{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:50:30Z","timestamp":1791039030528,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Inserm","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CNRS"},{"DOI":"10.13039\/501100003768","name":"Universit\u00e9 de Strasbourg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Soci\u00e9t\u00e9 de recherche dermatologique, Association pour la Recherche sur le Cancer, Ligue R\u00e9gionale contre le Cancer, Canc\u00e9rop\u00f4le Grand-Est ACI 2004"},{"name":"Institut National du Cancer"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ejcb.2010.09.003","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T05:57:19Z","timestamp":1289368639000},"page":"270-277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation"],"prefix":"10.1016","volume":"90","author":[{"given":"Cristina","family":"Niculescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitali","family":"Ganguli-Indra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Dup\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Messaddeq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le","family":"De Arcangelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Georges-Labouesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2010.09.003_bib0005","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.004481","article-title":"Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects","volume":"120","author":"Ackerl","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.0906-6705.2004.00183.x","article-title":"Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis","volume":"13","author":"Cook","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0015","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1172\/JCI119766","article-title":"Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype","volume":"100","author":"Cook","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0020","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1242\/dev.126.17.3957","article-title":"Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse","volume":"126","author":"De Arcangelis","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0945-053X(99)00047-5","article-title":"Restricted distribution of laminin alpha1 chain in normal adult mouse tissues","volume":"18","author":"Falk","year":"1999","journal-title":"Matrix Biol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0030","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0945-053X(00)00092-5","article-title":"Differential expression of laminin alpha chains during proliferative and differentiation stages in a model for skin morphogenesis","volume":"19","author":"Fleischmajer","year":"2000","journal-title":"Matrix Biol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0035","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/ng0796-370","article-title":"Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice","volume":"13","author":"Georges-Labouesse","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0040","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/path.2654","article-title":"Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis","volume":"220","author":"Germain","year":"2010","journal-title":"J Pathol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0045","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/nar\/27.22.4324","article-title":"Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases","volume":"27","author":"Indra","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0050","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/35036595","article-title":"Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis","volume":"407","author":"Li","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0055","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.tcb.2006.05.004","article-title":"Current insights into the formation and breakdown of hemidesmosomes","volume":"16","author":"Litjens","year":"2006","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0060","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.0022-202X.2005.23956.x","article-title":"Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication","volume":"125","author":"Lopez-Rovira","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0065","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and therapy of psoriasis","volume":"445","author":"Lowes","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0070","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/sj.jid.5700918","article-title":"Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS","volume":"127","author":"Lu","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0075","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/meth.2001.1159","article-title":"Site- and time-specific gene targeting in the mouse","volume":"24","author":"Metzger","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yexmp.2007.04.003","article-title":"Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury","volume":"83","author":"Nerusu","year":"2007","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0085","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1172\/JCI115782","article-title":"Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin","volume":"89","author":"Pellegrini","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00000372-199604000-00010","article-title":"Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases","volume":"18","author":"Piepkorn","year":"1996","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0945-053X(98)00005-5","article-title":"Mutation analysis and molecular genetics of epidermolysis bullosa","volume":"18","author":"Pulkkinen","year":"1999","journal-title":"Matrix Biol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0100","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1242\/jcs.01689","article-title":"Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice","volume":"118","author":"Raymond","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0105","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/jcp.21040","article-title":"Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes","volume":"212","author":"Rodius","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0110","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejcb.2006.07.004","article-title":"Biological function of laminin-5 and pathogenic impact of its deficiency","volume":"86","author":"Schneider","year":"2007","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jdermsci.2006.08.010","article-title":"Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis","volume":"45","author":"Shirakata","year":"2007","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0120","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.det.2009.10.017","article-title":"Nail involvement in epidermolysis bullosa","volume":"28","author":"Tosti","year":"2010","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0125","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.det.2009.10.018","article-title":"Alopecia in epidermolysis bullosa","volume":"28","author":"Tosti","year":"2010","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.ejcb.2010.09.003_bib0130","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/dvdy.22255","article-title":"The making of hemidesmosome structures in vivo","volume":"239","author":"Zhang","year":"2010","journal-title":"Dev Dyn"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933510001925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933510001925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:13:36Z","timestamp":1759252416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933510001925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":26,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0171933510001925"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2010.09.003","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2010.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier GmbH. Published by Elsevier GmbH All rights reserved.","name":"copyright","label":"Copyright"}]}}