{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:56:32Z","timestamp":1793174192366,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ejcb.2024.151446","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:09:50Z","timestamp":1721333390000},"page":"151446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Elimination of the extra chromosome of Dup15q syndrome iPSCs for cellular and molecular investigation"],"prefix":"10.1016","volume":"103","author":[{"given":"Haruka","family":"Munezane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitsu","family":"Hotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yukitake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2024.151446_bib1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.braindev.2004.08.006","article-title":"The inv dup(15) or idic(15) syndrome: A clinically recognisable neurogenetic disorder","volume":"27","author":"Battaglia","year":"2005","journal-title":"Brain Dev."},{"key":"10.1016\/j.ejcb.2024.151446_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2010.03.011","article-title":"Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11\u2013q13","volume":"39","author":"Chamberlain","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejcb.2024.151446_bib3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13229-020-00360-3","article-title":"Cerebral organoids as tools to identify the developmental roots of autism","volume":"11","author":"Chan","year":"2020","journal-title":"Mol. Autism"},{"key":"10.1016\/j.ejcb.2024.151446_bib4","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1093\/nar\/gkw524","article-title":"Probing the impact of chromatin conformation on genome editing tools","volume":"44","author":"Chen","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ejcb.2024.151446_bib5","first-page":"928","article-title":"Autism or atypical autism in maternally but not paternally derived proximal 15q duplication","volume":"60","author":"Cook","year":"1997","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.ejcb.2024.151446_bib6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/acssynbio.5b00299","article-title":"The impact of chromatin dynamics on Cas9-mediated genome editing in human cells","volume":"6","author":"Daer","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ejcb.2024.151446_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s11689-016-9152-y","article-title":"Identification of a distinct developmental and behavioral profile in children with Dup15q syndrome","volume":"8","author":"DiStefano","year":"2016","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.ejcb.2024.151446_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.stem.2008.09.002","article-title":"Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals","volume":"3","author":"Eiraku","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2024.151446_bib9","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.stemcr.2023.02.002","article-title":"The role of UBE3A in the autism and epilepsy-related Dup15q syndrome using patient-derived, CRISPR-corrected neurons","volume":"18","author":"Elamin","year":"2023","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ejcb.2024.151446_bib10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.biopsych.2021.07.018","article-title":"Hyperexcitable phenotypes in induced pluripotent stem cell\u2013derived neurons from patients with 15q11-q13 duplication syndrome, a genetic form of autism","volume":"90","author":"Fink","year":"2021","journal-title":"Biol. Psychiat"},{"key":"10.1016\/j.ejcb.2024.151446_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13229-019-0280-6","article-title":"Mechanisms underlying the EEG biomarker in Dup15q syndrome","volume":"10","author":"Frohlich","year":"2019","journal-title":"Mol. Autism"},{"key":"10.1016\/j.ejcb.2024.151446_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167179","article-title":"A quantitative electrophysiological biomarker of duplication 15q11.2-q13.1 syndrome","volume":"11","author":"Frohlich","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejcb.2024.151446_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/2040-2392-5-44","article-title":"Gene expression analysis of human induced pluripotent stem cell-derived neurons carrying copy number variants of chromosome 15q11-q13.1","volume":"5","author":"Germain","year":"2014","journal-title":"Mol. Autism"},{"key":"10.1016\/j.ejcb.2024.151446_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf3962","article-title":"The Src\/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis","volume":"9","author":"Imamura","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejcb.2024.151446_bib15","doi-asserted-by":"crossref","first-page":"34904","DOI":"10.1038\/srep34904","article-title":"Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons","volume":"6","author":"Imamura","year":"2016","journal-title":"Sci. Rep. -uk"},{"key":"10.1016\/j.ejcb.2024.151446_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/embj.201387098","article-title":"iPS cells: a game changer for future medicine","volume":"33","author":"Inoue","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.ejcb.2024.151446_bib17","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1038\/ncomms5742","article-title":"Enhanced synapse remodelling as a common phenotype in mouse models of autism","volume":"5","author":"Isshiki","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2024.151446_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nature12394","article-title":"Translating dosage compensation to trisomy 21","volume":"500","author":"Jiang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2024.151446_bib19","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/s42003-021-02242-7","article-title":"A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome","volume":"4","author":"Kawatani","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ejcb.2024.151446_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2017.10.109","article-title":"iPSC-based compound screening and in vitro trials identify a synergistic anti-amyloid \u03b2 combination for Alzheimer\u2019s disease","volume":"21","author":"Kondo","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejcb.2024.151446_bib21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.stem.2012.08.004","article-title":"Trisomy correction in down syndrome induced pluripotent stem cells","volume":"11","author":"Li","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2024.151446_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41586-023-06473-y","article-title":"Single-cell brain organoid screening identifies developmental defects in autism","volume":"621","author":"Li","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2024.151446_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nmeth973","article-title":"Targeted chromosome elimination from ES-somatic hybrid cells","volume":"4","author":"Matsumura","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejcb.2024.151446_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1603001","article-title":"Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice","volume":"3","author":"Nakai","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejcb.2024.151446_bib25","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cell.2009.04.024","article-title":"Abnormal behavior in a chromosome- engineered mouse model for human 15q11-13 duplication seen in autism","volume":"137","author":"Nakatani","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2024.151446_bib26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/stem.1293","article-title":"An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells","volume":"31","author":"Okita","year":"2013","journal-title":"STEM CELLS"},{"key":"10.1016\/j.ejcb.2024.151446_bib27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-021-04358-6","article-title":"Autism genes converge on asynchronous development of shared neuron classes","volume":"602","author":"Paulsen","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2024.151446_bib28","article-title":"Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism","author":"Perez","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.ejcb.2024.151446_bib29","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure","volume":"165","author":"Qian","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2024.151446_bib30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/ejhg.2010.237","article-title":"Deletions flanked by breakpoints 3 and 4 on 15q13 may contribute to abnormal phenotypes","volume":"19","author":"Rosenfeld","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ejcb.2024.151446_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13041-020-00655-9","article-title":"Upregulated 5-HT1A receptor-mediated currents in the prefrontal cortex layer 5 neurons in the 15q11\u201313 duplication mouse model of autism","volume":"13","author":"Saitow","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejcb.2024.151446_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107931","article-title":"Change in serotonergic modulation contributes to the synaptic imbalance of neuronal circuit at the prefrontal cortex in the 15q11-13 duplication mouse model of autism","volume":"165","author":"Saitow","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejcb.2024.151446_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s11689-020-09326-1","article-title":"Properties of beta oscillations in Dup15q syndrome","volume":"12","author":"Saravanapandian","year":"2020","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.ejcb.2024.151446_bib34","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1038\/s41380-020-0844-z","article-title":"Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids","volume":"25","author":"Sawada","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejcb.2024.151446_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s40142-017-0129-2","article-title":"Copy number variation disorders","volume":"5","author":"Shaikh","year":"2017","journal-title":"Curr. Genet. Med. Rep."},{"key":"10.1016\/j.ejcb.2024.151446_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/nrd.2016.245","article-title":"Induced pluripotent stem cell technology: a decade of progress","volume":"16","author":"Shi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejcb.2024.151446_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002627","article-title":"Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice","volume":"3","author":"Smith","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejcb.2024.151446_bib38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.conb.2017.12.004","article-title":"CNV biology in neurodevelopmental disorders","volume":"48","author":"Takumi","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejcb.2024.151446_bib39","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.celrep.2020.01.038","article-title":"Synthetic analyses of single-cell transcriptomes from multiple brain organoids and fetal brain","volume":"30","author":"Tanaka","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejcb.2024.151446_bib40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.stem.2019.08.002","article-title":"Complex oscillatory waves emerging from cortical organoids model early human brain network development","volume":"25","author":"Trujillo","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejcb.2024.151446_bib41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/aur.1284","article-title":"Autism and 15q duplication syndrome","volume":"6","author":"Urraca","year":"2013","journal-title":"Autism Res."},{"key":"10.1016\/j.ejcb.2024.151446_bib42","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41586-019-1289-x","article-title":"Individual brain organoids reproducibly form cell diversity of the human cerebral cortex","volume":"570","author":"Velasco","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejcb.2024.151446_bib43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12264-017-0111-8","article-title":"Distinct defects in spine formation or pruning in two gene duplication mouse models of autism","volume":"33","author":"Wang","year":"2017","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ejcb.2024.151446_bib44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tig.2015.05.010","article-title":"Human structural variation: mechanisms of chromosome rearrangements","volume":"31","author":"Weckselblatt","year":"2015","journal-title":"Trends Genet"},{"key":"10.1016\/j.ejcb.2024.151446_bib45","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13059-017-1354-4","article-title":"CRISPR\/Cas9-mediated targeted chromosome elimination","volume":"18","author":"Zuo","year":"2017","journal-title":"Genome Biol."}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933524000633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933524000633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T19:49:54Z","timestamp":1728503394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933524000633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0171933524000633"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2024.151446","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elimination of the extra chromosome of Dup15q syndrome iPSCs for cellular and molecular investigation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2024.151446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151446"}}