{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:39:10Z","timestamp":1790674750881,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"3-5","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ejcb.2016.02.003","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T20:25:54Z","timestamp":1455999954000},"page":"136-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sonic hedgehog is a chemotactic neural crest cell guide that is perturbed by ethanol exposure"],"prefix":"10.1016","volume":"95","author":[{"given":"Ezequiel J.","family":"Tolosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn E.","family":"Fern\u00e1ndez-Zapico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia L.","family":"Battiato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto A.","family":"Rovasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2016.02.003_bib0005","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.devcel.2012.02.003","article-title":"LTB4 is a signal-relay molecule during neutrophil chemotaxis","volume":"22","author":"Afonso","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ydbio.2012.01.020","article-title":"Indian hedgehog signaling is required for proper formation, maintenance and migration of Xenopus neural crest","volume":"364","author":"Ag\u00fcero","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0015","doi-asserted-by":"crossref","first-page":"10476","DOI":"10.1073\/pnas.162356199","article-title":"Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure","volume":"99","author":"Ahlgren","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0020","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/sj.bjc.6606056","article-title":"CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells","volume":"104","author":"Amatschek","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0025","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1634\/stemcells.2008-0297","article-title":"Chemoattractive activity of Sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb","volume":"26","author":"Angot","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.tcb.2010.02.002","article-title":"Evaluating Smoothened as a G-protein-coupled receptor for hedgehog signaling","volume":"20","author":"Ayers","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0035","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0003-2697(80)90151-7","article-title":"Methods for growth of culture cell in serum-free medium","volume":"102","author":"Barnes","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0040","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/10520299609117176","article-title":"Method for treatment and processing of whole chick embryos for autoradiography, immuno-cytochemistry and other techniques","volume":"71","author":"Battiato","year":"1996","journal-title":"Biotechnol. Histochem."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0045","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.cellsig.2007.08.011","article-title":"Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites","volume":"19","author":"Bijlsma","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0050","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0046-8177(74)80021-3","article-title":"The neurocristopathies: a unifying concept of disease arising in neural crest maldevelopment","volume":"5","author":"Bolande","year":"1974","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0055","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nn1396","article-title":"Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord","volume":"8","author":"Bourikas","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1084\/jem.115.3.453","article-title":"The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes","volume":"115","author":"Boyden","year":"1962","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0065","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1242\/dev.080275","article-title":"Chemokine and FGF signaling act as opposing guidance cues in formation of the lateral line primordium","volume":"139","author":"Breau","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0070","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S1097-2765(01)00271-4","article-title":"A Hedgehog-insensitive form of Patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube","volume":"7","author":"Briscoe","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ydbio.2011.12.042","article-title":"Development and evolution of the neural crest: an overview","volume":"366","author":"Bronner","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0085","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.biocel.2010.04.016","article-title":"Activation of Erk by Sonic hedgehog independent of canonical hedgehog signaling","volume":"42","author":"Chang","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0092-8674(03)00199-5","article-title":"The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance","volume":"113","author":"Charron","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0095","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1101\/gad.1025302","article-title":"Inhibition of hedgehog signaling by direct binding of cyclopamine to Smoothened","volume":"16","author":"Chen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0100","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0741-8329(99)00058-0","article-title":"Differential sensitivity of mouse neural crest cells to ethanol-induced toxicity","volume":"20","author":"Chen","year":"2000","journal-title":"Alcohol"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0105","series-title":"XVIII Congress of Bioengineering","first-page":"1","article-title":"Electroporator applying to research on molecular and developmental biology","author":"Chesini","year":"2011"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.200301041","article-title":"Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells","volume":"162","author":"De Bellard","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/dvdy.10456","article-title":"Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo","volume":"229","author":"Del Barrio","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0120","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0092-8674(01)00488-3","article-title":"Hedgehog signaling in germ cell migration","volume":"106","author":"Deshpande","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1242\/dev.043547","article-title":"Evidence for a role of vertebrate Disp1 in long-range Shh signaling","volume":"137","author":"Etheridge","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0130","doi-asserted-by":"crossref","first-page":"14669","DOI":"10.1073\/pnas.1116481109","article-title":"Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin","volume":"109","author":"Ferrario","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0135","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1242\/dev.126.19.4257","article-title":"Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis","volume":"126","author":"Franco","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.200401077","article-title":"Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut","volume":"166","author":"Fu","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0145","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2818.2008.02066.x","article-title":"Signal relay during chemotaxis","volume":"231","author":"Garc\u00eda","year":"2008","journal-title":"J. Microsc."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0150","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/BC20080023","article-title":"Repulsive guidance molecule A (RGM A) and its receptor neogenin during neural and neural crest cell development of Xenopus laevis","volume":"100","author":"Gessert","year":"2008","journal-title":"Biol. Cell"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0155","series-title":"Developmental Biology","author":"Gilbert","year":"2013"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0160","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1365-2605.1998.00201.x","article-title":"Mouse spermatozoa modify their motility parameters and chemotactic response to factors from the oocyte microenvironment","volume":"21","author":"Giojalas","year":"1998","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0165","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuron.2008.01.006","article-title":"Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target","volume":"57","author":"Gore","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0170","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1530\/REP-11-0478","article-title":"Sperm transport and retention at the fertilization site is orchestrated by a chemical guidance and oviduct movement","volume":"143","author":"Guidobaldi","year":"2012","journal-title":"Reproduction"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A series of normal stages in the development of the chick embryo","volume":"88","author":"Hamburger","year":"1951","journal-title":"J. Morphol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-micro-092611-150120","article-title":"Bacterial chemotaxis: the early years of molecular studies","volume":"66","author":"Hazelbauer","year":"2012","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0185","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1098\/rsif.2012.0542","article-title":"Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modeling","volume":"9","author":"Holmes","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0190","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1242\/dev.114835","article-title":"A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face","volume":"142","author":"Hu","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0195","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.mib.2007.10.004","article-title":"Chemotaxis in Dictyostelium: how to walk straight using parallel pathways","volume":"10","author":"Insall","year":"2007","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0200","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ntt.2011.03.003","article-title":"Trophic and proliferative perturbations of in vivo\/in vitro cephalic neural crest cells after ethanol exposure are prevented by Neurotrophin 3","volume":"33","author":"Jaurena","year":"2011","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0205","series-title":"The Chemokine Stromal Cell-Derived Factor-1 Participate in the Oriented Migration of Neural Crest Cells in Normal Ontogenesis and Exposed to Ethanol","first-page":"78","author":"Jaurena","year":"2011"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0210","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.cellsig.2009.01.033","article-title":"Hedgehog signalling: emerging evidence for non-canonical pathways","volume":"21","author":"Jenkins","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0215","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ydbio.2005.03.021","article-title":"Slit\/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk","volume":"282","author":"Jia","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0220","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/(SICI)1097-0177(200002)217:2<170::AID-DVDY4>3.0.CO;2-9","article-title":"Chemotactic migration of mesencephalic neural crest cells in the mouse","volume":"217","author":"Kubota","year":"2000","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0225","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.neuroscience.2010.07.059","article-title":"Inhibition of cerebellar granule cell turning by alcohol","volume":"170","author":"Kumada","year":"2010","journal-title":"Neurosci"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0235","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/dvdy.21577","article-title":"The eye organizes neural crest cell migration","volume":"237","author":"Langenberg","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0240","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainresrev.2007.06.023","article-title":"Role of the neural crest in face and brain development","volume":"55","author":"Le Douarin","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0245","series-title":"The Neural Crest","author":"Le Douarin","year":"1999"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0250","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.mod.2004.06.003","article-title":"The avian embryo as a model to study the development of the neural crest: a long and still ongoing story","volume":"121","author":"Le Douarin","year":"2004","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0255","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ydbio.2003.07.004","article-title":"Both neural crest and placode contribute to the ciliary ganglion and oculomotor nerve","volume":"263","author":"Lee","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0260","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1101\/gad.391106","article-title":"Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors","volume":"20","author":"Locker","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0265","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ydbio.2005.04.030","article-title":"Molecular interactions coordinating the development of the forebrain and face","volume":"284","author":"Marcucio","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0270","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1242\/dev.122.4.1225","article-title":"Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb","volume":"122","author":"Marigo","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0275","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/dbio.1996.0300","article-title":"Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development","volume":"80","author":"Marigo","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0280","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.121.8.2537","article-title":"Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo","volume":"121","author":"Mart\u00ed","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0285","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1093\/hmg\/ddn110","article-title":"A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy","volume":"17","author":"Matera","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0290","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1242\/dev.091751","article-title":"The neural crest","volume":"140","author":"Mayor","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0295","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ydbio.2009.12.022","article-title":"Vascular endothelial growth factor (VEGF) regulates cranial neural crest migration in vivo","volume":"339","author":"McLennan","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0300","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1242\/dev.081471","article-title":"Multiscale mechanisms of cell migration during development: theory and experiment","volume":"139","author":"McLennan","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0305","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.mcn.2007.07.012","article-title":"Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors","volume":"36","author":"Merch\u00e1n","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0310","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tins.2007.11.008","article-title":"Growth cone chemotaxis","volume":"31","author":"Mortimer","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0315","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/dvdy.22630","article-title":"Gdnf is mitogenic, neurotrophic, and chemoattractive to enteric neural crest cells in the embryonic colon","volume":"240","author":"Mwizerwa","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0320","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.mod.2004.05.013","article-title":"Gain- and loss-of-function in chick embryos by electroporation","volume":"121","author":"Nakamura","year":"2004","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0325","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0074-7696(08)60834-7","article-title":"The migration of neural crest cells","volume":"103","author":"Newgreen","year":"1986","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0330","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1170179","article-title":"Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis","volume":"324","author":"Nishikimi","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0335","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature05246","article-title":"Boc is a receptor for Sonic hedgehog in the guidance of commissural axons","volume":"444","author":"Okada","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0340","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1021\/tx1001749","article-title":"Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling","volume":"23","author":"Paganelli","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0345","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.mcn.2005.11.007","article-title":"GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream","volume":"31","author":"Paratcha","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0350","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/dbio.1999.9335","article-title":"Vertebrate homologs of Drosophila suppressor of Fused interact with the Gli family of transcriptional regulators","volume":"212","author":"Pearse","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0355","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.1166239","article-title":"An ABC transporter controls export of a Drosophila germ cell attractant","volume":"13","author":"Ricardo","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0360","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc3078","article-title":"Chemotaxis in cancer","volume":"11","author":"Roussos","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0365","first-page":"421","article-title":"Role of early migratory neural crest cells in developmental anomalies induced by ethanol","volume":"39","author":"Rovasio","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0370","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/j.1530-0277.2002.tb02669.x","article-title":"Ethanol induces morphological and dynamic changes on in vivo and in vitro neural crest cells","volume":"26","author":"Rovasio","year":"2002","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0375","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1083\/jcb.96.2.462","article-title":"Neural crest cell migration: requirements for exogenous fibronectin and high cell density","volume":"96","author":"Rovasio","year":"1983","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0380","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejcb.2011.12.007","article-title":"Insights into Stem Cell Factor chemotactic guidance of neural crest cells revealed by a real-time directionality-based assay","volume":"91","author":"Rovasio","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0385","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2184.1997.tb00923.x","article-title":"Exogenous retinoic acid decreases in vivo and in vitro proliferative activity during the early migratory stage of neural crest cells","volume":"30","author":"Salvarezza","year":"1997","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0390","series-title":"Molecular Cloning\u2014A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0395","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mcn.2010.07.006","article-title":"Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1\u2013Rac1 cascade during spine formation","volume":"45","author":"Sasaki","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0400","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1242\/dev.015412","article-title":"Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells","volume":"135","author":"Schwarz","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0405","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0925-4773(00)00458-5","article-title":"Similar expression and regulation of Gli2 and Gli3 in the chick limb bud","volume":"98","author":"Schweitzer","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0410","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1469-7580.2005.00484.x","article-title":"It's all in your head: new insights into craniofacial development and deformation","volume":"207","author":"Tapadia","year":"2005","journal-title":"J. Anat."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0415","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.devcel.2006.04.004","article-title":"The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice","volume":"10","author":"Tenzen","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0420","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/ncb2772","article-title":"Chase-and-run between adjacent cell populations promotes directional collective migration","volume":"15","author":"Theveneau","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0425","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1073\/pnas.0707057105","article-title":"Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet\u2013Biedl syndrome","volume":"105","author":"Tobin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0430","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1179\/2046023612Y.0000000008","article-title":"In situ hybridization of chemotactically bioactive molecules on cultured chick embryo","volume":"35","author":"Tolosa","year":"2012","journal-title":"J. Histotechnol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0435","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ydbio.2008.06.028","article-title":"Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells","volume":"321","author":"Toyofuku","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(07)63001-0","article-title":"Mechanisms of gradient detection: a comparison of axon pathfinding with eukaryotic cell migration","volume":"263","author":"von Philipsborn","year":"2007","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0445","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/01.scs.0000183470.31202.c9","article-title":"Gene expression changes of Sonic hedgehog signaling cascade in a mouse embryonic model of Fetal Alcohol Syndrome","volume":"16","author":"Yamada","year":"2005","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0450","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature08391","article-title":"FGF8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules","volume":"461","author":"Yu","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2016.02.003_bib0455","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejcb.2013.10.006","article-title":"Neurotrophic factor NT-3 displays a non-canonical cell guidance signalling function for cephalic neural crest cells","volume":"92","author":"Zanin","year":"2013","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ejcb.2016.02.003_bib0460","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.devcel.2005.01.001","article-title":"Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of cubitus interruptus","volume":"8","author":"Zhang","year":"2005","journal-title":"Dev. Cell"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933516300061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933516300061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T14:12:24Z","timestamp":1718374344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933516300061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":90,"journal-issue":{"issue":"3-5","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0171933516300061"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2016.02.003","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sonic hedgehog is a chemotactic neural crest cell guide that is perturbed by ethanol exposure","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2016.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}