{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:53:20Z","timestamp":1774954400356,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO 3270\/3-1"],"award-info":[{"award-number":["BO 3270\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ejcb.2023.151375","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:09:22Z","timestamp":1700305762000},"page":"151375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rel governs loser elimination during stem cell competition in the Drosophila testis"],"prefix":"10.1016","volume":"103","author":[{"given":"Silvana","family":"Hof-Michel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljubinka","family":"Cigoja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Huhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-6557","authenticated-orcid":false,"given":"Christian","family":"B\u00f6kel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2023.151375_bib1","doi-asserted-by":"crossref","DOI":"10.1242\/dev.156315","article-title":"Direct control of somatic stem cell proliferation factors by the Drosophila testis stem cell niche","author":"Albert","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2023.151375_bib2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.devcel.2018.08.001","article-title":"Spatially restricted regulation of spatzle\/toll signaling during cell competition","volume":"46","author":"Alpar","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1242\/dev.086413","article-title":"Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis","volume":"140","author":"Amoyel","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2023.151375_bib4","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.15252\/embj.201387500","article-title":"Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo","volume":"33","author":"Amoyel","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2023.151375_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005815","article-title":"Socs36E Controls niche competition by repressing MAPK signaling in the Drosophila Testis","volume":"12","author":"Amoyel","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ejcb.2023.151375_bib6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0092-8674(85)90274-0","article-title":"Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product","volume":"42","author":"Anderson","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib7","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41576-020-0262-8","article-title":"Emerging mechanisms of cell competition","volume":"21","author":"Baker","year":"2020","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.ejcb.2023.151375_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16070-6","article-title":"The NMDA receptor regulates competition of epithelial cells in the Drosophila wing","volume":"11","author":"Banreti","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2023.151375_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35954","article-title":"A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms","volume":"7","author":"Boukhatmi","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ejcb.2023.151375_bib10","doi-asserted-by":"crossref","DOI":"10.1242\/dev.167486","article-title":"Cell competition: the winners and losers of fitness selection","volume":"146","author":"Bowling","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2023.151375_bib11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1242\/dev.057901","article-title":"Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning","volume":"138","author":"Cheng","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2023.151375_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2013.09.007","article-title":"MEF2 is an in vivo immune-metabolic switch","volume":"155","author":"Clark","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1146\/annurev-biochem-062917-012341","article-title":"Defining adult stem cells by function, not by phenotype","volume":"87","author":"Clevers","year":"2018","journal-title":"Annu Rev. Biochem"},{"key":"10.1016\/j.ejcb.2023.151375_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0092-8674(04)00214-4","article-title":"Drosophila myc regulates organ size by inducing cell competition","volume":"117","author":"de la Cova","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cmet.2014.01.012","article-title":"Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability","volume":"19","author":"de la Cova","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejcb.2023.151375_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00485-9","article-title":"miR-9a modulates maintenance and ageing of Drosophila germline stem cells by limiting N-cadherin expression","volume":"8","author":"Epstein","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2023.151375_bib17","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/emboj\/17.5.1217","article-title":"A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway","volume":"17","author":"Ferrandon","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2023.151375_bib18","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri2194","article-title":"The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections","volume":"7","author":"Ferrandon","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejcb.2023.151375_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1126\/science.1140861","article-title":"Male and female Drosophila germline stem cells: two versions of immortality","volume":"316","author":"Fuller","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2023.151375_bib20","article-title":"ShinyGO: a graphical enrichment tool for animals and plants","author":"Ge","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejcb.2023.151375_bib21","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1242\/dev.122.8.2437","article-title":"The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis","volume":"122","author":"Gonczy","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2023.151375_bib22","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-5320(79)90108-4","article-title":"The germinal proliferation center in the testis of Drosophila melanogaster","volume":"69","author":"Hardy","year":"1979","journal-title":"J. Ultra Res."},{"key":"10.1016\/j.ejcb.2023.151375_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1097-2765(00)80392-5","article-title":"Relish, a central factor in the control of humoral but not cellular immunity in Drosophila","volume":"4","author":"Hedengren","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1126\/science.1176817","article-title":"JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche","volume":"326","author":"Issigonis","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2023.151375_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.stem.2007.10.021","article-title":"Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary","volume":"2","author":"Jin","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib26","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1126\/science.1066707","article-title":"Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue","volume":"294","author":"Kiger","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2023.151375_bib27","first-page":"4684","article-title":"Phosphorylation of the Smo tail is controlled by membrane localisation and is dispensable for clustering","volume":"12","author":"Kupinski","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2023.151375_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.stem.2008.05.001","article-title":"Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal","volume":"3","author":"Leatherman","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.ejcb.2023.151375_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ceb.2018.08.002","article-title":"Cell competition in development: information from flies and vertebrates","volume":"55","author":"Madan","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejcb.2023.151375_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000441","article-title":"A short receptor downregulates JAK\/STAT signalling to control the Drosophila cellular immune response","volume":"8","author":"Makki","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejcb.2023.151375_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/science.1258236","article-title":"An ancient defense system eliminates unfit cells from developing tissues during cell competition","volume":"346","author":"Meyer","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2023.151375_bib33","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1242\/dev.075242","article-title":"Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche","volume":"139","author":"Michel","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2023.151375_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0092-8674(04)00262-4","article-title":"dMyc transforms cells into super-competitors","volume":"117","author":"Moreno","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib35","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/416755a","article-title":"Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development","volume":"416","author":"Moreno","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2023.151375_bib36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.dci.2012.10.007","article-title":"Transcription factor zfh1 downregulates Drosophila Imd pathway","volume":"39","author":"Myllymaki","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ejcb.2023.151375_bib37","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1038\/emboj.2012.106","article-title":"Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells","volume":"31","author":"de Navascues","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2023.151375_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0030026","article-title":"A specific primed immune response in Drosophila is dependent on phagocytes","volume":"3","author":"Pham","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejcb.2023.151375_bib39","doi-asserted-by":"crossref","unstructured":"Pohlert, T., 2018. PMCMRplus: Calculate Pairwise Multiple Comparisons of Mean Rank Sums Extended. R package version 1.4.1.","DOI":"10.32614\/CRAN.package.PMCMRplus"},{"key":"10.1016\/j.ejcb.2023.151375_bib40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stem.2019.07.002","article-title":"Defining adult stem cell function at its simplest: the ability to replace lost cells through mitosis","volume":"25","author":"Post","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib41","doi-asserted-by":"crossref","first-page":"E3182","DOI":"10.1073\/pnas.1718646115","article-title":"Division-independent differentiation mandates proliferative competition among stem cells","volume":"115","author":"Reilein","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ejcb.2023.151375_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110774","article-title":"Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis","volume":"39","author":"Sainz de la Maza","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejcb.2023.151375_bib43","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejcb.2023.151375_bib44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0012-1606(81)90261-X","article-title":"Differential mitotic rates and patterns of growth in compartments in the Drosophila wing","volume":"85","author":"Simpson","year":"1981","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejcb.2023.151375_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10473","article-title":"The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis","volume":"7","author":"Singh","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2023.151375_bib46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cell.2010.09.016","article-title":"Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells","volume":"143","author":"Snippert","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004713","article-title":"Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis","volume":"10","author":"Stine","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ejcb.2023.151375_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000422","article-title":"Involvement of Lgl and Mahjong\/VprBP in cell competition","volume":"8","author":"Tamori","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejcb.2023.151375_bib49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.devcel.2021.12.004","article-title":"chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche","volume":"57","author":"Tseng","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejcb.2023.151375_bib50","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1126\/science.1066700","article-title":"Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling","volume":"294","author":"Tulina","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2023.151375_bib51","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.celrep.2019.06.037","article-title":"Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis","volume":"28","author":"Vara","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejcb.2023.151375_bib52","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nature07173","article-title":"Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis","volume":"454","author":"Voog","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2023.151375_bib53","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.dci.2008.12.002","article-title":"The N-terminal half of the Drosophila Rel\/NF-kappaB factor Relish, REL-68, constitutively activates transcription of specific Relish target genes","volume":"33","author":"Wiklund","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ejcb.2023.151375_bib54","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85251","article-title":"Tau polarizes an aging transcriptional signature to excitatory neurons and glia","volume":"12","author":"Wu","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.ejcb.2023.151375_bib55","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cub.2018.07.075","article-title":"Autophagy promotes tumor-like stem cell niche occupancy","volume":"28","author":"Zhao","year":"2018","journal-title":"Curr. Biol."}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933523000900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933523000900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:21:08Z","timestamp":1759252868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933523000900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0171933523000900"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2023.151375","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rel governs loser elimination during stem cell competition in the Drosophila testis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2023.151375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151375"}}