{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:06:37Z","timestamp":1775689597189,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejcb.2024.151409","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T05:17:54Z","timestamp":1711862274000},"page":"151409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cortactin interacts with \u03b1Dystrobrevin-1 and regulates murine neuromuscular junction morphology"],"prefix":"10.1016","volume":"103","author":[{"given":"Teresa","family":"De Cicco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"P\u0119zi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"W\u00f3jcicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhola Shankar","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Jab\u0142o\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Rottner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz J.","family":"Pr\u00f3szy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2024.151409_bib1","unstructured":"Abicht, A., Muller, J.S., Lochmuller, H., 1993. Congenital Myasthenic Syndromes Overview, in: Adam, M.P., Feldman, J., Mirzaa, G.M., Pagon, R.A., Wallace, S.E., Bean, L.J.H., Gripp, K.W., Amemiya, A. (Eds.), GeneReviews((R)), Seattle (WA)."},{"key":"10.1016\/j.ejcb.2024.151409_bib2","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1242\/jcs.198358","article-title":"Spatial distribution and molecular dynamics of dystrophin glycoprotein components at the neuromuscular junction in vivo","volume":"130","author":"Aittaleb","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2024.151409_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(98)00804-7","article-title":"Characterization of the tyrosine phosphorylation and distribution of dystrobrevin isoforms","volume":"432","author":"Balasubramanian","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejcb.2024.151409_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134833","article-title":"The role of the dystrophin glycoprotein complex on the neuromuscular system","volume":"722","author":"Belhasan","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejcb.2024.151409_bib5","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1038\/s41598-017-09590-7","article-title":"Liprin-alpha-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery","volume":"7","author":"Bernadzki","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejcb.2024.151409_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fnmol.2020.00104","article-title":"Arhgef5 Binds alpha-Dystrobrevin 1 and Regulates Neuromuscular Junction Integrity","volume":"13","author":"Bernadzki","year":"2020","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2024.151409_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1183101","article-title":"Duchenne muscular dystrophy: disease mechanism and therapeutic strategies","volume":"14","author":"Bez Batti Angulski","year":"2023","journal-title":"Front Physiol."},{"key":"10.1016\/j.ejcb.2024.151409_bib8","doi-asserted-by":"crossref","first-page":"7802","DOI":"10.1074\/jbc.271.13.7802","article-title":"Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein","volume":"271","author":"Blake","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2024.151409_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/BC20110018","article-title":"Agrin triggers the clustering of raft-associated acetylcholine receptors through actin cytoskeleton reorganization","volume":"103","author":"Cartaud","year":"2011","journal-title":"Biol. Cell"},{"key":"10.1016\/j.ejcb.2024.151409_bib10","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1242\/dev.053348","article-title":"Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons","volume":"137","author":"Chakkalakal","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.ejcb.2024.151409_bib11","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1083\/jcb.150.6.1321","article-title":"The actin-driven movement and formation of acetylcholine receptor clusters","volume":"150","author":"Dai","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151409_bib12","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.122.4.809","article-title":"A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin","volume":"122","author":"Ervasti","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151409_bib13","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.autrev.2014.08.039","article-title":"Cortactin autoantibodies in myasthenia gravis","volume":"13","author":"Gallardo","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejcb.2024.151409_bib14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/nyas.13500","article-title":"The molecular cross talk of the dystrophin-glycoprotein complex","volume":"1412","author":"Gawor","year":"2018","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.ejcb.2024.151409_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.181180","article-title":"Alpha-Dystrobrevin-1 recruits Grb2 and alpha-catulin to organize neurotransmitter receptors at the neuromuscular junction","author":"Gingras","year":"2016","journal-title":"J. Cell Sci. 129, 898-911"},{"key":"10.1016\/j.ejcb.2024.151409_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0896-6273(00)80894-6","article-title":"Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex","volume":"25","author":"Grady","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.ejcb.2024.151409_bib17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1083\/jcb.200209045","article-title":"Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions","volume":"160","author":"Grady","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151409_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00884","article-title":"Mechanism of synergistic activation of Arp2\/3 complex by cortactin and N-WASP","volume":"2","author":"Helgeson","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.ejcb.2024.151409_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134676","article-title":"MuSk function during health and disease","volume":"716","author":"Herbst","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejcb.2024.151409_bib20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ncl.2020.03.004","article-title":"Congenital Myasthenic Syndromes","volume":"38","author":"Iyadurai","year":"2020","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.ejcb.2024.151409_bib21","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.160240","article-title":"NMJ-morph reveals principal components of synaptic morphology influencing structure-function relationships at the neuromuscular junction","volume":"6","author":"Jones","year":"2016","journal-title":"Open Biol."},{"key":"10.1016\/j.ejcb.2024.151409_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1242\/jcs.01586","article-title":"Cortactin regulates cell migration through activation of N-WASP","volume":"118","author":"Kowalski","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2024.151409_bib23","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1091\/mbc.e08-12-1180","article-title":"Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases","volume":"20","author":"Lai","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejcb.2024.151409_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135304","article-title":"Alterations of neuromuscular junctions in Duchenne muscular dystrophy","volume":"737","author":"Lovering","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejcb.2024.151409_bib25","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/BF01187915","article-title":"Structure and function of the neuromuscular junction in young adult mdx mice","volume":"20","author":"Lyons","year":"1991","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.ejcb.2024.151409_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008478","article-title":"The function of cortactin in the clustering of acetylcholine receptors at the vertebrate neuromuscular junction","volume":"4","author":"Madhavan","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2024.151409_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2018.07.002","article-title":"Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: a mouse model for congenital myasthenia","volume":"120","author":"Magalhaes-Gomes","year":"2018","journal-title":"Neurochem Int"},{"key":"10.1016\/j.ejcb.2024.151409_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/joa.13228","article-title":"Morphological variability is greater at developing than mature mouse neuromuscular junctions","volume":"237","author":"Mech","year":"2020","journal-title":"J. Anat."},{"key":"10.1016\/j.ejcb.2024.151409_bib29","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1091\/mbc.e14-06-1174","article-title":"Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes","volume":"25","author":"Mihailovska","year":"2014","journal-title":"Mol. Biol. Cell"},{"issue":"Pt 17","key":"10.1016\/j.ejcb.2024.151409_bib30","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1242\/jcs.111.17.2595","article-title":"Characterisation of alpha-dystrobrevin in muscle","volume":"111","author":"Nawrotzki","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2024.151409_bib31","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1083\/jcb.201810023","article-title":"MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses","volume":"218","author":"Oury","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151409_bib32","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/dneu.20703","article-title":"Formation of complex AChR aggregates in vitro requires alpha-dystrobrevin","volume":"69","author":"Pawlikowski","year":"2009","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151409_bib33","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1018545827369","article-title":"Association of cortactin with developing neuromuscular specializations","volume":"26","author":"Peng","year":"1997","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.ejcb.2024.151409_bib34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1091\/mbc.e05-06-0488","article-title":"Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration","volume":"17","author":"Perrin","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejcb.2024.151409_bib35","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1038\/s41598-020-61347-x","article-title":"An improved method for culturing myotubes on laminins for the robust clustering of postsynaptic machinery","volume":"10","author":"Pezinski","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejcb.2024.151409_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222112051","article-title":"Tks5 regulates synaptic podosome formation and stabilization of the postsynaptic machinery at the neuromuscular junction","volume":"22","author":"Pezinski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2024.151409_bib37","doi-asserted-by":"crossref","first-page":"18373","DOI":"10.1073\/pnas.0910391106","article-title":"Podosomes are present in a postsynaptic apparatus and participate in its maturation","volume":"106","author":"Proszynski","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2024.151409_bib38","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.nmd.2021.07.400","article-title":"Congenital myasthenic syndromes: where do we go from here?","volume":"31","author":"Ramdas","year":"2021","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.ejcb.2024.151409_bib39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","article-title":"The interaction between N-WASP and the Arp2\/3 complex links Cdc42-dependent signals to actin assembly","volume":"97","author":"Rohatgi","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2024.151409_bib40","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1083\/jcb.201107083","article-title":"Neuregulin\/ErbB regulate neuromuscular junction development by phosphorylation of alpha-dystrobrevin","volume":"195","author":"Schmidt","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151409_bib41","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1084\/jem.20101920","article-title":"Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo","volume":"208","author":"Schnoor","year":"2011","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.ejcb.2024.151409_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tcb.2017.10.009","article-title":"Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein","volume":"28","author":"Schnoor","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151409_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2144\/000112036","article-title":"Identification of new fluorescent protein fragments for bimolecular fluorescence complementation analysis under physiological conditions","volume":"40","author":"Shyu","year":"2006","journal-title":"Biotechniques"},{"key":"10.1016\/j.ejcb.2024.151409_bib44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1749-6632.2012.06784.x","article-title":"Structure of the neuromuscular junction: function and cooperative mechanisms in the synapse","volume":"1274","author":"Takamori","year":"2012","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.ejcb.2024.151409_bib45","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/physrev.00033.2014","article-title":"Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting","volume":"95","author":"Tintignac","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejcb.2024.151409_bib46","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1093\/hmg\/ddac041","article-title":"Distinct roles of the dystrophin-glycoprotein complex: alpha-dystrobrevin and alpha-syntrophin in the maintenance of the postsynaptic apparatus of the neuromuscular synapse","volume":"31","author":"Valenzuela","year":"2022","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.ejcb.2024.151409_bib47","doi-asserted-by":"crossref","first-page":"22259","DOI":"10.1074\/jbc.270.38.22259","article-title":"Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix","volume":"270","author":"Vuori","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2024.151409_bib48","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0301-0082(00)00055-1","article-title":"Safety factor at the neuromuscular junction","volume":"64","author":"Wood","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151409_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135013","article-title":"Rapsyn as a signaling and scaffolding molecule in neuromuscular junction formation and maintenance","volume":"731","author":"Xing","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejcb.2024.151409_bib50","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2008.10.006","article-title":"LRP4 serves as a coreceptor of agrin","volume":"60","author":"Zhang","year":"2008","journal-title":"Neuron"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933524000268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933524000268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:33:03Z","timestamp":1739525583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933524000268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S0171933524000268"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2024.151409","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cortactin interacts with \u03b1Dystrobrevin-1 and regulates murine neuromuscular junction morphology","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2024.151409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151409"}}