{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:33:27Z","timestamp":1793406807603,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejcb.2024.151427","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T23:39:51Z","timestamp":1716939591000},"page":"151427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["The mechanical mechanism of angiotensin II induced activation of hepatic stellate cells promoting portal hypertension"],"prefix":"10.1016","volume":"103","author":[{"given":"Yiheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fansheng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianle","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2024.151427_bib1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82015","article-title":"Structural insights into actin isoforms","volume":"12","author":"Arora","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.ejcb.2024.151427_bib2","doi-asserted-by":"crossref","first-page":"1167067","DOI":"10.3389\/fsurg.2023.1167067","article-title":"The effects of mechanical force on fibroblast behavior in cutaneous injury","volume":"10","author":"Berry","year":"2023","journal-title":"Front Surg."},{"key":"10.1016\/j.ejcb.2024.151427_bib3","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.7150\/ijbs.37500","article-title":"Matrix mechanics as regulatory factors and therapeutic targets in hepatic fibrosis","volume":"15","author":"Chen","year":"2019","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.ejcb.2024.151427_bib4","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1016\/j.apsb.2021.07.027","article-title":"Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo","volume":"11","author":"Deng","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejcb.2024.151427_bib5","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1177\/1535370220949148","article-title":"Endothelin-1 in portal hypertension: the intricate role of hepatic stellate cells","volume":"245","author":"Ezhilarasan","year":"2020","journal-title":"Exp. Biol. Med (Maywood)"},{"key":"10.1016\/j.ejcb.2024.151427_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biochi.2021.06.001","article-title":"Relaxin in hepatic fibrosis: what is known and where to head?","volume":"187","author":"Ezhilarasan","year":"2021","journal-title":"Biochimie"},{"key":"10.1016\/j.ejcb.2024.151427_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202109189","article-title":"Mucus penetrating and cell-binding polyzwitterionic micelles as potent oral nanomedicine for cancer drug delivery","volume":"34","author":"Fan","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejcb.2024.151427_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-022-05289-6","article-title":"Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis","volume":"610","author":"Filliol","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2024.151427_bib9","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.12998\/wjcc.v10.i12.3662","article-title":"Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis","volume":"10","author":"Garbuzenko","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.ejcb.2024.151427_bib10","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1126\/science.1095087","article-title":"Elastic behavior of cross-linked and bundled actin networks","volume":"304","author":"Gardel","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151427_bib11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJMra1504367","article-title":"Treatment of patients with cirrhosis","volume":"375","author":"Ge","year":"2016","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.ejcb.2024.151427_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1098129","article-title":"Regulators, functions, and mechanotransduction pathways of matrix stiffness in hepatic disease","volume":"14","author":"Guo","year":"2023","journal-title":"Front Physiol."},{"key":"10.1016\/j.ejcb.2024.151427_bib13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1083\/jcb.201102039","article-title":"Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament","volume":"195","author":"Hayakawa","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151427_bib14","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.91.108102","article-title":"Deformation of cross-linked semiflexible polymer networks","volume":"91","author":"Head","year":"2003","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.ejcb.2024.151427_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3748\/wjg.v28.i1.123","article-title":"Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK\/Ras\/c-myc\/ENO1 pathway","volume":"28","author":"Huang","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejcb.2024.151427_bib16","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/s41467-018-04525-w","article-title":"Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing","volume":"9","author":"Ishihara","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2024.151427_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.semcdb.2019.12.003","article-title":"Regulation of actin isoforms in cellular and developmental processes","volume":"102","author":"Kashina","year":"2020","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.ejcb.2024.151427_bib18","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/j.bbamcr.2015.04.006","article-title":"A biomechanical perspective on stress fiber structure and function","volume":"1853","author":"Kassianidou","year":"2015","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.ejcb.2024.151427_bib19","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1016\/j.bpj.2009.02.035","article-title":"Filamin A is essential for active cell stiffening but not passive stiffening under external force","volume":"96","author":"Kasza","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejcb.2024.151427_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/hep.32256","article-title":"Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy","volume":"76","author":"Kawai","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.ejcb.2024.151427_bib21","doi-asserted-by":"crossref","first-page":"15192","DOI":"10.1073\/pnas.0903974106","article-title":"An active biopolymer network controlled by molecular motors","volume":"106","author":"Koenderink","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2024.151427_bib22","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00018-019-03328-6","article-title":"Qualitative analysis of contribution of intracellular skeletal changes to cellular elasticity","volume":"77","author":"Kwon","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ejcb.2024.151427_bib23","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41580-022-00508-4","article-title":"Biochemical and mechanical regulation of actin dynamics","volume":"23","author":"Lappalainen","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151427_bib24","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259089","article-title":"New insights into FAK structure and function in focal adhesions","volume":"135","author":"Le Coq","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2024.151427_bib25","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1038\/s41467-021-22422-7","article-title":"Reconstitution of contractile actomyosin rings in vesicles","volume":"12","author":"Litschel","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2024.151427_bib26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tcb.2021.10.002","article-title":"Mechanical communication in fibrosis progression","volume":"32","author":"Long","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151427_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ccr.2011.07.016","article-title":"Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL","volume":"20","author":"Mali","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ejcb.2024.151427_bib28","doi-asserted-by":"crossref","first-page":"20820","DOI":"10.1073\/pnas.1214753109","article-title":"F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex","volume":"109","author":"Murrell","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2024.151427_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hepr.12310","article-title":"Review of angiogenesis in hepatocellular carcinoma","volume":"45","author":"Muto","year":"2015","journal-title":"Hepatol. Res"},{"key":"10.1016\/j.ejcb.2024.151427_bib30","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.97.052409","article-title":"Mechanical characterization of disordered and anisotropic cellular monolayers","volume":"97","author":"Nestor-Bergmann","year":"2018","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.ejcb.2024.151427_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz0868","article-title":"Physical traits of cancer","volume":"370","author":"Nia","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2024.151427_bib32","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61078","article-title":"Calponin-homology domain mediated bending of membrane-associated actin filaments","volume":"10","author":"Palani","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.ejcb.2024.151427_bib33","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/rth2.12403","article-title":"Liver fibrosis is driven by protease-activated receptor-1 expressed by hepatic stellate cells in experimental chronic liver injury","volume":"4","author":"Poole","year":"2020","journal-title":"Res Pr. Thromb. Haemost."},{"key":"10.1016\/j.ejcb.2024.151427_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2022.106170","article-title":"Rab31 promotes activation of hepatic stellate cells by accelerating TGF-\u03b2 receptor II complex endocytosis","volume":"144","author":"Qiu","year":"2022","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejcb.2024.151427_bib35","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.celrep.2014.12.037","article-title":"Ligand-occupied integrin internalization links nutrient signaling to invasive migration","volume":"10","author":"Rainero","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejcb.2024.151427_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1152\/physrev.00026.2002","article-title":"Actin binding proteins: regulation of cytoskeletal microfilaments","volume":"83","author":"dos Remedios","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejcb.2024.151427_bib37","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1158\/1078-0432.CCR-22-0533","article-title":"Myosin light-chain kinase inhibition potentiates the antitumor effects of avapritinib in PDGFRA D842V-mutant gastrointestinal stromal tumor","volume":"29","author":"Rossi","year":"2023","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.ejcb.2024.151427_bib38","doi-asserted-by":"crossref","first-page":"0210071","DOI":"10.1115\/1.4035557","article-title":"On the Functional Role of Valve Interstitial Cell Stress Fibers: a continuum modeling approach","volume":"139","author":"Sakamoto","year":"2017","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.ejcb.2024.151427_bib39","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/clpt.2012.108","article-title":"Alanine aminotransferase: a clinical and regulatory tool for detecting liver injury-past, present, and future","volume":"92","author":"Senior","year":"2012","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.ejcb.2024.151427_bib40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1164\/ajrccm.163.1.2001089","article-title":"Contribution of small GTPase Rho and its target protein rock in a murine model of lung fibrosis","volume":"163","author":"Shimizu","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.ejcb.2024.151427_bib41","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1007\/s10620-018-5186-1","article-title":"\u03b2-Blockers Improve Presinusoidal Portal Hypertension","volume":"63","author":"S\u00f8rensen","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejcb.2024.151427_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11051295","article-title":"A Combination of an Angiotensin II Receptor and a Neprilysin Inhibitor Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation","volume":"11","author":"Suzuki","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejcb.2024.151427_bib43","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0023677214567748","article-title":"Induction of experimental obstructive cholestasis in mice","volume":"49","author":"Tag","year":"2015","journal-title":"Lab Anim."},{"key":"10.1016\/j.ejcb.2024.151427_bib44","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1073\/pnas.1812053116","article-title":"Torsional stress generated by ADF\/cofilin on cross-linked actin filaments boosts their severing","volume":"116","author":"Wioland","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejcb.2024.151427_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7932046","article-title":"Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA\/Rho-Kinase Pathway","volume":"2019","author":"Wu","year":"2019","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.ejcb.2024.151427_bib46","first-page":"1707","article-title":"Identification of miRNAs associated with the mechanical response of hepatic stellate cells by miRNA microarray analysis","volume":"16","author":"Yi","year":"2018","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.ejcb.2024.151427_bib47","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s00535-023-01957-0","article-title":"Portal vein thrombosis, hepatic decompensation, and survival in patients with porto-sinusoidal vascular disease and portal hypertension","volume":"58","author":"Zhang","year":"2023","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejcb.2024.151427_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25010025","article-title":"Myeloid Differentiation Protein 2 Mediates Angiotensin II-Induced Liver Inflammation and Fibrosis in Mice","volume":"25","author":"Zhang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejcb.2024.151427_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101112","article-title":"Intracellular ion and protein nanoparticle-induced osmotic pressure modify astrocyte swelling and brain edema in response to glutamate stimuli","volume":"21","author":"Zhang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejcb.2024.151427_bib50","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.arcmed.2010.10.010","article-title":"Expression of discoidin domain receptors (DDR2) in alcoholic liver fibrosis in rats","volume":"41","author":"Zhang","year":"2010","journal-title":"Arch. Med Res"},{"key":"10.1016\/j.ejcb.2024.151427_bib51","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1111\/febs.12818","article-title":"Tetramethylpyrazine inhibits angiotensin II-induced activation of hepatic stellate cells associated with interference of platelet-derived growth factor \u03b2 receptor pathways","volume":"281","author":"Zhang","year":"2014","journal-title":"Febs J."},{"key":"10.1016\/j.ejcb.2024.151427_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1183808","article-title":"Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis","volume":"10","author":"Zhao","year":"2023","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.ejcb.2024.151427_bib53","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gad.1843810","article-title":"A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017193352400044X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017193352400044X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:34:24Z","timestamp":1739525664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S017193352400044X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S017193352400044X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2024.151427","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanical mechanism of angiotensin II induced activation of hepatic stellate cells promoting portal hypertension","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2024.151427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151427"}}