{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:06:49Z","timestamp":1789060009750,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejcancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cancer"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejca.2026.116988","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:06:04Z","timestamp":1786633564000},"page":"116988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Immune remodelling and molecular profiling of progressive brain metastases following cranial radiotherapy"],"prefix":"10.1016","volume":"246","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-8301","authenticated-orcid":false,"given":"Ariane","family":"Steindl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-8461","authenticated-orcid":false,"given":"Angelika M.","family":"Starzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-2247","authenticated-orcid":false,"given":"Erwin","family":"Tomasich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kleinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzia","family":"Berchtold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-0273","authenticated-orcid":false,"given":"Georg","family":"Widhalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Gatterbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Hainfellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Wozelka-Oltjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekir","family":"Erguener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-5631","authenticated-orcid":false,"given":"Gerwin","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-2315","authenticated-orcid":false,"given":"Matthias","family":"Preusser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna.S.","family":"Berghoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejca.2026.116988_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejca.2021.12.005","article-title":"Changing characteristics, treatment approaches and survival of patients with brain metastasis: data from six thousand and thirty-one individuals over an observation period of 30 years","volume":"162","author":"Steindl","year":"2022","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejca.2026.116988_bib2","doi-asserted-by":"crossref","unstructured":"Steindl A., Berghoff A.S. Brain metastases in metastatic cancer: a review of recent advances in systemic therapies. Expert Review of Anticancer Therapy. 325-339. doi:10.1080\/14737140.2021.1851200.","DOI":"10.1080\/14737140.2021.1851200"},{"key":"10.1016\/j.ejca.2026.116988_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(16)30578-2","article-title":"Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment: a pooled analysis of individual patient data from randomised trials","author":"Long","year":"2016","journal-title":"Lancet Oncol"},{"issue":"13","key":"10.1016\/j.ejca.2026.116988_bib4","doi-asserted-by":"crossref","first-page":"10669","DOI":"10.3390\/ijms241310669","article-title":"Neurotoxicity from Old and New Radiation Treatments for Brain Tumors","volume":"24","author":"Soffietti","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.ejca.2026.116988_bib5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/14737175.2016.1184572","article-title":"Radionecrosis after stereotactic radiotherapy for brain metastases","volume":"16","author":"Le Rhun","year":"2016","journal-title":"Expert Rev Neurother"},{"issue":"2","key":"10.1016\/j.ejca.2026.116988_bib6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3171\/jns.1993.79.2.0210","article-title":"Surgical treatment of multiple brain metastases","volume":"79","author":"Bindal","year":"1993","journal-title":"J Neurosurg"},{"issue":"18","key":"10.1016\/j.ejca.2026.116988_bib7","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1016\/j.ejca.2012.07.002","article-title":"Trial design on prophylaxis and treatment of brain metastases: lessons learned from the EORTC Brain Metastases Strategic Meeting 2012","volume":"48","author":"Preusser","year":"2012","journal-title":"European journal cancer (Oxford England 1990)"},{"issue":"1","key":"10.1016\/j.ejca.2026.116988_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2017-000262","article-title":"Recent advances in the biology and treatment of brain metastases of non-small cell lung cancer: summary of a multidisciplinary roundtable discussion","volume":"3","author":"Preusser","year":"2018","journal-title":"ESMO Open"},{"issue":"2","key":"10.1016\/j.ejca.2026.116988_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btae029","article-title":"Conumee 2.0: enhanced copy-number variation analysis from DNA methylation arrays for humans and mice","volume":"40","author":"Daenekas","year":"2024","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.ejca.2026.116988_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2026.106940","article-title":"Peripheral blood DNA methylation profile and immune checkpoint inhibitor response in cancer patients","volume":"11","author":"Kleinberger","year":"2026","journal-title":"ESMO Open"},{"key":"10.1016\/j.ejca.2026.116988_bib11","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15244","article-title":"CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability","volume":"11","author":"Oza","year":"2023","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.ejca.2026.116988_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1057388","article-title":"Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases","volume":"5","author":"Berghoff","year":"2016","journal-title":"OncoImmunology"},{"issue":"8","key":"10.1016\/j.ejca.2026.116988_bib13","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/neuonc\/nou307","article-title":"Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma","volume":"17","author":"Berghoff","year":"2015","journal-title":"Neuro-Oncol"},{"key":"10.1016\/j.ejca.2026.116988_bib14","unstructured":"R Development Core team. R Core Team. R: A Language and Environment for Statistical Computing R Foundation for Statistical Computing, Vienna, Austria ISBN 3-900051-07-0, URL http:\/\/wwwR-project.org\/. Preprint posted online 2021."},{"key":"10.1016\/j.ejca.2026.116988_bib16","unstructured":"Lumley A.T. Package \u201csurvey\u201d: analysis of complex survey samples. R package version 3.31-5. R documentation. Published online 2016."},{"issue":"4","key":"10.1016\/j.ejca.2026.116988_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0895-4356(00)00314-0","article-title":"Adjusting for multiple testing - When and how?","volume":"54","author":"Bender","year":"2001","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"10.1016\/j.ejca.2026.116988_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13059-019-1664-9","article-title":"RnBeads 2.0: comprehensive analysis of DNA methylation data","volume":"20","author":"M\u00fcller","year":"2019","journal-title":"Genome Biol"},{"issue":"W1","key":"10.1016\/j.ejca.2026.116988_bib19","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.ejca.2026.116988_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3892\/mco.2013.107","article-title":"FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis","volume":"1","author":"TAKENAKA","year":"2013","journal-title":"Mol Clin Oncol"},{"issue":"7","key":"10.1016\/j.ejca.2026.116988_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/nri3015","article-title":"Macrophages join the FOXP3 suppressor gang","volume":"11","author":"Leavy","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.ejca.2026.116988_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.immuni.2011.12.012","article-title":"Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells","volume":"36","author":"Miyao","year":"2012","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.ejca.2026.116988_bib23","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/bjc.2014.47","article-title":"High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment","volume":"110","author":"Ma","year":"2014","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.ejca.2026.116988_bib24","article-title":"Immune microenvironment remodeling after radiation of a progressing brain metastasis","volume":"4","author":"Hudson","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.ejca.2026.116988_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(24)00735-6","article-title":"Ipilimumab plus nivolumab versus nivolumab alone in patients with melanoma brain metastases (ABC): 7-year follow-up of a multicentre, open-label, randomised, phase 2 study","author":"Long","year":"2025","journal-title":"Lancet Oncol"}],"container-title":["European Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804926007690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959804926007690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:10:45Z","timestamp":1789056645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959804926007690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":24,"alternative-id":["S0959804926007690"],"URL":"https:\/\/doi.org\/10.1016\/j.ejca.2026.116988","relation":{},"ISSN":["0959-8049"],"issn-type":[{"value":"0959-8049","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune remodelling and molecular profiling of progressive brain metastases following cranial radiotherapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejca.2026.116988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116988"}}