{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:05:33Z","timestamp":1789142733363,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program","doi-asserted-by":"crossref","award":["2008CB517401"],"award-info":[{"award-number":["2008CB517401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural and Science Foundation of China","doi-asserted-by":"crossref","award":["81030009"],"award-info":[{"award-number":["81030009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural and Science Foundation of China","doi-asserted-by":"crossref","award":["30971348"],"award-info":[{"award-number":["30971348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural and Science Foundation of China","doi-asserted-by":"crossref","award":["81170407"],"award-info":[{"award-number":["81170407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing","doi-asserted-by":"crossref","award":["7102016"],"award-info":[{"award-number":["7102016"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funding Project for Academic Human Resources Development in Institutions of Beijing Municipality","award":["PHR201006109"],"award-info":[{"award-number":["PHR201006109"]}]},{"DOI":"10.13039\/501100002888","name":"Beijing Municipal Commission of Education","doi-asserted-by":"crossref","award":["YB20101002501"],"award-info":[{"award-number":["YB20101002501"]}],"id":[{"id":"10.13039\/501100002888","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.ejcb.2012.03.004","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T16:15:34Z","timestamp":1336148134000},"page":"654-661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["15-Deoxy-\u039412,14-prostaglandin J2 attenuates the biological activities of monocyte\/macrophage cell lines"],"prefix":"10.1016","volume":"91","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2012.03.004_bib0005","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1038\/sj.onc.1203128","article-title":"Role of redox potential and reactive oxygen species in stress signaling","volume":"18","author":"Adler","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0010","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1476-5381.2010.01057.x","article-title":"Effects of 15d-PGJ(2)-loaded poly(d,l-lactide-co-glycolide) nanocapsules on inflammation","volume":"162","author":"Alves","year":"2011","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/83336","article-title":"PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation","volume":"7","author":"Chawla","year":"2001","journal-title":"Nature Medicine"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0020","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0026-895X(24)12195-5","article-title":"The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation","volume":"61","author":"Cuzzocrea","year":"2002","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0025","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.4049\/jimmunol.168.5.2508","article-title":"Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis","volume":"168","author":"Diab","year":"2002","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BJ20091193","article-title":"Modulation of mammary cancer cell migration by 15-deoxy-Delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy","volume":"430","author":"Diers","year":"2010","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0035","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1189\/jlb.69.4.631","article-title":"Differential effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation","volume":"69","author":"Guyton","year":"2001","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0040","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/bjp.2008.21","article-title":"Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts","volume":"153","author":"Hao","year":"2008","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0045","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1084\/jem.193.2.255","article-title":"Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2","volume":"193","author":"Hirai","year":"2001","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0050","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/MOG.0b013e3282ff8b0c","article-title":"Innate immunity in inflammatory bowel disease: state of the art","volume":"24","author":"Hisamatsu","year":"2008","journal-title":"Current Opinion in Gastroenterology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0055","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/34184","article-title":"PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines","volume":"391","author":"Jiang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.shk.0000167108.88376.f2","article-title":"15-Deoxy Delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock","volume":"24","author":"Kaplan","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0065","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.bcp.2006.07.030","article-title":"15-Deoxy-Delta(12,14)-prostaglandin J(2) as a potential endogenous regulator of redox-sensitive transcription factors","volume":"72","author":"Kim","year":"2006","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0070","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.biocel.2003.08.004","article-title":"Differential effects of gadolinium chloride on Kupffer cells in vivo and in vitro","volume":"36","author":"Lee","year":"2004","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0075","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0016-5085(03)00906-5","article-title":"Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts","volume":"125","author":"Li","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0080","doi-asserted-by":"crossref","first-page":"38152","DOI":"10.1074\/jbc.M101980200","article-title":"15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts\u2014a pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors","volume":"276","author":"Li","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0085","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1002\/jcp.22572","article-title":"Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation","volume":"226","author":"Liu","year":"2011","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0002-9440(10)65540-X","article-title":"Macrophages in human atheroma contain PPAR gamma\u2014differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPAR gamma) expression and reduction of MMP-9 activity through PPAR gamma activation in mononuclear phagocytes in vitro","volume":"153","author":"Marx","year":"1998","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0095","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4049\/jimmunol.180.1.609","article-title":"Peroxisome proliferator-activated receptor-gamma ligand,15-deoxy-Delta A(12,14)-prostaglandin J(2), reduces neutrophil migration via a nitric oxide pathway","volume":"180","author":"Napimoga","year":"2008","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0100","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/jlb.66.5.733","article-title":"The peroxisome proliferator-activated receptor gamma (PPAR gamma) as a regulator of monocyte\/macrophage function","volume":"66","author":"Ricote","year":"1999","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.smim.2006.09.002","article-title":"Adaptations of intestinal macrophages to an antigen-rich environment","volume":"19","author":"Schenk","year":"2007","journal-title":"Seminars in Immunology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0115","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.clim.2004.09.008","article-title":"15d-PGJ(2): the anti-inflammatory prostaglandin?","volume":"114","author":"Scher","year":"2005","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0120","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1172\/JCI7145","article-title":"A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response","volume":"104","author":"Su","year":"1999","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0125","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.4049\/jimmunol.164.2.1046","article-title":"Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo","volume":"164","author":"Thieringer","year":"2000","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0130","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/jcb.22657","article-title":"Rosiglitazone inhibits monocyte\/macrophage adhesion through de novo adiponectin production in human monocytes","volume":"110","author":"Tsai","year":"2010","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bcp.2003.10.016","article-title":"Nuclear receptor signaling in macrophages","volume":"67","author":"Valledor","year":"2004","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0140","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.prostaglandins.2011.01.004","article-title":"Induction of apoptosis by 15d-PGJ(2) via ROS formation: an alternative pathway without PPAR gamma activation in non-small cell lung carcinoma A549 cells","volume":"94","author":"Wang","year":"2011","journal-title":"Prostaglandins & Other Lipid Mediators"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0145","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.leukres.2003.07.005","article-title":"Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia","volume":"28","author":"Zang","year":"2004","journal-title":"Leukemia Research"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0150","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.4049\/jimmunol.166.12.7104","article-title":"Differential regulation of chemokine gene expression by 15-deoxy-Delta(12,14) prostaglandin J(2)","volume":"166","author":"Zhang","year":"2001","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0155","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00018-008-8308-7","article-title":"Monocytes and their pathophysiological role in Crohn's disease","volume":"66","author":"Zhou","year":"2009","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.ejcb.2012.03.004_bib0160","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.4049\/jimmunol.171.12.6827","article-title":"Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J(2) and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways","volume":"171","author":"Zingarelli","year":"2003","journal-title":"Journal of Immunology"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017193351200057X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017193351200057X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:14:22Z","timestamp":1759252462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S017193351200057X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S017193351200057X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2012.03.004","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"15-Deoxy-\u039412,14-prostaglandin J2 attenuates the biological activities of monocyte\/macrophage cell lines","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2012.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}