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(Lausanne)"},{"key":"10.1016\/j.ejcb.2024.151418_bib153","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.biopsych.2003.09.003","article-title":"Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression","volume":"54","author":"Holmes","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib154","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1128\/IAI.02113-14","article-title":"Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells","volume":"82","author":"Hoshi","year":"2014","journal-title":"Infect. 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Rep."},{"key":"10.1016\/j.ejcb.2024.151418_bib163","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1126\/science.1183021","article-title":"Regulation of adaptive immunity by the innate immune system","volume":"327","author":"Iwasaki","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib164","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41385-020-00368-1","article-title":"The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes","volume":"14","author":"Jacobson","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib165","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib166","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1592\/phco.27.11.1571","article-title":"Antidepressant agents for the treatment of chronic pain and depression","volume":"27","author":"Jann","year":"2007","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ejcb.2024.151418_bib167","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-510X(94)00280-2","article-title":"Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases","volume":"130","author":"Jauch","year":"1995","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejcb.2024.151418_bib168","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/schbul\/sbp110","article-title":"Sensory processing in schizophrenia: neither simple nor intact","volume":"35","author":"Javitt","year":"2009","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ejcb.2024.151418_bib169","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.aaf8924","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib170","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.4049\/jimmunol.0803104","article-title":"Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock","volume":"182","author":"Jung","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib171","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/intimm\/dxz083","article-title":"Bidirectional communication between neural and immune systems","volume":"32","author":"Kamimura","year":"2020","journal-title":"Int Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib172","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-6606-2-8","article-title":"Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice","volume":"2","author":"Kanai","year":"2009","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejcb.2024.151418_bib173","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111714","article-title":"Tryptophan: A Unique Role in the Critically Ill","volume":"22","author":"Kanova","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2024.151418_bib174","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/mp.2016.167","article-title":"Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions","volume":"23","author":"Kappelmann","year":"2018","journal-title":"Mol. 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USA"},{"key":"10.1016\/j.ejcb.2024.151418_bib181","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1471-4159.2002.00955.x","article-title":"Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain","volume":"82","author":"Kita","year":"2002","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ejcb.2024.151418_bib182","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-neuro-111020-105359","article-title":"Neuroimmune Interactions in Peripheral Organs","volume":"45","author":"Klein Wolterink","year":"2022","journal-title":"Annu Rev. Neurosci."},{"key":"10.1016\/j.ejcb.2024.151418_bib183","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. 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J. Neurosci."},{"key":"10.1016\/j.ejcb.2024.151418_bib188","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66706","article-title":"Sensing the world and its dangers: An evolutionary perspective in neuroimmunology","volume":"10","author":"Kraus","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.ejcb.2024.151418_bib189","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00109-007-0229-7","article-title":"IDO expression in the brain: a double-edged sword","volume":"85","author":"Kwidzinski","year":"2007","journal-title":"J. Mol. Med (Berl. )"},{"key":"10.1016\/j.ejcb.2024.151418_bib190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2019.11.014","article-title":"Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense","volume":"180","author":"Lai","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2024.151418_bib191","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1042\/BST20201114","article-title":"Latest update on chemokine receptors as therapeutic targets","volume":"49","author":"Lai","year":"2021","journal-title":"Biochem Soc. Trans."},{"key":"10.1016\/j.ejcb.2024.151418_bib192","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399407000245","article-title":"Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes","volume":"9","author":"Lam","year":"2007","journal-title":"Expert Rev. Mol. Med"},{"key":"10.1016\/j.ejcb.2024.151418_bib193","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ridd.2005.03.003","article-title":"Neurochemical correlates of autistic disorder: a review of the literature","volume":"27","author":"Lam","year":"2006","journal-title":"Res Dev. Disabil."},{"key":"10.1016\/j.ejcb.2024.151418_bib194","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med"},{"key":"10.1016\/j.ejcb.2024.151418_bib195","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.clnu.2018.11.021","article-title":"Muscle loss: The new malnutrition challenge in clinical practice","volume":"38","author":"Landi","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ejcb.2024.151418_bib196","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/s-0028-1094391","article-title":"Kynurenines as probable participants of depression","volume":"6","author":"Lapin","year":"1973","journal-title":"Pharmakopsychiatr. Neuropsychopharmakol"},{"key":"10.1016\/j.ejcb.2024.151418_bib197","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF01262727","article-title":"Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice","volume":"42","author":"Lapin","year":"1978","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejcb.2024.151418_bib198","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1001\/archneurpsyc.1958.02340070140021","article-title":"Observations of schizophrenic patients after iproniazid and tryptophan. AMA","volume":"80","author":"Lauer","year":"1958","journal-title":"Arch. Neurol. Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib199","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1742-2094-10-87","article-title":"Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors","volume":"10","author":"Lawson","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejcb.2024.151418_bib200","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.3389\/fimmu.2019.02054","article-title":"Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14(+)CD16(-) Monocytes.","volume":"10","author":"Lee","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib201","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41581-018-0005-7","article-title":"Mechanisms and treatment of organ failure in sepsis","volume":"14","author":"Lelubre","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejcb.2024.151418_bib202","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.immuni.2020.08.012","article-title":"Systemic Immunometabolism: Challenges and Opportunities","volume":"53","author":"Lercher","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.ejcb.2024.151418_bib203","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ajpath.2010.10.028","article-title":"Serotonin activates dendritic cell function in the context of gut inflammation","volume":"178","author":"Li","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejcb.2024.151418_bib204","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/sj.mp.4000586","article-title":"The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection","volume":"4","author":"Licinio","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib205","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1023\/A:1021869310702","article-title":"Serotonin transporter modulation in blood lymphocytes from patients with major depression","volume":"22","author":"Lima","year":"2002","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151418_bib206","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1073\/pnas.0706679105","article-title":"Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy","volume":"105","author":"Liu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2024.151418_bib207","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1684\/ecn.2015.0362","article-title":"TNFalpha mediates stress-induced depression by upregulating indoleamine 2,3-dioxygenase in a mouse model of unpredictable chronic mild stress","volume":"26","author":"Liu","year":"2015","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.ejcb.2024.151418_bib208","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/SHK.0b013e31819714fa","article-title":"Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis","volume":"32","author":"Logters","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.ejcb.2024.151418_bib209","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0006-3223(97)00484-8","article-title":"Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression","volume":"43","author":"L\u00f3pez","year":"1998","journal-title":"Biol. 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Mol. Sci."},{"key":"10.1016\/j.ejcb.2024.151418_bib214","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/S0024-3205(02)01853-2","article-title":"Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation","volume":"71","author":"Maes","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.ejcb.2024.151418_bib215","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1023\/A:1013256629600","article-title":"Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease","volume":"47","author":"Magro","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejcb.2024.151418_bib216","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Mahar","year":"2014","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ejcb.2024.151418_bib217","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s11064-012-0967-y","article-title":"The pro-inflammatory cytokine TNF-alpha regulates the activity and expression of the serotonin transporter (SERT) in astrocytes","volume":"38","author":"Malynn","year":"2013","journal-title":"Neurochem Res"},{"key":"10.1016\/j.ejcb.2024.151418_bib218","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00702-011-0681-y","article-title":"The kynurenine system and immunoregulation","volume":"119","author":"Mandi","year":"2012","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.ejcb.2024.151418_bib219","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1046\/j.0022-3042.2002.00805.x","article-title":"Direct evidence that release-stimulating alpha7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals","volume":"80","author":"Marchi","year":"2002","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ejcb.2024.151418_bib220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuron.2012.09.010","article-title":"Neuromodulation of neuronal circuits: back to the future","volume":"76","author":"Marder","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.ejcb.2024.151418_bib221","doi-asserted-by":"crossref","first-page":"C818","DOI":"10.1152\/ajpcell.00580.2019","article-title":"The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain","volume":"318","author":"Martin","year":"2020","journal-title":"Am. J. Physiol. 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Chem."},{"key":"10.1016\/j.ejcb.2024.151418_bib228","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.abi5200","article-title":"The spectrum of inflammatory responses","volume":"374","author":"Medzhitov","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib229","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1214935","article-title":"Disease tolerance as a defense strategy","volume":"335","author":"Medzhitov","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib230","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/schbul\/sbn022","article-title":"A review of the fetal brain cytokine imbalance hypothesis of schizophrenia","volume":"35","author":"Meyer","year":"2009","journal-title":"Schizophr. 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Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib234","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/jb\/mvad052","article-title":"Senso-immunology: the past, present, and future","volume":"174","author":"Miyamoto","year":"2023","journal-title":"J. Biochem"},{"key":"10.1016\/j.ejcb.2024.151418_bib235","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biopsych.2013.01.007","article-title":"Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies","volume":"74","author":"Modabbernia","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib236","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tips.2020.11.006","article-title":"Tryptophan Metabolism as a Pharmacological Target","volume":"42","author":"Modoux","year":"2021","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.ejcb.2024.151418_bib237","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1440-1711.2003.t01-1-01177.x","article-title":"Tryptophan and the immune response","volume":"81","author":"Moffett","year":"2003","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151418_bib238","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nm.4020","article-title":"Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis","volume":"22","author":"Mole","year":"2016","journal-title":"Nat. Med"},{"key":"10.1016\/j.ejcb.2024.151418_bib239","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3389\/fimmu.2019.00379","article-title":"Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy","volume":"10","author":"Mollica Poeta","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib240","first-page":"3907","article-title":"Effects of acute and chronic stress on telencephalic neurochemistry and gene expression in rainbow trout (Oncorhynchus mykiss)","volume":"219","author":"Moltesen","year":"2016","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ejcb.2024.151418_bib241","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1471-4159.1988.tb04852.x","article-title":"Presence of kynurenic acid in the mammalian brain","volume":"51","author":"Moroni","year":"1988","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ejcb.2024.151418_bib242","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.mp.4002006","article-title":"The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression","volume":"12","author":"Muller","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib243","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/157339510791823673","article-title":"Immune System and Schizophrenia","volume":"6","author":"Muller","year":"2010","journal-title":"Curr. Immunol. Rev."},{"key":"10.1016\/j.ejcb.2024.151418_bib244","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.it.2012.10.001","article-title":"Indoleamine 2,3 dioxygenase and metabolic control of immune responses","volume":"34","author":"Munn","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib245","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1126\/science.1073514","article-title":"Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase","volume":"297","author":"Munn","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib246","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2005.03.013","article-title":"GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase","volume":"22","author":"Munn","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.ejcb.2024.151418_bib247","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2019.03.027","article-title":"Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines","volume":"50","author":"Murakami","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.ejcb.2024.151418_bib248","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.1073\/pnas.94.14.7303","article-title":"Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells","volume":"94","author":"de Murcia","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2024.151418_bib249","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S1473-3099(03)00773-4","article-title":"Tryptophan depletion and HIV infection: a metabolic link to pathogenesis","volume":"3","author":"Murray","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejcb.2024.151418_bib250","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/ajcn\/32.3.593","article-title":"Anorexia of infection as a mechanism of host defense","volume":"32","author":"Murray","year":"1979","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ejcb.2024.151418_bib251","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.conb.2014.05.003","article-title":"Neuromodulation of neurons and synapses","volume":"29","author":"Nadim","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151418_bib252","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1084\/jem.20141132","article-title":"Control of lymphocyte egress from lymph nodes through beta2-adrenergic receptors","volume":"211","author":"Nakai","year":"2014","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.ejcb.2024.151418_bib253","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/intimm\/dxab009","article-title":"Control of immune cell trafficking through inter-organ communication","volume":"33","author":"Nakai","year":"2021","journal-title":"Int Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib254","first-page":"285","article-title":"Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies","author":"Nemeth","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.ejcb.2024.151418_bib255","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1440-1681.2006.04410.x","article-title":"5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT)","volume":"33","author":"Ni","year":"2006","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"10.1016\/j.ejcb.2024.151418_bib256","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1021\/cr078224o","article-title":"Serotonin receptors","volume":"108","author":"Nichols","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejcb.2024.151418_bib257","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0021-9258(19)84026-7","article-title":"Enzymic synthesis of niacin nucleotides from 3-hydroxyanthranilic acid in mammalian liver","volume":"238","author":"Nishizuka","year":"1963","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2024.151418_bib258","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.conb.2016.09.004","article-title":"Neuronal energy consumption: biophysics, efficiency and evolution","volume":"41","author":"Niven","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151418_bib259","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1523\/JNEUROSCI.5032-08.2009","article-title":"Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin","volume":"29","author":"O'Connor","year":"2009","journal-title":"J. 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Biochem Behav."},{"key":"10.1016\/j.ejcb.2024.151418_bib263","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/WNL.42.9.1702","article-title":"Kynurenine pathway abnormalities in Parkinson's disease","volume":"42","author":"Ogawa","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.ejcb.2024.151418_bib264","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1038\/ncomms7794","article-title":"Regulation of systemic energy homeostasis by serotonin in adipose tissues","volume":"6","author":"Oh","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2024.151418_bib265","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1471-4159.1998.70010299.x","article-title":"3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity","volume":"70","author":"Okuda","year":"1998","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ejcb.2024.151418_bib266","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/archpsyc.1995.03950240016004","article-title":"Glutamate receptor dysfunction and schizophrenia","volume":"52","author":"Olney","year":"1995","journal-title":"Arch. Gen. 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Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151418_bib270","doi-asserted-by":"crossref","first-page":"29355","DOI":"10.1074\/jbc.R200003200","article-title":"Cytokine and cytokine receptor pleiotropy and redundancy","volume":"277","author":"Ozaki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2024.151418_bib271","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ni.2077","article-title":"Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells","volume":"12","author":"Pallotta","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib272","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/bies.201300084","article-title":"The Warburg effect then and now: from cancer to inflammatory diseases","volume":"35","author":"Palsson-McDermott","year":"2013","journal-title":"Bioessays"},{"key":"10.1016\/j.ejcb.2024.151418_bib273","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1097\/01.CCM.0000145229.59014.6C","article-title":"Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels","volume":"32","author":"Panacek","year":"2004","journal-title":"Crit. Care Med"},{"key":"10.1016\/j.ejcb.2024.151418_bib274","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0005-2736(75)90347-8","article-title":"Kinetic analysis of blood-brain barrier transport of amino acids","volume":"401","author":"Pardridge","year":"1975","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.ejcb.2024.151418_bib275","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0028-3908(94)90089-2","article-title":"Tryptophan depletion in normal volunteers produces selective impairments in learning and memory","volume":"33","author":"Park","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejcb.2024.151418_bib276","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev-immunol-042617-053158","article-title":"Molecular and Functional Neuroscience in Immunity","volume":"36","author":"Pavlov","year":"2018","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib277","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/jamapsychiatry.2022.0609","article-title":"Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis","volume":"79","author":"Pearce","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib278","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2021.02.001","article-title":"Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System","volume":"44","author":"Peters","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejcb.2024.151418_bib279","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2018.04.006","article-title":"Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection","volume":"173","author":"Pinho-Ribeiro","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2024.151418_bib280","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108055","article-title":"Recent advances in clinical trials targeting the kynurenine pathway","volume":"236","author":"Pires","year":"2022","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.ejcb.2024.151418_bib281","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.1117634","article-title":"Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite","volume":"310","author":"Platten","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib282","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejcb.2024.151418_bib283","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2007.09.024","article-title":"Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review","volume":"63","author":"Potvin","year":"2008","journal-title":"Biol. 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Sci."},{"key":"10.1016\/j.ejcb.2024.151418_bib312","doi-asserted-by":"crossref","DOI":"10.1126\/science.ade0027","article-title":"Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation","volume":"380","author":"Sardar","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib313","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/j.1471-4159.2010.06675.x","article-title":"Dysfunctional kynurenine pathway metabolism in the R6\/2 mouse model of Huntington's disease","volume":"113","author":"Sathyasaikumar","year":"2010","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ejcb.2024.151418_bib314","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/schbul\/sbq112","article-title":"Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia","volume":"37","author":"Sathyasaikumar","year":"2011","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ejcb.2024.151418_bib315","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1002\/cncr.24561","article-title":"Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis","volume":"115","author":"Satin","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.ejcb.2024.151418_bib316","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41380-019-0414-4","article-title":"The kynurenine pathway: a finger in every pie","volume":"25","author":"Savitz","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib317","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri2941","article-title":"Recombination centres and the orchestration of V(D)J recombination","volume":"11","author":"Schatz","year":"2011","journal-title":"Nat. Rev. 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Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151418_bib323","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuropharm.2016.08.003","article-title":"The kynurenine pathway and the brain: Challenges, controversies and promises","volume":"112","author":"Schwarcz","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejcb.2024.151418_bib324","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.6849138","article-title":"Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain","volume":"219","author":"Schwarcz","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib325","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0006-3223(01)01078-2","article-title":"Increased cortical kynurenate content in schizophrenia","volume":"50","author":"Schwarcz","year":"2001","journal-title":"Biol. 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Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151418_bib329","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrn2994","article-title":"The integration of negative affect, pain and cognitive control in the cingulate cortex","volume":"12","author":"Shackman","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejcb.2024.151418_bib330","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00540-013-1722-5","article-title":"Subanalgesic ketamine enhances morphine-induced antinociceptive activity without cortical dysfunction in rats","volume":"28","author":"Shikanai","year":"2014","journal-title":"J. Anesth."},{"key":"10.1016\/j.ejcb.2024.151418_bib331","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/s12276-023-01054-5","article-title":"Reg3\u03b3: current understanding and future therapeutic opportunities in metabolic disease","volume":"55","author":"Shin","year":"2023","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.ejcb.2024.151418_bib332","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.6093256","article-title":"Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain","volume":"226","author":"Simon","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151418_bib333","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neuro.2009.03.004","article-title":"The effect of tumor necrosis factor antagonists on mood and mental health-associated quality of life: novel hypothesis-driven treatments for bipolar depression?","volume":"30","author":"Soczynska","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ejcb.2024.151418_bib334","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1385\/MN:30:2:117","article-title":"Serotonin in pain and analgesia: actions in the periphery","volume":"30","author":"Sommer","year":"2004","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151418_bib335","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3389\/fimmu.2019.02565","article-title":"Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target","volume":"10","author":"Sorgdrager","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib336","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1471-4159.1993.tb05840.x","article-title":"On the production and disposition of quinolinic acid in rat brain and liver slices","volume":"60","author":"Speciale","year":"1993","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ejcb.2024.151418_bib337","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2017.51","article-title":"Non-conventional features of peripheral serotonin signalling - the gut and beyond","volume":"14","author":"Spohn","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"933-944","key":"10.1016\/j.ejcb.2024.151418_bib338","article-title":"Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon","volume":"151","author":"Spohn","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejcb.2024.151418_bib339","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1742-2094-8-94","article-title":"Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?","volume":"8","author":"Steiner","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ejcb.2024.151418_bib340","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-alpha","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2024.151418_bib341","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.molimm.2008.07.022","article-title":"Stress and innate immunity in carp: corticosteroid receptors and pro-inflammatory cytokines","volume":"46","author":"Stolte","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejcb.2024.151418_bib342","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0031-6997(25)00441-7","article-title":"Neuropharmacology of quinolinic and kynurenic acids","volume":"45","author":"Stone","year":"1993","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.ejcb.2024.151418_bib343","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neuroscience.2021.06.007","article-title":"Relationships and Interactions between Ionotropic Glutamate Receptors and Nicotinic Receptors in the CNS","volume":"468","author":"Stone","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejcb.2024.151418_bib344","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrd870","article-title":"Endogenous kynurenines as targets for drug discovery and development","volume":"1","author":"Stone","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejcb.2024.151418_bib345","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0014-2999(81)90587-2","article-title":"Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS","volume":"72","author":"Stone","year":"1981","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.ejcb.2024.151418_bib346","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1002004","article-title":"An integrated cytokine and kynurenine network as the basis of neuroimmune communication","volume":"16","author":"Stone","year":"2022","journal-title":"Front Neurosci."},{"key":"10.1016\/j.ejcb.2024.151418_bib347","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.euroneuro.2015.06.007","article-title":"Inflammation and clinical response to treatment in depression: A meta-analysis","volume":"25","author":"Strawbridge","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ejcb.2024.151418_bib348","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00535-016-1220-2","article-title":"Indole compounds may be promising medicines for ulcerative colitis","volume":"51","author":"Sugimoto","year":"2016","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejcb.2024.151418_bib349","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2020.06.022","article-title":"RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis","volume":"182","author":"Sugisawa","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2024.151418_bib350","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110462","article-title":"Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia","volume":"38","author":"Sugisawa","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejcb.2024.151418_bib351","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107478","article-title":"In situ imaging of monoamine localization and dynamics","volume":"208","author":"Sugiyama","year":"2020","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.ejcb.2024.151418_bib352","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.cmet.2012.09.014","article-title":"Gut-derived serotonin is a multifunctional determinant to fasting adaptation","volume":"16","author":"Sumara","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejcb.2024.151418_bib353","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.3748\/wjg.v27.i29.4900","article-title":"Effects of permissive hypocaloric vs standard enteral feeding on gastrointestinal function and outcomes in sepsis","volume":"27","author":"Sun","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejcb.2024.151418_bib354","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1084\/jem.20160723","article-title":"Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes","volume":"213","author":"Suzuki","year":"2016","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.ejcb.2024.151418_bib355","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jinf.2011.07.003","article-title":"Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia","volume":"63","author":"Suzuki","year":"2011","journal-title":"J. Infect."},{"key":"10.1016\/j.ejcb.2024.151418_bib356","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3389\/fpsyt.2020.00443","article-title":"Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis","volume":"11","author":"Tafet","year":"2020","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.ejcb.2024.151418_bib357","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2024.151418_bib358","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1016\/S0021-9258(17)35696-X","article-title":"Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase","volume":"261","author":"Takikawa","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejcb.2024.151418_bib359","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nature21350","article-title":"Scaling single-cell genomics from phenomenology to mechanism","volume":"541","author":"Tanay","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2024.151418_bib360","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1086\/650996","article-title":"Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock","volume":"201","author":"Tattevin","year":"2010","journal-title":"J. Infect. 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