{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:12:25Z","timestamp":1787170345712,"version":"build-2736575974"},"reference-count":227,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ejcb.2020.151097","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T15:55:32Z","timestamp":1593186932000},"page":"151097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Mesenchymal stromal cells (MSCs) for neurodegenerative disease: A promising frontier"],"prefix":"10.1016","volume":"99","author":[{"given":"Ali","family":"Shariati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Nemati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Sadeghipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoda","family":"Yaghoubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Baghbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Javidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hassanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2020.151097_bib0005","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1089\/scd.2016.0020","article-title":"Mesenchymal Stromal\/Stem cells do not ameliorate experimental autoimmune encephalomyelitis and are not detectable in the central nervous system of transplanted mice","volume":"25","author":"Abramowski","year":"2016","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ejcb.2020.151097_bib0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.placenta.2017.04.003","article-title":"Immunomodulatory properties of human placental mesenchymal stem\/stromal cells","volume":"59","author":"Abumaree","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.ejcb.2020.151097_bib0015","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.2174\/1567205014666170203141151","article-title":"Commonalities in biological pathways, genetics, and cellular mechanism between Alzheimer disease and other neurodegenerative diseases: an in silico-updated overview","volume":"14","author":"Ahmad","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0020","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1177\/0960327114524238","article-title":"Do adipose tissue-derived mesenchymal stem cells ameliorate Parkinson\u2019s disease in rat model?","volume":"33","author":"Ahmed","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2019.101442","article-title":"Analysis of mesenchymal cells (MSCs) from bone marrow, synovial fluid and mesenteric, neck and tail adipose tissue sources from equines","volume":"37","author":"Arevalo-Turrubiarte","year":"2019","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0030","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13287-016-0352-x","article-title":"Platelet lysate as a substitute for animal serum for the ex-vivo expansion of mesenchymal stem\/stromal cells: present and future","volume":"7","author":"Astori","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0035","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/glia.20841","article-title":"Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis","volume":"57","author":"Bai","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.ejcb.2020.151097_bib0040","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/glia.20841","article-title":"Human bone marrow\u2010derived mesenchymal stem cells induce Th2\u2010polarized immune response and promote endogenous repair in animal models of multiple sclerosis","volume":"57","author":"Bai","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.ejcb.2020.151097_bib0045","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nn.3109","article-title":"Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models","volume":"15","author":"Bai","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0050","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.npep.2019.04.001","article-title":"Effect of mesenchymal stem cells on glial cells population in cuprizone induced demyelination model","volume":"75","author":"Barati","year":"2019","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejcb.2020.151097_bib0055","doi-asserted-by":"crossref","first-page":"13952","DOI":"10.1002\/jcb.28670","article-title":"Mesenchymal stem cell mediated effects on microglial phenotype in cuprizone-induced demyelination model","volume":"120","author":"Barati","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejcb.2020.151097_bib0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12031-009-9302-8","article-title":"Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis","volume":"41","author":"Barhum","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12031-009-9302-8","article-title":"Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis","volume":"41","author":"Barhum","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0070","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.euroneuro.2013.03.007","article-title":"Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?","volume":"25","author":"Bayer","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0075","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2008.03.002","article-title":"Mesenchymal stem cells: revisiting history, concepts, and assays","volume":"2","author":"Bianco","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2020.151097_bib0080","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1634\/stemcells.22-4-625","article-title":"Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood","volume":"22","author":"Bieback","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0085","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.jcyt.2014.02.003","article-title":"Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis","volume":"16","author":"Boido","year":"2014","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0090","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.jcyt.2014.02.003","article-title":"Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis","volume":"16","author":"Boido","year":"2014","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0095","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2174\/157488812804484648","article-title":"Autologous mesenchymal stem cell therapy in progressive multiple sclerosis: an open label study","volume":"7","author":"Bonab","year":"2012","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jcyt.2017.09.011","article-title":"PARKIN overexpression in human mesenchymal stromal cells from Wharton\u2019s jelly suppresses 6-hydroxydopamine-induced apoptosis: potential therapeutic strategy in Parkinson\u2019s disease","volume":"20","author":"Bonilla-Porras","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbr.2015.10.001","article-title":"Social cognition in Huntington\u2019s disease: a meta-analysis","volume":"297","author":"Bora","year":"2016","journal-title":"Behav. Brain Res. SreeTestContent1"},{"key":"10.1016\/j.ejcb.2020.151097_bib0110","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.expneurol.2008.04.030","article-title":"In vitro evidence for impaired neuroprotective capacities of adult mesenchymal stem cells derived from a rat model of familial amyotrophic lateral sclerosis (hSOD1(G93A))","volume":"212","author":"Boucherie","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0115","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/jnr.22038","article-title":"Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis","volume":"87","author":"Boucherie","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13287-016-0304-5","article-title":"Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis","volume":"7","author":"Bravo","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0125","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.imlet.2015.06.007","article-title":"The secretome of mesenchymal stromal cells: role of extracellular vesicles in immunomodulation","volume":"168","author":"Bruno","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ejcb.2020.151097_bib0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.tvjl.2012.06.004","article-title":"Growth and differentiation characteristics of equine mesenchymal stromal cells derived from different sources","volume":"195","author":"Burk","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.ejcb.2020.151097_bib0135","doi-asserted-by":"crossref","first-page":"492a","DOI":"10.1016\/j.bpj.2019.11.2725","article-title":"Quantifying the thermodynamic stability of amyloid fibrils","volume":"118","author":"Callaghan","year":"2020","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejcb.2020.151097_bib0140","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/sj.bmt.1705798","article-title":"Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts","volume":"40","author":"Capelli","year":"2007","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0145","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.7150\/ijms.8182","article-title":"Opposite effects of bone marrow-derived cells transplantation in MPTP-rat model of Parkinson\u2019s disease: a comparison study of mononuclear and mesenchymal stem cells","volume":"11","author":"Capitelli","year":"2014","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0150","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.exphem.2008.03.012","article-title":"Optimization of mesenchymal stem cell expansion procedures by cell separation and culture conditions modification","volume":"36","author":"Carrancio","year":"2008","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0155","first-page":"10","article-title":"Immunomodulatory effect of MSC on B cells is independent of secreted extracellular vesicles","author":"Carreras-Planella","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0160","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2105607","article-title":"Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view","volume":"2019","author":"Cenini","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejcb.2020.151097_bib0165","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.5966\/sctm.2015-0023","article-title":"Intracarotid infusion of mesenchymal stem cells in an animal model of Parkinson\u2019s disease, focusing on cell distribution and neuroprotective and behavioral effects","volume":"4","author":"Cerri","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1755-8794-4-65","article-title":"MicroRNA-34a modulates genes involved in cellular motility and oxidative phosphorylation in neural precursors derived from human umbilical cord mesenchymal stem cells","volume":"4","author":"Chang","year":"2011","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.ejcb.2020.151097_bib0175","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1423-0127-18-54","article-title":"Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells","volume":"18","author":"Chang","year":"2011","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0180","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000355261","article-title":"The therapeutic effects of human adipose-derived stem cells in Alzheimer\u2019s disease mouse models","volume":"13","author":"Chang","year":"2014","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib0185","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3727\/096368912X637019","article-title":"Neural induction with neurogenin 1 enhances the therapeutic potential of mesenchymal stem cells in an amyotrophic lateral sclerosis mouse model","volume":"22","author":"Chan-Il","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0190","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3727\/096368912X637019","article-title":"Neural induction with neurogenin 1 enhances the therapeutic potential of mesenchymal stem cells in an amyotrophic lateral sclerosis mouse model","volume":"22","author":"Chan-Il","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneuroim.2009.09.003","article-title":"Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson\u2019s disease","volume":"216","author":"Chao","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0200","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/scrt8","article-title":"A novel serum-free medium for the expansion of human mesenchymal stem cells","volume":"1","author":"Chase","year":"2010","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0205","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1166\/jnn.2014.9126","article-title":"Mesenchymal stem cell therapy for neurodegenerative diseases","volume":"14","author":"Chen","year":"2014","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0210","article-title":"Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2020.151097_bib0215","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1189\/jlb.3A0513-242R","article-title":"Induction of immunomodulatory monocytes by human mesenchymal stem cell\u2010derived hepatocyte growth factor through ERK1\/2","volume":"96","author":"Chen","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0220","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nm.3831","article-title":"Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection","volume":"21","author":"Chen","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0225","first-page":"5","article-title":"Metals and neurodegeneration","author":"Chen","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.ejcb.2020.151097_bib0230","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/jnr.23879","article-title":"Therapeutic effects of intranigral transplantation of mesenchymal stem cells in rat models of Parkinson\u2019s disease","volume":"95","author":"Chen","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0235","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.biomaterials.2009.09.043","article-title":"Osteoblastic differentiation of human mesenchymal stem cells with platelet lysate","volume":"31","author":"Chevallier","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejcb.2020.151097_bib0240","doi-asserted-by":"crossref","first-page":"87s","DOI":"10.1177\/0963689719891134","article-title":"The effect of human umbilical cord mesenchymal stromal cells in protection of dopaminergic neurons from apoptosis by reducing oxidative stress in the early stage of a 6-OHDA-induced Parkinson\u2019s disease model","volume":"28","author":"Chi","year":"2019","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0245","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejpb.2017.09.014","article-title":"Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson\u2019s disease related toxin 6-hydroxydopamine","volume":"121","author":"Chierchia","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejcb.2020.151097_bib0250","first-page":"8","article-title":"Placental mesenchymal stem cell-derived extracellular vesicles promote myelin regeneration in an animal model of multiple sclerosis","author":"Clark","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0255","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3727\/096368912X657404","article-title":"Mesenchymal stem cells expressing vasoactive intestinal peptide ameliorate symptoms in a model of chronic multiple sclerosis","volume":"22","author":"Cobo","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0260","series-title":"Calcium Signaling in Aging and Neurodegenerative Diseases 2019","author":"Cortes","year":"2020"},{"key":"10.1016\/j.ejcb.2020.151097_bib0265","article-title":"Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils","author":"Cruz","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.ejcb.2020.151097_bib0270","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbr.2016.12.021","article-title":"Human umbilical cord mesenchymal stem cells transplantation improves cognitive function in Alzheimer\u2019s disease mice by decreasing oxidative stress and promoting hippocampal neurogenesis","volume":"320","author":"Cui","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0275","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbr.2016.12.021","article-title":"Human umbilical cord mesenchymal stem cells transplantation improves cognitive function in Alzheimer\u2019s disease mice by decreasing oxidative stress and promoting hippocampal neurogenesis","volume":"320","author":"Cui","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0280","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijdevneu.2017.01.003","article-title":"Stem cells for ALS: an overview of possible therapeutic approaches","volume":"57","author":"Czarzasta","year":"2017","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0285","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/cns.12759","article-title":"Mesenchymal stem cells and conditioned media in the treatment of multiple sclerosis patients: Clinical, ophthalmological and radiological assessments of safety and efficacy","volume":"23","author":"Dahbour","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0290","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P","article-title":"Multipotent mesenchymal stem cells from adult human synovial membrane","volume":"44","author":"De Bari","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejcb.2020.151097_bib0295","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbr.2010.05.023","article-title":"Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington\u2019s disease","volume":"214","author":"Dey","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0300","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s11064-018-2641-5","article-title":"Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer\u2019s Disease","volume":"43","author":"Ding","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0305","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.3727\/096368914X685104","article-title":"Human Wharton\u2019s jelly-derived stem cells display immunomodulatory properties and transiently improve rat experimental autoimmune encephalomyelitis","volume":"24","author":"Donders","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0310","first-page":"24","article-title":"Mesenchymal stem cells in multiple sclerosis-translation to clinical trials","volume":"8","author":"Dulamea","year":"2015","journal-title":"J. Med. Life"},{"key":"10.1016\/j.ejcb.2020.151097_bib0315","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13287-017-0567-5","article-title":"Alzheimer\u2019s disease, dementia, and stem cell therapy","volume":"8","author":"Duncan","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0320","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12640-018-9884-4","article-title":"Human umbilical cord matrix stem cells reverse oxidative stress-induced cell death and ameliorate motor function and striatal atrophy in rat model of Huntington disease","volume":"34","author":"Ebrahimi","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0325","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.aanat.2014.12.002","article-title":"Beneficial effects of bone marrow-derived mesenchymal stem cell transplantation in a non-immune model of demyelination","volume":"198","author":"El-Akabawy","year":"2015","journal-title":"Ann. Anat."},{"key":"10.1016\/j.ejcb.2020.151097_bib0330","first-page":"8","article-title":"Intracerebral injection of extracellular vesicles from mesenchymal stem cells exerts reduced abeta plaque burden in early stages of a preclinical model of Alzheimer\u2019s disease","author":"Elia","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0335","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1089\/scd.2018.0015","article-title":"Human fetal liver mesenchymal stem cell-derived exosomes impair natural killer cell function","volume":"28","author":"Fan","year":"2019","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ejcb.2020.151097_bib0340","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12031-012-9805-6","article-title":"Transplantation of placenta-derived mesenchymal stem cells in the EAE mouse model of MS","volume":"48","author":"Fisher-Shoval","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0345","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3109\/14653249.2011.592521","article-title":"Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis","volume":"13","author":"Forostyak","year":"2011","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0350","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1002\/stem.1812","article-title":"Intrathecal delivery of mesenchymal stromal cells protects the structure of altered perineuronal nets in SOD1 rats and amends the course of ALS","volume":"32","author":"Forostyak","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0355","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/987678","article-title":"Expression of neural markers by undifferentiated mesenchymal-like stem cells from different sources","volume":"2014","author":"Foudah","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0360","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/imm.12275","article-title":"Intranasal delivery of central nervous system-retargeted human mesenchymal stromal cells prolongs treatment efficacy of experimental autoimmune encephalomyelitis","volume":"142","author":"Fransson","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.ejcb.2020.151097_bib0365","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-immunol-032712-095919","article-title":"Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine","volume":"31","author":"Frenette","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0370","doi-asserted-by":"crossref","DOI":"10.2174\/1389203721666200204122732","article-title":"Process, outcomes and possible elimination of aggregation with special reference to Heme proteins; likely remediation of proteinopathies","author":"Furkan","year":"2020","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0375","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.327","article-title":"Mesenchymal stem cells and immunomodulation: current status and future prospects","volume":"7","author":"Gao","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib0380","first-page":"6","article-title":"Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer\u2019s disease","author":"Garcia","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0385","series-title":"Mesenchymal Stem Cells, Principles of Regenerative Medicine","first-page":"205","author":"Gazit","year":"2019"},{"key":"10.1016\/j.ejcb.2020.151097_bib0390","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.12655","article-title":"Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment","volume":"23","author":"Golpich","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.05.048","article-title":"Extracellular vesicles from mesenchymal stem cells prevent contact hypersensitivity through the suppression of Tc1 and Th1 cells and expansion of regulatory T cells","volume":"74","author":"Guo","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0400","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3760\/cma.j.issn.0366-6999.20120064","article-title":"Human adipose-derived mesenchymal stem cells: a better cell source for nervous system regeneration","volume":"127","author":"Han","year":"2014","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.ejcb.2020.151097_bib0405","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fnins.2018.00333","article-title":"MicroRNA Let-7f-5p promotes bone marrow mesenchymal stem cells survival by targeting Caspase-3 in Alzheimer disease model","volume":"12","author":"Han","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0410","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jns.2011.08.036","article-title":"Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis","volume":"313","author":"Harris","year":"2012","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0415","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/term.2677","article-title":"Advances in osteobiologic materials for bone substitutes","volume":"12","author":"Hasan","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0420","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.expneurol.2009.11.019","article-title":"Neurodegeneration in autoimmune CNS inflammation","volume":"225","author":"Herz","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0425","first-page":"705","article-title":"The effects of hyperthermia on the immunomodulatory properties of human umbilical cord vein mesenchymal stem cells (MSCs)","volume":"33","author":"Hesami","year":"2017","journal-title":"Int. J. Hyperth."},{"key":"10.1016\/j.ejcb.2020.151097_bib0430","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neuroscience.2015.07.014","article-title":"GDNF-secreting mesenchymal stem cells provide localized neuroprotection in an inflammation-driven rat model of Parkinson\u2019s disease","volume":"303","author":"Hoban","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejcb.2020.151097_bib0435","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neuroscience.2015.07.014","article-title":"GDNF-secreting mesenchymal stem cells provide localized neuroprotection in an inflammation-driven rat model of Parkinson\u2019s disease","volume":"303","author":"Hoban","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejcb.2020.151097_bib0440","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/01.moh.0000245697.54887.6f","article-title":"Mesenchymal stromal cells","volume":"13","author":"Horwitz","year":"2006","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0445","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jneuroim.2014.06.001","article-title":"Interferon beta-secreting mesenchymal stem cells combined with minocycline attenuate experimental autoimmune encephalomyelitis","volume":"274","author":"Hou","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0450","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jneuroim.2014.06.001","article-title":"Interferon \u03b2-secreting mesenchymal stem cells combined with minocycline attenuate experimental autoimmune encephalomyelitis","volume":"274","author":"Hou","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0455","first-page":"224","article-title":"Effects of epidermal growth factor and basic fibroblast growth factor on the proliferation and osteogenic and neural differentiation of adipose-derived stem cells","volume":"15","author":"Hu","year":"2013","journal-title":"Cell. Reprogram. (Formerly\u201c Cloning and Stem Cells\u201d)"},{"key":"10.1016\/j.ejcb.2020.151097_bib0460","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/951512","article-title":"Mesenchymal stem cells for regenerative therapy: optimization of cell preparation protocols","volume":"2014","author":"Ikebe","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.ejcb.2020.151097_bib0465","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/01616412.2016.1139292","article-title":"Mesenchymal stem cell therapy for the streptozotocin-induced neurodegeneration in rats","volume":"38","author":"Isik","year":"2016","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0470","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1517\/14712591003610606","article-title":"Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells","volume":"10","author":"Jackson","year":"2010","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0475","first-page":"1","article-title":"The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations","volume":"110C","author":"Jellinger","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0480","doi-asserted-by":"crossref","first-page":"17986","DOI":"10.3390\/ijms140917986","article-title":"Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy","volume":"14","author":"Jin","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0485","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/term.504","article-title":"Transplantation of porcine umbilical cord matrix mesenchymal stem cells in a mouse model of Parkinson\u2019s disease","volume":"7","author":"Kang","year":"2013","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0490","first-page":"789","article-title":"17\u03b2-Estradiol enhances the efficacy of adipose-derived mesenchymal stem cells on remyelination in mouse model of multiple sclerosis","author":"Kashani","year":"2012","journal-title":"Acta Med. Iran."},{"key":"10.1016\/j.ejcb.2020.151097_bib0495","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/08820139.2017.1391841","article-title":"Nicotine augments the beneficial effects of mesenchymal stem cell-based therapy in rat model of multiple sclerosis","volume":"47","author":"Khezri","year":"2018","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.ejcb.2020.151097_bib0500","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/jnr.22054","article-title":"Stem cell\u2010based cell therapy in neurological diseases: a review","volume":"87","author":"Kim","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0505","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/glia.20731","article-title":"Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action","volume":"57","author":"Kim","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.ejcb.2020.151097_bib0510","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3727\/096368913X673450","article-title":"Transplantation of human adipose tissue-derived stem cells delays clinical onset and prolongs life span in ALS mouse model","volume":"23","author":"Kim","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0515","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1089\/scd.2014.0487","article-title":"GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer\u2019s disease model","volume":"24","author":"Kim","year":"2015","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ejcb.2020.151097_bib0520","first-page":"95","article-title":"Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer\u2019s disease dementia: a phase 1 clinical trial","volume":"1","author":"Kim","year":"2015","journal-title":"Alzheimer\u2019s & Dementia: Translational Research & Clinical Interventions"},{"key":"10.1016\/j.ejcb.2020.151097_bib0525","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bbrc.2018.09.012","article-title":"Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer\u2019s disease","volume":"504","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejcb.2020.151097_bib0530","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1177\/0963689718766324","article-title":"Dual effects of human placenta-derived neural cells on neuroprotection and the inhibition of neuroinflammation in a rodent model of parkinson\u2019s disease","volume":"27","author":"Kim","year":"2018","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0535","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2017.11.010","article-title":"Effective combination of methylprednisolone and interferon \u03b2-secreting mesenchymal stem cells in a model of multiple sclerosis","volume":"314","author":"Kim","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0540","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/14653240903080367","article-title":"Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration","volume":"11","author":"Kode","year":"2009","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0545","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202590","article-title":"Therapeutic potential of extracellular vesicles derived from human mesenchymal stem cells in a model of progressive multiple sclerosis","volume":"13","author":"Laso-Garcia","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2020.151097_bib0550","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000080341","article-title":"Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue","volume":"14","author":"Lee","year":"2004","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejcb.2020.151097_bib0555","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neulet.2008.11.059","article-title":"Bone marrow-derived mesenchymal stem cells reduce brain amyloid-\u03b2 deposition and accelerate the activation of microglia in an acutely induced Alzheimer\u2019s disease mouse model","volume":"450","author":"Lee","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejcb.2020.151097_bib0560","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2174\/156720510792231739","article-title":"Bone marrow-derived mesenchymal stem cells attenuate amyloid beta-induced memory impairment and apoptosis by inhibiting neuronal cell death","volume":"7","author":"Lee","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0565","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/stem.277","article-title":"Intracerebral transplantation of bone marrow\u2010derived mesenchymal stem cells reduces amyloid\u2010beta deposition and rescues memory deficits in Alzheimer\u2019s disease mice by modulation of immune responses","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0570","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neurobiolaging.2010.03.024","article-title":"Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer\u2019s disease mouse model through modulation of neuroinflammation","volume":"33","author":"Lee","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejcb.2020.151097_bib0575","doi-asserted-by":"crossref","first-page":"39340","DOI":"10.1038\/srep39340","article-title":"Agouti related peptide secreted via human mesenchymal stem cells upregulates proteasome activity in an Alzheimer\u2019s disease model","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejcb.2020.151097_bib0580","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0304-3940(01)02384-9","article-title":"Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease","volume":"316","author":"Li","year":"2001","journal-title":"Neurosci. Lett."},{"issue":"Suppl 1","key":"10.1016\/j.ejcb.2020.151097_bib0585","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.3727\/096368914X685005","article-title":"The potential of human umbilical cord-derived mesenchymal stem cells as a novel cellular therapy for multiple sclerosis","volume":"23","author":"Li","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0590","article-title":"Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington\u2019s disease mouse models","volume":"6","author":"Lin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2020.151097_bib0595","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000430356","article-title":"Therapeutic effects of transplantation of As-MiR-937-Expressing mesenchymal stem cells in murine model of Alzheimer\u2019s disease","volume":"37","author":"Liu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejcb.2020.151097_bib0600","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s10616-017-0175-3","article-title":"Human peripheral blood-derived mesenchymal stem cells with NTRK1 over-expression enhance repairing capability in a rat model of Parkinson\u2019s disease","volume":"70","author":"Liu","year":"2018","journal-title":"Cytotechnology"},{"key":"10.1016\/j.ejcb.2020.151097_bib0605","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1002\/jcp.26192","article-title":"Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases","volume":"233","author":"Lo Furno","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0610","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresprot.2005.03.002","article-title":"Therapeutic benefit of TH-engineered mesenchymal stem cells for Parkinson\u2019s disease","volume":"15","author":"Lu","year":"2005","journal-title":"Brain Res. Protoc."},{"key":"10.1016\/j.ejcb.2020.151097_bib0615","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9628536","article-title":"Challenges and controversies in human mesenchymal stem cell therapy","volume":"2019","author":"Lukomska","year":"2019","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ejcb.2020.151097_bib0620","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/scrt216","article-title":"Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells","volume":"4","author":"Luz-Crawford","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0625","doi-asserted-by":"crossref","DOI":"10.1039\/C9TB02669J","article-title":"Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases","author":"Ma","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejcb.2020.151097_bib0630","first-page":"31","article-title":"The neuroprotective effect of mesenchymal stem cells on an experimentally induced model for multiple sclerosis in mice","author":"Mahfouz","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0635","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-60761-999-4_14","article-title":"Dynamic expansion culture for mesenchymal stem cells","volume":"698","author":"Majd","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0640","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.semcdb.2019.06.003","article-title":"ALS and FTD: Where RNA metabolism meets protein quality control","author":"Mandrioli","year":"2020","journal-title":"In Semin Cell Dev Biol"},{"key":"10.1016\/j.ejcb.2020.151097_bib0645","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuroscience.2013.05.034","article-title":"Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model","volume":"248","author":"Marconi","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejcb.2020.151097_bib0650","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/bph.13674","article-title":"Gene therapy with mesenchymal stem cells expressing IFN-ss ameliorates neuroinflammation in experimental models of multiple sclerosis","volume":"174","author":"Marin-Banasco","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0655","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1021\/acs.chemrev.8b00532","article-title":"Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis","volume":"119","author":"Marinko","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejcb.2020.151097_bib0660","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.28152","article-title":"Epigenetic mechanisms are behind the regulation of the key genes associated with the osteoblastic differentiation of the mesenchymal stem cells: The role of zoledronic acid on tuning the epigenetic changes","author":"Marofi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0665","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/jcp.27152","article-title":"Mesenchymal stem cells as the game\u2010changing tools in the treatment of various organs disorders: mirage or reality?","volume":"234","author":"Marofi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0670","doi-asserted-by":"crossref","first-page":"312","DOI":"10.29252\/ibj.22.5.312","article-title":"Effect of multiple intraperitoneal injections of human bone marrow mesenchymal stem cells on cuprizone model of multiple sclerosis","volume":"22","author":"Marzban","year":"2018","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.ejcb.2020.151097_bib0675","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12311-013-0536-1","article-title":"Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 1","volume":"13","author":"Matsuura","year":"2014","journal-title":"Cerebellum"},{"key":"10.1016\/j.ejcb.2020.151097_bib0680","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jneuroim.2008.05.006","article-title":"Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment","volume":"199","author":"Mazzanti","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0685","series-title":"Transplantation of Mesenchymal Stem Cells in ALS, Progress in Brain Research","first-page":"333","author":"Mazzini","year":"2012"},{"key":"10.1016\/j.ejcb.2020.151097_bib0690","first-page":"459","article-title":"Stem cell therapy for Alzheimer\u2019s disease","volume":"10","author":"ME Abdel-Salam","year":"2011","journal-title":"CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders)"},{"key":"10.1016\/j.ejcb.2020.151097_bib0695","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0700","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fbioe.2019.00294","article-title":"Bone marrow mesenchymal stem cells\u2019 secretome exerts neuroprotective effects in a Parkinson\u2019s disease rat model","volume":"7","author":"Mendes-Pinheiro","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0705","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1479-5876-5-57","article-title":"Endometrial regenerative cells: a novel stem cell population","volume":"5","author":"Meng","year":"2007","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0710","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jnr.23698","article-title":"Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice","volume":"94","author":"Mieda","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0715","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2217\/rme-2016-0032","article-title":"Effect of mesenchymal stem cells and galantamine nanoparticles in rat model of Alzheimer\u2019s disease","volume":"11","author":"Misra","year":"2016","journal-title":"Regen. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0720","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/1574888X13666180723111249","article-title":"Intrahippocampal transplantation of undifferentiated human chorionic- derived mesenchymal stem cells does not improve learning and memory in the rat model of sporadic Alzheimer disease","volume":"14","author":"Mohammadi","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0725","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.clim.2016.06.015","article-title":"Evaluation of AD-MSC (adipose-derived mesenchymal stem cells) as a vehicle for IFN-beta delivery in experimental autoimmune encephalomyelitis","volume":"169","author":"Mohammadzadeh","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0730","first-page":"50","article-title":"Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study","volume":"4","author":"Mohyeddin Bonab","year":"2007","journal-title":"Iran. J. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0735","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.msec.2017.02.178","article-title":"Combining NT3-overexpressing MSCs and PLGA microcarriers for brain tissue engineering: a potential tool for treatment of Parkinson\u2019s disease","volume":"76","author":"Moradian","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ejcb.2020.151097_bib0740","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s11011-019-00421-4","article-title":"Melatonin-pretreated adipose-derived mesenchymal stem cells efficeintly improved learning, memory, and cognition in an animal model of Alzheimer\u2019s disease","volume":"34","author":"Nasiri","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib0745","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/stem.3151","article-title":"Effects of mesenchymal stromal cells on regulatory T cells: current understanding and clinical relevance","volume":"38","author":"Negi","year":"2020","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0750","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.3390\/ijms20102406","article-title":"Genetic stability of mesenchymal stromal cells for regenerative medicine applications: a fundamental biosafety aspect","volume":"20","author":"Neri","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0755","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-6147(03)00028-2","article-title":"Immunomodulation in multiple sclerosis: from immunosuppression to neuroprotection","volume":"24","author":"Neuhaus","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"issue":"Supplementum","key":"10.1016\/j.ejcb.2020.151097_bib0760","first-page":"133","article-title":"Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson\u2019s disease","author":"Offen","year":"2007","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejcb.2020.151097_bib0765","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3727\/096368914X679237","article-title":"Mesenchymal stem cells increase hippocampal neurogenesis and neuronal differentiation by enhancing the wnt signaling pathway in an Alzheimer\u2019s disease model","volume":"24","author":"Oh","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0770","doi-asserted-by":"crossref","first-page":"949","DOI":"10.5966\/sctm.2016-0111","article-title":"The cleavage effect of mesenchymal stem cell and its derived matrix Metalloproteinase-2 on extracellular alpha-synuclein aggregates in parkinsonian models","volume":"6","author":"Oh","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0775","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/stem.2650","article-title":"Mesenchymal stem cells stabilize axonal transports for autophagic clearance of alpha-synuclein in parkinsonian models","volume":"35","author":"Oh","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0780","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.neurobiolaging.2014.01.028","article-title":"Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model","volume":"35","author":"Park","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejcb.2020.151097_bib0785","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/01.tp.0000173794.72151.88","article-title":"Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp","volume":"80","author":"Pierdomenico","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.ejcb.2020.151097_bib0790","series-title":"The Impact of Post Translational Modification on the Aggregation of the \u00df-amyloid Peptide in the Presence or Absence of Lipids","author":"Pilkington","year":"2019"},{"key":"10.1016\/j.ejcb.2020.151097_bib0795","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/mt.2016.12","article-title":"Human mesenchymal stem cells genetically engineered to overexpress brain-derived neurotrophic factor improve outcomes in Huntington\u2019s disease mouse models","volume":"24","author":"Pollock","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0800","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/S0020-1383(08)70006-8","article-title":"Mesenchymal stem cell tissue engineering: techniques for isolation, expansion and application","volume":"38","author":"Pountos","year":"2007","journal-title":"Injury"},{"key":"10.1016\/j.ejcb.2020.151097_bib0805","first-page":"12","article-title":"Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis","author":"Prasad","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0810","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/cell.2017.0012","article-title":"Prolonged expansion induces spontaneous neural progenitor differentiation from human gingiva-derived mesenchymal stem cells","volume":"19","author":"Rajan","year":"2017","journal-title":"Cell. Reprogram."},{"key":"10.1016\/j.ejcb.2020.151097_bib0815","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/cns.12844","article-title":"Disrupted striatal neuron inputs and outputs in Huntington\u2019s disease","volume":"24","author":"Reiner","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0820","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","article-title":"Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide","volume":"2","author":"Ren","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2020.151097_bib0825","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10616-009-9183-2","article-title":"Characterization of human skin-derived mesenchymal stem cell proliferation rate in different growth conditions","volume":"58","author":"Riekstina","year":"2008","journal-title":"Cytotechnology"},{"key":"10.1016\/j.ejcb.2020.151097_bib0830","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jcyt.2019.03.001","article-title":"Translation of a standardized manufacturing protocol for mesenchymal stromal cells: a systematic comparison of validation and manufacturing data","volume":"21","author":"Rojewski","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0835","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/stem.1508","article-title":"Transplants of adult mesenchymal and neural stem cells provide neuroprotection and behavioral sparing in a transgenic rat model of Huntington\u2019s disease","volume":"32","author":"Rossignol","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib0840","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/scrt545","article-title":"Reductions in behavioral deficits and neuropathology in the R6\/2 mouse model of Huntington\u2019s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number","volume":"6","author":"Rossignol","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0845","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/ijms17020152","article-title":"Mesenchymal stem cells preserve working memory in the 3xTg-AD mouse model of Alzheimer\u2019s disease","volume":"17","author":"Ruzicka","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0850","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ncl.2015.07.012","article-title":"Neuropathology of amyotrophic lateral sclerosis and its variants","volume":"33","author":"Saberi","year":"2015","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.ejcb.2020.151097_bib0855","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000369101","article-title":"Amyloid-beta: a crucial factor in Alzheimer\u2019s disease","volume":"24","author":"Sadigh-Eteghad","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.ejcb.2020.151097_bib0860","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13287-019-1156-6","article-title":"Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors","volume":"10","author":"Salda\u00f1a","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0865","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1182\/blood-2006-02-002246","article-title":"Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells","volume":"109","author":"Sato","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ejcb.2020.151097_bib0870","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1089\/10430349950016870","article-title":"Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease","volume":"10","author":"Schwarz","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0875","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.jcyt.2016.06.002","article-title":"Neuroprotective effects of placenta-derived mesenchymal stromal cells in a rat model of experimental autoimmune encephalomyelitis","volume":"18","author":"Selim","year":"2016","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0880","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10072-010-0385-3","article-title":"The effect of lentivirus-mediated TH and GDNF genetic engineering mesenchymal stem cells on Parkinson\u2019s disease rat model","volume":"32","author":"Shi","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0885","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4161\/auto.26508","article-title":"Mesenchymal stem cells enhance autophagy and increase \u03b2-amyloid clearance in Alzheimer disease models","volume":"10","author":"Shin","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.ejcb.2020.151097_bib0890","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.scr.2017.11.005","article-title":"Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of SOD1G93A mice","volume":"25","author":"Sironi","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0895","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1471-4159.2006.04212.x","article-title":"Alois Alzheimer and Alzheimer\u2019s disease: a centennial perspective","volume":"99","author":"Small","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejcb.2020.151097_bib0900","doi-asserted-by":"crossref","first-page":"e9347","DOI":"10.1371\/journal.pone.0009347","article-title":"Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington\u2019s disease","volume":"5","author":"Snyder","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2020.151097_bib0905","first-page":"5","article-title":"Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington\u2019s disease","author":"Snyder","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2020.151097_bib0910","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020420","article-title":"Astrogliosis","volume":"7","author":"Sofroniew","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0915","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.bbmt.2010.06.006","article-title":"Intranigral transplantation of epigenetically induced BDNF-Secreting human mesenchymal stem cells: implications for cell-based therapies in parkinson\u2019s disease","volume":"16","author":"Somoza","year":"2010","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.ejcb.2020.151097_bib0920","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13287-018-0841-1","article-title":"TSG-6 released from intraperitoneally injected canine adipose tissue-derived mesenchymal stem cells ameliorate inflammatory bowel disease by inducing M2 macrophage switch in mice","volume":"9","author":"Song","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0925","series-title":"Neurodegeneration During Aging: The Role of Oxidative Stress Through Epigenetic Modifications, Models, Molecules and Mechanisms in Biogerontology","first-page":"43","author":"Srivas","year":"2019"},{"key":"10.1016\/j.ejcb.2020.151097_bib0930","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1089\/scd.2011.0137","article-title":"Mesenchymal stem cells prime proliferating adult neural progenitors toward an oligodendrocyte fate","volume":"21","author":"Steffenhagen","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ejcb.2020.151097_bib0935","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00293","article-title":"Motor neurons and the generation of spinal motor neuron diversity","volume":"8","author":"Stifani","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib0940","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00441-014-1903-z","article-title":"Multiple systemic transplantations of human amniotic mesenchymal stem cells exert therapeutic effects in an ALS mouse model","volume":"357","author":"Sun","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0945","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neulet.2014.10.039","article-title":"Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats","volume":"584","author":"Suzuki","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejcb.2020.151097_bib0950","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2174\/1574888X09666140923101110","article-title":"Mesenchymal stem cells: potential in treatment of neurodegenerative diseases","volume":"9","author":"Tanna","year":"2014","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.ejcb.2020.151097_bib0955","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson\u2019s disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib0960","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.29803","article-title":"Mesenchymal stromal cells; a new horizon in regenerative medicine","author":"Tavakoli","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0965","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2016.09.012","article-title":"The effect of transplanted human Wharton\u2019s jelly mesenchymal stem cells treated with IFN-gamma on experimental autoimmune encephalomyelitis mice","volume":"311","author":"Torkaman","year":"2017","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib0970","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2756068","article-title":"It is all about (U)biquitin: role of altered ubiquitin-proteasome system and UCHL1 in Alzheimer disease","volume":"2016","author":"Tramutola","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejcb.2020.151097_bib0975","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4103\/1673-5374.156953","article-title":"The therapeutic potential of mesenchymal stem cells in Alzheimer\u2019s disease: converging mechanisms","volume":"10","author":"Turgeman","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib0980","doi-asserted-by":"crossref","first-page":"794","DOI":"10.2119\/molmed.2011.00498","article-title":"Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis","volume":"18","author":"Uccelli","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0985","doi-asserted-by":"crossref","first-page":"794","DOI":"10.2119\/molmed.2011.00498","article-title":"Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis","volume":"18","author":"Uccelli","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib0990","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213032","article-title":"Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: an approach for their use in neural regeneration therapies","volume":"14","author":"Urrutia","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2020.151097_bib0995","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.trsl.2009.07.006","article-title":"Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson\u2019s disease","volume":"155","author":"Venkataramana","year":"2010","journal-title":"Transl. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib1000","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/931902","article-title":"Bilateral transplantation of allogenic adult human bone marrow-derived mesenchymal stem cells into the subventricular zone of Parkinson\u2019s disease: a pilot clinical study","volume":"2012","author":"Venkataramana","year":"2012","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ejcb.2020.151097_bib1005","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.nbd.2008.05.016","article-title":"Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis","volume":"31","author":"Vercelli","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib1010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.nbd.2008.05.016","article-title":"Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis","volume":"31","author":"Vercelli","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib1015","first-page":"154","article-title":"Biological properties of mesenchymal stem cells from different sources","volume":"2","author":"Via","year":"2012","journal-title":"Muscles Ligaments Tendons J."},{"key":"10.1016\/j.ejcb.2020.151097_bib1020","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1093\/brain\/awz256","article-title":"Is cytoplasmic FUS a feature of all ALS?","volume":"142","author":"Vidal","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.ejcb.2020.151097_bib1025","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.stem.2010.11.011","article-title":"A mesoderm-derived precursor for mesenchymal stem and endothelial cells","volume":"7","author":"Vodyanik","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2020.151097_bib1030","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","article-title":"Mesenchymal stem cells in the Wharton\u2019s jelly of the human umbilical cord","volume":"22","author":"Wang","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib1035","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ni.3002","article-title":"Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications","volume":"15","author":"Wang","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib1040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/21645515.2015.1030549","article-title":"Comparative analysis of human mesenchymal stem cells from fetal-bone marrow, adipose tissue, and Warton\u2019s jelly as sources of cell immunomodulatory therapy","volume":"12","author":"Wang","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.ejcb.2020.151097_bib1045","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3233\/JAD-170848","article-title":"Mesenchymal stem cell-derived extracellular vesicles suppresses iNOS expression and ameliorates neural impairment in Alzheimer\u2019s disease mice","volume":"61","author":"Wang","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib1050","first-page":"1583","article-title":"The lentiviral-mediated Nurr1 genetic engineering mesenchymal stem cells protect dopaminergic neurons in a rat model of Parkinson\u2019s disease","volume":"10","author":"Wang","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib1055","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4636397","article-title":"Curcumin-activated mesenchymal stem cells derived from human umbilical cord and their effects on MPTP-Mouse model of parkinson\u2019s disease: a new biological therapy for parkinson\u2019s disease","volume":"2020","author":"Wang","year":"2020","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ejcb.2020.151097_bib1060","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s12195-019-00588-x","article-title":"Examination of hydrogels and mesenchymal stem cell sources for bioprinting of artificial osteogenic tissues","volume":"12","author":"Wehrle","year":"2019","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.ejcb.2020.151097_bib1065","first-page":"10","article-title":"Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs","author":"Weiss","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib1070","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10238-015-0375-0","article-title":"Wharton\u2019s Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-beta deposition in an APP\/PS1 transgenic mouse model","volume":"16","author":"Xie","year":"2016","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib1075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jneuroim.2010.07.013","article-title":"Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study","volume":"227","author":"Yamout","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ejcb.2020.151097_bib1080","article-title":"Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AbetaPPswe\/PS1dE9 transgenic mice","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2020.151097_bib1085","doi-asserted-by":"crossref","first-page":"72537","DOI":"10.18632\/oncotarget.12345","article-title":"Umbilical cord-derived mesenchymal stem cells reversed the suppressive deficiency of T regulatory cells from peripheral blood of patients with multiple sclerosis in a co-culture - a preliminary study","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejcb.2020.151097_bib1090","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.29800","article-title":"Induced pluripotent stem cells (iPSCs) as game-changing tools in the treatment of neurodegenerative disease: mirage or reality?","author":"Yousefi","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejcb.2020.151097_bib1095","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s12031-016-0819-3","article-title":"Synergistic and superimposed effect of bone marrow-derived mesenchymal stem cells combined with fasudil in experimental autoimmune encephalomyelitis","volume":"60","author":"Yu","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib1100","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.490","article-title":"Placenta-derived mesenchymal stem cells improve memory dysfunction in an A\u03b21\u201342-infused mouse model of Alzheimer\u2019s disease","volume":"4","author":"Yun","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejcb.2020.151097_bib1105","first-page":"8","article-title":"Intranasal administration of mesenchymal stem cells ameliorates the abnormal dopamine transmission system and inflammatory reaction in the R6\/2 mouse model of huntington disease","author":"Yu-Taeger","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ejcb.2020.151097_bib1110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/14653240902806986","article-title":"Multiple administrations of human marrow stromal cells through cerebrospinal fluid prolong survival in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"11","author":"Zhang","year":"2009","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib1115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00109-019-01745-5","article-title":"Are glutamate transporters neuroprotective or neurodegenerative during cerebral ischemia?","volume":"97","author":"Zhang","year":"2019","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.ejcb.2020.151097_bib1120","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/14653240701376413","article-title":"Human mesenchymal stromal cells ameliorate the phenotype of SOD1-G93A ALS mice","volume":"9","author":"Zhao","year":"2007","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejcb.2020.151097_bib1125","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00140","article-title":"Transplantation of human menstrual blood-derived mesenchymal stem cells alleviates alzheimer\u2019s disease-like pathology in APP\/PS1 transgenic mice","volume":"11","author":"Zhao","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2020.151097_bib1130","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1007\/s11064-017-2226-8","article-title":"Amniotic mesenchymal stem cells decrease abeta deposition and improve memory in APP\/PS1 transgenic mice","volume":"42","author":"Zheng","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejcb.2020.151097_bib1135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neuroscience.2011.06.088","article-title":"Mesenchymal stem cells rescue the Alzheimer\u2019s disease cell model from cell death induced by misfolded truncated tau","volume":"193","author":"Zilka","year":"2011","journal-title":"Neuroscience"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933520300364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933520300364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:19:22Z","timestamp":1759252762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933520300364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":227,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0171933520300364"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2020.151097","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stromal cells (MSCs) for neurodegenerative disease: A promising frontier","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2020.151097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151097"}}