026.116739_bib26","doi-asserted-by":"crossref","DOI":"10.1177\/03008916241312530","article-title":"MLH1promoter hypermethylation and Lynch Syndrome: When to test for constitutional epimutations of MLH1 gene?","author":"Cazzaniga","year":"2025","journal-title":"Tumori"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/PGP.0000000000000312","article-title":"Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome","volume":"36","author":"Watkins","year":"2017","journal-title":"Int J Gynecol Pathol"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ygyno.2020.10.012","article-title":"Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients","volume":"160","author":"Hampel","year":"2021","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejca.2026.116739_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-13957-9_1","article-title":"The pre-analytical phase in surgical pathology","volume":"199","author":"Bussolati","year":"2015","journal-title":"Recent Results Cancer Res"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41416-022-02063-3","article-title":"Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value","volume":"128","author":"Berg","year":"2023","journal-title":"Br J Cancer"},{"issue":"10","key":"10.1016\/j.ejca.2026.116739_bib31","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1200\/JCO.2011.38.4719","article-title":"Reflex immunohistochemistry and microsatellite instability testing of colorectal tumors for Lynch syndrome among US cancer programs and follow-up of abnormal results","volume":"30","author":"Beamer","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejca.2026.116739_bib32","unstructured":"N.H.S. England. National genomic test directory. In Testing Criteria for Rare and Inherited Disease, NHS England: England, UK, 2025; Vol. Version 8.1. Available at: \u3008https:\/\/www.england.nhs.uk\/publication\/national-genomic-test-directories\/\u3009 (accessed March 25, 2026)."},{"issue":"11","key":"10.1016\/j.ejca.2026.116739_bib33","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1002\/ijc.25501","article-title":"Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma","volume":"127","author":"Obermair","year":"2010","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib34","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ygyno.2019.12.031","article-title":"High homogeneity of MMR deficiency in ovarian cancer","volume":"156","author":"Fraune","year":"2020","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejca.2026.116739_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ygyno.2022.12.008","article-title":"Mismatch-repair deficiency, microsatellite instability, and lynch syndrome in ovarian cancer: A systematic review and meta-analysis","volume":"170","author":"Mitric","year":"2023","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejca.2026.116739_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejca.2015.12.005","article-title":"Ovarian cancer in Lynch syndrome; a systematic review","volume":"55","author":"Helder-Woolderink","year":"2016","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2026.116739_bib37","doi-asserted-by":"crossref","first-page":"q807","DOI":"10.1136\/bmj.q807","article-title":"Ovarian cancer: identifying and managing familial and genetic risk-summary of new NICE guidance","volume":"385","author":"Slade","year":"2024","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.ejca.2026.116739_bib38","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1136\/ijgc-2024-005756","article-title":"British Gynaecological Cancer Society\/British Association of Gynaecological Pathology consensus for genetic testing in epithelial ovarian cancer in the United Kingdom","volume":"34","author":"Leung","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejca.2026.116739_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejogrb.2024.06.025","article-title":"British Gynaecological Cancer Society (BGCS) ovarian, tubal and primary peritoneal cancer guidelines: Recommendations for practice update 2024","volume":"300","author":"Moss","year":"2024","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"10","key":"10.1016\/j.ejca.2026.116739_bib40","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.annonc.2023.06.011","article-title":"ESMO study on the availability and accessibility of biomolecular technologies in oncology in Europe","volume":"34","author":"Bayle","year":"2023","journal-title":"Ann Oncol"},{"issue":"8","key":"10.1016\/j.ejca.2026.116739_bib41","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ajg.2014.186","article-title":"Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer","volume":"109","author":"Giardiello","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"10.1016\/j.ejca.2026.116739_bib42","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1158\/1940-6207.CAPR-19-0069","article-title":"For Women, Lynch Syndrome Is About More than Colon Cancer","volume":"12","author":"Parker","year":"2019","journal-title":"Cancer Prev Res (Phila)"},{"issue":"7","key":"10.1016\/j.ejca.2026.116739_bib43","first-page":"2813","article-title":"Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer","volume":"61","author":"Schweizer","year":"2001","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib44","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/ijgc-2019-000277","article-title":"Impact of gene-specific germline pathogenic variants on presentation of endometrial cancer in Lynch syndrome","volume":"29","author":"Bogani","year":"2019","journal-title":"Int J Gynecol Cancer"},{"issue":"36","key":"10.1016\/j.ejca.2026.116739_bib45","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1200\/JCO.2005.03.5915","article-title":"Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?","volume":"23","author":"Soliman","year":"2005","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.ejca.2026.116739_bib46","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/cncr.10380","article-title":"The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma","volume":"94","author":"Dove-Edwin","year":"2002","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2026.116739_bib47","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/ijgc-2021-003132","article-title":"Screening and risk reducing surgery for endometrial or ovarian cancers in Lynch syndrome: a systematic review","volume":"32","author":"Lim","year":"2022","journal-title":"Int J Gynecol Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10689-009-9252-x","article-title":"Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome","volume":"8","author":"Gerritzen","year":"2009","journal-title":"Fam Cancer"},{"issue":"6","key":"10.1016\/j.ejca.2026.116739_bib49","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00404-012-2492-2","article-title":"Annual outpatient hysteroscopy and endometrial sampling (OHES) in HNPCC\/Lynch syndrome (LS)","volume":"286","author":"Manchanda","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"10","key":"10.1016\/j.ejca.2026.116739_bib50","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/s41436-019-0489-y","article-title":"The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome","volume":"21","author":"Crosbie","year":"2019","journal-title":"Genet Med"},{"issue":"7","key":"10.1016\/j.ejca.2026.116739_bib51","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.3390\/cancers12071874","article-title":"Cost-Effectiveness of Early Detection and Prevention Strategies for Endometrial Cancer-A Systematic Review","volume":"12","author":"Sroczynski","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.ejca.2026.116739_bib52","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/jmedgenet-2015-103216","article-title":"Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study","volume":"52","author":"Harkness","year":"2015","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejca.2026.116739_bib53","first-page":"51","article-title":"No Evidence of Increased Risk of Breast Cancer in Women With Lynch Syndrome Identified by Multigene Panel Testing. JCO Precis","volume":"4","author":"Stoll","year":"2020","journal-title":"Oncol"},{"issue":"9233","key":"10.1016\/j.ejca.2026.116739_bib54","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0140-6736(00)02677-5","article-title":"Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen","volume":"356","author":"Bergman","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib55","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMoa052627","article-title":"Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome","volume":"354","author":"Schmeler","year":"2006","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.ejca.2026.116739_bib56","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.3390\/cancers12113419","article-title":"Assessing Effectiveness of Colonic and Gynecological Risk Reducing Surgery in Lynch Syndrome Individuals","volume":"12","author":"Due\u00f1as","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"19","key":"10.1016\/j.ejca.2026.116739_bib57","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1002\/cam4.4080","article-title":"Cost-effectiveness of prophylactic hysterectomy in first-degree female relatives with Lynch syndrome of patients diagnosed with colorectal cancer in the United States: a microsimulation study","volume":"10","author":"Alblas","year":"2021","journal-title":"Cancer Med"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib58","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41436-020-01029-1","article-title":"Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report","volume":"23","author":"Dominguez-Valentin","year":"2021","journal-title":"Genet Med"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib59","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/PAS.0b013e3182796e27","article-title":"Histologic evaluation of prophylactic hysterectomy and oophorectomy in Lynch syndrome","volume":"37","author":"Karamurzin","year":"2013","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib60","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ygyno.2013.10.033","article-title":"Prevalence of occult gynecologic malignancy at the time of risk reducing and nonprophylactic surgery in patients with Lynch syndrome","volume":"132","author":"Lachiewicz","year":"2014","journal-title":"Gynecol Oncol"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib61","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00404-021-06296-0","article-title":"Synchronous\/metachronous endometrial and colorectal malignancies in Taiwanese women: a population-based nationwide study","volume":"306","author":"Chao","year":"2022","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib62","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/gyno.2001.6279","article-title":"International Collaborative Group on HNPCC. The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer","volume":"82","author":"Watson","year":"2001","journal-title":"Gynecol Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10689-024-00387-y","article-title":"Impact of hormonal contraception on endometrial histology in patients with Lynch syndrome, a retrospective pilot study","volume":"23","author":"Mawet","year":"2024","journal-title":"Fam Cancer"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib64","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jama.2015.6789","article-title":"Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome","volume":"314","author":"Dashti","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.ejca.2026.116739_bib65","doi-asserted-by":"crossref","unstructured":"Collaborative Groupon Epidemiological Studies of Ovarian Cancer; Beral V, Doll R, Hermon C, Peto R, Reeves G. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls Lancet2008 Jan 26. 3719609303314.","DOI":"10.1016\/S0140-6736(08)60167-1"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004188","article-title":"Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested case-control study and meta-analysis","volume":"20","author":"Fitzpatrick","year":"2023","journal-title":"PLoS Med"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib67","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/13625180701300194","article-title":"Combined hormonal contraception and venous thromboembolism","volume":"12","author":"Mart\u00ednez","year":"2007","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"8","key":"10.1016\/j.ejca.2026.116739_bib68","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1158\/1940-6207.CAPR-13-0020","article-title":"Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrome","volume":"6","author":"Lu","year":"2013","journal-title":"Cancer Prev Res (Phila)"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib69","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ygyno.2018.02.006","article-title":"Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Results from the NOWAC Study","volume":"149","author":"Jareid","year":"2018","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejca.2026.116739_bib70","unstructured":"\u201cIntrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome\u201d. NCT00566644. Available at: \u3008https:\/\/clinicaltrials.gov\/study\/NCT00566644?cond=POET%20endometrial%20cancer&rank=21\u3009 (accessed May 1, 2025)."},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib71","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/humupd\/dmac038","article-title":"Contraceptives and cancer risks in BRCA1\/2 pathogenic variant carriers: a systematic review and meta-analysis","volume":"29","author":"Van Bommel","year":"2023","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib72","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ygyno.2015.12.009","article-title":"Non-steroidal anti-inflammatory drug use and risk of endometrial cancer: A systematic review and meta-analysis of observational studies","volume":"140","author":"Verdoodt","year":"2016","journal-title":"Gynecol Oncol"},{"issue":"5","key":"10.1016\/j.ejca.2026.116739_bib73","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1158\/1940-6207.CAPR-11-0106","article-title":"International CAPP consortium. A randomized placebo-controlled prevention trial of aspirin and\/or resistant starch in young people with familial adenomatous polyposis","volume":"4","author":"Burn","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"issue":"9809","key":"10.1016\/j.ejca.2026.116739_bib74","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0140-6736(11)61049-0","article-title":"CAPP2 Investigators. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial","volume":"378","author":"Burn","year":"2011","journal-title":"Lancet"},{"issue":"10240","key":"10.1016\/j.ejca.2026.116739_bib75","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0140-6736(20)30366-4","article-title":"CAPP2 Investigators. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial","volume":"395","author":"Burn","year":"2020","journal-title":"Lancet"},{"issue":"36","key":"10.1016\/j.ejca.2026.116739_bib76","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1200\/JCO.21.01900","article-title":"Modification of the Association Between Frequent Aspirin Use and Ovarian Cancer Risk: A Meta-Analysis Using Individual-Level Data From Two Ovarian Cancer Consortia","volume":"40","author":"Hurwitz","year":"2022","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib77","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djt431","article-title":"Ovarian Cancer Association Consortium. Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium","volume":"106","author":"Trabert","year":"2014","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.ejca.2026.116739_bib78","doi-asserted-by":"crossref","first-page":"77","DOI":"10.7326\/0003-4819-159-2-201307160-00002","article-title":"Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial","volume":"159","author":"Cook","year":"2013","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib79","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.gastro.2007.09.035","article-title":"Aspirin dose and duration of use and risk of colorectal cancer in men","volume":"134","author":"Chan","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejca.2026.116739_bib80","unstructured":"Press Office. Aspirin a day keeps bowel cancer at bay. Published on: 24 June 2025. Available at: \u3008https:\/\/www.ncl.ac.uk\/press\/articles\/latest\/2025\/06\/capp3trial\/\u3009 (accessed July 20, 2025)."},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib81","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/bjc.2016.193","article-title":"Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study","volume":"115","author":"Staff","year":"2016","journal-title":"Br J Cancer"},{"issue":"7","key":"10.1016\/j.ejca.2026.116739_bib82","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/GME.0000000000001315","article-title":"Endometrial safety of low-dose vaginal estrogens in menopausal women: a systematic evidence review","volume":"26","author":"Constantine","year":"2019","journal-title":"Menopause"},{"issue":"9470","key":"10.1016\/j.ejca.2026.116739_bib83","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0140-6736(05)66455-0","article-title":"Million Women Study Collaborators. Endometrial cancer and hormone-replacement therapy in the Million Women Study","volume":"365","author":"Beral","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejca.2026.116739_bib84","article-title":"Modifiable risk factors and risk of colorectal and endometrial cancers in lynch syndrome: a systematic review and meta-analysis","volume":"8","author":"Power","year":"2024","journal-title":"JCO Precis Oncol"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib85","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10689-019-00135-7","article-title":"Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review","volume":"18","author":"Coletta","year":"2019","journal-title":"Fam Cancer"},{"issue":"4","key":"10.1016\/j.ejca.2026.116739_bib86","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/AOG.0b013e3182110ea3","article-title":"Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers","volume":"117","author":"Win","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejca.2026.116739_bib87","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/tog.12706","article-title":"Lynch syndrome for the gynaecologist","volume":"23","author":"Ryan","year":"2021","journal-title":"Obstet Gynaecol"},{"key":"10.1016\/j.ejca.2026.116739_bib88","doi-asserted-by":"crossref","unstructured":"Spinella F., Bronet F., Carvalho F., et al. ESHRE PGT Consortium data collection XXI: PGT analyses in 2018. Hum Reprod Open. 2023 Apr 19;2023(2):hoad010.","DOI":"10.1093\/hropen\/hoad010"},{"issue":"3","key":"10.1016\/j.ejca.2026.116739_bib89","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10689-011-9448-8","article-title":"Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch syndrome","volume":"10","author":"Dewanwala","year":"2011","journal-title":"Fam Cancer"},{"issue":"5","key":"10.1016\/j.ejca.2026.116739_bib90","doi-asserted-by":"crossref","first-page":"a036681","DOI":"10.1101\/cshperspect.a036681","article-title":"Regulating preimplantation genetic testing across the world: a comparison of international policy and ethical perspectives","volume":"10","author":"Ginoza","year":"2020","journal-title":"Cold Spring Harb Perspect Med"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804926005204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804926005204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:22:52Z","timestamp":1779294172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804926005204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":90,"alternative-id":["S0959804926005204"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2026.116739","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ESGO Consensus Statement on endometrial cancer prevention, risk reduction strategies, and management of women with Lynch syndrome","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2026.116739","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116739"}}