{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:26:48Z","timestamp":1791923208977,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.ejcb.2006.08.004","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T12:32:13Z","timestamp":1161174733000},"page":"1253-1264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes"],"prefix":"10.1016","volume":"85","author":[{"given":"Yumei","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Dayalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Scharenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2006.08.004_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1212\/WNL.59.3.306","article-title":"The neurogenetics of mucolipidosis type IV","volume":"59","author":"Altarescu","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.ejcb.2006.08.004_bib2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/77842","article-title":"Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation","volume":"1","author":"Anderson","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0854.2004.00246.x","article-title":"A protein's final ESCRT","volume":"6","author":"Babst","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.ejcb.2006.08.004_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1023\/A:1005362123443","article-title":"Mucolipidosis type IV: abnormal transport of lipids to lysosomes","volume":"20","author":"Bargal","year":"1997","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ejcb.2006.08.004_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/79095","article-title":"Identification of the gene causing mucolipidosis type IV","volume":"26","author":"Bargal","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejcb.2006.08.004_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1055\/s-2002-34496","article-title":"Mucolipidosis IV: novel mutation and diverse ultrastructural spectrum in the skin","volume":"33","author":"Bargal","year":"2002","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ejcb.2006.08.004_bib7","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/S0002-9297(07)62941-3","article-title":"Cloning of the gene encoding a novel integral membrane protein, mucolipidin, and identification of the two major founder mutations causing mucolipidosis type IV","volume":"67","author":"Bassi","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ejcb.2006.08.004_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tcb.2004.02.004","article-title":"Membrane specializations and endosome maturation in dendritic cells and B cells","volume":"14","author":"Boes","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib9","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/intimm\/dxh267","article-title":"Exosomal-like vesicles are present in human blood plasma","volume":"17","author":"Caby","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib10","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1073\/pnas.95.11.6373","article-title":"Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease","volume":"95","author":"Chen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2006.08.004_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1749-6632.2003.tb06030.x","article-title":"Molecular mechanisms of B cell antigen receptor trafficking","volume":"987","author":"Clark","year":"2003","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ejcb.2006.08.004_bib12","doi-asserted-by":"crossref","first-page":"14994","DOI":"10.1073\/pnas.222425399","article-title":"Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice","volume":"99","author":"Di Palma","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2006.08.004_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00005072-199503000-00002","article-title":"Mucolipidosis IV: morphology and histochemistry of an autopsy case","volume":"54","author":"Folkerth","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0198-8859(02)00458-5","article-title":"Lipid rafts, major histocompatibility complex molecules, and immune regulation","volume":"63","author":"Goebel","year":"2002","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1203\/00006450-199506000-00003","article-title":"Cultured skin fibroblasts derived from patients with mucolipidosis 4 are auto-fluorescent","volume":"37","author":"Goldin","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejcb.2006.08.004_bib16","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1074\/jbc.M209885200","article-title":"Phosphoinositide 3-kinase activation by Igbeta controls de novo formation of an antigen-processing compartment","volume":"278","author":"Granboulan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2006.08.004_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0952-7915(01)00295-3","article-title":"Trafficking of MHC class II molecules in the late secretory pathway","volume":"14","author":"Hiltbold","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1034\/j.1600-0749.2002.02074.x","article-title":"Hermansky-Pudlak syndrome: vesicle formation from yeast to man","volume":"15","author":"Huizing","year":"2002","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.ejcb.2006.08.004_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00441150","article-title":"Ultrastructural pathology of human lymphocytes in lysosomal disorders: a contribution to their morphological diagnosis","volume":"138","author":"Ikeda","year":"1982","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ejcb.2006.08.004_bib20","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nrm973","article-title":"Receptor downregulation and multivesicular-body sorting","volume":"3","author":"Katzmann","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/A:1026528921085","article-title":"Lipid membrane domains in cell surface and vacuolar systems","volume":"17","author":"Kobayashi","year":"2000","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.ejcb.2006.08.004_bib22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.20011543","article-title":"Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation","volume":"195","author":"Lankar","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejcb.2006.08.004_bib23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.febslet.2004.04.080","article-title":"Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organization","volume":"567","author":"Manzoni","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejcb.2006.08.004_bib24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1385\/IR:27:2-3:409","article-title":"Melanosomes and MHC class II antigen-processing compartments: a tinted view of intracellular trafficking and immunity","volume":"27","author":"Marks","year":"2003","journal-title":"Immunol. Res."},{"key":"10.1016\/j.ejcb.2006.08.004_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1034\/j.1600-0854.2003.00072.x","article-title":"Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway","volume":"4","author":"Mobius","year":"2003","journal-title":"Traffic"},{"key":"10.1016\/j.ejcb.2006.08.004_bib26","doi-asserted-by":"crossref","unstructured":"Montell, C., 2005. The TRP superfamily of cation channels. Sci STKE 2005, re3.","DOI":"10.1126\/stke.2722005re3"},{"key":"10.1016\/j.ejcb.2006.08.004_bib27","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/35079092","article-title":"LTRPC7 is a Mg-ATP-regulated divalent cation channel required for cell viability","volume":"411","author":"Nadler","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2006.08.004_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.coi.2003.11.009","article-title":"Association of MHC class II-peptide complexes with plasma membrane lipid microdomains","volume":"1","author":"Poloso","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/14084","article-title":"Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases","volume":"1","author":"Puri","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1247\/csf.27.443","article-title":"Lysosome-related organelles: a view from immunity and pigmentation","volume":"27","author":"Raposo","year":"2002","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.ejcb.2006.08.004_bib31","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1073\/pnas.95.3.1207","article-title":"Constitutive achlorhydria in mucolipidosis type IV","volume":"95","author":"Schiffmann","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2006.08.004_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0952-7915(00)00178-3","article-title":"The control and facilitation of MHC class II antigen processing by the BCR","volume":"13","author":"Siemasko","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2174\/1566524023362276","article-title":"The molecular basis of mucolipidosis type IV","volume":"2","author":"Slaugenhaupt","year":"2002","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.ejcb.2006.08.004_bib35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1084952102000563","article-title":"The molecular machinery for the biogenesis of lysosome-related organelles: lessons from Hermansky-Pudlak syndrome","volume":"13","author":"Starcevic","year":"2002","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ejcb.2006.08.004_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1095291","article-title":"Linking albinism and immunity: the secrets of secretory lysosomes","volume":"305","author":"Stinchcombe","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2006.08.004_bib37","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1093\/hmg\/9.17.2471","article-title":"Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel","volume":"9","author":"Sun","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejcb.2006.08.004_bib38","doi-asserted-by":"crossref","first-page":"17517","DOI":"10.1074\/jbc.M600807200","article-title":"Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1","volume":"281","author":"Venkatachalam","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933506001440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933506001440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:06:02Z","timestamp":1759251962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933506001440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0171933506001440"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2006.08.004","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2006.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}