{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:40:50Z","timestamp":1791988850689,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2018-2022"],"award-info":[{"award-number":["2018-2022"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004769","name":"Universit\u00e0 degli Studi di Pavia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Governo Italiano Ministero dell'Istruzione dell'Universita e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ejcb.2023.151373","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T12:45:05Z","timestamp":1700743505000},"page":"151373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of heat and cold shock on epigenetics and chromatin structure"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-8262","authenticated-orcid":false,"given":"Claudio","family":"Casali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Galgano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Zannino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Siciliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Mazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Biggiogera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2023.151373_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04679-3","article-title":"HSP70-binding motifs function as protein quality control degrons","volume":"80","author":"Abildgaard","year":"2023","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41588-020-0708-0","article-title":"Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure","volume":"52","author":"Akdemir","year":"2020","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ejcb.2023.151373_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.scienta.2021.110761","article-title":"Low-temperature modified DNA methylation level, genome template stability, enzyme activity, and proline content in pepper (Capsicum annuum L.) genotypes","volume":"294","author":"Araz","year":"2022","journal-title":"Sci. Hortic."},{"key":"10.1016\/j.ejcb.2023.151373_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.926577","article-title":"Histone acetylation dynamics in repair of DNA double-strand breaks","volume":"13","author":"Aricthota","year":"2022","journal-title":"Front. Genet"},{"key":"10.1016\/j.ejcb.2023.151373_bib5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1101\/gad.334730.119","article-title":"Nuclear PARPs and genome integrity","volume":"34","author":"Azarm","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejcb.2023.151373_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0022-5320(69)80016-X","article-title":"A new staining procedure for electron microscopical cytology","volume":"27","author":"Bernhard","year":"1969","journal-title":"J. Ultra Res"},{"key":"10.1016\/j.ejcb.2023.151373_bib7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/EDE.0000000000000120","article-title":"Effects of temperature and relative humidity on DNA methylation","volume":"25","author":"Bind","year":"2014","journal-title":"Epidemiology"},{"key":"10.1016\/j.ejcb.2023.151373_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29142-6","article-title":"Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia","volume":"13","author":"Binder","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2023.151373_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/ics.12530","article-title":"A preliminary study of an alternative method for evaluating skin sensitizing potential of chemicals","volume":"41","author":"Buzzella","year":"2019","journal-title":"Int J. Cosmet. Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3390\/ijms24010153","article-title":"Oxidative stress and nuclear reprogramming: a pilot study of the effects of reactive oxygen species on architectural and epigenetic landscapes","volume":"24","author":"Casali","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib11","doi-asserted-by":"crossref","DOI":"10.4081\/ejh.2022.3409","article-title":"Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry","volume":"66","author":"Casali","year":"2022","journal-title":"Eur. J. Histochem"},{"key":"10.1016\/j.ejcb.2023.151373_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2023.151373_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2023.1136926","article-title":"Genome-wide DNA methylation and transcription analysis reveal the potential epigenetic mechanism of heat stress response in the sea cucumber Apostichopus japonicus","volume":"10","author":"Chang","year":"2023","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s13072-018-0251-8","article-title":"Histone H3 lysine K4 methylation and its role in learning and memory","volume":"12","author":"Collins","year":"2019","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.ejcb.2023.151373_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00920","article-title":"Heat-shock proteins in neuroinflammation","volume":"10","author":"Dukay","year":"2019","journal-title":"Front. Pharm."},{"key":"10.1016\/j.ejcb.2023.151373_bib16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease","volume":"20","author":"Greenberg","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24425-w","article-title":"Tissue-specific 5-hydroxymethylcytosine landscape of the human genome","volume":"12","author":"He","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2023.151373_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1217637","article-title":"Quantitative super-resolution microscopy reveals the differences in the nanoscale distribution of nuclear phosphatidylinositol 4,5-bisphosphate in human healthy skin and skin warts","volume":"11","author":"Hoboth","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1182\/blood.2019004262","article-title":"Epigenetic deregulation in myeloid malignancies","volume":"138","author":"Huang","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.ejcb.2023.151373_bib20","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04396-x","article-title":"Mechanisms that regulate the activities of TET proteins","volume":"79","author":"Joshi","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.106155","article-title":"Molecular mechanisms in governing genomic stability and tumor suppression by the SETD2 H3K36 methyltransferase","volume":"144","author":"Lam","year":"2022","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2022.106315","article-title":"Changes in epigenetic information during the occurrence and development of gastric cancer","volume":"153","author":"Li","year":"2022","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib23","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1021\/acs.accounts.1c00463","article-title":"Integrative chemical biology approaches to deciphering the histone code: a problem-driven journey","volume":"54","author":"Li","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejcb.2023.151373_bib24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.envres.2016.11.019","article-title":"Modulation of blood pressure in response to low ambient temperature: the role of DNA methylation of zinc finger genes","volume":"153","author":"Lim","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.ejcb.2023.151373_bib25","doi-asserted-by":"crossref","first-page":"14768","DOI":"10.1016\/S0021-9258(17)36691-7","article-title":"Transient cold shock induces the heat shock response upon recovery at 37 degrees C in human cells","volume":"269","author":"Liu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2023.151373_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jpy.13305","article-title":"The global dynamic of DNA methylation in response to heat stress revealed epigenetic mechanism of heat acclimation in Saccharina japonica","volume":"59","author":"Liu","year":"2023","journal-title":"J. Phycol."},{"key":"10.1016\/j.ejcb.2023.151373_bib27","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/jxb\/erw496","article-title":"Cold acclimation alters DNA methylation patterns and confers tolerance to heat and increases growth rate in Brassica rapa","volume":"68","author":"Liu","year":"2017","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.ejcb.2023.151373_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-89951-5","article-title":"Heat stress and immune response phenotype affect DNA methylation in blood mononuclear cells from Holstein dairy cows","volume":"11","author":"Livernois","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejcb.2023.151373_bib29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-4939-6788-9_18","article-title":"Fluorochromes for DNA staining and quantitation","volume":"1560","author":"Mazzini","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib30","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/icb\/icaa049","article-title":"Epigenetic responses to temperature and climate","volume":"60","author":"McCaw","year":"2020","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib31","first-page":"20171667","article-title":"Persistent and plastic effects of temperature on DNA methylation across the genome of threespine stickleback (Gasterosteus aculeatus)","volume":"284","author":"Metzger","year":"2017","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41422-021-00606-6","article-title":"Mechanisms of Polycomb group protein function in cancer","volume":"32","author":"Parreno","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.ejcb.2023.151373_bib33","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nclimate3352","article-title":"Less Than 2 \u00b0C Warming by 2100 Unlikely","volume":"7","author":"Raftery","year":"2017","journal-title":"Nat. Clim. Chang"},{"key":"10.1016\/j.ejcb.2023.151373_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-09798-2","article-title":"scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation","volume":"12","author":"Raine","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejcb.2023.151373_bib35","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","article-title":"The use of lead citrate at high pH as an electron-opaque stain in electron microscopy","volume":"17","author":"Reynolds","year":"1963","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.ejcb.2023.151373_bib37","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s00018-019-03335-7","article-title":"Tet3 regulates cellular identity and DNA methylation in neural progenitor cells","volume":"77","author":"Santiago","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/nmeth.2019","article-title":"Fiji - an Open Source platform for biological image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejcb.2023.151373_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113160","article-title":"Combinatorial epigenetic mechanisms of sulforaphane, genistein and sodium butyrate in breast cancer inhibition","volume":"416","author":"Sharma","year":"2022","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejcb.2023.151373_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25521-7","article-title":"The concurrence of DNA methylation and demethylation is associated with transcription regulation","volume":"12","author":"Shi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2023.151373_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.976862","article-title":"5-methylcytosine turnover: mechanisms and therapeutic implications in cancer","volume":"9","author":"Turpin","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejcb.2023.151373_bib42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s11010-020-03895-4","article-title":"Epigenetic memory: gene writer, eraser and homocysteine","volume":"476","author":"Tyagi","year":"2021","journal-title":"Mol. Cell Biochem"},{"key":"10.1016\/j.ejcb.2023.151373_bib43","article-title":"TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2023.151373_bib44","article-title":"Ten Years of EWAS","volume":"8","author":"Wei","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib45","article-title":"Recent advances in genetic and epigenetic modulation of animal exposure to high temperature","volume":"11","author":"Wu","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.ejcb.2023.151373_bib46","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20209653","article-title":"Single\u2010cell imaging of genome organization and dynamics","volume":"17","author":"Xie","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.ejcb.2023.151373_bib47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/brainsci12010096","article-title":"The effects of intraoperative hypothermia on postoperative cognitive function in the rat hippocampus and its possible mechanisms","volume":"12","author":"Xu","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.ejcb.2023.151373_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113840","article-title":"Environmental temperature and human epigenetic modifications: a systematic review","volume":"259","author":"Xu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ejcb.2023.151373_bib49","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.theriogenology.2022.09.027","article-title":"HSP90AA1 promotes viability and lactate production but inhibits hormone secretion of porcine immature Sertoli cells","volume":"194","author":"Yang","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.ejcb.2023.151373_bib50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/jb\/mvaa091","article-title":"The dynamics of the nuclear environment and their impact on gene function","volume":"169","author":"Zannino","year":"2021","journal-title":"J. Biochem"},{"key":"10.1016\/j.ejcb.2023.151373_bib51","doi-asserted-by":"crossref","first-page":"25151","DOI":"10.1074\/jbc.M115.662650","article-title":"The histone demethylase UTX promotes brown adipocyte thermogenic program via coordinated regulation of H3K27 demethylation and acetylation","volume":"290","author":"Zha","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.ejcb.2023.151373_bib52","first-page":"00140","article-title":"Epigenetic and transcription factors synergistically promote the high temperature response in plants","author":"Zhu","year":"2023","journal-title":"Trends Biochem Sci. S0968-0004"},{"key":"10.1016\/j.ejcb.2023.151373_bib53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2016.08.029","article-title":"Abiotic stress signaling and responses in plants","volume":"167","author":"Zhu","year":"2016","journal-title":"Cell"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933523000882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933523000882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:21:41Z","timestamp":1759252901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933523000882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0171933523000882"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2023.151373","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of heat and cold shock on epigenetics and chromatin structure","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2023.151373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151373"}}