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Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0340","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1083\/jcb.200704169","article-title":"Positive feedback between Cdc42 activity and H+ efflux by the Na\u2013H exchanger NHE1 for polarity of migrating cells","volume":"179","author":"Frantz","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0345","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.cell.2011.11.016","article-title":"Cancer invasion and the microenvironment: plasticity and reciprocity","volume":"147","author":"Friedl","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0350","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nature07017","article-title":"Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate","volume":"453","author":"Gallagher","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0355","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrc882","article-title":"Molecular imaging of cancer with positron emission tomography","volume":"2","author":"Gambhir","year":"2002","journal-title":"Nat. Rev. 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Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0385","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jmri.10181","article-title":"MRI of the tumor microenvironment","volume":"16","author":"Gillies","year":"2002","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0390","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1476-5586(03)80037-4","article-title":"Extracellular acidification alters lysosomal trafficking in human breast cancer cells","volume":"5","author":"Glunde","year":"2003","journal-title":"Neoplasia"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0395","first-page":"G259","article-title":"Regulation of intracellular pH gradients by identified Na\/H exchanger isoforms and a short-chain fatty acid","volume":"276","author":"Gonda","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0400","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jmb.2005.11.001","article-title":"Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain","volume":"355","author":"Grey","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0405","doi-asserted-by":"crossref","first-page":"14829","DOI":"10.1074\/jbc.M108180200","article-title":"Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B","volume":"277","author":"Guo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0410","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/8756-3282(95)00455-6","article-title":"Cellular distribution and regulation of NHE-1 isoform of the NA\u2013H exchanger in the avian osteoclast","volume":"18","author":"Gupta","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0415","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02556011","article-title":"Optimal bone resorption by isolated rat osteoclasts requires chloride\/bicarbonate exchange","volume":"45","author":"Hall","year":"1989","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0420","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/jcp.1041420227","article-title":"Na+\/H+ antiporter is the primary proton transport system used by osteoclasts during bone resorption","volume":"142","author":"Hall","year":"1990","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0425","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0006-291X(92)91344-P","article-title":"Na+\/H(+)-antiporter activity is essential for the induction, but not the maintenance of osteoclastic bone resorption and cytoplasmic spreading","volume":"188","author":"Hall","year":"1992","journal-title":"Biochem. Biophys. Res. 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Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0465","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1479-5876-8-57","article-title":"Proton dynamics in cancer","volume":"8","author":"Huber","year":"2010","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0470","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.bone.2010.01.368","article-title":"The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo","volume":"46","author":"Idris","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0475","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbrc.2005.09.054","article-title":"Identification of acid-sensing ion channels in bone","volume":"337","author":"Jahr","year":"2005","journal-title":"Biochem. Biophys. Res. 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Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0495","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00424-002-0989-4","article-title":"Calcitonin inhibits proton extrusion in resorbing rat osteoclasts via protein kinase A","volume":"445","author":"Kajiya","year":"2003","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0500","doi-asserted-by":"crossref","first-page":"10938","DOI":"10.1074\/jbc.M411313200","article-title":"Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling","volume":"280","author":"Kato","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0505","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/jcp.1041580212","article-title":"Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins","volume":"158","author":"Kelly","year":"1994","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0510","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00418-004-0639-3","article-title":"Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator","volume":"121","author":"Kindzelskii","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0515","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/bj2640467","article-title":"Cathepsin S from bovine spleen. 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Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0530","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1073\/pnas.0406874102","article-title":"Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium\/calcineurin\/NFAT pathway in osteoclasts","volume":"102","author":"Komarova","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0535","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(01)00206-9","article-title":"Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man","volume":"104","author":"Kornak","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0540","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/hmg\/9.13.2059","article-title":"Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis","volume":"9","author":"Kornak","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0545","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0014-5793(99)00897-2","article-title":"Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases","volume":"455","author":"Kostoulas","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0550","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000217977","article-title":"Implications of acidic tumor microenvironment for neoplastic growth and cancer treatment: a computer analysis","volume":"17","author":"Kraus","year":"1996","journal-title":"Tumour Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0555","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ccr.2008.05.005","article-title":"Tumor cell metabolism: cancer's Achilles\u2019 heel","volume":"13","author":"Kroemer","year":"2008","journal-title":"Cancer Cell."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0560","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2334\/josnusd1959.33.81","article-title":"Enzymatic regulation of glycolysis and gluconeogenesis in rabbit periodontal ligament under various physiological pH conditions","volume":"33","author":"Kuwata","year":"1991","journal-title":"J. Nihon Univ. Sch. Dent."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0565","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/sj.cdd.4401466","article-title":"Alterations of intracellular pH homeostasis in apoptosis: origins and roles","volume":"11","author":"Lagadic-Gossmann","year":"2004","journal-title":"Cell Death Differ."},{"issue":"Pt 20","key":"10.1016\/j.ejcb.2012.04.004_bib0570","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1242\/jcs.113.20.3649","article-title":"Regulation of the formation of tumor cell pseudopodia by the Na(+)\/H(+) exchanger NHE1","volume":"113","author":"Lagana","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0575","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1172\/JCI117235","article-title":"Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase","volume":"93","author":"Laitala","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0580","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jbmr.5650080115","article-title":"Proton channel part of vacuolar H(+)-ATPase and carbonic anhydrase II expression is stimulated in resorbing osteoclasts","volume":"8","author":"Laitala","year":"1993","journal-title":"J. Bone Miner. Res."},{"issue":"Pt 3","key":"10.1016\/j.ejcb.2012.04.004_bib0585","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1242\/jcs.104.3.663","article-title":"Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy","volume":"104","author":"Lakkakorpi","year":"1993","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0590","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1097-0029(19960201)33:2<171::AID-JEMT7>3.0.CO;2-W","article-title":"Cytoskeletal changes in osteoclasts during the resorption cycle","volume":"33","author":"Lakkakorpi","year":"1996","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0595","doi-asserted-by":"crossref","first-page":"37854","DOI":"10.1074\/jbc.M705460200","article-title":"Model structure of the Na+\/H+ exchanger 1 (NHE1): functional and clinical implications","volume":"282","author":"Landau","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0600","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.biochi.2007.08.011","article-title":"Biochemical properties and regulation of cathepsin K activity","volume":"90","author":"Lecaille","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0605","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1021\/cr0101656","article-title":"Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design","volume":"102","author":"Lecaille","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0610","doi-asserted-by":"crossref","first-page":"29164","DOI":"10.1074\/jbc.274.41.29164","article-title":"Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation","volume":"274","author":"Lee","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0615","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bbrc.2008.01.168","article-title":"NHE10, a novel osteoclast-specific member of the Na+\/H+ exchanger family, regulates osteoclast differentiation and survival","volume":"369","author":"Lee","year":"2008","journal-title":"Biochem. Biophys. Res. 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Tissue Int."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0645","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.yexcr.2011.05.026","article-title":"NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP","volume":"317","author":"Lin","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0650","article-title":"NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP","author":"Lin","year":"2011","journal-title":"Cell Biochem. 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A."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0670","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-cellbio-092910-154216","article-title":"Degrading devices: invadosomes in proteolytic cell invasion","volume":"27","author":"Linder","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0675","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.4049\/jimmunol.1000436","article-title":"P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases","volume":"185","author":"Lopez-Castejon","year":"2010","journal-title":"J. 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Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0730","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1359\/jbmr.1997.12.5.753","article-title":"Characterization and cellular distribution of the osteoclast ruffled membrane vacuolar H+-ATPase B-subunit using isoform-specific antibodies","volume":"12","author":"Mattsson","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0735","doi-asserted-by":"crossref","first-page":"C676","DOI":"10.1152\/ajpcell.2000.278.4.C676","article-title":"Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes","volume":"278","author":"McLean","year":"2000","journal-title":"Am. J. Physiol. 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Cell Sci."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0770","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrm3141","article-title":"The \u2018ins\u2019 and \u2018outs\u2019 of podosomes and invadopodia: characteristics, formation and function","volume":"12","author":"Murphy","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0775","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jcp.21103","article-title":"The in vitro effect of pH on osteoclasts and bone resorption in the cat: implications for the pathogenesis of FORL","volume":"213","author":"Muzylak","year":"2007","journal-title":"J. Cell. Physiol."},{"issue":"Pt 22","key":"10.1016\/j.ejcb.2012.04.004_bib0780","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1242\/jcs.112.22.3985","article-title":"Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone","volume":"112","author":"Nakamura","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0785","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","article-title":"Interfering with pH regulation in tumours as a therapeutic strategy","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.ejcb.2012.04.004_bib0790","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/excr.2000.4929","article-title":"Purification and characterization of beta-actin-rich tumor cell pseudopodia: role of glycolysis","volume":"258","author":"Nguyen","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0795","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1074\/jbc.270.5.2203","article-title":"Regulation of cytoplasmic pH in osteoclasts. Contribution of proton pumps and a proton-selective conductance","volume":"270","author":"Nordstrom","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0800","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.1074\/jbc.272.10.6354","article-title":"Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts","volume":"272","author":"Nordstrom","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0805","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jbmr.5650030213","article-title":"Effect of vitamin A on bone resorption: evidence for direct stimulation of isolated chicken osteoclasts by retinol and retinoic acid","volume":"3","author":"Oreffo","year":"1988","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0810","doi-asserted-by":"crossref","first-page":"22373","DOI":"10.1074\/jbc.272.36.22373","article-title":"Na+\/H+ exchangers of mammalian cells","volume":"272","author":"Orlowski","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0815","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00424-003-1110-3","article-title":"Diversity of the mammalian sodium\/proton exchanger SLC9 gene family","volume":"447","author":"Orlowski","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0820","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1242\/jcs.068163","article-title":"Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia","volume":"123","author":"Oser","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0825","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1083\/jcb.200812176","article-title":"Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation","volume":"186","author":"Oser","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0830","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.yexcr.2005.03.035","article-title":"Subconfluent endothelial cells form podosomes downstream of cytokine and RhoGTPase signaling","volume":"307","author":"Osiak","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0835","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tips.2007.10.011","article-title":"Cysteine cathepsin proteases as pharmacological targets in cancer","volume":"29","author":"Palermo","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0840","doi-asserted-by":"crossref","first-page":"R616","DOI":"10.1186\/bcr922","article-title":"The Na+\u2013H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells","volume":"6","author":"Paradiso","year":"2004","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0845","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bpj.2010.12.3733","article-title":"Sensing and modulation of invadopodia across a wide range of rigidities","volume":"100","author":"Parekh","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0850","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","article-title":"Carbonic anhydrases: current state of the art, therapeutic applications and future prospects","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0855","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.200412145","article-title":"A developmentally regulated Na\u2013H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis","volume":"169","author":"Patel","year":"2005","journal-title":"J. Cell Biol."},{"issue":"Pt 3","key":"10.1016\/j.ejcb.2012.04.004_bib0860","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1042\/bj2820797","article-title":"Regulation of glycogen synthesis and glycolysis by insulin, pH and cell volume. Interactions between swelling and alkalinization in mediating the effects of insulin","volume":"282","author":"Peak","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0865","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1242\/jcs.034561","article-title":"Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia","volume":"122","author":"Poincloux","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0870","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejcb.2005.09.012","article-title":"Re-arrangements of podosome structures are observed when Hck is activated in myeloid cells","volume":"85","author":"Poincloux","year":"2006","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0875","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1074\/jbc.M310148200","article-title":"Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor","volume":"279","author":"Pope","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0880","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature04871","article-title":"Hypoxia signalling in cancer and approaches to enforce tumour regression","volume":"441","author":"Pouyssegur","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0885","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0014-5793(85)80439-7","article-title":"Cytoplasmic pH, a key determinant of growth factor-induced DNA synthesis in quiescent fibroblasts","volume":"190","author":"Pouyssegur","year":"1985","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0890","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2164-5-46","article-title":"Expression profile of genes regulated by activity of the Na\u2013H exchanger NHE1","volume":"5","author":"Putney","year":"2004","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0895","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev.pharmtox.42.092001.143801","article-title":"The changing face of the Na+\/H+ exchanger, NHE1: structure, regulation, and cellular actions","volume":"42","author":"Putney","year":"2002","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0900","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.matbio.2007.07.001","article-title":"Control of matrix metalloproteinase catalytic activity","volume":"26","author":"Ra","year":"2007","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0905","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1074\/jbc.275.8.5361","article-title":"Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)\/H(+) exchange, motility, and invasion induced by serum deprivation","volume":"275","author":"Reshkin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0910","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1096\/fj.00-0029com","article-title":"Na+\/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes","volume":"14","author":"Reshkin","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0915","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.matbio.2010.01.003","article-title":"Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1","volume":"29","author":"Riihonen","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0920","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.bone.2006.11.028","article-title":"Membrane-bound carbonic anhydrases in osteoclasts","volume":"40","author":"Riihonen","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0925","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1158\/0008-5472.CAN-07-5575","article-title":"Bicarbonate increases tumor pH and inhibits spontaneous metastases","volume":"69","author":"Robey","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0930","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1158\/0008-5472.CAN-06-0983","article-title":"Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice","volume":"66","author":"Rofstad","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0935","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bone.2008.10.056","article-title":"The endovanilloid\/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption","volume":"44","author":"Rossi","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0940","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S8756-3282(02)00672-5","article-title":"Osteoclastic acidification pathways during bone resorption","volume":"30","author":"Rousselle","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0945","first-page":"6517","article-title":"Pericellular pH affects distribution and secretion of cathepsin B in malignant cells","volume":"54","author":"Rozhin","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0950","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1083\/jcb.200709076","article-title":"The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA","volume":"181","author":"Sakurai-Yageta","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0955","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejcb.2010.05.011","article-title":"Invadosomes: intriguing structures with promise","volume":"90","author":"Saltel","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib0960","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1091\/mbc.e04-06-0522","article-title":"Apatite-mediated actin dynamics in resorbing osteoclasts","volume":"15","author":"Saltel","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejcb.2012.04.004_bib0965","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J. Am. Acad. 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Physiol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1113\/jphysiol.2001.013268","article-title":"Facilitation of intracellular H(+) ion mobility by CO(2)\/HCO(3)(\u2212) in rabbit ventricular myocytes is regulated by carbonic anhydrase","volume":"541","author":"Spitzer","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1756-9966-29-44","article-title":"Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy","volume":"29","author":"Spugnini","year":"2010","journal-title":"J. Exp. Clin. 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(Oxf.)"},{"key":"10.1016\/j.ejcb.2012.04.004_bib1070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1113\/jphysiol.2007.145185","article-title":"pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution","volume":"585","author":"Stuwe","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1075","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-291X(90)91709-2","article-title":"Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption","volume":"168","author":"Sundquist","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. 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Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1130","doi-asserted-by":"crossref","first-page":"9147","DOI":"10.1158\/0008-5472.CAN-07-5127","article-title":"Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts","volume":"68","author":"Tu","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1135","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1021\/bi00052a046","article-title":"Kinetics of the pH-induced inactivation of human cathepsin L","volume":"32","author":"Turk","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejcb.2012.04.004_bib1140","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1083\/jcb.111.3.1305","article-title":"Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts","volume":"111","author":"Vaananen","year":"1990","journal-title":"J. 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Chem."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1170","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1152\/physrev.00045.2003","article-title":"Renal vacuolar H+-ATPase","volume":"84","author":"Wagner","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejcb.2012.04.004_bib1175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10585-006-9014-1","article-title":"Invadopodia: specialized cell structures for cancer invasion","volume":"23","author":"Weaver","year":"2006","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.ejcb.2012.04.004_bib1180","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc3110","article-title":"Dysregulated pH: a perfect storm for cancer progression","volume":"11","author":"Webb","year":"2011","journal-title":"Nat. Rev. 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