{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:42:55Z","timestamp":1786542175416,"version":"build-2736575974"},"reference-count":106,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Cell Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejcb.2026.151539","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:42:22Z","timestamp":1776408142000},"page":"151539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting the Danio rerio model and bioinformatics to explore the effects and molecular networks of Parkinson\u2019s disease drugs in human melanoma"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-1120","authenticated-orcid":false,"given":"Danuta","family":"Krasowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Mordzi\u0144ska-Rak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Odrzywolski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"B\u0142aszczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Ma\u0142ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Kurzepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Boguszewska-Czubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejcb.2026.151539_bib1","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-22-0273","article-title":"Trabectedin impairs invasiveness and metastasis in adrenocortical carcinoma preclinical models","volume":"30","author":"Abate","year":"2023","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ejcb.2026.151539_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/srep29490","article-title":"A crystal-clear zebrafish for in vivo imaging","volume":"6","author":"Antinucci","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejcb.2026.151539_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000097851","article-title":"Mortality due to amyotrophic lateral sclerosis and Parkinson\u2019s disease among melanoma patients","volume":"28","author":"Baade","year":"2007","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.ejcb.2026.151539_bib4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/87895","article-title":"The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor\/vascular endothelial growth factor","volume":"7","author":"Basu","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejcb.2026.151539_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413417","article-title":"Zebrafish embryos and larvae as alternative animal models for toxicity testing","volume":"22","author":"Bauer","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151539_bib6","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1042\/BST20201058","article-title":"Protein-fragment complementation assays for large-scale analysis of protein-protein interactions","volume":"49","author":"Blaszczak","year":"2021","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejcb.2026.151539_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022991","article-title":"Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling","volume":"6","author":"Bohnsack","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejcb.2026.151539_bib8","first-page":"385","article-title":"Parkinson\u2019s disease and melanoma: co-occurrence and mechanisms","volume":"8","author":"Bose","year":"2018","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.ejcb.2026.151539_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00314331","article-title":"Amantadine sulphate in treating Parkinson\u2019s disease: clinical effects, psychometric tests and serum concentrations","volume":"236","author":"Brenner","year":"1989","journal-title":"J. Neurol."},{"key":"10.1016\/j.ejcb.2026.151539_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1124\/jpet.118.247650","article-title":"Pharmacokinetic\/pharmacodynamic correlation analysis of amantadine for levodopa-induced dyskinesia","volume":"367","author":"Brigham","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejcb.2026.151539_bib11","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/mds.24998","article-title":"Are high doses of carbidopa a concern? A randomized, clinical trial in Parkinson\u2019s disease: high-dose carbidopa","volume":"27","author":"Brod","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ejcb.2026.151539_bib12","first-page":"84","article-title":"Rapamycin, autophagy, and Alzheimer\u2019s disease","volume":"1","author":"Cai","year":"2013","journal-title":"J. Biochem. Pharmacol. Res."},{"key":"10.1016\/j.ejcb.2026.151539_bib13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bcp.2014.11.012","article-title":"DJ-1 as a human oncogene and potential therapeutic target","volume":"93","author":"Cao","year":"2015","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.ejcb.2026.151539_bib14","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1158\/1535-7163.MCT-12-1226-T","article-title":"Metformin blocks melanoma invasion and metastasis development in AMPK\/p53-dependent manner","volume":"12","author":"Cerezo","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ejcb.2026.151539_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41389-020-0236-x","article-title":"Carbidopa suppresses prostate cancer via aryl hydrocarbon receptor-mediated ubiquitination and degradation of androgen receptor","volume":"9","author":"Chen","year":"2020","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ejcb.2026.151539_bib16","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1080\/15548627.2020.1755119","article-title":"1-phenyl 2-thiourea (PTU) activates autophagy in zebrafish embryos","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.ejcb.2026.151539_bib17","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1007\/s10637-022-01289-5","article-title":"Carbidopa suppresses estrogen receptor-positive breast cancer via AhR-mediated proteasomal degradation of ER\u03b1","volume":"40","author":"Chen","year":"2022","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.ejcb.2026.151539_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.mcn.2010.03.007","article-title":"Cooperative regulation of neurotransmitter release by Rab3a and synapsin II","volume":"44","author":"Coleman","year":"2010","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejcb.2026.151539_bib19","doi-asserted-by":"crossref","first-page":"e2021161S","DOI":"10.5826\/dpc.11S1a161S","article-title":"Epidemiology and risk factors of melanoma: a review","volume":"11","author":"Conforti","year":"2021","journal-title":"Dermatol. Pract. Concept"},{"key":"10.1016\/j.ejcb.2026.151539_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejcb.2026.151539_bib21","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.mayocp.2017.03.014","article-title":"Parkinson disease and melanoma: confirming and reexamining an association","volume":"92","author":"Dalvin","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ejcb.2026.151539_bib22","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/mds.28655","article-title":"Linking Parkinson\u2019s disease and melanoma: Interplay between \u03b1-synuclein and Pmel17 amyloid formation","volume":"36","author":"Dean","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ejcb.2026.151539_bib23","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1158\/1055-9965.EPI-07-0038","article-title":"A prospective cohort study of cancer incidence following the diagnosis of Parkinson\u2019s disease","volume":"16","author":"Driver","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.ejcb.2026.151539_bib24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/biom9090409","article-title":"Carbidopa alters tryptophan metabolism in breast cancer and melanoma cells leading to the formation of indole-3-acetonitrile, a pro-proliferative metabolite","volume":"9","author":"Duarte","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejcb.2026.151539_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12920-016-0164-y","article-title":"Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease","volume":"9","author":"Dumitriu","year":"2016","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.ejcb.2026.151539_bib26","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1096\/fj.02-0736com","article-title":"Tyrosinase: a developmentally specific major determinant of peripheral dopamine","volume":"17","author":"Eisenhofer","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.ejcb.2026.151539_bib27","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s12031-014-0425-1","article-title":"The melanocortin 1 receptor (Mc1r) variants do not account for the co-occurrence of Parkinson\u2019s disease and malignant melanoma","volume":"54","author":"Elincx-Benizri","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejcb.2026.151539_bib28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1353-8020(03)00040-3","article-title":"Malignant melanoma and levodopa in Parkinson\u2019s disease: causality or coincidence?","volume":"9","author":"Fiala","year":"2003","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.ejcb.2026.151539_bib29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00702-020-02142-w","article-title":"The discovery and development of rasagiline as a new anti-Parkinson medication","volume":"127","author":"Finberg","year":"2020","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejcb.2026.151539_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41419-023-06291-0","article-title":"Zebrafish xenograft as a tool for the study of colorectal cancer: a review","volume":"15","author":"Fontana","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejcb.2026.151539_bib31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ana.24419","article-title":"Nonsynonymous variants in MC1R are rare in Chinese Parkinson disease cases: Letters\/Replies","volume":"78","author":"Foo","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejcb.2026.151539_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000087447","article-title":"Amyotrophic lateral sclerosis mortality in 1.9 million US cancer survivors","volume":"25","author":"Freedman","year":"2005","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.ejcb.2026.151539_bib33","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1038\/s41467-018-07012-4","article-title":"Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau","volume":"9","author":"Freilich","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2026.151539_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/biology10040252","article-title":"The Zebrafish xenograft models for investigating cancer and cancer therapeutics","volume":"10","author":"Gamble","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.ejcb.2026.151539_bib35","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1212\/WNL.0b013e3181bd13a1","article-title":"Family history of melanoma and Parkinson disease risk","volume":"73","author":"Gao","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.ejcb.2026.151539_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100628","article-title":"The hyperproliferation mechanism of cholesteatoma based on proteomics: SNCA promotes autophagy-mediated cell proliferation through the PI3K\/AKT\/CyclinD1 signaling pathway","volume":"22","author":"Gao","year":"2023","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.ejcb.2026.151539_bib37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejca.2022.04.018","article-title":"European consensus-based interdisciplinary guideline for melanoma. Part 2: treatment - Update 2022","volume":"170","author":"Garbe","year":"2022","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejcb.2026.151539_bib38","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1016\/j.bmcl.2009.05.002","article-title":"Oxidation of carbidopa by tyrosinase and its effect on murine melanoma","volume":"19","author":"Gasowska-Bajger","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejcb.2026.151539_bib39","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejcb.2026.151539_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuae011","article-title":"Diving into drug-screening: zebrafish embryos as an in vivo platform for antimicrobial drug discovery and assessment","volume":"48","author":"Habjan","year":"2024","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ejcb.2026.151539_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40035-015-0044-y","article-title":"The association between Parkinson\u2019s disease and melanoma: a systematic review and meta-analysis","volume":"4","author":"Huang","year":"2015","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.ejcb.2026.151539_bib42","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/ana.24802","article-title":"Cutaneous malignant melanoma and Parkinson disease: common pathways?","volume":"80","author":"Inzelberg","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejcb.2026.151539_bib43","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tips.2013.04.007","article-title":"Targeting protein-protein interactions as an anticancer strategy","volume":"34","author":"Ivanov","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejcb.2026.151539_bib44","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/pds.5422","article-title":"The risk of melanoma with rasagiline compared with other antiparkinsonian medications: a retrospective cohort study in the United States medicare database","volume":"31","author":"Johannes","year":"2022","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.ejcb.2026.151539_bib45","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2021.39.15_suppl.e21558","article-title":"Transcriptomic profiling of peripheral blood mononuclear cells in patients with multiple primary melanoma","volume":"39","author":"Karapetyan","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejcb.2026.151539_bib46","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1042\/BCJ20210851","article-title":"Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth","volume":"479","author":"Korac","year":"2022","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejcb.2026.151539_bib47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/mds.29260","article-title":"Melanin and neuromelanin: Linking skin pigmentation and Parkinson\u2019s disease","volume":"38","author":"Krainc","year":"2023","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ejcb.2026.151539_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23147653","article-title":"Anticancer activity of amantadine and evaluation of its interactions with selected cytostatics in relation to human melanoma cells","volume":"23","author":"Krasowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151539_bib49","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.3390\/cancers15235541","article-title":"Melanin\u2014the \u00c9minence grise of melanoma and Parkinson\u2019s disease development","volume":"15","author":"Krasowska","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.ejcb.2026.151539_bib50","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/cancers14010108","article-title":"BRCA1 and metastasis: outcome of defective DNA repair","volume":"14","author":"Krishnan","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ejcb.2026.151539_bib51","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3892\/ijmm.2015.2289","article-title":"Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro","volume":"36","author":"Lan","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejcb.2026.151539_bib52","first-page":"467","article-title":"Rasagiline \u2013 a novel MAO B inhibitor in Parkinson\u2019s disease therapy","volume":"3","author":"Lecht","year":"2007","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.ejcb.2026.151539_bib53","first-page":"467","article-title":"Rasagiline - a novel MAO B inhibitor in Parkinson\u2019s disease therapy","volume":"3","author":"Lecht","year":"2007","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.ejcb.2026.151539_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2147\/CIA.S4145","article-title":"The role of rasagiline in the treatment of Parkinson\u2019s disease","author":"Leegwater-Kim","year":"2010","journal-title":"CIA"},{"key":"10.1016\/j.ejcb.2026.151539_bib55","series-title":"StatPearls","article-title":"Carbidopa","author":"Leyden","year":"2024"},{"key":"10.1016\/j.ejcb.2026.151539_bib56","doi-asserted-by":"crossref","first-page":"14356","DOI":"10.1038\/ncomms14356","article-title":"The OncoPPi network of cancer-focused protein\u2013protein interactions to inform biological insights and therapeutic strategies","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2026.151539_bib57","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12964-025-02071-9","article-title":"\u03922 integrin regulates neutrophil trans endothelial migration following traumatic brain injury","volume":"23","author":"Li","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.ejcb.2026.151539_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.571747","article-title":"Pharmacokinetics and bioequivalence of rasagiline tablets in Chinese healthy subjects under fasting and fed conditions: an open, randomized, single-dose, double-cycle, two-sequence, crossover trial","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharm."},{"key":"10.1016\/j.ejcb.2026.151539_bib59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3892\/ol.2012.986","article-title":"Rapamycin induces autophagy in the melanoma cell line M14 via regulation of the expression levels of Bcl-2 and Bax","volume":"5","author":"Li","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejcb.2026.151539_bib60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13195-023-01372-w","article-title":"Unraveling the intercellular communication disruption and key pathways in Alzheimer\u2019s disease: an integrative study of single-nucleus transcriptomes and genetic association","volume":"16","author":"Liu","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.ejcb.2026.151539_bib61","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1212\/WNL.0b013e31821e554e","article-title":"Meta-analysis of the relationship between Parkinson disease and melanoma","volume":"76","author":"Liu","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.ejcb.2026.151539_bib62","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(23)00821-8","article-title":"Cutaneous melanoma","volume":"402","author":"Long","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ejcb.2026.151539_bib63","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41419-024-07228-x","article-title":"Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest","volume":"15","author":"Luo","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejcb.2026.151539_bib64","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tins.2006.03.006","article-title":"LRRK2 in Parkinson\u2019s disease: protein domains and functional insights","volume":"29","author":"Mata","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejcb.2026.151539_bib65","series-title":"Epidemiology of Melanoma","author":"Matthews","year":"2017"},{"key":"10.1016\/j.ejcb.2026.151539_bib66","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/15569527.2012.676119","article-title":"Comparison of oral and transdermal administration of rasagiline mesylate on human melanoma tumor growth in vivo","volume":"31","author":"Meier-Davis","year":"2012","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.ejcb.2026.151539_bib67","first-page":"23","article-title":"Rasagiline in treatment of Parkinson\u2019s disease","volume":"4","author":"Nayak","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.ejcb.2026.151539_bib68","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.parkreldis.2008.08.005","article-title":"Plasma amantadine concentrations in patients with Parkinson\u2019s disease","volume":"15","author":"Nishikawa","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.ejcb.2026.151539_bib69","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/humu.21277","article-title":"Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update","volume":"31","author":"Nuytemans","year":"2010","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ejcb.2026.151539_bib70","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1208\/s12248-012-9439-1","article-title":"Pharmacokinetics of levodopa, carbidopa, and 3-O-methyldopa following 16-hour jejunal infusion of levodopa-carbidopa intestinal gel in advanced Parkinson\u2019s disease patients","volume":"15","author":"Nyholm","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.ejcb.2026.151539_bib71","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.bjc.6602279","article-title":"Atypical cancer pattern in patients with Parkinson\u2019s disease","volume":"92","author":"Olsen","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejcb.2026.151539_bib72","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/ijc.25912","article-title":"The association between Parkinson\u2019s disease and melanoma: association between PD and Melanoma","volume":"128","author":"Pan","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejcb.2026.151539_bib73","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3390\/biom11101508","article-title":"Mitochondrial dysfunction, protein misfolding and neuroinflammation in Parkinson\u2019s disease: roads to biomarker discovery","volume":"11","author":"Picca","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejcb.2026.151539_bib74","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng0498-345","article-title":"Vertebrate genome evolution and the zebrafish gene map","volume":"18","author":"Postlethwait","year":"1998","journal-title":"Nat. Genet"},{"key":"10.1016\/j.ejcb.2026.151539_bib75","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41467-021-21421-y","article-title":"Innate immune evasion revealed in a colorectal zebrafish xenograft model","volume":"12","author":"P\u00f3voa","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejcb.2026.151539_bib76","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.6900","article-title":"Uncovering potential diagnostic and pathophysiological roles of \u03b1-synuclein and DJ-1 in melanoma","volume":"13","author":"Quesnel","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.ejcb.2026.151539_bib77","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s40478-020-01062-w","article-title":"PINK1\/PARKIN signalling in neurodegeneration and neuroinflammation","volume":"8","author":"Quinn","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ejcb.2026.151539_bib78","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(21)00249-0","article-title":"Amantadine in the treatment of Parkinson\u2019s disease and other movement disorders","volume":"20","author":"Rascol","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejcb.2026.151539_bib79","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3389\/fendo.2018.00400","article-title":"The therapeutic potential of metformin in neurodegenerative diseases","volume":"9","author":"Rotermund","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejcb.2026.151539_bib80","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/ijc.27443","article-title":"Malignant melanoma, breast cancer and other cancers in patients with Parkinson\u2019s disease","volume":"131","author":"Rugbjerg","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejcb.2026.151539_bib81","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s13671-020-00311-4","article-title":"Epidemiologic burden of skin cancer in the US and Worldwide","volume":"9","author":"Rundle","year":"2020","journal-title":"Curr. Dermatol. Rep."},{"key":"10.1016\/j.ejcb.2026.151539_bib82","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1042\/BCJ20170728","article-title":"Carbidopa: a selective Ah receptor modulator (SAhRM)","volume":"474","author":"Safe","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejcb.2026.151539_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/medsci9040063","article-title":"Epidemiology of Melanoma","volume":"9","author":"Saginala","year":"2021","journal-title":"Med Sci."},{"key":"10.1016\/j.ejcb.2026.151539_bib84","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0933-3657(02)00087-8","article-title":"A multiple classifier system for early melanoma diagnosis","volume":"27","author":"Sboner","year":"2003","journal-title":"Artif. Intell. Med."},{"key":"10.1016\/j.ejcb.2026.151539_bib85","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100844118","article-title":"Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2","volume":"118","author":"Schmidt","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejcb.2026.151539_bib86","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13054-020-02915-5","article-title":"Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics","volume":"24","author":"Schulz","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.ejcb.2026.151539_bib87","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/WNF.0000000000000345","article-title":"Subcutaneous administration of carbidopa enhances oral levodopa pharmacokinetics: a series of studies conducted in pigs, mice, and healthy volunteers: a series of studies conducted in pigs, mice, and healthy volunteers","volume":"42","author":"Shaltiel-Karyo","year":"2019","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.ejcb.2026.151539_bib88","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejcb.2026.151539_bib89","first-page":"556","article-title":"Multiple primary melanoma following administration of levodopa","volume":"93","author":"Skibba","year":"1972","journal-title":"Arch. Pathol."},{"key":"10.1016\/j.ejcb.2026.151539_bib90","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/exd.12618","article-title":"The role of melanin pigment in melanoma","volume":"24","author":"Slominski","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.ejcb.2026.151539_bib91","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nn1776","article-title":"Kinase activity of mutant LRRK2 mediates neuronal toxicity","volume":"9","author":"Smith","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejcb.2026.151539_bib92","series-title":"Cancer Biomarkers: Methods and Protocols","first-page":"45","article-title":"Zebrafish Xenograft Model to Study Human Cancer","author":"Somasagara","year":"2022"},{"key":"10.1016\/j.ejcb.2026.151539_bib93","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1080\/14786419.2021.2012672","article-title":"Evaluation of anti-cancer effect of zerumbone and cisplatin on N-nitrosodiethylamine induced hepatic cancer in freshwater fish (Danio rerio)","volume":"36","author":"Srimathi Devi","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.ejcb.2026.151539_bib94","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.3390\/ijms25073899","article-title":"Association between Parkinson\u2019s disease and cancer: new findings and possible mediators","volume":"25","author":"Surguchov","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151539_bib95","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70386","article-title":"Melanoma metabolism: molecular mechanisms and therapeutic implications in cutaneous oncology","volume":"13","author":"Tan","year":"2024","journal-title":"Cancer Med."},{"key":"10.1016\/j.ejcb.2026.151539_bib96","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1124\/mol.120.119909","article-title":"Inhibition of brain epidermal growth factor receptor activation: a novel target in neurodegenerative diseases and brain injuries","volume":"98","author":"Tavassoly","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejcb.2026.151539_bib97","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/ana.24373","article-title":"The MC1R melanoma risk variant p.R160W is associated with Parkinson disease: MC1Rp.R160W","volume":"77","author":"Tell-Marti","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejcb.2026.151539_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106571","article-title":"Clinical characteristics and pathophysiological properties of newly discovered LRRK2 variants associated with Parkinson\u2019s disease","volume":"199","author":"Tezuka","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejcb.2026.151539_bib99","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/ijms25010010","article-title":"B-cell receptor signaling and beyond: The role of ig\u03b1 (CD79a)\/Ig\u03b2 (CD79b) in normal and malignant B cells","volume":"25","author":"Tkachenko","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejcb.2026.151539_bib100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41531-025-00928-x","article-title":"Linking Parkinson\u2019s disease and melanoma: the impact of copper-driven cuproptosis and related mechanisms","volume":"11","author":"Wang","year":"2025","journal-title":"NPJ Park. Dis."},{"key":"10.1016\/j.ejcb.2026.151539_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23541","article-title":"Serpin family H member 1 and its related collagen gene network are the potential prognostic biomarkers and anticancer targets for glioma","volume":"38","author":"Wang","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejcb.2026.151539_bib102","doi-asserted-by":"crossref","first-page":"357","DOI":"10.20517\/2394-4722.2016.08","article-title":"Function of cancer cell-derived extracellular matrix in tumor progression","volume":"2","author":"Xiong","year":"2016","journal-title":"J. Cancer Metastas. Treat."},{"key":"10.1016\/j.ejcb.2026.151539_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.581615","article-title":"FCGR1A serves as a novel biomarker and correlates with immune infiltration in four cancer types","volume":"7","author":"Xu","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejcb.2026.151539_bib104","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnagi.2020.00060","article-title":"Association between Parkinson\u2019s disease and melanoma: putting the pieces together","volume":"12","author":"Ye","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejcb.2026.151539_bib105","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3390\/biom13040612","article-title":"LRRK2 structure-based activation mechanism and pathogenesis","volume":"13","author":"Zhang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejcb.2026.151539_bib106","article-title":"Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson\u2019s disease","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Genet"}],"container-title":["European Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171933526000105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:24:35Z","timestamp":1786541075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171933526000105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":106,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0171933526000105"],"URL":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151539","relation":{},"ISSN":["0171-9335"],"issn-type":[{"value":"0171-9335","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploiting the Danio rerio model and bioinformatics to explore the effects and molecular networks of Parkinson\u2019s disease drugs in human melanoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejcb.2026.151539","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151539"}}