{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:02:35Z","timestamp":1779674555576,"version":"3.53.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["24PRE1193707"],"award-info":[{"award-number":["24PRE1193707"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM122741"],"award-info":[{"award-number":["GM122741"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS121578"],"award-info":[{"award-number":["R21NS121578"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS136621"],"award-info":[{"award-number":["R01NS136621"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejcb.2025.151508","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:33:21Z","timestamp":1752626001000},"page":"151508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphology"],"prefix":"10.1016","volume":"104","author":[{"given":"Cassandra L.","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith F.","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Armao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-4585","authenticated-orcid":false,"given":"Natasha T.","family":"Snider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2025.151508_bib1","first-page":"4774","article-title":"Subunit composition of the human cytoplasmic dynein-2 complex","volume":"127","author":"Asante","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejcb.2025.151508_bib2","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E23-03-0094","article-title":"Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN)","volume":"34","author":"Battaglia","year":"2023","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejcb.2025.151508_bib3","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1093\/brain\/awab179","article-title":"Giant axonal neuropathy: cross-sectional analysis of a large natural history cohort","volume":"144","author":"Bharucha-Goebel","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.ejcb.2025.151508_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/2051-5960-2-47","article-title":"The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic test","volume":"2","author":"Boizot","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ejcb.2025.151508_bib5","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/81701","article-title":"The gene encoding gigaxonin, a new member of the cytoskeletal BTB\/kelch repeat family, is mutated in giant axonal neuropathy","volume":"26","author":"Bomont","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejcb.2025.151508_bib6","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/cr.2009.118","article-title":"Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody","volume":"19","author":"Cai","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.ejcb.2025.151508_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg7492","article-title":"Accurate proteome-wide missense variant effect prediction with AlphaMissense","volume":"381","author":"Cheng","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ejcb.2025.151508_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1479-7364-7-13","article-title":"Update on the Kelch-like (KLHL) gene family","volume":"7","author":"Dhanoa","year":"2013","journal-title":"Hum. Genom."},{"key":"10.1016\/j.ejcb.2025.151508_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell Proteom."},{"key":"10.1016\/j.ejcb.2025.151508_bib10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/mus.24321","article-title":"Giant axonal neuropathy: An updated perspective on its pathology and pathogenesis","volume":"50","author":"Johnson-Kerner","year":"2014","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ejcb.2025.151508_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140157","article-title":"Kelch domain of gigaxonin interacts with intermediate filament proteins affected in giant axonal neuropathy","volume":"10","author":"Johnson-Kerner","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2025.151508_bib12","doi-asserted-by":"crossref","first-page":"D1062","DOI":"10.1093\/nar\/gkx1153","article-title":"ClinVar: improving access to variant interpretations and supporting evidence","volume":"46","author":"Landrum","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ejcb.2025.151508_bib13","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3389\/fphys.2020.01022","article-title":"E3 Ubiquitin ligases in neurological diseases: focus on gigaxonin and autophagy","volume":"11","author":"Lescouzeres","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejcb.2025.151508_bib14","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1172\/JCI66387","article-title":"Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation","volume":"123","author":"Mahammad","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejcb.2025.151508_bib15","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202202119R","article-title":"Gigaxonin is required for intermediate filament transport","volume":"37","author":"Renganathan","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.ejcb.2025.151508_bib16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/tra.12070","article-title":"Distinct functions of nuclear distribution proteins LIS1, Ndel1 and NudCL in regulating axonal mitochondrial transport","volume":"14","author":"Shao","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.ejcb.2025.151508_bib17","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejcb.2025.151508_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104404","article-title":"Kelch-like proteins: Physiological functions and relationships with diseases","volume":"148","author":"Shi","year":"2019","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejcb.2025.151508_bib19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2014.05.039","article-title":"A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways","volume":"158","author":"Taipale","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejcb.2025.151508_bib20","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1091\/mbc.e09-04-0304","article-title":"Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments","volume":"20","author":"Uchida","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejcb.2025.151508_bib21","doi-asserted-by":"crossref","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","article-title":"UniProt: the universal protein knowledgebase in 2023","volume":"51","author":"UniProt","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejcb.2025.151508_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39655","article-title":"Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function","volume":"7","author":"Vuolo","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ejcb.2025.151508_bib23","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.1073\/pnas.0602916103","article-title":"A mammalian NudC-like protein essential for dynein stability and cell viability","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933525000330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933525000330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T01:20:56Z","timestamp":1779672056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933525000330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0171933525000330"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2025.151508","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.03.10.641328","asserted-by":"object"}]},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphology","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2025.151508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151508"}}