{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:43:19Z","timestamp":1786542199557,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejcb.2026.151538","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:10:01Z","timestamp":1776233401000},"page":"151538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human adipose stem cell conditioned medium has a pro-fibrotic and EMT-stimulating effect on urethral fibroblasts in vitro"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-3057","authenticated-orcid":false,"given":"Povilas","family":"Barasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilija","family":"Baltrukonyte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Simoliune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aivaras","family":"Grybas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiva","family":"Baltriukiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2026.151538_bib1","doi-asserted-by":"crossref","unstructured":"Allaire J.M., Darsigny M., Marcoux S.S., B Roy S.A., Schmouth J.F., Umans L., et al. Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis [Internet]. 2011. doi:10.1152\/ajpgi.00041.2010.-The.","DOI":"10.1152\/ajpgi.00041.2010"},{"issue":"4","key":"10.1016\/j.ejcb.2026.151538_bib2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.biotechadv.2018.03.011","article-title":"Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells \u2013 a review","volume":"36","author":"Bacakova","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ejcb.2026.151538_bib3","unstructured":"Baranyi U., Winter B., Gugerell A., Hegedus B., Brostjan C., Laufer G., et al. Primary Human Fibroblasts in Culture Switch to a Myofibroblast-Like Phenotype Independently of TGF Beta.(n.d)."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051203","article-title":"Mesenchymal stromal cell secretome for post-covid-19 pulmonary fibrosis: a new therapy to treat the long-term lung sequelae?","volume":"10","author":"Bari","year":"2021","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051272","article-title":"Secretome of mesenchymal stromal cells prevents myofibroblasts differentiation by transferring fibrosis-associated microRNAs within extracellular vesicles","volume":"9","author":"Basalova","year":"2020","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.ejcb.2026.151538_bib6","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/s41590-023-01551-9","article-title":"Immunology of human fibrosis","volume":"24","author":"Bhattacharya","year":"2023","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151538_bib7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-016-0559-z","article-title":"The IL-1 cytokine family and its role in inflammation and fibrosis in the lung","volume":"38","author":"Borthwick","year":"2016","journal-title":"Semin Immunopathol."},{"issue":"16","key":"10.1016\/j.ejcb.2026.151538_bib8","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3390\/cells13161334","article-title":"Cancer-Associated-Fibroblast-Mediated Paracrine and Autocrine SDF-1\/CXCR4 Signaling Promotes Stemness and Aggressiveness of Colorectal Cancers","volume":"13","author":"Chen","year":"2024","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-024-03678-4","article-title":"Human umbilical cord\/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro","volume":"15","author":"Choi","year":"2024","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib10","article-title":"Anti-fibrogenic effect of umbilical cord\u2013derived mesenchymal stem cell\u2013conditioned media in human esophageal fibroblasts","volume":"14","author":"Choi","year":"2024","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.ejcb.2026.151538_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22147575","article-title":"Tgf-\u03b2 signaling: From tissue fibrosis to tumor microenvironment","volume":"22","author":"Chung","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.ejcb.2026.151538_bib12","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1128\/MCB.01026-14","article-title":"ALK5 and ALK1 Play Antagonistic Roles in Transforming Growth Factor \u03b2-Induced Podosome Formation in Aortic Endothelial Cells","volume":"34","author":"Curado","year":"2014","journal-title":"Mol. Cell Biol."},{"issue":"25","key":"10.1016\/j.ejcb.2026.151538_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/app.52412","article-title":"Modulus and adhesion of Sylgard 184, Solaris, and Ecoflex 00-30 silicone elastomers with varied mixing ratios","volume":"139","author":"Darby","year":"2022","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.ejcb.2026.151538_bib14","first-page":"301","article-title":"Fibroblasts and myofibroblasts in wound healing","volume":"7","author":"Darby","year":"2014","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"8","key":"10.1016\/j.ejcb.2026.151538_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901682","article-title":"Engineered Biomaterial Platforms to Study Fibrosis","volume":"9","author":"Davidson","year":"2020","journal-title":"Adv. Health Mater."},{"issue":"12","key":"10.1016\/j.ejcb.2026.151538_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41584-019-0322-7","article-title":"Shared and distinct mechanisms of fibrosis","volume":"15","author":"Distler","year":"2019","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.ejcb.2026.151538_bib17","article-title":"Human platelet lysate (hPL) alters the lineage commitment and paracrine functions of human mesenchymal stem cells via mitochondrial metabolism","volume":"26","author":"Du","year":"2022","journal-title":"Appl. Mater. Today"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67175-3","article-title":"Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts","volume":"10","author":"El-Hattab","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151538_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/jcm5030037","article-title":"New Insights into the Crossroads between EMT and Stemness in the Context of Cancer","volume":"5","author":"Fabregat","year":"2016","journal-title":"J. Clin. Med"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/med.21596","article-title":"Small molecule inhibitors of epithelial-mesenchymal transition for the treatment of cancer and fibrosis","volume":"40","author":"Feng","year":"2020","journal-title":"Med Res Rev."},{"issue":"9","key":"10.1016\/j.ejcb.2026.151538_bib21","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/ijms23094570","article-title":"Anti-Inflammatory and Anti-Fibrotic Effect of Immortalized Mesenchymal-Stem-Cell-Derived Conditioned Medium on Human Lung Myofibroblasts and Epithelial Cells","volume":"23","author":"Filidou","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"ember 2019","key":"10.1016\/j.ejcb.2026.151538_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.semcdb.2019.11.013","article-title":"Non-canonical (non-SMAD2\/3) TGF-\u03b2 signaling in fibrosis: Mechanisms and targets","volume":"101","author":"Finnson","year":"2020","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.ejcb.2026.151538_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yjmcc.2015.12.024","article-title":"The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction","volume":"91","author":"Francis Stuart","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151538_bib24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.carpath.2010.10.001","article-title":"Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices","volume":"20","author":"Galie","year":"2011","journal-title":"Cardiovasc Pathol."},{"issue":"40","key":"10.1016\/j.ejcb.2026.151538_bib25","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1038\/onc.2016.57","article-title":"Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen \u03b11(VI)","volume":"35","author":"Garc\u00eda-Palmero","year":"2016","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.ejcb.2026.151538_bib26","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3390\/cancers15041059","article-title":"HIPK2 as a Novel Regulator of Fibrosis","volume":"15","author":"Garufi","year":"2023","journal-title":"Cancers"},{"issue":"19","key":"10.1016\/j.ejcb.2026.151538_bib27","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.218222","article-title":"SRF\u2019ing and SAP\u2019ing - The role of MRTF proteins in cell migration","volume":"131","author":"Gau","year":"2018","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151538_bib28","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.22783","article-title":"PAI-1 in tissue fibrosis","volume":"227","author":"Ghosh","year":"2012","journal-title":"J. Cell Physiol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41578-019-0169-1","article-title":"The stiffness of living tissues and its implications for tissue engineering","volume":"5","author":"Guimar\u00e3es","year":"2020","journal-title":"Nat. Rev. Mater."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050467","article-title":"Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome","volume":"8","author":"Harrell","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ajur.2015.04.005","article-title":"Current trends in urethral stricture management","volume":"1","author":"Hillary","year":"2014","journal-title":"Asian J. Urol."},{"key":"10.1016\/j.ejcb.2026.151538_bib32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-\u03b21: Tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejcb.2026.151538_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exer.2015.07.009","article-title":"Myofibroblasts","volume":"142","author":"Hinz","year":"2015","journal-title":"Exp. Eye Res"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/iju.15053","article-title":"Myofibroblast-dominant proliferation associated with severe fibrosis in abulbar urethral strictures","volume":"30","author":"Hirano","year":"2023","journal-title":"Int J. Urol."},{"issue":"9","key":"10.1016\/j.ejcb.2026.151538_bib35","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/s41401-023-01070-1","article-title":"Targeted VEGFA therapy in regulating early acute kidney injury and late fibrosis","volume":"44","author":"Huang","year":"2023","journal-title":"Acta Pharm. Sin."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151538_bib36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1165\/rcmb.2012-0050OC","article-title":"Matrix Stiffness\u2013Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction","volume":"47","author":"Huang","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"10","key":"10.1016\/j.ejcb.2026.151538_bib37","doi-asserted-by":"crossref","first-page":"7184","DOI":"10.1007\/s12035-015-9585-4","article-title":"Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro","volume":"53","author":"Iser","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1165\/rcmb.2019-0092OC","article-title":"Impaired Myofibroblast Dedifferentiation Contributes to Nonresolving Fibrosis in Aging","volume":"62","author":"Kato","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41536-019-0070-y","article-title":"Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential","volume":"4","author":"Kehl","year":"2019","journal-title":"Npj Regen. Med"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1165\/rcmb.2016-0217OC","article-title":"A novel antifibrotic mechanism of nintedanib and pirfenidone inhibition of collagen fibril assembly","volume":"57","author":"Knuppel","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.ejcb.2026.151538_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.job.2012.02.003","article-title":"Role of Smad phosphatases in BMP-Smad signaling axis-induced osteoblast differentiation","volume":"54","author":"Kokabu","year":"2012","journal-title":"J. Oral. Biosci."},{"issue":"4","key":"10.1016\/j.ejcb.2026.151538_bib42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/JME-18-0078","article-title":"ADSC-conditioned media elicit an ex vivo anti-inflammatory macrophage response","volume":"61","author":"Kruger","year":"2018","journal-title":"J. Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.ejcb.2026.151538_bib43","article-title":"Shear stress alterations activate BMP4\/pSMAD5 signaling and induce endothelial mesenchymal transition in varicose veins","volume":"10","author":"Latha","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.ejcb.2026.151538_bib44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12272-019-01153-w","article-title":"Targeting ROCK\/LIMK\/cofilin signaling pathway in cancer","volume":"42","author":"Lee","year":"2019","journal-title":"Arch. Pharm. Res"},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib45","doi-asserted-by":"crossref","first-page":"775","DOI":"10.5851\/kosfa.2022.e46","article-title":"Review of the Current Research on Fetal Bovine Serum and the Development of Cultured Meat","volume":"42","author":"Lee","year":"2022","journal-title":"Food Sci. Anim. Resour."},{"issue":"3","key":"10.1016\/j.ejcb.2026.151538_bib46","article-title":"Foetal bovine serum influence on in vitro extracellular vesicle analyses","volume":"10","author":"Lehrich","year":"2021","journal-title":"J. Extra Vesicles"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-016-0328-5","article-title":"Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis","volume":"17","author":"Lehtonen","year":"2016","journal-title":"Respir. Res"},{"issue":"4","key":"10.1016\/j.ejcb.2026.151538_bib48","doi-asserted-by":"crossref","first-page":"8515","DOI":"10.1080\/21655979.2022.2051838","article-title":"Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-\u03b22 and Notch-1 expression","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"issue":"3","key":"10.1016\/j.ejcb.2026.151538_bib49","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10529-014-1710-3","article-title":"Conditioned medium from mesenchymal stem cells enhances the migration of hepatoma cells through CXCR4 up-regulation and F-actin remodeling","volume":"37","author":"Li","year":"2015","journal-title":"Biotechnol. Lett."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/ijms21010049","article-title":"Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cell Culture Prevents UVB-Induced Skin Aging in Human Keratinocytes and Dermal Fibroblasts","volume":"21","author":"Li","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s10020-024-00961-1","article-title":"Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases","volume":"30","author":"Lin","year":"2024","journal-title":"Mol. Med"},{"issue":"S1","key":"10.1016\/j.ejcb.2026.151538_bib52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1755-1536-5-S1-S24","article-title":"CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis","volume":"5","author":"Lipson","year":"2012","journal-title":"Fibrogenes. Tissue Repair"},{"issue":"4","key":"10.1016\/j.ejcb.2026.151538_bib53","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00604-2022","article-title":"Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone","volume":"61","author":"Ma","year":"2023","journal-title":"Eur. Respir. J."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151538_bib54","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/MOU.0b013e32833ee8d5","article-title":"Management of anterior urethral stricture: an evidence-based approach","volume":"20","author":"Mangera","year":"2010","journal-title":"Curr. Opin. Urol."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib55","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1038\/s41598-018-24671-x","article-title":"Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterisation of soft biomaterials","volume":"8","author":"Megone","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151538_bib56","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: The master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"11","key":"10.1016\/j.ejcb.2026.151538_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116040","article-title":"Mrtf: Basic biology and role in kidney disease","volume":"22","author":"Miranda","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151538_bib58","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cytogfr.2013.08.002","article-title":"ALK1-Smad1\/5 signaling pathway in fibrosis development: Friend or foe?","volume":"24","author":"Mu\u00f1oz-F\u00e9lix","year":"2013","journal-title":"Cytokine Growth Factor Rev."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib59","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3390\/ijms22052565","article-title":"A Simple Method for In-Depth Proteome Analysis of Mammalian Cell Culture Conditioned Media Containing Fetal Bovine Serum","volume":"22","author":"Nakamura","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151538_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.104069","article-title":"Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem\/stromal cells and dermal fibroblasts","volume":"232","author":"Niada","year":"2021","journal-title":"J. Proteom."},{"key":"10.1016\/j.ejcb.2026.151538_bib61","article-title":"Anti-fibrotic effect of adipose-derived mesenchymal stem cell conditioned medium in muscle fibrosis","volume":"25","author":"Oki","year":"2021","journal-title":"Eur. Rev. Med Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib62","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbrc.2016.12.107","article-title":"Substrate stiffness promotes latent TGF-\u03b21 activation in hepatocellular carcinoma","volume":"483","author":"Pang","year":"2017","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.ejcb.2026.151538_bib63","first-page":"227","article-title":"Imbalance in extracellular matrix degradation in urethral stricture","volume":"10","author":"Prihadi","year":"2018","journal-title":"Res Rep. Urol."},{"issue":"5","key":"10.1016\/j.ejcb.2026.151538_bib64","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1042\/EBC20190015","article-title":"Actin dynamics in cell migration","volume":"63","author":"Schaks","year":"2019","journal-title":"Essays Biochem"},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib65","article-title":"Comparative analysis of differentially secreted proteins in serum-free and serum-containing media by using BONCAT and pulsed SILAC","volume":"9","author":"Shin","year":"2019","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.ejcb.2026.151538_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21165875","article-title":"The new model of snail expression regulation: The role of mrtfs in fast and slow endothelial\u2013mesenchymal transition","volume":"21","author":"Sobierajska","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejcb.2026.151538_bib67","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/biom11060878","article-title":"Adipose-derived stem cells secretome and its potential application in \u201cstem cell-free therapy","volume":"11","author":"Trzyna","year":"2021","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.ejcb.2026.151538_bib68","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/biom11060878","article-title":"Adipose-derived stem cells secretome and its potential application in \u201cstem cell-free therapy","volume":"11","author":"Trzyna","year":"2021","journal-title":"Biomolecules"},{"issue":"19","key":"10.1016\/j.ejcb.2026.151538_bib69","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.3390\/cancers13194985","article-title":"Vimentin Is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis","volume":"13","author":"Usman","year":"2021","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.ejcb.2026.151538_bib70","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.devcel.2014.10.005","article-title":"SRF regulates craniofacial development through selective recruitment of MRTF cofactors by PDGF signaling","volume":"31","author":"Vasudevan","year":"2014","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.ejcb.2026.151538_bib71","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3390\/bioengineering10090998","article-title":"Substrate stiffness modulates TGF-\u03b2 activation and ECM-associated gene expression in fibroblasts","volume":"10","author":"Verma","year":"2023","journal-title":"Bioengineering"},{"issue":"12","key":"10.1016\/j.ejcb.2026.151538_bib72","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/s41551-021-00709-w","article-title":"Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts","volume":"5","author":"Walker","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.ejcb.2026.151538_bib73","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13287-024-03749-6","article-title":"Insights into the role of adipose-derived stem cells and secretome: potential biology and clinical applications in hypertrophic scarring","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell Res Ther."},{"issue":"7","key":"10.1016\/j.ejcb.2026.151538_bib74","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/carcin\/20.7.1185","article-title":"A human prostatic stromal myofibroblast cell line WPMY-1: A model for stromal-epithelial interactions in prostatic neoplasia","volume":"20","author":"Webber","year":"1999","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.ejcb.2026.151538_bib75","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.21037\/gs-21-4","article-title":"The effect of inhibiting exosomes derived from adipose-derived stem cells via the TGF-\u03b21\/Smad pathway on the fibrosis of keloid fibroblasts","volume":"10","author":"Wu","year":"2021","journal-title":"Gland Surg."},{"key":"10.1016\/j.ejcb.2026.151538_bib76","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.reth.2022.03.009","article-title":"Effects of conditioned medium obtained from human adipose-derived stem cells on skin inflammation","volume":"20","author":"Yano","year":"2022","journal-title":"Regen. Ther."},{"key":"10.1016\/j.ejcb.2026.151538_bib77","doi-asserted-by":"crossref","DOI":"10.1097\/BCR.0000000000000558","article-title":"The effects of adipose stem cell\u2013conditioned media on fibrogenesis of dermal fibroblasts stimulated by transforming growth factor-\u03b21","author":"Yuan","year":"2017","journal-title":"J. Burn Care Res"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:26:18Z","timestamp":1786541178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933526000099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0171933526000099"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151538","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human adipose stem cell conditioned medium has a pro-fibrotic and EMT-stimulating effect on urethral fibroblasts in vitro","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151538","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151538"}}